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Automated sulfur-[18F]fluoride exchange radiolabelling of a prostate specific membrane antigen (PSMA) targeted ligand using the GE FASTlab™ cassette-based platform (2023)
Journal Article
Yang, Z., Barnes, C., Domarkas, J., Koch-Paszkowski, J., Wright, J., Amgheib, A., Renard, I., Fu, R., Archibald, S., Aboagye, E. O., & Allott, L. (2023). Automated sulfur-[18F]fluoride exchange radiolabelling of a prostate specific membrane antigen (PSMA) targeted ligand using the GE FASTlab™ cassette-based platform. Reaction Chemistry and Engineering, 8(10), 2403-2407. https://doi.org/10.1039/d3re00307h

Sulfur-[18F]fluoride exchange radiochemistry is a rapid and convenient method for incorporating fluorine-18 into biologically active molecules. We report a fully automated radiolabelling procedure for the synthesis of a [18F]SO3F-bearing prostate spe... Read More about Automated sulfur-[18F]fluoride exchange radiolabelling of a prostate specific membrane antigen (PSMA) targeted ligand using the GE FASTlab™ cassette-based platform.

Abnormal acinar–β-cell crosstalk in type 2 diabetes (2023)
Journal Article
Geravandi, S., & Ardestani, A. (2023). Abnormal acinar–β-cell crosstalk in type 2 diabetes. Trends in Endocrinology & Metabolism, 34(11), 685-687. https://doi.org/10.1016/j.tem.2023.08.006

Cellular crosstalk plays a vital role in maintaining pancreas homeostasis. Recently, in Cell Metabolism, Basile et al. demonstrated that aberrant upregulation of acinar-cell-specific pancreatic elastase CELA3B within endocrine islets reduces β-cell v... Read More about Abnormal acinar–β-cell crosstalk in type 2 diabetes.

Abstract A020: Calcitonin receptor-like receptor is expressed in blood vessels in clear cell renal cell carcinoma and upregulated in endothelial cells co-cultured with tumor cells (2023)
Presentation / Conference Contribution
Morfitt, M. A., Greenman, J., Maraveyas, A., Harris, A. L., & Nikitenko, L. L. Abstract A020: Calcitonin receptor-like receptor is expressed in blood vessels in clear cell renal cell carcinoma and upregulated in endothelial cells co-cultured with tumor cells. Presented at AACR Special Conference on Advances in Kidney Cancer Research, Austin, Texas, U.S.A

Introduction. Clear cell renal cell carcinoma (ccRCC) is a highly vascularized and clinically aggressive kidney cancer, with high rates of metastasis and recurrence after cytoreductive nephrectomy. ccRCC can be treated with anti-angiogenic drugs, how... Read More about Abstract A020: Calcitonin receptor-like receptor is expressed in blood vessels in clear cell renal cell carcinoma and upregulated in endothelial cells co-cultured with tumor cells.

Abstract B001: Calcitonin receptor-like receptor agonists induce p44/42 MAPK phosphorylation in VEGF-A-stimulated human blood endothelial cells after bevacizumab treatment (2023)
Presentation / Conference Contribution
Morfitt, M. A., Greenman, J., Maraveyas, A., & Nikitenko, L. L. Abstract B001: Calcitonin receptor-like receptor agonists induce p44/42 MAPK phosphorylation in VEGF-A-stimulated human blood endothelial cells after bevacizumab treatment. Presented at AACR Special Conference: Advances in Kidney Cancer Research, Austin, Texas, U.S.A

Introduction. Clear cell renal cell carcinoma (ccRCC) is a highly vascularized and clinically aggressive cancer. In the UK, there are around 9000 diagnoses and 3000 deaths annually. Targeted therapies that inhibit angiogenic regulators, such as bevac... Read More about Abstract B001: Calcitonin receptor-like receptor agonists induce p44/42 MAPK phosphorylation in VEGF-A-stimulated human blood endothelial cells after bevacizumab treatment.

