All Outputs (77)

RHOBTB1 (Rho-related BTB domain containing 1) (2016)
Journal Article
Cai, S., Rivero-Crespo, F., & Schenková, K. (2016). RHOBTB1 (Rho-related BTB domain containing 1). Atlas of genetics and cytogenetics in oncology and haematology, 20(10), 512-515. https://doi.org/10.4267/2042/66084

RhoBTB1 is one of the three members of the RhoBTB family. All RhoBTB proteins are characterized by a GTPase domain followed by a proline-rich region, a tandem of two BTB domains and a C-terminal putative RING finger domain. RHOBTB1 is a putative tumo... Read More about RHOBTB1 (Rho-related BTB domain containing 1).

Systematic review and meta-analysis of optimal P2Y₁₂ blockade in dual antiplatelet therapy for patients with diabetes with acute coronary syndrome (2016)
Journal Article
Rossington, J. A., Brown, O. I., & Hoye, A. (2016). Systematic review and meta-analysis of optimal P2Y₁₂ blockade in dual antiplatelet therapy for patients with diabetes with acute coronary syndrome. Open heart, 3(1), e000296. https://doi.org/10.1136/openhrt-2015-000296

Background: Patients with diabetes are at increased risk of acute coronary syndromes (ACS) and their mortality and morbidity outcomes are significantly worse following ACS events, independent of other comorbidities. This systematic review sought to e... Read More about Systematic review and meta-analysis of optimal P2Y₁₂ blockade in dual antiplatelet therapy for patients with diabetes with acute coronary syndrome.

Low temperature plasmas as emerging cancer therapeutics: the state of play and thoughts for the future (2016)
Journal Article
Hirst, A. M., Frame, F. M., Arya, M., Maitland, N. J., & O’Connell, D. (2016). Low temperature plasmas as emerging cancer therapeutics: the state of play and thoughts for the future. Tumor Biology, 37(6), 7021-7031. https://doi.org/10.1007/s13277-016-4911-7

The field of plasma medicine has seen substantial advances over the last decade, with applications developed for bacterial sterilisation, wound healing and cancer treatment. Low temperature plasmas (LTPs) are particularly suited for medical purposes... Read More about Low temperature plasmas as emerging cancer therapeutics: the state of play and thoughts for the future.

Expression and function of transient receptor potential channels in the female bovine reproductive tract (2016)
Journal Article
Ghavideldarestani, M., Atkin, S. L., Leese, H. J., & Sturmey, R. G. (2016). Expression and function of transient receptor potential channels in the female bovine reproductive tract. Theriogenology, 86(2), 551-561. https://doi.org/10.1016/j.theriogenology.2016.02.005

© 2016 Elsevier Inc. The epithelium lining the oviduct is critical for early reproductive events, many of which are mediated via intracellular calcium ions. Despite this, little is known about the regulation of calcium homeostasis in the oviductal ep... Read More about Expression and function of transient receptor potential channels in the female bovine reproductive tract.

Oestrogen promotes healing in a bacterial LPS model of delayed cutaneous wound repair (2016)
Journal Article
Crompton, R., Williams, H., Ansell, D., Campbell, L., Holden, K., Cruickshank, S., & Hardman, M. J. (2016). Oestrogen promotes healing in a bacterial LPS model of delayed cutaneous wound repair. Laboratory investigation, 96(4), 439-449. https://doi.org/10.1038/labinvest.2015.160

Wound infection is a major clinical problem, yet understanding of bacterial host interactions in the skin remains limited. Microbe-derived molecules, known as pathogen-associated molecular patterns, are recognised in barrier tissues by pattern-recogn... Read More about Oestrogen promotes healing in a bacterial LPS model of delayed cutaneous wound repair.

On-chip acoustophoretic isolation of microflora including S. typhimurium from raw chicken, beef and blood samples (2016)
Journal Article
Ngamsom, B., Lopez-Martinez, M. J., Raymond, J.-C., Broyer, P., Patel, P., & Pamme, N. (2016). On-chip acoustophoretic isolation of microflora including S. typhimurium from raw chicken, beef and blood samples. Journal of microbiological methods, 123, 79-86. https://doi.org/10.1016/j.mimet.2016.01.016

Pathogen analysis in food samples routinely involves lengthy growth-based pre-enrichment and selective enrichment of food matrices to increase the ratio of pathogen to background flora. Similarly, for blood culture analysis, pathogens must be isolate... Read More about On-chip acoustophoretic isolation of microflora including S. typhimurium from raw chicken, beef and blood samples.

