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Effects of exercise prescribed at different levels of claudication pain on walking performance in patients with intermittent claudication: a protocol for a randomised controlled trial (2022)
Journal Article
Birkett, S., Sinclair, J., Seed, S., Pymer, S., Caldow, E., Ingle, L., Harwood, A., & Egun, A. (2022). Effects of exercise prescribed at different levels of claudication pain on walking performance in patients with intermittent claudication: a protocol for a randomised controlled trial. Therapeutic Advances in Cardiovascular Disease, 16, https://doi.org/10.1177/17539447221108817

Background: Peripheral artery disease affects over 236 million people globally and the classic symptom is intermittent claudication (IC) which is associated with reduction in physical activity. The evidence that supervised exercise programmes (SEPs)... Read More about Effects of exercise prescribed at different levels of claudication pain on walking performance in patients with intermittent claudication: a protocol for a randomised controlled trial.

Phytochemicals as Modulators of Paraoxonase‐1 in Health and Diseases (2022)
Journal Article
Arab, Z. N., Khayatan, D., Razavi, S. M., Zare, K., Kheradkhah, E., Momtaz, S., Ferretti, G., Bacchetti, T., Sathyapalan, T., Emami, S. A., Abdolghaffari, A. H., & Sahebkar, A. (2022). Phytochemicals as Modulators of Paraoxonase‐1 in Health and Diseases. Antioxidants, 11(7), Article 1273. https://doi.org/10.3390/antiox11071273

Chronic diseases such as cardiovascular disease (CVD), atherosclerosis, chronic liver disease, and neurodegenerative diseases are major causes of mortality. These diseases have gained much attention due to their complications, and therefore novel app... Read More about Phytochemicals as Modulators of Paraoxonase‐1 in Health and Diseases.

Evaluating the feasibility and acceptability of an exercise and behaviour change intervention in socioeconomically deprived patients with peripheral arterial disease: The textpad study protocol (2022)
Journal Article
Cucato, G., Snowden, C., McCone, E., Nesbitt, C., Nandhra, S., Fong, M., Kane, E., Rowland, M., Bhattarai, N., Court, P., Bell, O., Saxton, J. M., & Prentis, J. (2022). Evaluating the feasibility and acceptability of an exercise and behaviour change intervention in socioeconomically deprived patients with peripheral arterial disease: The textpad study protocol. PLoS ONE, 17(6), Article e0269999. https://doi.org/10.1371/journal.pone.0269999

This pilot randomised controlled trial aims to assess the feasibility and acceptability of a 12-week home-based telehealth exercise and behavioural intervention delivered in socioeconomically deprived patients with peripheral artery disease (PAD). Th... Read More about Evaluating the feasibility and acceptability of an exercise and behaviour change intervention in socioeconomically deprived patients with peripheral arterial disease: The textpad study protocol.

Symptom Control and Survival for People Severely ill With COVID: A Multicentre Cohort Study (CovPall-Symptom) (2022)
Journal Article
Higginson, I. J., Hocaoglu, M., Fraser, L. K., Maddocks, M., Sleeman, K. E., Oluyase, A. O., Chambers, R. L., Preston, N., Dunleavy, L., Bradshaw, A., Bajwah, S., Murtagh, F. E., Walshe, C., & On behalf of theCovPall study team. (2022). Symptom Control and Survival for People Severely ill With COVID: A Multicentre Cohort Study (CovPall-Symptom). Journal of pain and symptom management, 64(4), 377-390. https://doi.org/10.1016/j.jpainsymman.2022.06.009

Context: Evidence of symptom control outcomes in severe COVID is scant. Objectives: To determine changes in symptoms among people severely ill or dying with COVID supported by palliative care, and associations with treatments and survival. Methods: M... Read More about Symptom Control and Survival for People Severely ill With COVID: A Multicentre Cohort Study (CovPall-Symptom).

Substituting bouts of sedentary behavior with physical activity: adopting positive lifestyle choices in people with a history of cancer (2022)
Journal Article
Ingle, L., Ruilova, S., Cui, Y., DeClercq, V., Sweeney, E., Yu, Z. M., & Forbes, C. C. (2022). Substituting bouts of sedentary behavior with physical activity: adopting positive lifestyle choices in people with a history of cancer. Cancer Causes and Control, https://doi.org/10.1007/s10552-022-01592-9

Purpose: To determine in people with a history of cancer, whether substituting sitting time with other daily activities (i.e., sleeping, walking, moderate and vigorous physical activity) was associated with changes in waist circumference (WC), an imp... Read More about Substituting bouts of sedentary behavior with physical activity: adopting positive lifestyle choices in people with a history of cancer.