Consensus Statements Highlight the Need of Harmonizing Chronic Lymphocytic Leukemia Management Worldwide (2023)
Journal Article
Molica, S., Rossi, M., & Allsup, D. (2023). Consensus Statements Highlight the Need of Harmonizing Chronic Lymphocytic Leukemia Management Worldwide. Acta Haematologica, 147(3), 257-259. https://doi.org/10.1159/000533349

In addition to the European Society for Medical Oncology (ESMO) and National Comprehensive Cancer Network (NCCN) guidelines that are reference standards for the treatment of chronic lymphocytic leukemia (CLL) in Europe and the USA, several consensus... Read More about Consensus Statements Highlight the Need of Harmonizing Chronic Lymphocytic Leukemia Management Worldwide.

Bridging the attainment gap between undergraduate Criminology with Forensic Science students and their Forensic Science peers for separation science calculation questions (2023)
Presentation / Conference Contribution
Williams, J. R. (2023, July). Bridging the attainment gap between undergraduate Criminology with Forensic Science students and their Forensic Science peers for separation science calculation questions. Presented at University of Hull Teaching Excellence Academy Teaching and Learning Conference 2023: Assessment and Feedback for Student Success, online

Anecdotal evidence suggested BA in Criminology with Forensic Science (Crim with FS) students on the mandatory Year 1 (Level 4) Module 400060 Introduction to DNA and Chromatography find separation science calculation questions more challenging than th... Read More about Bridging the attainment gap between undergraduate Criminology with Forensic Science students and their Forensic Science peers for separation science calculation questions.

Advancements in the Treatment of CLL: The Rise of Zanubrutinib as a Preferred Therapeutic Option (2023)
Journal Article
Molica, S., Tam, C., Allsup, D., & Polliack, A. (2023). Advancements in the Treatment of CLL: The Rise of Zanubrutinib as a Preferred Therapeutic Option. Cancers, 15(14), Article 3737. https://doi.org/10.3390/cancers15143737

Ibrutinib, the first-in-class Bruton’s tyrosine kinase inhibitor (BTKi), is a commonly deployed therapeutic option for previously untreated and relapsed/refractory (R/R) patients with chronic lymphocytic leukemia (CLL). The use of ibrutinib is, howev... Read More about Advancements in the Treatment of CLL: The Rise of Zanubrutinib as a Preferred Therapeutic Option.

Biochemical characterisation of the interaction of the myosin light chain phosphatase with the regulatory subunits of protein kinase A in cells of the circulatory system (2023)
Thesis
Saldanha, P. A. C. B. D. S. Biochemical characterisation of the interaction of the myosin light chain phosphatase with the regulatory subunits of protein kinase A in cells of the circulatory system. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4790706

Regulation of actomyosin-driven contraction is important for numerous cardiovascular cell functions, including smooth muscle tone, endothelial cell permeability and platelet shape change and spreading. These processes are primarily regulated by the p... Read More about Biochemical characterisation of the interaction of the myosin light chain phosphatase with the regulatory subunits of protein kinase A in cells of the circulatory system.

A Direct Comparison, and Prioritisation, of the Immunotherapeutic Targets Expressed by Adult and Paediatric Acute Myeloid Leukaemia Cells: A Systematic Review and Meta-Analysis (2023)
Journal Article
Morris, V., Ghazi, H., Fletcher, D., & Guinn, B. A. (2023). A Direct Comparison, and Prioritisation, of the Immunotherapeutic Targets Expressed by Adult and Paediatric Acute Myeloid Leukaemia Cells: A Systematic Review and Meta-Analysis. International Journal of Molecular Sciences, 24(11), Article 9667. https://doi.org/10.3390/ijms24119667

Acute myeloid leukaemia (AML) is characterized by impaired myeloid differentiation resulting in an accumulation of immature blasts in the bone marrow and peripheral blood. Although AML can occur at any age, the incidence peaks at age 65. The pathobio... Read More about A Direct Comparison, and Prioritisation, of the Immunotherapeutic Targets Expressed by Adult and Paediatric Acute Myeloid Leukaemia Cells: A Systematic Review and Meta-Analysis.

