All Outputs (273)

Assessing the androgenic and metabolic heterogeneity in polycystic ovary syndrome using cluster analysis (2022)
Journal Article
Deshmukh, H., Akbar, S., Bhaiji, A., Saeed, Y., Shah, N., Adeleke, K., …Sathyapalan, T. (2023). Assessing the androgenic and metabolic heterogeneity in polycystic ovary syndrome using cluster analysis. Clinical Endocrinology, 98(3), 400-406. https://doi.org/10.1111/cen.14847

Introduction: Some but not all women with polycystic ovary syndrome (PCOS) develop the metabolic syndrome (MS). The objective of this study was to determine if a subset of women with PCOS had higher androgen levels predisposing them to MS and whether... Read More about Assessing the androgenic and metabolic heterogeneity in polycystic ovary syndrome using cluster analysis.

Renal Effects of Empagliflozin in Patients with Type 2 Diabetes Mellitus (2022)
Journal Article
Yaribeygi, H., Maleki, M., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2022). Renal Effects of Empagliflozin in Patients with Type 2 Diabetes Mellitus. Current medicinal chemistry, 30(25), 2850-2863. https://doi.org/10.2174/0929867329666220831151645

Type 2 diabetes mellitus (T2DM) is one of the main causes of mortality and morbidity worldwide. It leads to various long-term complications such as diabetic nephropathy. Diabetes nephropathy is the leading cause of renal failure in patients with chro... Read More about Renal Effects of Empagliflozin in Patients with Type 2 Diabetes Mellitus.

The Role of High-density Lipoprotein in Oral and Dental Diseases (2022)
Journal Article
Sadeghalbanaei, L., Shirban, F., Bagherniya, M., Sathyapalan, T., & Sahebkar, A. (2023). The Role of High-density Lipoprotein in Oral and Dental Diseases. Current medicinal chemistry, 30(20), 2226-2246. https://doi.org/10.2174/0929867329666220901120654

High-density lipoprotein (HDL) is the smallest and densest of the lipoproteins. Beyond its well-known cardiovascular protective function, it has other actions, including structural function, anti-inflammatory, antioxidant, anti-thrombotic effects, tr... Read More about The Role of High-density Lipoprotein in Oral and Dental Diseases.

Impact of metformin on the clinical and metabolic parameters of women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials (2022)
Journal Article
Abdalla, M. A., Shah, N., Deshmukh, H., Sahebkar, A., Östlundh, L., Al-Rifai, R. H., …Sathyapalan, T. (2022). Impact of metformin on the clinical and metabolic parameters of women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials. Therapeutic Advances in Endocrinology and Metabolism, 13, https://doi.org/10.1177/20420188221127142

Context: Polycystic ovary syndrome (PCOS) is one of the commonest endocrine disorders affecting women of reproductive age, and metformin is a widely used medication in managing this condition. Aim: To review the available literature comprehensively o... Read More about Impact of metformin on the clinical and metabolic parameters of women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials.

The severity and duration of Hypoglycemia affect platelet-derived protein responses in Caucasians (2022)
Journal Article
Moin, A. S. M., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2022). The severity and duration of Hypoglycemia affect platelet-derived protein responses in Caucasians. Cardiovascular Diabetology, 21(1), Article 202. https://doi.org/10.1186/s12933-022-01639-w

Objective: Severe hypoglycemia is associated with increased cardiovascular death risk, and platelet responses to hypoglycemia (hypo) have been described. However, the impact of deep transient hypo (deep-hypo) versus prolonged milder hypo (mild-hypo)... Read More about The severity and duration of Hypoglycemia affect platelet-derived protein responses in Caucasians.

Components of the Complement Cascade Differ in Polycystic Ovary Syndrome (2022)
Journal Article
Butler, A. E., Moin, A. S. M., Sathyapalan, T., & Atkin, S. L. (2022). Components of the Complement Cascade Differ in Polycystic Ovary Syndrome. International Journal of Molecular Sciences, 23(20), Article 12232. https://doi.org/10.3390/ijms232012232

Complement pathway proteins are reported to be increased in polycystic ovary syndrome (PCOS) and may be affected by obesity and insulin resistance. To investigate this, a proteomic analysis of the complement system was undertaken, including inhibitor... Read More about Components of the Complement Cascade Differ in Polycystic Ovary Syndrome.

Association between Thyroid Hormones and Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis in Obese Individuals Undergoing Bariatric Surgery (2022)
Journal Article
Ganjooei, N. A., Jamialahmadi, T., Nematy, M., Shah, N. Z., Jangjoo, S., Emami, N., Jangjoo, A., Faridnia, R., Alidadi, M., Sathyapalan, T., & Sahebkar, A. (2022). Association between Thyroid Hormones and Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis in Obese Individuals Undergoing Bariatric Surgery. Middle East Journal of Digestive Diseases, 14(4), 410-421. https://doi.org/10.34172/mejdd.2022.302

Background: Non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and hepatic fibrosis have emerged as one of the leading causes of chronic liver disease. The prevalence of the NAFLD spectrum has increased, which can be att... Read More about Association between Thyroid Hormones and Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis in Obese Individuals Undergoing Bariatric Surgery.

