All Outputs (725)

Benz(2-heteroaryl)cyanoximes and their Tl(i) complexes: new room temperature blue emitters (2008)
Journal Article
Ilkun, O. T., Archibald, S. J., Barnes, C. L., Gerasimchuk, N., Biagioni, R., Silchenko, S., Gerasimchuk, O. A., & Nemykin, V. N. (2008). Benz(2-heteroaryl)cyanoximes and their Tl(i) complexes: new room temperature blue emitters. Dalton Transactions : an international journal of inorganic chemistry, 5715-5729. https://doi.org/10.1039/b803846e

A series of five 2-heteroarylcyanoximes such as: α-oximino-(2-benzimidazolyl)acetonitrile (HBIHCO), α-oximino-(N-methy-l-2-benzimidazolyl)acetonitrile (HBIMCO), α-oximino-(2-benzoxazolyl)acetonitrile (HBOCO), α-oximino-(2-benzothiazolyl)acetonitrile... Read More about Benz(2-heteroaryl)cyanoximes and their Tl(i) complexes: new room temperature blue emitters.

Tissue factor-containing microparticles released from mesangial cells in response to high glucose and AGE induce tube formation in microvascular cells (2008)
Journal Article
Ettelaie, C., Su, S., Li, C., & Collier, M. E. W. (2008). Tissue factor-containing microparticles released from mesangial cells in response to high glucose and AGE induce tube formation in microvascular cells. Microvascular Research, 76(3), 152-160. https://doi.org/10.1016/j.mvr.2008.07.007

Hyperglycaemia and the associated formation of advanced glycation end-products (AGE) have been implicated in the pathogenesis of diabetic vasculopathy. In addition to its role in coagulation, tissue factor (TF) is known to regulate vascular prolifera... Read More about Tissue factor-containing microparticles released from mesangial cells in response to high glucose and AGE induce tube formation in microvascular cells.

An internal polyadenylation signal substantially increases expression levels of lentivirus-delivered transgenes but has the potential to reduce viral titer in a promoter-dependent manner (2008)
Journal Article
Hager, S., Frame, F. M., Collins, A. T., Burns, J. E., & Maitland, N. J. (2008). An internal polyadenylation signal substantially increases expression levels of lentivirus-delivered transgenes but has the potential to reduce viral titer in a promoter-dependent manner. Human Gene Therapy, 19(8), 840-850. https://doi.org/10.1089/hum.2007.165

In lentiviral gene delivery systems, transgene expression cassettes are commonly cloned without a polyadenylation signal to prevent disruption of full-length lentiviral genomes on mRNA maturation in producer cells. The lack of the polyadenylation sig... Read More about An internal polyadenylation signal substantially increases expression levels of lentivirus-delivered transgenes but has the potential to reduce viral titer in a promoter-dependent manner.

The on-line synthesis of enzyme functionalized silica nanoparticles in a microfluidic reactor using polyethylenimine polymer and R5 peptide (2008)
Journal Article
He, P., Greenway, G., & Haswell, S. J. (2008). The on-line synthesis of enzyme functionalized silica nanoparticles in a microfluidic reactor using polyethylenimine polymer and R5 peptide. Nanotechnology, 19(31), 315603. https://doi.org/10.1088/0957-4484/19/31/315603

A simple microfluidic reactor system is described for the effective synthesis of enzyme functionalized nanoparticles which offers many advantages over batch reactions, including excellent enzyme efficiencies. Better control of the process parameters... Read More about The on-line synthesis of enzyme functionalized silica nanoparticles in a microfluidic reactor using polyethylenimine polymer and R5 peptide.

Linking Ras to myosin function: RasGEF Q, a Dictyostelium exchange factor for RasB, affects myosin II functions (2008)
Journal Article
Mondal, S., Bakthavatsalam, D., Steimle, P., Gassen, B., Rivero, F., & Noegel, A. A. (2008). Linking Ras to myosin function: RasGEF Q, a Dictyostelium exchange factor for RasB, affects myosin II functions. Journal of Cell Biology, 181(5), 747-760. https://doi.org/10.1083/jcb.200710111

Ras guanine nucleotide exchange factor (GEF) Q, a nucleotide exchange factor from Dictyostelium discoideum, is a 143-kD protein containing RasGEF domains and a DEP domain. We show that RasGEF Q can bind to F-actin, has the potential to form complexes... Read More about Linking Ras to myosin function: RasGEF Q, a Dictyostelium exchange factor for RasB, affects myosin II functions.

