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All Outputs (921)

Anticancer properties of essential oils and other natural products (2018)
Journal Article
Blowman, K., Magalhães, M., Lemos, M. F., Cabral, C., & Pires, I. M. (2018). Anticancer properties of essential oils and other natural products. Evidence-based complementary and alternative medicine : eCAM, 2018, 1-12. https://doi.org/10.1155/2018/3149362

Essential oils are secondary metabolites with a key-role in plants protection, consisting primarily of terpenes with a volatile nature and a diverse array of chemical structures. Essential oils exhibit a wide range of bioactivities, especially antimi... Read More about Anticancer properties of essential oils and other natural products.

A plant-like mitochondrial carrier family protein facilitates mitochondrial transport of di- and tricarboxylates in Trypanosoma brucei (2018)
Journal Article
Colasante, C., Zheng, F., Kemp, C., & Voncken, F. (2018). A plant-like mitochondrial carrier family protein facilitates mitochondrial transport of di- and tricarboxylates in Trypanosoma brucei. Molecular and Biochemical Parasitology, 221, 36-51. https://doi.org/10.1016/j.molbiopara.2018.03.003

The procyclic form of the human parasite Trypanosoma brucei harbors one single, large mitochondrion containing all tricarboxylic acid (TCA) cycle enzymes and respiratory chain complexes present also in higher eukaryotes. Metabolite exchange among sub... Read More about A plant-like mitochondrial carrier family protein facilitates mitochondrial transport of di- and tricarboxylates in Trypanosoma brucei.

A practical microwave method for the synthesis of fluoromethy 4-methylbenzenesulfonate in tert-amyl alcohol (2018)
Journal Article
Brocklesby, K. L., Waby, J. S., Cawthorne, C., & Smith, G. D. (2018). A practical microwave method for the synthesis of fluoromethy 4-methylbenzenesulfonate in tert-amyl alcohol. Tetrahedron letters; the international organ for the rapid publication of preliminary communications in organic chemistry, 59(17), 1635-1637. https://doi.org/10.1016/j.tetlet.2018.03.039

Fluorine substitution is an established tool in medicinal chemistry to favourably alter the molecular properties of a lead compound of interest. However, gaps still exist in the library of synthetic methods for accessing certain fluorine-substituted... Read More about A practical microwave method for the synthesis of fluoromethy 4-methylbenzenesulfonate in tert-amyl alcohol.

WSB-1 regulates the metastatic potential of hormone receptor negative breast cancer (2018)
Journal Article
Poujade, F.-A., Mannion, A., Brittain, N., Theodosi, A., Beeby, E., Leszczynska, K. B., Hammond, E. M., Greenman, J., Cawthorne, C., & Pires, I. M. (2018). WSB-1 regulates the metastatic potential of hormone receptor negative breast cancer. The British Journal of Cancer, 118(9), 1229-1237. https://doi.org/10.1038/s41416-018-0056-3

© 2018 Cancer Research UK. Background: Metastatic spread is responsible for the majority of cancer-associated deaths. The tumour microenvironment, including hypoxia, is a major driver of metastasis. The aim of this study was to investigate the role o... Read More about WSB-1 regulates the metastatic potential of hormone receptor negative breast cancer.

Short-Term Training and Detraining Effects of Supervised vs. Unsupervised Resistance Exercise in Aging Adults (2018)
Journal Article
Orange, S. T., Marshall, P., Madden, L. A., & Vince, R. V. (2019). Short-Term Training and Detraining Effects of Supervised vs. Unsupervised Resistance Exercise in Aging Adults. Journal of strength and conditioning research, 33(10), 2733-2742. https://doi.org/10.1519/JSC.0000000000002536

Orange, ST, Marshall, P, Madden, LA, and Vince, RV. Short-term training and detraining effects of supervised vs. unsupervised resistance exercise in aging adults. J Strength Cond Res 33(10): 2733-2742, 2019-This study compared the effects of a 4-week... Read More about Short-Term Training and Detraining Effects of Supervised vs. Unsupervised Resistance Exercise in Aging Adults.