Ca2+ Influx through TRPC Channels Is Regulated by Homocysteine–Copper Complexes (2023)
Journal Article
Chen, G.-L., Zeng, B., Jiang, H., Daskoulidou, N., Saurabh, R., Chitando, R. J., & Xu, S.-Z. (2023). Ca2+ Influx through TRPC Channels Is Regulated by Homocysteine–Copper Complexes. Biomolecules, 13(6), Article 952. https://doi.org/10.3390/biom13060952

An elevated level of circulating homocysteine (Hcy) has been regarded as an independent risk factor for cardiovascular disease; however, the clinical benefit of Hcy lowering-therapy is not satisfying. To explore potential unrevealed mechanisms, we in... Read More about Ca2+ Influx through TRPC Channels Is Regulated by Homocysteine–Copper Complexes.

Quantitative proteomics of pancreatic cyst fluid for early diagnosis of cancer. (2023)
Presentation / Conference Contribution
Nikitenko, L. L., Manolis, D., O'Brien, D. P., Adekeye, A., Kessler, B. M., Collins, C., Kramer, H., Chang, D., & Maraveyas, A. Quantitative proteomics of pancreatic cyst fluid for early diagnosis of cancer. Presented at The London Pancreas Workshop 2023, London, United Kingdom

In our EARLY DIAgnosis of PAncreatic Cancer (EARLY DIAPAC) study, we aim to analyse molecular changes or “signatures” associated with early stages of pancreatic carcinogenesis by using the combination of: (i) Label-Free Quantitative Proteomics (LFQP)... Read More about Quantitative proteomics of pancreatic cyst fluid for early diagnosis of cancer..

A Combination of the Immunotherapeutic Drug Anti-Programmed Death 1 with Lenalidomide Enhances Specific T Cell Immune Responses against Acute Myeloid Leukemia Cells (2023)
Journal Article
Guinn, B. A., Schuler, P. J., Schrezenmeier, H., Hofmann, S., Weiss, J., Bulach, C., Götz, M., & Greiner, J. (2023). A Combination of the Immunotherapeutic Drug Anti-Programmed Death 1 with Lenalidomide Enhances Specific T Cell Immune Responses against Acute Myeloid Leukemia Cells. International Journal of Molecular Sciences, 24(11), Article 9285. https://doi.org/10.3390/ijms24119285

Immune checkpoint inhibitors can block inhibitory molecules on the surface of T cells, switching them from an exhausted to an active state. One of these inhibitory immune checkpoints, programmed cell death protein 1 (PD-1) is expressed on T cell subp... Read More about A Combination of the Immunotherapeutic Drug Anti-Programmed Death 1 with Lenalidomide Enhances Specific T Cell Immune Responses against Acute Myeloid Leukemia Cells.

Investigating the effects of arginine methylation inhibitors on microdissected brain tumour biopsies maintained in a miniaturised perfusion system (2023)
Journal Article
Barry, A., Samuel, S. F., Hosni, I., Moursi, A., Feugere, L., Sennett, C. J., Deepak, S., Achawal, S., Rajaraman, C., Iles, A., Wollenberg Valero, K. C., Scott, I. S., Green, V., Stead, L. F., Greenman, J., Wade, M. A., & Beltran-Alvarez, P. (2023). Investigating the effects of arginine methylation inhibitors on microdissected brain tumour biopsies maintained in a miniaturised perfusion system. Lab on a chip, 23(11), 2664-2682. https://doi.org/10.1039/d3lc00204g

Arginine methylation is a post-translational modification that consists of the transfer of one or two methyl (CH3) groups to arginine residues in proteins. Several types of arginine methylation occur, namely monomethylation, symmetric dimethylation a... Read More about Investigating the effects of arginine methylation inhibitors on microdissected brain tumour biopsies maintained in a miniaturised perfusion system.