Synthetic CD4+ T cell-targeted antigen-presenting cells elicit protective antitumor responses (2008)
Journal Article
Caserta, S., Alessi, P., Guarnerio, J., Basso, V., & Mondino, A. (2008). Synthetic CD4+ T cell-targeted antigen-presenting cells elicit protective antitumor responses. Cancer Research, 68(8), 3010-3018. https://doi.org/10.1158/0008-5472.can-07-5796

CD4 + helper T cells are critical for protective immune responses and yet suboptimally primed in response to tumors. Cell-based vaccination strategies are under evaluation in clinical trials but limited by the need to derive antigenpresenting cells... Read More about Synthetic CD4+ T cell-targeted antigen-presenting cells elicit protective antitumor responses.

Microparticle-associated vascular adhesion molecule-1 and tissue factor follow a circadian rhythm in healthy human subjects (2008)
Journal Article
Madden, L. A., Vince, R. V., Sandström, M. E., Taylor, L., McNaughton, L., & Laden, G. (2008). Microparticle-associated vascular adhesion molecule-1 and tissue factor follow a circadian rhythm in healthy human subjects. Thrombosis and haemostasis, 99(5), 909 - 915. https://doi.org/10.1160/th08-01-0030

An increased risk of death or severe injury due to late-morning thrombotic events is well established. Tissue factor (TF) is the initiator of the coagulation cascade, and endothelial stresses, coupled with production of pro-coagulant microparticles (... Read More about Microparticle-associated vascular adhesion molecule-1 and tissue factor follow a circadian rhythm in healthy human subjects.

Distinguishing Properties of Cells From the Myocardial Sleeves of the Pulmonary Veins: A Comparison of Normal and Abnormal Pacemakers (2008)
Journal Article
Jones, S. A., Yamamoto, M., Tellez, J. O., Billeter, R., Boyett, M. R., Honjo, H., & Lancaster, M. K. (2008). Distinguishing Properties of Cells From the Myocardial Sleeves of the Pulmonary Veins: A Comparison of Normal and Abnormal Pacemakers. Circulation. Arrhythmia and electrophysiology, 1(1), 39-48. https://doi.org/10.1161/CIRCEP.107.748467

BACKGROUND: A common source of arrhythmogenic spontaneous activity instigating atrial fibrillation is the myocardial tissue, or sleeves, at the base of the pulmonary veins. This study compared the properties of cells from the myocardial sleeves of th... Read More about Distinguishing Properties of Cells From the Myocardial Sleeves of the Pulmonary Veins: A Comparison of Normal and Abnormal Pacemakers.

Dictyostelium Sun-1 connects the centrosome to chromatin and ensures genome stability (2008)
Journal Article
Rivero, F., Xiong, H., Rivero-Crespo, F., Euteneuer, U., Mondal, S., Mana-Capelli, S., Larochelle, D., Vogel, A., Gassen, B., & Noegel, A. A. (2008). Dictyostelium Sun-1 connects the centrosome to chromatin and ensures genome stability. Traffic, 9(5), 708-724. https://doi.org/10.1111/j.1600-0854.2008.00721.x

The centrosome-nucleus attachment is a prerequisite for faithful chromosome segregation during mitosis. We addressed the function of the nuclear envelope (NE) protein Sun-1 in centrosome-nucleus connection and the maintenance of genome stability in D... Read More about Dictyostelium Sun-1 connects the centrosome to chromatin and ensures genome stability.

Investigation of the mechanisms of tissue factor-mediated evasion of tumour cells from cellular cytotoxicity (2008)
Journal Article
Li, C., Collier, M. E. W., Frentzou, G. A., Greenman, J., & Ettelaie, C. (2008). Investigation of the mechanisms of tissue factor-mediated evasion of tumour cells from cellular cytotoxicity. Cancer Immunology, Immunotherapy, 57(9), 1347-1355. https://doi.org/10.1007/s00262-008-0469-6

Aims We previously reported that overexpression of tissue factor (TF) protected HT29 tumour cells from cellular cytotoxicity through a mechanism requiring the presence of the cytoplasmic domain of TF. In this investigation the mechanism of TF-mediate... Read More about Investigation of the mechanisms of tissue factor-mediated evasion of tumour cells from cellular cytotoxicity.