Current advances in ligand design for inorganic positron emission tomography tracers ⁶⁸Ga, ⁶⁴Cu, ⁸⁹Zr and ⁴⁴Sc (2016)
Journal Article
Price, T. W., Greenman, J., & Stasiuk, G. J. (2016). Current advances in ligand design for inorganic positron emission tomography tracers ⁶⁸Ga, ⁶⁴Cu, ⁸⁹Zr and ⁴⁴Sc. Dalton Transactions : an international journal of inorganic chemistry, 45(40), 15702-15724. https://doi.org/10.1039/c5dt04706d

A key part of the development of metal based Positron Emission Tomography probes is the chelation of the radiometal. In this review the recent developments in the chelation of four positron emitting radiometals, 68Ga, 64Cu, 89Zr and 44Sc, are explore... Read More about Current advances in ligand design for inorganic positron emission tomography tracers ⁶⁸Ga, ⁶⁴Cu, ⁸⁹Zr and ⁴⁴Sc.

Ectodysplasin A Pathway Contributes to Human and Murine Skin Repair (2016)
Journal Article
Garcin, C. L., Huttner, K. M., Kirby, N., Schneider, P., & Hardman, M. J. (2016). Ectodysplasin A Pathway Contributes to Human and Murine Skin Repair. Journal of Investigative Dermatology, 136(5), 1022-1030. https://doi.org/10.1016/j.jid.2015.09.002

The highly conserved ectodysplasin A (EDA)/EDA receptor signaling pathway is critical during development for the formation of skin appendages. Mutations in genes encoding components of the EDA pathway disrupt normal appendage development, leading to... Read More about Ectodysplasin A Pathway Contributes to Human and Murine Skin Repair.

Family caregivers who would be unwilling to provide care at the end of life again: findings from the Health Survey for England population survey (2016)
Journal Article
Johnson, M. J., Allgar, V., Macleod, U., Jones, A., Oliver, S., & Currow, D. (2016). Family caregivers who would be unwilling to provide care at the end of life again: findings from the Health Survey for England population survey. PLoS ONE, 11(1), e0146960. https://doi.org/10.1371/journal.pone.0146960

Background Family caregivers provide significant care at the end of life. We aimed to describe caregiver characteristics, and of those unwilling to repeat this role under the same circumstances. Methods Observational study of adults in private househ... Read More about Family caregivers who would be unwilling to provide care at the end of life again: findings from the Health Survey for England population survey.

Mono- and bis-alkylation of glyoxal-bridged tetraazamacrocycles using mechanochemistry (2016)
Journal Article
Abdulwahaab, B. H., Burke, B. P., Domarkas, J., Silversides, J. D., Prior, T. J., & Archibald, S. J. (2016). Mono- and bis-alkylation of glyoxal-bridged tetraazamacrocycles using mechanochemistry. Journal of Organic Chemistry, 81(3), 890-898. https://doi.org/10.1021/acs.joc.5b02464

Glyoxal-bridged bisaminal tetraazamacrocyclic derivatives of 1,4,7,10-tetraazacyclododecane (cyclen) and 1,4,8,11-tetraazacyclotetradecane (cyclam) can be N-functionalized to incorporate coordinating groups or for conjugation to biomolecules. Herein,... Read More about Mono- and bis-alkylation of glyoxal-bridged tetraazamacrocycles using mechanochemistry.

Analysis of the potential of cancer cell lines to release tissue factor-containing microvesicles: correlation with tissue factor and PAR2 expression (2016)
Journal Article
Ettelaie, C., Collier, M. E. W., Featherby, S., Benelhaj, N. E., Greenman, J., & Maraveyas, A. (2016). Analysis of the potential of cancer cell lines to release tissue factor-containing microvesicles: correlation with tissue factor and PAR2 expression. Thrombosis journal, 14(2), Article ARTN 2. https://doi.org/10.1186/s12959-016-0075-3

Background
Despite the association of cancer-derived circulating tissue factor (TF)-containing microvesicles and hypercoagulable state, correlations with the incidence of thrombosis remain unclear.

Methods
In this study the upregulation of TF re... Read More about Analysis of the potential of cancer cell lines to release tissue factor-containing microvesicles: correlation with tissue factor and PAR2 expression.