Potential Role of SUMO and SUMOylation in the Pathogenesis of Diabetes Mellitus (2022)
Journal Article
Sadeghi, M., Dehnavi, S., Shohan, M., Jamialahmadi, T., Sathyapalan, T., & Sahebkar, A. (2023). Potential Role of SUMO and SUMOylation in the Pathogenesis of Diabetes Mellitus. Current medicinal chemistry, 30(14), 1623-1637. https://doi.org/10.2174/0929867329666220817142848

Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia and associated with multiple organ systems complications. The incidence and prevalence of diabetes are increasing in an epidemic proportion worldwide. In addition to e... Read More about Potential Role of SUMO and SUMOylation in the Pathogenesis of Diabetes Mellitus.

Protective effects of curcumin on ischemia/reperfusion injury (2022)
Journal Article
Mohamadian, M., Parsamanesh, N., Chiti, H., Sathyapalan, T., & Sahebkar, A. (2022). Protective effects of curcumin on ischemia/reperfusion injury. Phytotherapy Research, https://doi.org/10.1002/ptr.7620

Ischemia/reperfusion (I/R) injury is a term used to describe phenomena connected to the dysfunction of various tissue damage due to reperfusion after ischemic injury. While I/R may result in systemic inflammatory response syndrome or multiple organ d... Read More about Protective effects of curcumin on ischemia/reperfusion injury.

The effect of concomitant use of Colony-Stimulating factors on bleomycin pulmonary toxicity – A systematic review and meta-analysis (2022)
Journal Article
Mahdi Seyedzadeh Sani, S., Sahranavard, M., Jannati Yazdanabad, M., Seddigh Shamsi, M., Elyasi, S., Hooshang Mohammadpour, A., …Sahebkar, A. (2022). The effect of concomitant use of Colony-Stimulating factors on bleomycin pulmonary toxicity – A systematic review and meta-analysis. International immunopharmacology, 112, Article 109227. https://doi.org/10.1016/j.intimp.2022.109227

Background: Changes in the incidence of bleomycin pulmonary toxicity (BPT) as a result of adding colony-stimulating factors (CSF) to bleomycin regimens has been investigated in numerous studies. We performed a systematic review and meta-analysis to a... Read More about The effect of concomitant use of Colony-Stimulating factors on bleomycin pulmonary toxicity – A systematic review and meta-analysis.

Probiotics as an adjuvant for management of gastrointestinal cancers through their anti-inflammatory effects: a mechanistic review (2022)
Journal Article
Javid, H., Karimi-Shahri, M., Khorramdel, M., Mashhad, A. S., Tabrizi, A. T., Sathyapalan, T., …Sahebkar, A. (2023). Probiotics as an adjuvant for management of gastrointestinal cancers through their anti-inflammatory effects: a mechanistic review. Current medicinal chemistry, 30(4), 390-406. https://doi.org/10.2174/0929867329666220511185745

The immune system's role in maintaining the health of the gastrointestinal (GI) system is like a double-edged sword. Simultaneously, it could reduce the risk of pathogen invasion by the inflammatory response. However, if regulated improperly, it coul... Read More about Probiotics as an adjuvant for management of gastrointestinal cancers through their anti-inflammatory effects: a mechanistic review.

Inflammatory Markers in Non-Obese Women with Polycystic Ovary Syndrome Are Not Elevated and Show No Correlation with Vitamin D Metabolites (2022)
Journal Article
Moin, A. S. M., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2022). Inflammatory Markers in Non-Obese Women with Polycystic Ovary Syndrome Are Not Elevated and Show No Correlation with Vitamin D Metabolites. Nutrients, 14(17), Article 3540. https://doi.org/10.3390/nu14173540

INTRODUCTION: Chronic low-grade inflammation is a characteristic of women with polycystic ovary syndrome (PCOS), although this may be obesity-driven rather than an intrinsic facet of PCOS; furthermore, vitamin D deficiency, another common feature of... Read More about Inflammatory Markers in Non-Obese Women with Polycystic Ovary Syndrome Are Not Elevated and Show No Correlation with Vitamin D Metabolites.

Time in range following flash glucose monitoring: Relationship with glycaemic control, diabetes-related distress and resource utilisation in the Association of British Clinical Diabetologists national audit (2022)
Journal Article
Deshmukh, H., Wilmot, E., Pieri, B., Choudhary, P., Shah, N., Gregory, R., …Sathyapalan, T. (2022). Time in range following flash glucose monitoring: Relationship with glycaemic control, diabetes-related distress and resource utilisation in the Association of British Clinical Diabetologists national audit. Diabetic medicine, Article e14942. https://doi.org/10.1111/dme.14942

Aims: The aim of this study was to understand the relationship between time in range (TIR) achieved using the isCGM with changes in glycaemic control, diabetes-related distress (DRD) and resource utilisation in people living with diabetes. Methods: C... Read More about Time in range following flash glucose monitoring: Relationship with glycaemic control, diabetes-related distress and resource utilisation in the Association of British Clinical Diabetologists national audit.

Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release (2022)
Journal Article
Diego-Taboada, A., Sathyapalan, T., Courts, F., Lorch, M., Almutairi, F., Burke, B. P., …Mackenzie, G. (2022). Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release. Journal of controlled release : official journal of the Controlled Release Society, 350, 244-255. https://doi.org/10.1016/j.jconrel.2022.08.017

Sporopollenin exine capsules (SpECs) are microcapsules derived from the outer shells (exines) of plant spore and pollen grains. This work reports the first clinical study on healthy volunteers to show enhanced bioavailability of vitamin D encapsulate... Read More about Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release.

Impaired awareness of hypoglycaemia: Prevalence and associated factors before and after FreeStyle Libre use in the Association of British Clinical Diabetologists audit (2022)
Journal Article
Pieri, B., Deshmukh, H., Wilmot, E. G., Choudhary, P., Shah, N., Gregory, R., …Sathyapalan, T. (2023). Impaired awareness of hypoglycaemia: Prevalence and associated factors before and after FreeStyle Libre use in the Association of British Clinical Diabetologists audit. Diabetes, Obesity and Metabolism, 25(1), 302-305. https://doi.org/10.1111/dom.14841

MiRNA and associated inflammatory changes from baseline to hypoglycemia in type 2 diabetes (2022)
Journal Article
Ramanjaneya, M., Priyanka, R., Bensila, M., Jerobin, J., Pawar, K., Sathyapalan, T., …Butler, A. E. (2022). MiRNA and associated inflammatory changes from baseline to hypoglycemia in type 2 diabetes. Frontiers in endocrinology, 13, Article 917041. https://doi.org/10.3389/fendo.2022.917041

Objective: Hypoglycemia in type 2 diabetes (T2D) increases morbidity and mortality but the underlying physiological response is still not fully understood, though physiological changes are still apparent 24 hours after the event. Small noncoding micr... Read More about MiRNA and associated inflammatory changes from baseline to hypoglycemia in type 2 diabetes.

Ethnic disparities in people accessing FreeStyle Libre in the UK: insights from the Association of British Clinical Diabetologists audit (2022)
Journal Article
Deshmukh, H., Adeleke, K. A., Wilmot, E., Shah, N., Patmore, J., Walton, C., Ryder, R. E. J., & Sathyapalan, T. (2022). Ethnic disparities in people accessing FreeStyle Libre in the UK: insights from the Association of British Clinical Diabetologists audit. Future Healthcare Journal, 9(Suppl 2), 11-11. https://doi.org/10.7861/fhj.9-2-s11

The Translational Role of miRNA in Polycystic Ovary Syndrome: From Bench to Bedside—A Systematic Literature Review (2022)
Journal Article
Vitale, S. G., Fulghesu, A. M., Mikuš, M., Watrowski, R., D’Alterio, M. N., Lin, L. T., …Angioni, S. (2022). The Translational Role of miRNA in Polycystic Ovary Syndrome: From Bench to Bedside—A Systematic Literature Review. Biomedicines, 10(8), Article 1816. https://doi.org/10.3390/biomedicines10081816

MicroRNAs (miRNAs) are small, non-coding RNAs that are essential for the regulation of post-transcriptional gene expression during tissue development and differentiation. They are involved in the regulation of manifold metabolic and hormonal processe... Read More about The Translational Role of miRNA in Polycystic Ovary Syndrome: From Bench to Bedside—A Systematic Literature Review.

Therapeutic effects of statins on osteoarthritis: A review (2022)
Journal Article
Saberianpour, S., Abolbashari, S., Modaghegh, M. H., Karimian, M. S., Eid, A. H., Sathyapalan, T., & Sahebkar, A. (2022). Therapeutic effects of statins on osteoarthritis: A review. Journal of Cellular Biochemistry, 123(8), 1285-1297. https://doi.org/10.1002/jcb.30309

Osteoarthritis (OA) is a progressive joint disease. The etiology of OA is considered to be multifactorial. Currently, there is no definitive treatment for OA, and the existing treatments are not very effective. Hypercholesterolemia is considered a no... Read More about Therapeutic effects of statins on osteoarthritis: A review.

The Effect of Probiotic and Synbiotic Consumption on the Most Prevalent Chemotherapy-related Complications: A Systematic Review of Current Literature (2022)
Journal Article
Arab, A., Karimi, E., Bagherniya, M., Sathyapalan, T., & Sahebkar, A. (2022). The Effect of Probiotic and Synbiotic Consumption on the Most Prevalent Chemotherapy-related Complications: A Systematic Review of Current Literature. Current medicinal chemistry, 29(33), 5462-5473. https://doi.org/10.2174/0929867329666220415114343

Background: To date, many investigations have employed pro-/synbiotic to examine their effects on chemotherapy-related side effects; nevertheless, their findings are inconclu-sive. To address this issue, we carried out a systematic review to explore... Read More about The Effect of Probiotic and Synbiotic Consumption on the Most Prevalent Chemotherapy-related Complications: A Systematic Review of Current Literature.