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Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds (2020)
Journal Article
Wilkinson, H. N., & Hardman, M. J. (2020). Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds. Frontiers in Cell and Developmental Biology, 8, Article 773. https://doi.org/10.3389/fcell.2020.00773

© Copyright © 2020 Wilkinson and Hardman. Cellular senescence is a fundamental stress response that restrains tumour formation. Yet, senescence cells are also present in non-cancerous states, accumulating exponentially with chronological age and cont... Read More about Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds.

Paper-based analytical devices for colorimetric detection of: S. aureus and E. coli and their antibiotic resistant strains in milk (2020)
Journal Article
Khan, Q. M., Asif, M., Awan, F. R., Khan, Q. . M., Ngamsom, B., & Pamme, N. (2020). Paper-based analytical devices for colorimetric detection of: S. aureus and E. coli and their antibiotic resistant strains in milk. Analyst, 145(22), 7320-7329. https://doi.org/10.1039/d0an01075h

Animal derived milk which is an important part of human diet due to its high nutritional value not only supports humans but also presents a growth environment for pathogenic bacteria. Milk may become contaminated with bacteria through udder infection... Read More about Paper-based analytical devices for colorimetric detection of: S. aureus and E. coli and their antibiotic resistant strains in milk.

Efficiency of donning and doffing medical examination gloves (2020)
Journal Article
Preece, D., Lewis, R., & Carré, M. J. (2020). Efficiency of donning and doffing medical examination gloves. International Journal of Ergonomics, 10(1), 1-17

Quickly donning and doffing medical gloves is of vital importance for high-pressure environments. The efficiency of glove donning, however, is sometimes hindered because of moisture on the hand. A variety of commercial glove coatings exist that are s... Read More about Efficiency of donning and doffing medical examination gloves.

Doxorubicin Enhances Procoagulant Activity of Endothelial Cells after Exposure to Tumour Microparticles on Microfluidic Devices (2020)
Journal Article
Algarni, A., Greenman, J., & Madden, L. A. (2020). Doxorubicin Enhances Procoagulant Activity of Endothelial Cells after Exposure to Tumour Microparticles on Microfluidic Devices. Hemato, 1(1), 23-34. https://doi.org/10.3390/bloods1010006

The majority of cancer patients undergoing chemotherapy have a significantly increased risk of venous thromboembolism via a mechanism not yet fully elucidated but which most probably involves tumour microparticles (MP) combined with damaged/activated... Read More about Doxorubicin Enhances Procoagulant Activity of Endothelial Cells after Exposure to Tumour Microparticles on Microfluidic Devices.

The Changing Face of in vitro Culture Models for Thyroid Cancer Research: A Systematic Literature Review (2020)
Journal Article
Chew, D., Green, V., Riley, A., England, R. J., & Greenman, J. (2020). The Changing Face of in vitro Culture Models for Thyroid Cancer Research: A Systematic Literature Review. Frontiers in Surgery, 7, Article 43. https://doi.org/10.3389/fsurg.2020.00043

© Copyright © 2020 Chew, Green, Riley, England and Greenman. Background: Thyroid cancer is the most common endocrine malignancy worldwide. Primary treatment with surgery and radioactive iodine is usually successful, however, there remains a small pro... Read More about The Changing Face of in vitro Culture Models for Thyroid Cancer Research: A Systematic Literature Review.

Pre-Clinical Assessment of Single-Use Negative Pressure Wound Therapy During In Vivo Porcine Wound Healing (2020)
Journal Article
Brownhill, V., Huddleston, E., Bell, A., Hart, J., Webster, I., Hardman, M., & Wilkinson, H. (2021). Pre-Clinical Assessment of Single-Use Negative Pressure Wound Therapy During In Vivo Porcine Wound Healing. Advances in wound care, 10(7), 345-356. https://doi.org/10.1089/wound.2020.1218

Objective: Traditional negative pressure wound therapy systems can be large and cumbersome, limiting patient mobility and adversely affecting quality of life. PICO™, a no canister single-use system offers a lightweight, portable alternative to tradit... Read More about Pre-Clinical Assessment of Single-Use Negative Pressure Wound Therapy During In Vivo Porcine Wound Healing.

Characterization of large in-frame von Willebrand factor deletions highlights differing pathogenic mechanisms (2020)
Journal Article
Cartwright, A., Webster, S. J., de Jong, A., Dirven, R. J., Bloomer, L. D. S., Al-Buhairan, A. M., Budde, U., Halldén, C., Habart, D., Goudemand, J., Peake, I. R., Eikenboom, J. C. J., Goodeve, A. C., & Hampshire, D. J. (2020). Characterization of large in-frame von Willebrand factor deletions highlights differing pathogenic mechanisms. Blood Advances, 4(13), 2979-2990. https://doi.org/10.1182/bloodadvances.2018027813

Copy number variation (CNV) is known to cause all von Willebrand disease (VWD) types, although the associated pathogenic mechanisms involved have not been extensively studied. Notably, in-frame CNV provides a unique opportunity to investigate how spe... Read More about Characterization of large in-frame von Willebrand factor deletions highlights differing pathogenic mechanisms.