Fluvastatin reduces oxidative damage in human vascular endothelial cells by upregulating Bcl-2 (2008)
Journal Article
Xu, S. Z., Zhong, W., Watson, N. M., Dickerson, E., Wake, J. D., Lindow, S. W., Newton, C. J., & Atkin, S. L. (2008). Fluvastatin reduces oxidative damage in human vascular endothelial cells by upregulating Bcl-2. Journal of thrombosis and haemostasis : JTH, 6(4), 692-700. https://doi.org/10.1111/j.1538-7836.2008.02913.x

Background: 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have been widely used in clinical practise and their efficacy in reducing cardiovascular risk has been well described. Objectives: To investigate the effect of low doses... Read More about Fluvastatin reduces oxidative damage in human vascular endothelial cells by upregulating Bcl-2.

TRPC channel activation by extracellular thioredoxin (2008)
Journal Article
Xu, S.-Z., Sukumar, P., Zeng, F., Li, J., Jairaman, A., English, A., Naylor, J., Ciurtin, C., Majeed, Y., Milligan, C. J., Bahnasi, Y. M., Al-Shawaf, E., Porter, K. E., Jiang, L.-H., Emery, P., Sivaprasadarao, A., & Beech, D. J. (2008). TRPC channel activation by extracellular thioredoxin. Nature, 451(7174), 69-72. https://doi.org/10.1038/nature06414

Mammalian homologues of Drosophila melanogaster transient receptor potential (TRP) are a large family of multimeric cation channels that act, or putatively act, as sensors of one or more chemical factor. Major research objectives are the identificati... Read More about TRPC channel activation by extracellular thioredoxin.

Development of a microfluidic device for the maintenance and interrogation of viable tissue biopsies (2008)
Journal Article
Dyer, C. E., Greenman, J., Haswell, S. J., & Hattersley, S. M. (2008). Development of a microfluidic device for the maintenance and interrogation of viable tissue biopsies. Lab on a chip, 8(11), 1842-1846. https://doi.org/10.1039/b809345h

A microfluidic based experimental methodology has been developed that offers a biomimetic microenvironment in which pseudo in vivo tissue studies can be carried out under in vitro conditions. Using this innovative technique, which utilizes the inhere... Read More about Development of a microfluidic device for the maintenance and interrogation of viable tissue biopsies.

The collagen receptor Endo180 (CD280) is expressed on basal-like breast tumor cells and promotes tumor growth in vivo (2007)
Journal Article
Wienke, D., Davies, G. C., Johnson, D. A., Sturge, J., Lambros, M. B., Savage, K., Elsheikh, S. E., Green, A. R., Ellis, I. O., Robertson, D., Reis-Filho, J. S., & Isacke, C. M. (2007). The collagen receptor Endo180 (CD280) is expressed on basal-like breast tumor cells and promotes tumor growth in vivo. Cancer Research, 67(21), 10230-10240. https://doi.org/10.1158/0008-5472.CAN-06-3496

Tumor cell invasion into the surrounding stroma requires increased cell motility and extensive remodeling of the extracellular matrix. Endo180 (CD280, MRC2, urokinase-type plasminogen activator receptor-associated protein) is a recycling endocytic re... Read More about The collagen receptor Endo180 (CD280) is expressed on basal-like breast tumor cells and promotes tumor growth in vivo.