A 18F radiolabelled Zn(ii) sensing fluorescent probe (2018)
Journal Article
Price, T. W., Firth, G., Eling, C. J., Kinnon, M., Long, N. J., Sturge, J., & Stasiuk, G. J. (2018). A 18F radiolabelled Zn(ii) sensing fluorescent probe. Chemical communications : Chem comm / the Royal Society of Chemistry, 54(26), 3227-3230. https://doi.org/10.1039/c8cc00687c

A selective fluorescent probe for Zn(ii), AQA-F, has been synthesized. AQA-F exhibits a ratiometric shift in emission of up to 80 nm upon binding Zn(ii) ([AQA-F] = 0.1 mM, [Zn(ii)Cl 2 ] = 0-300 μM). An enhancement of quantum yield from Φ = 4.2% to Φ... Read More about A 18F radiolabelled Zn(ii) sensing fluorescent probe.

Interleukin-7 unveils Pathogen-Specific T Cells by enhancing Antigen-Recall responses (2018)
Journal Article
Terrazzini, N., Mantegani, P., Kern, F., Fortis, C., Mondino, A., & Caserta, S. (2018). Interleukin-7 unveils Pathogen-Specific T Cells by enhancing Antigen-Recall responses. The journal of infectious diseases : official publication of the Infectious Diseases Society of America, 217(12), 1997-2007. https://doi.org/10.1093/infdis/jiy096

© 2018 The Author(s). Background Interleukin (IL)-7 promotes the generation, expansion, and survival of memory T cells. Previous mouse and human studies showed that IL-7 can support immune cell reconstitution in lymphopenic conditions, expand tumor-r... Read More about Interleukin-7 unveils Pathogen-Specific T Cells by enhancing Antigen-Recall responses.

Cancer patients’ experiences of living with venous thromboembolism: A systematic review and qualitative thematic synthesis (2018)
Journal Article
Benelhaj, N. B., Hutchinson, A., Maraveyas, A. M., Seymour, J. D., Ilyas, M. W., & Johnson, M. J. (2018). Cancer patients’ experiences of living with venous thromboembolism: A systematic review and qualitative thematic synthesis. Palliative medicine, 32(5), 1010-1020. https://doi.org/10.1177/0269216318757133

Background: Cancer-Associated thrombosis is common. Recommended treatment is daily injected low-molecular-weight heparin for 6months. Most studies focus on prophylaxis and treatment; few have explored patients’ experience. Aims To identify and sy... Read More about Cancer patients’ experiences of living with venous thromboembolism: A systematic review and qualitative thematic synthesis.

Reversal of stress fibre formation by Nitric Oxide mediated RhoA inhibition leads to reduction in the height of preformed thrombi (2018)
Journal Article
Atkinson, L., Yusuf, M. Z., Aburima, A., Ahmed, Y., Thomas, S. G., Naseem, K. M., & Calaminus, S. D. J. (2018). Reversal of stress fibre formation by Nitric Oxide mediated RhoA inhibition leads to reduction in the height of preformed thrombi. Scientific reports, 8(1), Article ARTN 3032. https://doi.org/10.1038/s41598-018-21167-6

© 2018 The Author(s). Evidence has emerged to suggest that thrombi are dynamic structures with distinct areas of differing platelet activation and inhibition. We hypothesised that Nitric oxide (NO), a platelet inhibitor, can modulate the actin cytosk... Read More about Reversal of stress fibre formation by Nitric Oxide mediated RhoA inhibition leads to reduction in the height of preformed thrombi.