Skin Aging in Long-Lived Naked Mole-Rats Is Accompanied by Increased Expression of Longevity-Associated and Tumor Suppressor Genes (2022)
Journal Article
Fatima, I., Chen, G., Botchkareva, N. V., Sharov, A. A., Thornton, D., Wilkinson, H. N., Hardman, M. J., Grutzkau, A., Pedro de Magalhaes, J., Seluanov, A., St J Smith, E., Gorbunova, V., Mardaryev, A. N., Faulkes, C. G., & Botchkarev, V. A. (in press). Skin Aging in Long-Lived Naked Mole-Rats Is Accompanied by Increased Expression of Longevity-Associated and Tumor Suppressor Genes. Journal of Investigative Dermatology, https://doi.org/10.1016/j.jid.2022.04.028

Naked mole-rats (NMRs) (Heterocephalus glaber) are long-lived mammals that possess a natural resistance to cancer and other age-related pathologies, maintaining a healthy life span >30 years. In this study, using immunohistochemical and RNA-sequencin... Read More about Skin Aging in Long-Lived Naked Mole-Rats Is Accompanied by Increased Expression of Longevity-Associated and Tumor Suppressor Genes.

Metabolic risk is associated with sociodemographic characteristics in adolescents from both rural and urban regions from southern Brazil (2022)
Journal Article
de Souza, S., Francisco de Castro Silveira, J., Marques, K. C., Gaya, A. R., Franke, S. I. R., Renner, J. D. P., Hobkirk, J. P., Carroll, S., & Reuter, C. P. (2022). Metabolic risk is associated with sociodemographic characteristics in adolescents from both rural and urban regions from southern Brazil. BMC Pediatrics, 22(1), Article 324. https://doi.org/10.1186/s12887-022-03386-z

Background: The prevalence of several cardiovascular metabolic disorders are increasingly cause for concern in adolescents worldwide. Given the complex interrelations between metabolic risk (MR) and sociodemographic variables, the present study aims... Read More about Metabolic risk is associated with sociodemographic characteristics in adolescents from both rural and urban regions from southern Brazil.

Anatomy Nights: An international public engagement event increases audience knowledge of brain anatomy (2022)
Journal Article
Sanders, K. A., Philp, J. A., Jordan, C. Y., Cale, A. S., Cunningham, C. L., & Organ, J. M. (2022). Anatomy Nights: An international public engagement event increases audience knowledge of brain anatomy. PLoS ONE, 17(6 June), Article e0267550. https://doi.org/10.1371/journal.pone.0267550

Anatomy Nights is an international public engagement event created to bring anatomy and anatomists back to public spaces with the goal of increasing the public's understanding of their own anatomy by comparison with non-human tissues. The event consi... Read More about Anatomy Nights: An international public engagement event increases audience knowledge of brain anatomy.

Safety, Pharmacodynamics, and Pharmacokinetics of P2X3 Receptor Antagonist Eliapixant (BAY 1817080) in Healthy Subjects: Double-Blind Randomized Study (2022)
Journal Article
Friedrich, C., Francke, K., Gashaw, I., Scheerans, C., Klein, S., Fels, L., Smith, J. A., Hummel, T., & Morice, A. (2022). Safety, Pharmacodynamics, and Pharmacokinetics of P2X3 Receptor Antagonist Eliapixant (BAY 1817080) in Healthy Subjects: Double-Blind Randomized Study. Clinical Pharmacokinetics, 61, 1143–1156. https://doi.org/10.1007/s40262-022-01126-1

Background and Objective: There is no licensed treatment for refractory chronic cough; off-label therapies have limited efficacy and can produce adverse effects. Excessive adenosine triphosphate signaling via P2X3 receptors is implicated in refractor... Read More about Safety, Pharmacodynamics, and Pharmacokinetics of P2X3 Receptor Antagonist Eliapixant (BAY 1817080) in Healthy Subjects: Double-Blind Randomized Study.

Demographic, clinical, and patient-reported outcome data from 2 global, phase 3 trials of chronic cough (2022)
Journal Article
Dicpinigaitis, P. V., Birring, S. S., Blaiss, M., McGarvey, L. P., Morice, A. H., Pavord, I. D., Satia, I., Smith, J. A., La Rosa, C., Li, Q., Nguyen, A. M., Schelfhout, J., Tzontcheva, A., & Muccino, D. (2023). Demographic, clinical, and patient-reported outcome data from 2 global, phase 3 trials of chronic cough. Annals of Allergy, Asthma and Immunology, 130(1), 60-66. https://doi.org/10.1016/j.anai.2022.05.003

Background: The current characterization of patients with refractory or unexplained chronic cough (RCC and UCC, respectively) primarily stems from relatively small clinical studies. Objective: To report the baseline medical history and clinical chara... Read More about Demographic, clinical, and patient-reported outcome data from 2 global, phase 3 trials of chronic cough.

