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All Outputs (76)

Oligoubiquitination of tissue factor on Lys255 promotes Ser253-dephosphorylation and terminates TF release (2016)
Journal Article
Ettelaie, C., Collier, M. E., Featherby, S., Greenman, J., & Maraveyas, A. (2016). Oligoubiquitination of tissue factor on Lys255 promotes Ser253-dephosphorylation and terminates TF release. BBA - Molecular Cell Research, 1863(11), 2846-2857. https://doi.org/10.1016/j.bbamcr.2016.09.005

Restriction of tissue factor (TF) activity at the cell surface and TF release are critical for prevention of excessive coagulation. This study examined the regulation of TF dephosphorylation and its release through ubiquitination. A plasmid containin... Read More about Oligoubiquitination of tissue factor on Lys255 promotes Ser253-dephosphorylation and terminates TF release.

Percutaneous device closure of paravalvular leak (2016)
Journal Article
Calvert, P. A., Northridge, D. B., Malik, I. S., Shapiro, L., Ludman, P., Qureshi, S. A., …Hildick-Smith, D. (2016). Percutaneous device closure of paravalvular leak. Circulation, 134(13), 934-944. https://doi.org/10.1161/CIRCULATIONAHA.116.022684

Background: Paravalvular leak (PVL) occurs in 5% to 17% of patients following surgical valve replacement. Percutaneous device closure represents an alternative to repeat surgery. Methods: All UK and Ireland centers undertaking percutaneous PVL closur... Read More about Percutaneous device closure of paravalvular leak.

The test-retest reliability of four functional mobility tests in apparently healthy adults (2016)
Journal Article
Northgraves, M. J., Hayes, S. C., Marshall, P., Madden, L. A., & Vince, R. V. (2016). The test-retest reliability of four functional mobility tests in apparently healthy adults. Isokinetics and Exercise Science, 24(3), 171-179. https://doi.org/10.3233/ies-160614

Background: Simple field tests are often used to assess functional mobility in clinical settings. Despite having many benefits, these tests are susceptible to measurement error and individual variation. Objectives: To examine the test-retest and abso... Read More about The test-retest reliability of four functional mobility tests in apparently healthy adults.

The relationship between endogenous thymidine concentrations and [18F]FLT uptake in a range of preclinical tumour models (2016)
Journal Article
Heinzmann, K., Honess, D. J., Lewis, D. Y., Smith, D., Cawthorne, C., Keen, H., …Brindle, K. M. (2016). The relationship between endogenous thymidine concentrations and [18F]FLT uptake in a range of preclinical tumour models. EJNMMI Research, 6(1), Article 63. https://doi.org/10.1186/s13550-016-0218-3

Background Recent studies have shown that 3′-deoxy-3′-[18F] fluorothymidine ([18F]FLT)) uptake depends on endogenous tumour thymidine concentration. The purpose of this study was to investigate tumour thymidine concentrations and whether they correla... Read More about The relationship between endogenous thymidine concentrations and [18F]FLT uptake in a range of preclinical tumour models.

Functional diversity of cytomegalovirus-specific T cells is maintained in older people and significantly associated with protein specificity and response size (2016)
Journal Article
Bajwa, M., Vita, S., Vescovini, R., Larsen, M., Sansoni, P., Terrazzini, N., …Kern, F. (2016). Functional diversity of cytomegalovirus-specific T cells is maintained in older people and significantly associated with protein specificity and response size. The journal of infectious diseases : official publication of the Infectious Diseases Society of America, 214(9), 1430-1437. https://doi.org/10.1093/infdis/jiw371

© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. Background. Parallel upregulation of several T-cell effector functions (ie, polyfunctionality) is believed to be critical for... Read More about Functional diversity of cytomegalovirus-specific T cells is maintained in older people and significantly associated with protein specificity and response size.

Enhanced exercise and regenerative capacity in a mouse model that violates size constraints of oxidative muscle fibres (2016)
Journal Article
Omairi, S., Matsakas, A., Degens, H., Kretz, O., Hansson, K. A., Solbrå, A. V., …Patel, K. (2016). Enhanced exercise and regenerative capacity in a mouse model that violates size constraints of oxidative muscle fibres. eLife, 5(AUGUST), Article 16940. https://doi.org/10.7554/elife.16940

A central tenet of skeletal muscle biology is the existence of an inverse relationship between the oxidative fibre capacity and its size. However, robustness of this relationship is unknown. We show that superimposition of Estrogen-related receptor g... Read More about Enhanced exercise and regenerative capacity in a mouse model that violates size constraints of oxidative muscle fibres.