The effect of a simulated commercial flight environment with hypoxia and low humidity on clotting, platelet, and endothelial function in participants with type 2 diabetes - A cross-over study (2018)
Journal Article
Konya, J., Spurgeon, B. E. J., Al Qaissi, A., Sathyapalan, T., Ajjan, R., Madden, L., Naseem, K. M., Garrett, A. T., Kilpatrick, E., & Atkin, S. L. (2018). The effect of a simulated commercial flight environment with hypoxia and low humidity on clotting, platelet, and endothelial function in participants with type 2 diabetes - A cross-over study. Frontiers in endocrinology, 9(FEB), Article 26. https://doi.org/10.3389/fendo.2018.00026

© 2018 Konya, Al Qaissi, Sathyapalan, Ajjan, Madden, Naseem, Garrett, Kilpatrick and Atkin. Aims: To determine if clotting, platelet, and endothelial function were affected by simulated short-haul commercial air flight conditions (SF) in participants... Read More about The effect of a simulated commercial flight environment with hypoxia and low humidity on clotting, platelet, and endothelial function in participants with type 2 diabetes - A cross-over study.

Severity of Systemic Inflammatory Response Syndrome Affects the Blood Levels of Circulating Inflammatory-Relevant MicroRNAs (2018)
Journal Article
Caserta, S., Mengozzi, M., Kern, F., Newbury, S. F., Ghezzi, P., & Llewelyn, M. J. (2018). Severity of Systemic Inflammatory Response Syndrome Affects the Blood Levels of Circulating Inflammatory-Relevant MicroRNAs. Frontiers in immunology, 8, Article ARTN 1977. https://doi.org/10.3389/fimmu.2017.01977

The systemic inflammatory response syndrome (SIRS) is a potentially lethal response triggered by diverse forms of tissue injury and infection. When systemic inflammation is triggered by infection, the term sepsis is used. Understanding how inflammati... Read More about Severity of Systemic Inflammatory Response Syndrome Affects the Blood Levels of Circulating Inflammatory-Relevant MicroRNAs.

Duchenne muscular dystrophy: genome editing gives new hope for treatment (2018)
Journal Article
Crispi, V., & Matsakas, A. (2018). Duchenne muscular dystrophy: genome editing gives new hope for treatment. Postgraduate Medical Journal, 94(1111), 296-304. https://doi.org/10.1136/postgradmedj-2017-135377

© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. Duchenne muscular dystrophy (DMD) is a progressive wasting dis... Read More about Duchenne muscular dystrophy: genome editing gives new hope for treatment.

Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms (2018)
Journal Article
Pridgeon, C. S., Schlott, C., Wong, M. W., Heringa, M. B., Heckel, T., Leedale, J., Launay, L., Gryshkova, V., Przyborski, S., Bearon, R. N., Wilkinson, E. L., Ansari, T., Greenman, J., Hendriks, D. F. G., Gibbs, S., Sidaway, J., Sison-Young, R. L., Walker, P., Cross, M. J., Park, B. K., & Goldring, C. E. P. (2018). Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms. Archives of Toxicology, 92(2), 557-569. https://doi.org/10.1007/s00204-018-2152-9

The development of improved, innovative models for the detection of toxicity of drugs, chemicals, or chemicals in cosmetics is crucial to efficiently bring new products safely to market in a cost-effective and timely manner. In addition, improvement... Read More about Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms.

Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability (2018)
Journal Article
Williams, J. J., Alotaiq, N., Mullen, W., Burchmore, R., Liu, L., Baillie, G. S., Schaper, F., Pilch, P. F., & Palmer, T. M. (2018). Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability. Nature communications, 9(1), Article 168. https://doi.org/10.1038/s41467-017-02585-y

Effective suppression of JAK–STAT signalling by the inducible inhibitor “suppressor of cytokine signalling 3” (SOCS3) is essential for limiting signalling from cytokine receptors. Here we show that cavin-1, a component of caveolae, is a functionally... Read More about Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability.