Strengthening Capacity for Prostate Cancer Early Diagnosis in West Africa Amidst the COVID-19 Pandemic: A Realist Approach to Rethinking and Operationalizing the World Health Organization 2017 Guide to Cancer Early Diagnosis (2022)
Journal Article
Ezenwankwo, E. F., Nnate, D. A., Oladoyinbo, C. A., Dogo, H. M., Idowu, A. A., Onyeso, C. P., Ogo, C. N., Ogunsanya, M., Bamidele, O., & Nnaji, C. A. (2022). Strengthening Capacity for Prostate Cancer Early Diagnosis in West Africa Amidst the COVID-19 Pandemic: A Realist Approach to Rethinking and Operationalizing the World Health Organization 2017 Guide to Cancer Early Diagnosis. Annals of Global Health, 88(1), https://doi.org/10.5334/aogh.3519

Two years after SARS-CoV-2 (COVID-19) was declared a global public health emergency, the restoration, at least, to the pre-pandemic level of early diagnostic services for prostate cancer has remained enormously challenging for many health systems, wo... Read More about Strengthening Capacity for Prostate Cancer Early Diagnosis in West Africa Amidst the COVID-19 Pandemic: A Realist Approach to Rethinking and Operationalizing the World Health Organization 2017 Guide to Cancer Early Diagnosis.

Unmarried Adolescents’ Experiences of Using Reproductive and Maternal Health Services in Nigeria and Uganda: A Qualitative Study (2022)
Journal Article
Onukwugha, F., Agaba, P., Hayter, M., & Orton, B. (2022). Unmarried Adolescents’ Experiences of Using Reproductive and Maternal Health Services in Nigeria and Uganda: A Qualitative Study. Social Sciences, 11(5), Article 203. https://doi.org/10.3390/socsci11050203

Adolescents’ access and use of reproductive and maternal health (RMH) services is a critical part of the global strategy for achieving the Sustainable Development Goals (SDGs). However, previous studies have shown that a complex range of factors, inc... Read More about Unmarried Adolescents’ Experiences of Using Reproductive and Maternal Health Services in Nigeria and Uganda: A Qualitative Study.

Persisting breathlessness and activities reduced or ceased: a population study in older men (2022)
Journal Article
Kochovska, S., Currow, D., Chang, S., Johnson, M., Ferreira, D., Morgan, D., Olsson, M., & Ekström, M. (2022). Persisting breathlessness and activities reduced or ceased: a population study in older men. BMJ Open Respiratory Research, 9(1), Article e001168. https://doi.org/10.1136/bmjresp-2021-001168

INTRODUCTION: Breathlessness is debilitating and increases in prevalence with age, with people progressively reducing their everyday activities to 'self-manage' it. This study aimed to evaluate the impact of breathlessness on function in terms of act... Read More about Persisting breathlessness and activities reduced or ceased: a population study in older men.

Etiopathogenesis of Psoriasis from Genetic Perspective: An updated Review (2022)
Journal Article
Babaie, F., Omraninava, M., Gorabi, A. M., Khosrojerdi, A., Aslani, S., Yazdchi, A., Torkamandi, S., Mikaeili, H., Sathyapalan, T., & Sahebkar, A. (2022). Etiopathogenesis of Psoriasis from Genetic Perspective: An updated Review. Current Genomics, 23(3), 163-174. https://doi.org/10.2174/1389202923666220527111037

Psoriasis is an organ-specific autoimmune disease characterized by the aberrant proliferation and differentiation of keratinocytes, leading to skin lesions. Abnormal immune responses mediated by T cells and dendritic cells and increased production of... Read More about Etiopathogenesis of Psoriasis from Genetic Perspective: An updated Review.

Perspectives of Adolescents, Parents, Service Providers, and Teachers on Mobile Phone Use for Sexual Reproductive Health Education (2022)
Journal Article
Ochieng, B. M., Smith, L., Orton, B., Hayter, M., Kaseje, M., Wafula, C. O., Ocholla, P., Onukwugha, F., & Kaseje, D. C. O. (2022). Perspectives of Adolescents, Parents, Service Providers, and Teachers on Mobile Phone Use for Sexual Reproductive Health Education. Social Sciences, 11(5), Article 196. https://doi.org/10.3390/socsci11050196

Mobile health (mHealth) programs offer opportunities to improve the sexual and reproductive health (SRH) of adolescents by providing information. This paper reports the findings of a study carried out in Homabay County, Kenya, to assess stakeholders’... Read More about Perspectives of Adolescents, Parents, Service Providers, and Teachers on Mobile Phone Use for Sexual Reproductive Health Education.

A record of microplastic in the marine nearshore waters of South Georgia (2022)
Journal Article
Buckingham, J. W., Manno, C., Waluda, C. M., & Waller, C. L. (2022). A record of microplastic in the marine nearshore waters of South Georgia. Environmental pollution, 306, Article 119379. https://doi.org/10.1016/j.envpol.2022.119379

The polar plastics research community have recommended the spatial coverage of microplastic investigations in Antarctica and the Southern Ocean be increased. Presented here is a baseline estimate of microplastics in the nearshore waters of South Geor... Read More about A record of microplastic in the marine nearshore waters of South Georgia.