Diminution in sperm quantity and quality in mouse models of Duchenne Muscular Dystrophy induced by a myostatin-based muscle growth-promoting intervention (2020)
Journal Article
Vaughan, D., Kretz, O., Alqallaf, A., Mitchell, R., von der Heide, J., Vaiyapuri, S., Matsakas, A., Pasternack, A., Collins-Hooper, H., Ritvos, O., Ballesteros, R., Huber, T. B., Amthor, H., Mukherjee, A., & Patel, K. (in press). Diminution in sperm quantity and quality in mouse models of Duchenne Muscular Dystrophy induced by a myostatin-based muscle growth-promoting intervention. European Journal of Translational Myology, 30(2), 276-285. https://doi.org/10.4081/ejtm.0.8904

Duchenne Muscular Dystrophy is a devastating disease caused by the absence of a functional rod-shaped cytoplasmic protein called dystrophin. Several avenues are being developed aimed to restore dystrophin expression in boys affected by this X-linked... Read More about Diminution in sperm quantity and quality in mouse models of Duchenne Muscular Dystrophy induced by a myostatin-based muscle growth-promoting intervention.

Use of non-Gaussian time-of-flight kernels for image reconstruction of Monte Carlo simulated data of ultra-fast PET scanners (2020)
Journal Article
Efthimiou, N., Thielemans, K., Emond, E., Cawthorne, C., Archibald, S. J., & Tsoumpas, C. (in press). Use of non-Gaussian time-of-flight kernels for image reconstruction of Monte Carlo simulated data of ultra-fast PET scanners. EJNMMI Physics, 7(1), Article 42. https://doi.org/10.1186/s40658-020-00309-8

Introduction: Time-of-flight (TOF) positron emission tomography (PET) scanners can provide significant benefits by improving the noise properties of reconstructed images. In order to achieve this, the timing response of the scanner needs to be modell... Read More about Use of non-Gaussian time-of-flight kernels for image reconstruction of Monte Carlo simulated data of ultra-fast PET scanners.

The effects of empagliflozin vs metformin on endothelial microparticles in overweight/obese women with polycystic ovary syndrome (2020)
Journal Article
Javed, Z., Papageorgiou, M., Madden, L. A., Rigby, A. S., Kilpatrick, E. S., Atkin, S. L., & Sathyapalan, T. (2020). The effects of empagliflozin vs metformin on endothelial microparticles in overweight/obese women with polycystic ovary syndrome. Endocrine Connections, 9(6), 563-569. https://doi.org/10.1530/EC-20-0173

Context: Endothelial microparticles (EMPs) are novel, surrogate biomarkers of endothelial function and have been shown to be elevated in women with polycystic ovary syndrome (PCOS). It remains poorly understood how pharmacological options for managin... Read More about The effects of empagliflozin vs metformin on endothelial microparticles in overweight/obese women with polycystic ovary syndrome.

On-chip electrochemical detection of glucose towards the miniaturised quality control of carbohydrate-based radiotracers (2020)
Journal Article
Patinglag, L., Esfahani, M. M. N., Ragunathan, K., He, P., Brown, N. J., Archibald, S. J., Pamme, N., & Tarn, M. D. (2020). On-chip electrochemical detection of glucose towards the miniaturised quality control of carbohydrate-based radiotracers. Analyst, 145(14), 4920-4930. https://doi.org/10.1039/c9an01881f

The miniaturisation of positron emission tomography (PET) radiotracer production is facilitating a move towards a dose-on-demand strategy that would enable a stratified approach to patient diagnostics, but while the on-chip synthesis steps have been... Read More about On-chip electrochemical detection of glucose towards the miniaturised quality control of carbohydrate-based radiotracers.

An ethylene cross-bridged pentaazamacrocycle and its Cu2+ complex: constrained ligand topology and excellent kinetic stability (2020)
Journal Article
Shircliff, A. D., Burke, B. P., Davilla, D. J., Burgess, G. E., Okorocha, F. A., Shrestha, A., Allbritton, E. M. A., Nguyen, P. T., Lamar, R. L., Jones, D. G., Gorbet, M. J., Allen, M. B., Eze, J. I., Fernandez, A. T., Ramirez, D., Archibald, S. J., Prior, T. J., Krause, J. A., Oliver, A. G., & Hubin, T. J. (2020). An ethylene cross-bridged pentaazamacrocycle and its Cu2+ complex: constrained ligand topology and excellent kinetic stability. Chemical communications : Chem comm / the Royal Society of Chemistry, 56(54), 7519-7522. https://doi.org/10.1039/d0cc00919a

Rigid and topologically constrained ethylene cross-bridged tetraazamacrocycles have been increasingly utilised for thirty years as they form remarkably stable transition metal complexes for catalysis, biomedical imaging, and inorganic drug molecule a... Read More about An ethylene cross-bridged pentaazamacrocycle and its Cu2+ complex: constrained ligand topology and excellent kinetic stability.

Quantitative Redox Biology of Exercise (2020)
Journal Article
Nikolaidis, M. G., Margaritelis, N. V., & Matsakas, A. (2020). Quantitative Redox Biology of Exercise. International journal of sports medicine, 41(10), 633-645. https://doi.org/10.1055/a-1157-9043

© Georg Thieme Verlag KG Stuttgart · New York. Biology is rich in claims that reactive oxygen and nitrogen species are involved in every biological process and disease. However, many quantitative aspects of redox biology remain elusive. The important... Read More about Quantitative Redox Biology of Exercise.

Whole-genome sequencing of a sporadic primary immunodeficiency cohort (2020)
Journal Article
Cooper, N., Abbs, S., Farmery, J. H., Deevi, S. V., Thaventhiran, J. E., Adhya, Z., Adlard, J., Afzal, M., Ahmed, I., Ahmed, M., Ahmed, S., Aitman, T. J., Alachkar, H., Anderson, J., Alamelu, J., Alikhan, R., Allen, C. E., Allen, L., Alvi, A., Ambegaonkar, G., …Smith, K. G. C. (2020). Whole-genome sequencing of a sporadic primary immunodeficiency cohort. Nature, 583(7814), 90-95. https://doi.org/10.1038/s41586-020-2265-1

Primary immunodeficiency (PID) is characterized by recurrent and often life-threatening infections, autoimmunity and cancer, and it poses major diagnostic and therapeutic challenges. Although the most severe forms of PID are identified in early child... Read More about Whole-genome sequencing of a sporadic primary immunodeficiency cohort.

Glucose concentration during equine in vitro maturation alters mitochondrial function (2020)
Journal Article
Lewis, N., Hinrichs, K., Leese, H. J., McGregor Argo, C., Brison, D. R., & Sturmey, R. G. (2020). Glucose concentration during equine in vitro maturation alters mitochondrial function. Reproduction, 160(2), 227-237. https://doi.org/10.1530/REP-20-0032

The use of in vitro embryo production in the horse is increasing in clinical and research settings, however, protocols are yet to be optimised. Notably, the two most commonly used base media for in vitro maturation (IVM) supply glucose at markedly di... Read More about Glucose concentration during equine in vitro maturation alters mitochondrial function.

The EAHAD blood coagulation factor VII variant database (2020)
Journal Article
Kemball-Cook, G., Giansily-Blaizot, M., Giansily‐Blaizot, M., Rallapalli, P. M., Perkins, S. J., Kemball‐Cook, G., Hampshire, D. J., Gomez, K., Ludlam, C. A., & McVey, J. H. (2020). The EAHAD blood coagulation factor VII variant database. Human Mutation, 41(7), 1209-1219. https://doi.org/10.1002/humu.24025

Hereditary blood coagulation factor VII (FVII) deficiency is a rare autosomal recessive bleeding disorder resulting from variants in the gene encoding FVII (F7 ). Integration of genetic variation with functional consequences on protein function is es... Read More about The EAHAD blood coagulation factor VII variant database.

The mitochondrial phosphate carrier TbMCP11 is essential for mitochondrial function in the procyclic form of Trypanosoma brucei (2020)
Journal Article
Gao, F., Voncken, F., & Colasante, C. (2020). The mitochondrial phosphate carrier TbMCP11 is essential for mitochondrial function in the procyclic form of Trypanosoma brucei. Molecular and Biochemical Parasitology, 237, Article 111275. https://doi.org/10.1016/j.molbiopara.2020.111275

Conserved amongst all eukaryotes is a family of mitochondrial carrier proteins (SLC25A) responsible for the import of various solutes across the inner mitochondrial membrane. We previously reported that the human parasite Trypanosoma brucei possesses... Read More about The mitochondrial phosphate carrier TbMCP11 is essential for mitochondrial function in the procyclic form of Trypanosoma brucei.

Do age-associated changes of voltage-gated sodium channel isoforms expressed in the mammalian heart predispose the elderly to atrial fibrillation? (2020)
Journal Article
Isaac, E., Cooper, S. M., Jones, S. A., & Loubani, M. (2020). Do age-associated changes of voltage-gated sodium channel isoforms expressed in the mammalian heart predispose the elderly to atrial fibrillation?. World Journal of Cardiology, 12(4), 123-135. https://doi.org/10.4330/wjc.v12.i4.123

© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide. The prevalence of the disease increases with age, strongly implying an age-related proc... Read More about Do age-associated changes of voltage-gated sodium channel isoforms expressed in the mammalian heart predispose the elderly to atrial fibrillation?.

Metabolic profile of in vitro derived human embryos is not affected by the mode of fertilization (2020)
Journal Article
Sturmey, R. G., & Leary, C. (2020). Metabolic profile of in vitro derived human embryos is not affected by the mode of fertilization. Molecular Human Reproduction, 26(4), 277-287. https://doi.org/10.1093/molehr/gaaa015

The pattern of metabolism by early embryos in vitro has been linked to a range of phenotypes, including viability. However, the extent to which metabolic function of embryos is modified by specific methods used during ART has yet to be fully describ... Read More about Metabolic profile of in vitro derived human embryos is not affected by the mode of fertilization.