Ibrutinib and rituximab versus fludarabine, cyclophosphamide, and rituximab for patients with previously untreated chronic lymphocytic leukaemia (FLAIR): interim analysis of a multicentre, open-label, randomised, phase 3 trial (2023)
Journal Article
Hillmen, P., Pitchford, A., Bloor, A., Broom, A., Young, M., Kennedy, B., Walewska, R., Furtado, M., Preston, G., Neilson, J. R., Pemberton, N., Sidra, G., Morley, N., Cwynarski, K., Schuh, A., Forconi, F., Elmusharaf, N., Paneesha, S., Fox, C. P., Howard, D. R., …Munir, T. (2023). Ibrutinib and rituximab versus fludarabine, cyclophosphamide, and rituximab for patients with previously untreated chronic lymphocytic leukaemia (FLAIR): interim analysis of a multicentre, open-label, randomised, phase 3 trial. The lancet oncology, 24(5), 535-552. https://doi.org/10.1016/S1470-2045%2823%2900144-4

Background: The approval of Bruton tyrosine kinase (BTK) inhibitors in patients with previously untreated chronic lymphocytic leukaemia (CLL) was based on trials which compared ibrutinib with alkylating agents in patients considered unfit for fludara... Read More about Ibrutinib and rituximab versus fludarabine, cyclophosphamide, and rituximab for patients with previously untreated chronic lymphocytic leukaemia (FLAIR): interim analysis of a multicentre, open-label, randomised, phase 3 trial.

The Host-Microbiota Axis in Chronic Wound Healing (2023)
Thesis
Stafford, A. R. The Host-Microbiota Axis in Chronic Wound Healing. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4424929

Chronic, non-healing skin wounds represent a substantial area of unmet clinical need, leading to debilitating morbidity and mortality in affected individuals. Due to their high prevalence and recurrence, chronic wounds pose a significant economic bur... Read More about The Host-Microbiota Axis in Chronic Wound Healing.

Factor VII deficiency: a cause of (or risk factor for) bleeding? (2023)
Journal Article
Hampshire, D. J. (2023). Factor VII deficiency: a cause of (or risk factor for) bleeding?. British journal of haematology, 202(3), 457-458. https://doi.org/10.1111/bjh.18806

Among the rare bleeding disorders factor VII deficiency is the most common, but correlating deficiency with bleeding phenotype is challenging. In their study Lou and colleagues investigate a large cohort of unrelated factor VII deficient patients pro... Read More about Factor VII deficiency: a cause of (or risk factor for) bleeding?.

An updated perspective on immunoglobulin replacement in chronic lymphocytic leukaemia in the era of targeted therapies (2023)
Journal Article
Khan, S., Allsup, D., & Molica, S. (2023). An updated perspective on immunoglobulin replacement in chronic lymphocytic leukaemia in the era of targeted therapies. Frontiers in Oncology, 13, Article 1135812. https://doi.org/10.3389/fonc.2023.1135812

Chronic lymphocytic leukaemia (CLL) is a malignancy of clonally expanded antigen-switched, neoplastic, mature B cells. CLL is characterised by a variable degree of immunosuppression and secondary hypogammaglobulinemia. B-cell depleting therapies have... Read More about An updated perspective on immunoglobulin replacement in chronic lymphocytic leukaemia in the era of targeted therapies.

Digital Health Solutions for Weight Loss and Obesity: A Narrative Review (2023)
Journal Article
Irvin, L., Madden, L. A., Marshall, P., & Vince, R. V. (2023). Digital Health Solutions for Weight Loss and Obesity: A Narrative Review. Nutrients, 15(8), Article 1858. https://doi.org/10.3390/nu15081858

Personal exercise programmes have long been used and prescribed for weight loss and the improvement of quality of life in obese patients. While individualised programmes are usually the preferred option, they can be more costly and challenging to del... Read More about Digital Health Solutions for Weight Loss and Obesity: A Narrative Review.

Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells (2023)
Thesis
Haque, F. Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4371279

The premalignant pancreatic cellular genotype can remain stable for years before rapid malignant transformation, often associated with inflammation. Tissue factor (TF) is an inflammatory modulator regulated by factor VIIa (fVIIa) for its levels and a... Read More about Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells.