All Outputs (954)

Differentiating between monozygotic twins through DNA methylation-specific high-resolution melt curve analysis (2015)
Journal Article
Stewart, L., Evans, N., Bexon, K. J., Van Der Meer, D. J., & Williams, G. A. (2015). Differentiating between monozygotic twins through DNA methylation-specific high-resolution melt curve analysis. Analytical Biochemistry, 476, 36-39. https://doi.org/10.1016/j.ab.2015.02.001

Although short tandem repeat profiling is extremely powerful in identifying individuals from crime scene stains, it is unable to differentiate between monozygotic (MZ) twins. Efforts to address this include mutation analysis through whole genome sequ... Read More about Differentiating between monozygotic twins through DNA methylation-specific high-resolution melt curve analysis.

Does radiation-induced c-MYC amplification initiate breast oncogenesis? (2015)
Journal Article
Wade, M. A., May, F. E., Onel, K., & Allan, J. M. (2016). Does radiation-induced c-MYC amplification initiate breast oncogenesis?. Molecular and Cellular Oncology, 3(1), Article e1010950. https://doi.org/10.1080/23723556.2015.1010950

© 2016 Taylor and Francis Group, LLC. The MYC (v-myc avian myelocytomatosis viral oncogene homolog; c-MYC) locus on chromosome 8q is susceptible to high-level amplification following exposure of human breast cells to ionizing radiation, and c-MYC amp... Read More about Does radiation-induced c-MYC amplification initiate breast oncogenesis?.

Extracellular vesicles, tissue factor, cancer and thrombosis – discussion themes of the ISEV 2014 Educational Day (2015)
Journal Article
Gardiner, C., Harrison, P., Belting, M., Böing, A., Campello, E., Carter, B. S., Collier, M. E., Coumans, F., Ettelaie, C., Van Es, N., Hochberg, F. H., Mackman, N., Rennert, R. C., Thaler, J., Rak, J., & Nieuwland, R. (2015). Extracellular vesicles, tissue factor, cancer and thrombosis – discussion themes of the ISEV 2014 Educational Day. Journal of Extracellular Vesicles, 4(1), 1-14. https://doi.org/10.3402/jev.v4.26901

Although the association between cancer and venous thromboembolism (VTE) has long been known, the mechanisms are poorly understood. Circulating tissue factor-bearing extracellular vesicles have been proposed as a possible explanation for the increase... Read More about Extracellular vesicles, tissue factor, cancer and thrombosis – discussion themes of the ISEV 2014 Educational Day.

Infrequent expression of the Cancer-Testis antigen, PASD1, in ovarian cancer (2015)
Journal Article
Khan, G., Brooks, S. E., Mills, K. I., & Guinn, B.-A. (2015). Infrequent expression of the Cancer-Testis antigen, PASD1, in ovarian cancer. Biomarkers in Cancer, 7, 31–38. https://doi.org/10.4137/bic.s28378

Ovarian cancer is very treatable in the early stages of disease; however, it is usually detected in the later stages, at which time, treatment is no longer as effective. If discovered early (Stage I), there is a 90% chance of five-year survival. Ther... Read More about Infrequent expression of the Cancer-Testis antigen, PASD1, in ovarian cancer.

Effects of candesartan, an angiotensin II receptor type I blocker, on atrial remodeling in spontaneously hypertensive rats (2015)
Journal Article
Choisy, S. C., Kim, S.-J., Hancox, J. C., Jones, S. A., & James, A. F. (2015). Effects of candesartan, an angiotensin II receptor type I blocker, on atrial remodeling in spontaneously hypertensive rats. Physiological Reports, 3(1), e12274. https://doi.org/10.14814/phy2.12274

Hypertension-induced structural remodeling of the left atrium (LA) has been suggested to involve the renin–angiotensin system. This study investigated whether treatment with an angiotensin receptor blocker, candesartan, regresses atrial remodeling in... Read More about Effects of candesartan, an angiotensin II receptor type I blocker, on atrial remodeling in spontaneously hypertensive rats.

New AMD3100 derivatives for CXCR4 chemokine receptor targeted molecular imaging studies: synthesis, anti-HIV-1 evaluation and binding affinities (2015)
Journal Article
Poty, S., Désogère, P., Goze, C., Boschetti, F., D‘huys, T., Schols, D., Cawthorne, C., Archibald, S. J., Maëcke, H. R., & Denat, F. (2015). New AMD3100 derivatives for CXCR4 chemokine receptor targeted molecular imaging studies: synthesis, anti-HIV-1 evaluation and binding affinities. Dalton Transactions : an international journal of inorganic chemistry, 44(11), 5004-5016. https://doi.org/10.1039/c4dt02972k

CXCR4 is a target of growing interest for the development of new therapeutic drugs and imaging agents as its role in multiple disease states has been demonstrated. AMD3100, a CXCR4 chemokine receptor antagonist that is in current clinical use as a ha... Read More about New AMD3100 derivatives for CXCR4 chemokine receptor targeted molecular imaging studies: synthesis, anti-HIV-1 evaluation and binding affinities.

⁹⁹ᵐTc SPECT imaging agent based on cFLFLFK for the detection of FPR1 in inflammation (2015)
Journal Article
Stasiuk, G. J., Holloway, P. M., Rivas, C., Trigg, W., Luthra, S. K., Morrison Iveson, V., Gavins, F. N., & Long, N. J. (2015). ⁹⁹ᵐTc SPECT imaging agent based on cFLFLFK for the detection of FPR1 in inflammation. Dalton Transactions : an international journal of inorganic chemistry, 44(11), 4986-4993. https://doi.org/10.1039/c4dt02980a

Non-invasive imaging of the inflammatory process can provide a great deal of insight into a wide variety of diseases states, aiding diagnosis, evaluation and effective targeted treatment. During inflammation, blood borne leukocytes are recruited, thr... Read More about ⁹⁹ᵐTc SPECT imaging agent based on cFLFLFK for the detection of FPR1 in inflammation.

AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival (2014)
Journal Article
Rodriguez-Teja, M., Gronau, J. H., Breit, C., Zhang, Y. Z., Minamidate, A., Caley, M. P., McCarthy, A., Cox, T. R., Erler, J. T., Gaughan, L., Darby, S., Robson, C., Mauri, F., Waxman, J., & Sturge, J. (2015). AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival. Journal of Pathology, 235(4), 581-592. https://doi.org/10.1002/path.4485

Biomechanical strain imposed by age-related thickening of the basal lamina and augmented tissue stiffness in the prostate gland coincides with increased cancer risk. Here we hypothesized that the structural alterations in the basal lamina associated... Read More about AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival.

LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression (2014)
Journal Article
Mura, M., Hopkins, T. G., Michael, T., Abd-Latip, N., Weir, J., Aboagye, E., Mauri, F., Jameson, C., Sturge, J., Gabra, H., Bushell, M., Willis, A. E., Curry, E., & Blagden, S. P. (2015). LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression. Oncogene, 34(39), 5025-5036. https://doi.org/10.1038/onc.2014.428

RNA-binding proteins (RBPs) bind to and post-transcriptionally regulate the stability of mRNAs. La-related protein 1 (LARP1) is a conserved RBP that interacts with poly-A-binding protein and is known to regulate 5′-terminal oligopyrimidine tract (TOP... Read More about LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression.

c-MYC is a radiosensitive locus in human breast cells (2014)
Journal Article
Wade, M. A., Sunter, N. J., Fordham, S. E., Long, A., Masic, D., Russell, L. J., Harrison, C. J., Rand, V., Elstob, C., Bown, N., Rowe, D., Lowe, C., Cuthbert, G., Bennett, S., Crosier, S., Bacon, C. M., Onel, K., Scott, K., Scott, D., Travis, L. B., …Allan, J. M. (2015). c-MYC is a radiosensitive locus in human breast cells. Oncogene, 34(38), 4985-4994. https://doi.org/10.1038/onc.2014.427

Ionising radiation is a potent human carcinogen. Epidemiological studies have shown that adolescent and young women are at increased risk of developing breast cancer following exposure to ionising radiation compared with older women, and that risk is... Read More about c-MYC is a radiosensitive locus in human breast cells.

Towards understanding the design of dual-modal MR/fluorescent probes to sense zinc ions (2014)
Journal Article
Rivas, C., Stasiuk, G. J., Sae-Heng, M., & Long, N. J. (2015). Towards understanding the design of dual-modal MR/fluorescent probes to sense zinc ions. Dalton Transactions : an international journal of inorganic chemistry, 44(11), 4976-4985. https://doi.org/10.1039/c4dt02981j

A series of gadolinium complexes were synthesised in order to test the design of dual-modal probes that display a change in fluorescence or relaxivity response upon binding of zinc. A dansyl-DO3ATA gadolinium complex [GdL1] displayed an increase and... Read More about Towards understanding the design of dual-modal MR/fluorescent probes to sense zinc ions.

Interplay between R513 methylation and S516 phosphorylation of the cardiac voltage-gated sodium channel (2014)
Journal Article
Beltran-Alvarez, P., Feixas, F., Osuna, S., Díaz-Hernández, R., Brugada, R., & Pagans, S. (2015). Interplay between R513 methylation and S516 phosphorylation of the cardiac voltage-gated sodium channel. Amino acids, 47(2), 429-434. https://doi.org/10.1007/s00726-014-1890-0

Arginine methylation is a novel post-translational modification within the voltage-gated ion channel superfamily, including the cardiac sodium channel, Naᵥ1.5. We show that Naᵥ1.5 R513 methylation decreases S516 phosphorylation rate by 4 orders of ma... Read More about Interplay between R513 methylation and S516 phosphorylation of the cardiac voltage-gated sodium channel.

The histone demethylase enzyme KDM3A is a key estrogen receptor regulator in breast cancer (2014)
Journal Article
Wade, M. A., Jones, D., Wilson, L., Stockley, J., Coffey, K., Robson, C. N., & Gaughan, L. (2015). The histone demethylase enzyme KDM3A is a key estrogen receptor regulator in breast cancer. Nucleic Acids Research, 43(1), 196-207. https://doi.org/10.1093/nar/gku1298

Endocrine therapy has successfully been used to treat estrogen receptor (ER)-positive breast cancer, but this invariably fails with cancers becoming refractory to treatment. Emerging evidence has suggested that fluctuations in ER co-regulatory protei... Read More about The histone demethylase enzyme KDM3A is a key estrogen receptor regulator in breast cancer.

High glucose enhances store-operated calcium entry by upregulating ORAI/STIM via calcineurin-NFAT signalling (2014)
Journal Article
Daskoulidou, N., Xu, S. Z., Zeng, B., Gomez, M. F., Berglund, L. M., Atkin, S. L., Jiang, H., Griffin, S., Ayoola, J., Bhandari, S., Kotova, O., Chen, G. L., Griffin, S., Jiang, H., Berglund, L. M., Zeng, B., & Daskoulidou, N. (2015). High glucose enhances store-operated calcium entry by upregulating ORAI/STIM via calcineurin-NFAT signalling. Journal of Molecular Medicine, 93(5), 511-521. https://doi.org/10.1007/s00109-014-1234-2

© 2014, Springer-Verlag Berlin Heidelberg. Abstract: ORAI and stromal interaction molecule (STIM) are store-operated channel molecules that play essential roles in human physiology through a coupling mechanism of internal Ca 2+ store to Ca 2+ influx.... Read More about High glucose enhances store-operated calcium entry by upregulating ORAI/STIM via calcineurin-NFAT signalling.

Human embryos from overweight and obese women display phenotypic and metabolic abnormalities (2014)
Journal Article
Leary, C., Leese, H. J., & Sturmey, R. G. (2015). Human embryos from overweight and obese women display phenotypic and metabolic abnormalities. Human Reproduction, 30(1), 122-132. https://doi.org/10.1093/humrep/deu276

STUDY QUESTION Is the developmental timing and metabolic regulation disrupted in embryos from overweight or obese women? SUMMARY ANSWER Oocytes from overweight or obese women are smaller than those from women of healthy weight, yet post-fertilization... Read More about Human embryos from overweight and obese women display phenotypic and metabolic abnormalities.

Survival outcome and EMT suppression mediated by a lectin domain interaction of Endo180 and CD147 (2014)
Journal Article
Rodriguez-Teja, M., Gronau, J. H., Minamidate, A., Darby, S., Gaughan, L., Robson, C., Mauri, F., Waxman, J., & Sturge, J. (2015). Survival outcome and EMT suppression mediated by a lectin domain interaction of Endo180 and CD147. Molecular cancer research, 13(3), 538-547. https://doi.org/10.1158/1541-7786.mcr-14-0344-t

Epithelial cell-cell contacts maintain normal glandular tissue homeostasis, and their breakage can trigger epithelial-to-mesenchymal transition (EMT), a fundamental step in the development of metastatic cancer. Despite the ability of C-type lectin do... Read More about Survival outcome and EMT suppression mediated by a lectin domain interaction of Endo180 and CD147.

Common variation at 12q24.13 (OAS3) influences chronic lymphocytic leukemia risk (2014)
Journal Article
Sava, G. P., Speedy, H. E., Di Bernardo, M. C., Dyer, M. J., Holroyd, A., Sunter, N. J., Marr, H., Mansouri, L., Deaglio, S., Karabon, L., Frydecka, I., Jamroziak, K., Woszczyk, D., Juliusson, G., Smedby, K. E., Jayne, S., Majid, A., Wang, Y., Dearden, C., Hall, A. G., …Houlston, R. S. (2015). Common variation at 12q24.13 (OAS3) influences chronic lymphocytic leukemia risk. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 29(3), 748-751. https://doi.org/10.1038/leu.2014.311

Label-free real-time acoustic sensing of microvesicle release from prostate cancer (PC3) cells using a Quartz Crystal Microbalance (2014)
Journal Article
Stratton, D., Lange, S., Kholia, S., Jorfi, S., Antwi-Baffour, S., & Inal, J. (2014). Label-free real-time acoustic sensing of microvesicle release from prostate cancer (PC3) cells using a Quartz Crystal Microbalance. Biochemical and biophysical research communications, 453(3), 619-624. https://doi.org/10.1016/j.bbrc.2014.09.132

© 2014 Elsevier Inc. All rights reserved. Using a Quartz Crystal Microbalance with dissipation monitoring, QCM-D (label-free system) measuring changes in resonant frequency (Δf) that equate to mass deposited on a sensor, we showed the attachment, ove... Read More about Label-free real-time acoustic sensing of microvesicle release from prostate cancer (PC3) cells using a Quartz Crystal Microbalance.

On-chip determination of C-reactive protein using magnetic particles in continuous flow (2014)
Journal Article
Phurimsak, C., Tarn, M. D., Peyman, S. A., Greenman, J., & Pamme, N. (2014). On-chip determination of C-reactive protein using magnetic particles in continuous flow. Analytical chemistry, 86(21), 10552-10559. https://doi.org/10.1021/ac5023265

We demonstrate the application of a multilaminar flow platform, in which functionalized magnetic particles are deflected through alternating laminar flow streams of reagents and washing solutions via an external magnet, for the rapid detection of the... Read More about On-chip determination of C-reactive protein using magnetic particles in continuous flow.

Faucicola mancuniensis gen. nov., sp. nov., isolated from the human oropharynx (2014)
Journal Article
Humphreys, G. J., Oates, A., Ledder, R. G., & McBain, A. J. (2015). Faucicola mancuniensis gen. nov., sp. nov., isolated from the human oropharynx. International Journal of Systematic and Evolutionary Microbiology, 65(1), 11-14. https://doi.org/10.1099/ijs.0.066837-0

© 2015 IUMS. An aerobic, Gram-stain-negative, non-motile coccus, designated strain GVCNT2T, was isolated from the tonsils of a healthy adult female. Cells were oxidase- and catalase-positive, positive for the production of esterase (C4), esterase lip... Read More about Faucicola mancuniensis gen. nov., sp. nov., isolated from the human oropharynx.