How does rhinovirus cause the common cold cough? (2016)
Journal Article
Atkinson, S. K., Sadofsky, L. R., & Morice, A. H. (2016). How does rhinovirus cause the common cold cough?. BMJ Open Respiratory Research, 3(1), Article e000118. https://doi.org/10.1136/bmjresp-2015-000118

© 2016, BMJ Publishing Group. All rights reserved. Cough is a protective reflex to prevent aspiration and can be triggered by a multitude of stimuli. The commonest form of cough is caused by upper respiratory tract infection and has no benefit to the... Read More about How does rhinovirus cause the common cold cough?.

Microvascular dysfunction in the immediate aftermath of chronic total coronary occlusion recanalization (2016)
Journal Article
Ladwiniec, A., Cunnington, M. S., Rossington, J., Thackray, S., Alamgir, F., & Hoye, A. (2016). Microvascular dysfunction in the immediate aftermath of chronic total coronary occlusion recanalization. Catheterization and Cardiovascular Interventions, 87(6), 1071-1079. https://doi.org/10.1002/ccd.26392

Objectives The aim of this study was to compare microvascular resistance under both baseline and hyperemic conditions immediately after percutaneous coronary intervention (PCI) of a chronic total occlusion (CTO) with an unobstructed reference vessel... Read More about Microvascular dysfunction in the immediate aftermath of chronic total coronary occlusion recanalization.

Hair Follicle Bulge Stem Cells Appear Dispensable for the Acute Phase of Wound Re-epithelialization (2016)
Journal Article
Garcin, C. L., Ansell, D. M., Headon, D. J., Paus, R., & Hardman, M. J. (2016). Hair Follicle Bulge Stem Cells Appear Dispensable for the Acute Phase of Wound Re-epithelialization. STEM CELLS, 34(5), 1377-1385. https://doi.org/10.1002/stem.2289

The cutaneous healing response has evolved to occur rapidly, in order to minimize infection and to re-establish epithelial homeostasis. Rapid healing is achieved through complex coordination of multiple cell types, which importantly includes specific... Read More about Hair Follicle Bulge Stem Cells Appear Dispensable for the Acute Phase of Wound Re-epithelialization.

Endo180 at the cutting edge of bone cancer treatment and beyond (2016)
Journal Article
Sturge, J. (2016). Endo180 at the cutting edge of bone cancer treatment and beyond. Journal of Pathology, 238(4), 485-488. https://doi.org/10.1002/path.4673

Skeletal bone is an attractive site for secondary tumour growth and is also home to spontaneous primary cancer. Treatment of bone metastasis is focused on limiting the vicious cycle of bone destruction with bisphosphonates or inhibition of receptor a... Read More about Endo180 at the cutting edge of bone cancer treatment and beyond.

Growth of MRSA and Pseudomonas aeruginosa in a fine-celled foam model containing sessile commensal skin bacteria (2016)
Journal Article
Oates, A., & McBain, A. J. (2016). Growth of MRSA and Pseudomonas aeruginosa in a fine-celled foam model containing sessile commensal skin bacteria. Biofouling, 32(1), 25-33. https://doi.org/10.1080/08927014.2015.1117607

Sessile cultures of the skin bacteria Staphylococcus saprophyticus and Corynebacterium xerosis were grown using novel fine-celled foam substrata to test the outcome of challenge by methicillin-resistant Staphylococcus aureus or Pseudomonas aeruginosa... Read More about Growth of MRSA and Pseudomonas aeruginosa in a fine-celled foam model containing sessile commensal skin bacteria.

Microfluidic culture of head and neck tumour maintains viability, as shown by single cell analysis, providing potential for novel applications and personalised medicine (2016)
Presentation / Conference Contribution
Bower, R., Green, V., Kuvshinov, D., Crank, S., Stafford, N., & Greenman, J. (2016, October). Microfluidic culture of head and neck tumour maintains viability, as shown by single cell analysis, providing potential for novel applications and personalised medicine. Presented at 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016, Dublin, Ireland

The current paper details a succinct characterisation of an in-house designed microfluidic culture device. The maintenance of tissue viability was determined by studying single cells, following dissociation, of head and neck tumour pre and post cultu... Read More about Microfluidic culture of head and neck tumour maintains viability, as shown by single cell analysis, providing potential for novel applications and personalised medicine.