Perspectives of general practitioners on the issues surrounding the late diagnosis of Alzheimer's disease (2018)
Journal Article
Bature, F., Guinn, B., Pang, D., The Luton, Dunstable, Milton Keynes General Practise consortium, & Pappas, Y. (2018). Perspectives of general practitioners on the issues surrounding the late diagnosis of Alzheimer's disease. Journal of Alzheimer's Disease Reports, 2(1), 207-212. https://doi.org/10.3233/ADR-180064

We set out to investigate the insights general practitioners (GPs) have into the early signs and symptoms of Alzheimer's disease (AD), factors that may be responsible for the late diagnosis, as well as their recommendations for early diagnosis of AD.... Read More about Perspectives of general practitioners on the issues surrounding the late diagnosis of Alzheimer's disease.

The Secret Science of Superheroes (2017)
Book
Lorch, M., Mackenwells, B., Jesson, D., Pires, I., Day, K., Gentle, L., Whiting, M., Miles, R., Kundu, S., Verran, J., Coxon, P., Rathi, A., Byrne, K., & Heathcoate-Marcz, F. (2017). M. Lorch, & A. Miah (Eds.). The Secret Science of Superheroes. Royal Society of Chemistry

Ever wondered what a superhero eats for breakfast? Do they need a special diet to feed their superpowers? The odd metabolisms of superheroes must mean they have strange dietary needs, from the high calorie diets to fuel flaming bodies and super speed... Read More about The Secret Science of Superheroes.

Identification of survivin as a promising target for the immunotherapy of adult B-cell acute lymphoblastic leukemia (2017)
Journal Article
Boullosa, L. F., Savaliya, P., Bonney, S., Orchard, L., Wickenden, H., Lee, C., Smits, E., Banham, A. H., Mills, K. I., Orchard, K., & Guinn, B. A. (2018). Identification of survivin as a promising target for the immunotherapy of adult B-cell acute lymphoblastic leukemia. Oncotarget, 9(3), 3853-3866. https://doi.org/10.18632/oncotarget.23380

B-cell acute lymphoblastic leukemia (B-ALL) is a rare heterogeneous disease characterized by a block in lymphoid differentiation and a rapid clonal expansion of immature, non-functioning B cells. Adult B-ALL patients have a poor prognosis with less t... Read More about Identification of survivin as a promising target for the immunotherapy of adult B-cell acute lymphoblastic leukemia.

ORAI channels are critical for receptor-mediated endocytosis of albumin (2017)
Journal Article
Zeng, B., Chen, G.-L., Garcia-Vaz, E., Bhandari, S., Daskoulidou, N., Berglund, L. M., Jiang, H., Hallett, T., Zhou, L.-P., Huang, L., Xu, Z.-H., Nair, V., Nelson, R. G., Ju, W., Kretzler, M., Atkin, S. L., Gomez, M. F., & Xu, S.-Z. (2017). ORAI channels are critical for receptor-mediated endocytosis of albumin. Nature communications, 8(1), Article 1920. https://doi.org/10.1038/s41467-017-02094-y

Impaired albumin reabsorption by proximal tubular epithelial cells (PTECs) has been highlighted in diabetic nephropathy (DN), but little is known about the underlying molecular mechanisms. Here we find that ORAI1-3, are preferentially expressed in PT... Read More about ORAI channels are critical for receptor-mediated endocytosis of albumin.

Lck is a relevant target in chronic lymphocytic leukaemia cells whose expression variance is unrelated to disease outcome (2017)
Journal Article
Till, K. J., Allen, J. C., Talab, F., Lin, K., Allsup, D., Cawkwell, L., Bentley, A., Ringshausen, I., Duckworth, A. D., Pettitt, A. R., Kalakonda, N., & Slupsky, J. R. (2017). Lck is a relevant target in chronic lymphocytic leukaemia cells whose expression variance is unrelated to disease outcome. Scientific reports, 7(1), Article ARTN 16784. https://doi.org/10.1038/s41598-017-17021-w

© 2017 The Author(s). Pathogenesis of chronic lymphocytic leukaemia (CLL) is contingent upon antigen receptor (BCR) expressed by malignant cells of this disease. Studies on somatic hypermutation of the antigen binding region, receptor expression leve... Read More about Lck is a relevant target in chronic lymphocytic leukaemia cells whose expression variance is unrelated to disease outcome.