Biological optimisation, the Goldilocks principle, and how much is lagom in the preimplantation embryo (2016)
Journal Article
Leese, H. J., Guérif, F., Allgar, V., Brison, D. R., Lundin, K., & Sturmey, R. G. (2016). Biological optimisation, the Goldilocks principle, and how much is lagom in the preimplantation embryo. Molecular Reproduction and Development, 83(9), 748-754. https://doi.org/10.1002/mrd.22684

The quiet embryo hypothesis postulates that early embryo viability is associated with a relatively low metabolism (Leese. 2002. BioEssays 24: 845-849). This proposal is re-visited here using retrospective and prospective data on the metabolic activit... Read More about Biological optimisation, the Goldilocks principle, and how much is lagom in the preimplantation embryo.

Aspartate-Based CXCR4 Chemokine Receptor Binding of Cross-Bridged Tetraazamacrocyclic Copper(II) and Zinc(II) Complexes (2016)
Journal Article
Maples, R. D., Cain, A. N., Burke, B. P., Silversides, J. D., Mewis, R. E., D'huys, T., …Hubin, T. J. (2016). Aspartate-Based CXCR4 Chemokine Receptor Binding of Cross-Bridged Tetraazamacrocyclic Copper(II) and Zinc(II) Complexes. Chemistry: a European journal, 22(36), 12916-12930. https://doi.org/10.1002/chem.201601468

© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim The CXCR4 chemokine receptor is implicated in a number of diseases including HIV infection and cancer development and metastasis. Previous studies have demonstrated that configurationally restricted... Read More about Aspartate-Based CXCR4 Chemokine Receptor Binding of Cross-Bridged Tetraazamacrocyclic Copper(II) and Zinc(II) Complexes.

CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells (2016)
Journal Article
Sinclair, A., Park, L., Shah, M., Drotar, M., Calaminus, S., Hopcroft, L. E., …Holyoake, T. L. (2016). CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells. Blood, 128(3), 371-383. https://doi.org/10.1182/blood-2015-08-661785

The regulation of hematopoietic stem cell (HSC) survival and self-renewal within the bone marrow (BM) niche is not well understood. We therefore investigated global transcriptomic profiling of normal human HSC/hematopoietic progenitor cells [HPCs], r... Read More about CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells.

Dedicated Bifurcation Stent for the Treatment of Bifurcation Lesions InvolvingLarge Side Branches: Outcomes From the Tryton Confirmatory Study (2016)
Journal Article
Généreux, P., Kumsars, I., Schneider, J. E., Lesiak, M., Redfors, B., Cornelis, K., …Leon, M. B. (2016). Dedicated Bifurcation Stent for the Treatment of Bifurcation Lesions InvolvingLarge Side Branches: Outcomes From the Tryton Confirmatory Study. JACC: Cardiovascular Interventions, 9(13), 1338-1346. https://doi.org/10.1016/j.jcin.2016.03.042

Objectives: The aim of this study was to prospectively study and confirm the safety and efficacy of the Tryton Side Branch Stent in the treatment of coronary artery bifurcations involving large side branches (SBs). Background The TRYTON Pivotal rando... Read More about Dedicated Bifurcation Stent for the Treatment of Bifurcation Lesions InvolvingLarge Side Branches: Outcomes From the Tryton Confirmatory Study.

Biomarkers of coronary endothelial health: correlation with invasive measures of collateral function, flow and resistance in chronically occluded coronary arteries and the effect of recanalization (2016)
Journal Article
Ladwiniec, A., Ettelaie, C., Cunnington, M. S., Rossington, J., Thackray, S., Alamgir, F., & Hoye, A. (2016). Biomarkers of coronary endothelial health: correlation with invasive measures of collateral function, flow and resistance in chronically occluded coronary arteries and the effect of recanalization. Coronary Artery Disease, 27(4), 287-294. https://doi.org/10.1097/mca.0000000000000360

Objectives: In the presence of a chronically occluded coronary artery, the collateral circulation matures by a process of arteriogenesis; however, there is considerable variation between individuals in the functional capacity of that collateral netwo... Read More about Biomarkers of coronary endothelial health: correlation with invasive measures of collateral function, flow and resistance in chronically occluded coronary arteries and the effect of recanalization.