The design and synthesis of pyrazine amide ligands suitable for the "tiles" approach to molecular weaving with octahedral metal ions (2007)
Journal Article
Cockriel, D. L., McClain, J. M., Patel, K. C., Ullom, R., Hasley, T. R., Archibald, S. J., & Hubin, T. J. (2008). The design and synthesis of pyrazine amide ligands suitable for the "tiles" approach to molecular weaving with octahedral metal ions. Inorganic Chemistry Communications, 11(1), 1-4. https://doi.org/10.1016/j.inoche.2007.10.006

The pyrazine-containing ligands 1 (pyrazine-2-carboxylic acid (pyridine-2-ylmethyl)-amide) and 2 (pyrazine-2,5-dicarboxylic acid bis[(pyridine-2-yimethyl)-amide]) have been synthesized and characterized in order to probe their ability to form polynuc... Read More about The design and synthesis of pyrazine amide ligands suitable for the "tiles" approach to molecular weaving with octahedral metal ions.

The influence of exogenous tissue factor on the regulators of proliferation and apoptosis in endothelial cells (2007)
Journal Article
Pradier, A., & Ettelaie, C. (2007). The influence of exogenous tissue factor on the regulators of proliferation and apoptosis in endothelial cells. Journal of vascular research, 45(1), 19-32. https://doi.org/10.1159/000109074

Background: The exposure of tissue factor (TF) at the site of injury or trauma is a rapid process that leads to the initiation of blood coagulation as well as homeostatic processes giving rise to vascular repair. Aims and Methods: By exposing human e... Read More about The influence of exogenous tissue factor on the regulators of proliferation and apoptosis in endothelial cells.

Tumors hamper the immunogenic competence of CD4+T cell-directed dendritic cell vaccination (2007)
Journal Article
Zimmermann, V. S., Casati, A., Schiering, C., Caserta, S., Hess Michelini, R., Basso, V., & Mondino, A. (2007). Tumors hamper the immunogenic competence of CD4+T cell-directed dendritic cell vaccination. Journal of Immunology, 179(5), 2899-2909. https://doi.org/10.4049/jimmunol.179.5.2899

Dendritic cells loaded with tumor-derived peptides induce protective CTL responses and are under evaluation in clinical trails. We report in this study that prophylactic administration of dendritic cells loaded with a MHC class II-restricted peptide... Read More about Tumors hamper the immunogenic competence of CD4+T cell-directed dendritic cell vaccination.

Mannose receptor regulation of macrophage cell migration (2007)
Journal Article
Sturge, J., Todd, S. K., Kogianni, G., McCarthy, A., & Isacke, C. M. (2007). Mannose receptor regulation of macrophage cell migration. Journal of Leukocyte Biology, 82(3), 585-593. https://doi.org/10.1189/jlb.0107053

The migration of macrophages through peripheral tissues is an essential step in the host response to infection, inflammation, and ischemia as well as in tumor progression and tissue repair. The mannose receptor (MR; CD206, previously known as the mac... Read More about Mannose receptor regulation of macrophage cell migration.

Plasma tissue factor is a predictor for restenosis after femoropopliteal angioplasty (2007)
Journal Article
Ray, B., Chetter, I. C., Lee, H. L. D., Ettelaie, C., & McCollum, P. T. (2007). Plasma tissue factor is a predictor for restenosis after femoropopliteal angioplasty. British journal of surgery, 94(9), 1092-1095. https://doi.org/10.1002/bjs.5759

Background:In vitro studies suggest an association between raised levels of tissue factor and restenosis after coronary percutaneous transluminal angioplasty (PTA). This prospective, controlled study examined the association between plasma tissue fac... Read More about Plasma tissue factor is a predictor for restenosis after femoropopliteal angioplasty.

Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6 and G-protein-coupled receptor regulate angiopoietin-2 expression in lymphatic endothelial cells (2007)
Journal Article
Vart, R. J., Nikitenko, L. L., Lagos, D., Trotter, M. W., Cannon, M., Bourboulia, D., Gratrix, F., Takeuchi, Y., & Boshoff, C. (2007). Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6 and G-protein-coupled receptor regulate angiopoietin-2 expression in lymphatic endothelial cells. Cancer Research, 67(9), 4042-4051. https://doi.org/10.1158/0008-5472.CAN-06-3321

Kaposi's sarcoma (KS) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and consists of proliferating spindle cells, which are related to lymphatic endothelial cells (LEC). Angiopoietin-2 (Ang2) is a secreted proangiogenic and lymphangiogen... Read More about Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6 and G-protein-coupled receptor regulate angiopoietin-2 expression in lymphatic endothelial cells.