Monolith-based68Ga processing: A new strategy for purification to facilitate direct radiolabelling methods (2016)
Journal Article
He, P., Burke, B. P., Clemente, G. S., Brown, N., Pamme, N., & Archibald, S. J. (2016). Monolith-based68Ga processing: A new strategy for purification to facilitate direct radiolabelling methods. Reaction Chemistry and Engineering, 1(4), 361-365. https://doi.org/10.1039/c6re00081a

The post-processing of68Ga generator eluate by means of a novel high capacity cation-exchange silica monolith column has been validated in this work. Quantitative release of a purified68Ga solution in high concentration can be achieved using weak aci... Read More about Monolith-based68Ga processing: A new strategy for purification to facilitate direct radiolabelling methods.

Circulating plasma microRNAs can differentiate Human Sepsis and Systemic Inflammatory Response Syndrome (SIRS) (2016)
Journal Article
Caserta, S., Kern, F., Cohen, J., Drage, S., Newbury, S. F., & Llewelyn, M. J. (2016). Circulating plasma microRNAs can differentiate Human Sepsis and Systemic Inflammatory Response Syndrome (SIRS). Scientific reports, 6(1), Article 28006. https://doi.org/10.1038/srep28006

Systemic inflammation in humans may be triggered by infection, termed sepsis, or non-infective processes, termed non-infective systemic inflammatory response syndrome (SIRS). MicroRNAs regulate cellular processes including inflammation and may be det... Read More about Circulating plasma microRNAs can differentiate Human Sepsis and Systemic Inflammatory Response Syndrome (SIRS).

Whole exome sequencing identifies genetic variants in inherited thrombocytopenia with secondary qualitative function defects (2016)
Journal Article
Johnson, B., Lowe, G. C., Futterer, J., Lordkipanidzé, M., Macdonald, D., Simpson, M. A., …on behalf of the UK GAPP Study Group. (2016). Whole exome sequencing identifies genetic variants in inherited thrombocytopenia with secondary qualitative function defects. Haematologica, 101(10), 1170-1179. https://doi.org/10.3324/haematol.2016.146316

© 2016 Ferrata Storti Foundation. Inherited thrombocytopenias are a heterogeneous group of disorders characterized by abnormally low platelet counts which can be associated with abnormal bleeding. Next-generation sequencing has previously been employ... Read More about Whole exome sequencing identifies genetic variants in inherited thrombocytopenia with secondary qualitative function defects.

Atypical Rho GTPases of the RhoBTB Subfamily: Roles in vesicle trafficking and tumorigenesis (2016)
Journal Article
Ji, W., & Rivero, F. (2016). Atypical Rho GTPases of the RhoBTB Subfamily: Roles in vesicle trafficking and tumorigenesis. Cells, 5(2), 28. https://doi.org/10.3390/cells5020028

RhoBTB proteins constitute a subfamily of atypical Rho GTPases represented in mammals by RhoBTB1, RhoBTB2, and RhoBTB3. Their characteristic feature is a carboxyl terminal extension that harbors two BTB domains capable of assembling cullin 3-dependen... Read More about Atypical Rho GTPases of the RhoBTB Subfamily: Roles in vesicle trafficking and tumorigenesis.

Congenital macrothrombocytopenia is a heterogeneous disorder in India (2016)
Journal Article
Ali, S., Ghosh, K., Daly, M. E., Hampshire, D. J., Makris, M., Ghosh, M., …Shetty, S. (2016). Congenital macrothrombocytopenia is a heterogeneous disorder in India. Haemophilia, 22(4), 570-582. https://doi.org/10.1111/hae.12917

Introduction: Inherited macrothrombocytopenia represents a heterogeneous group of disorders which are characterized by the presence of a reduced number of abnormally large platelets in the circulation, which may or may not be associated with a bleedi... Read More about Congenital macrothrombocytopenia is a heterogeneous disorder in India.

Harvesting human prostate tissue material and culturing primary prostate epithelial cells (2016)
Book Chapter
Frame, F. M., Pellacani, D., Collins, A. T., & Maitland, N. J. (2016). Harvesting human prostate tissue material and culturing primary prostate epithelial cells. In I. J. McEwan (Ed.), The nuclear receptor superfamily: methods and protocols (181-201). New York, NY: Humana Press. https://doi.org/10.1007/978-1-4939-3724-0_12

In order to fully explore the biology of a complex solid tumor such as prostate cancer, it is desirable to work with patient tissue. Only by working with cells from a tissue can we take into account patient variability and tumor heterogeneity. Cell l... Read More about Harvesting human prostate tissue material and culturing primary prostate epithelial cells.