All Outputs (917)

CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells (2016)
Journal Article
Sinclair, A., Park, L., Shah, M., Drotar, M., Calaminus, S., Hopcroft, L. E., Kinstrie, R., Guitart, A. V., Dunn, K., Abraham, S. A., Sansom, O., Michie, A. M., Machesky, L., Kranc, K. R., Graham, G. J., Pellicano, F., & Holyoake, T. L. (2016). CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells. Blood, 128(3), 371-383. https://doi.org/10.1182/blood-2015-08-661785

The regulation of hematopoietic stem cell (HSC) survival and self-renewal within the bone marrow (BM) niche is not well understood. We therefore investigated global transcriptomic profiling of normal human HSC/hematopoietic progenitor cells [HPCs], r... Read More about CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells.

Dedicated Bifurcation Stent for the Treatment of Bifurcation Lesions InvolvingLarge Side Branches: Outcomes From the Tryton Confirmatory Study (2016)
Journal Article
Généreux, P., Kumsars, I., Schneider, J. E., Lesiak, M., Redfors, B., Cornelis, K., Selmon, M. R., Dens, J., Hoye, A., Metzger, D. C., Muyldermans, L., Slagboom, T., Francese, D. P., Ayele, G. M., Laak, L. L., Bartorelli, A. L., Cutlip, D. E., Kaplan, A. V., & Leon, M. B. (2016). Dedicated Bifurcation Stent for the Treatment of Bifurcation Lesions InvolvingLarge Side Branches: Outcomes From the Tryton Confirmatory Study. JACC: Cardiovascular Interventions, 9(13), 1338-1346. https://doi.org/10.1016/j.jcin.2016.03.042

Objectives: The aim of this study was to prospectively study and confirm the safety and efficacy of the Tryton Side Branch Stent in the treatment of coronary artery bifurcations involving large side branches (SBs). Background The TRYTON Pivotal rando... Read More about Dedicated Bifurcation Stent for the Treatment of Bifurcation Lesions InvolvingLarge Side Branches: Outcomes From the Tryton Confirmatory Study.

Conflicting perceptions of the status of field biology and identification skills in UK education (2016)
Journal Article
Goulder, R., & Scott, G. W. (2016). Conflicting perceptions of the status of field biology and identification skills in UK education. Journal of Biological Education, 50(3), 233-238. https://doi.org/10.1080/00219266.2016.1202489

There is an enormous degree of engagement between people and the outdoors in the UK; 58% of the adult population of England, about 24 million people, make at least one visit a week to parks, urban green spaces, the countryside or other outdoor destin... Read More about Conflicting perceptions of the status of field biology and identification skills in UK education.

Biomarkers of coronary endothelial health: correlation with invasive measures of collateral function, flow and resistance in chronically occluded coronary arteries and the effect of recanalization (2016)
Journal Article
Ladwiniec, A., Ettelaie, C., Cunnington, M. S., Rossington, J., Thackray, S., Alamgir, F., & Hoye, A. (2016). Biomarkers of coronary endothelial health: correlation with invasive measures of collateral function, flow and resistance in chronically occluded coronary arteries and the effect of recanalization. Coronary Artery Disease, 27(4), 287-294. https://doi.org/10.1097/mca.0000000000000360

Objectives: In the presence of a chronically occluded coronary artery, the collateral circulation matures by a process of arteriogenesis; however, there is considerable variation between individuals in the functional capacity of that collateral netwo... Read More about Biomarkers of coronary endothelial health: correlation with invasive measures of collateral function, flow and resistance in chronically occluded coronary arteries and the effect of recanalization.

Monolith-based68Ga processing: A new strategy for purification to facilitate direct radiolabelling methods (2016)
Journal Article
He, P., Burke, B. P., Clemente, G. S., Brown, N., Pamme, N., & Archibald, S. J. (2016). Monolith-based68Ga processing: A new strategy for purification to facilitate direct radiolabelling methods. Reaction Chemistry and Engineering, 1(4), 361-365. https://doi.org/10.1039/c6re00081a

The post-processing of68Ga generator eluate by means of a novel high capacity cation-exchange silica monolith column has been validated in this work. Quantitative release of a purified68Ga solution in high concentration can be achieved using weak aci... Read More about Monolith-based68Ga processing: A new strategy for purification to facilitate direct radiolabelling methods.

Circulating plasma microRNAs can differentiate Human Sepsis and Systemic Inflammatory Response Syndrome (SIRS) (2016)
Journal Article
Caserta, S., Kern, F., Cohen, J., Drage, S., Newbury, S. F., & Llewelyn, M. J. (2016). Circulating plasma microRNAs can differentiate Human Sepsis and Systemic Inflammatory Response Syndrome (SIRS). Scientific reports, 6(1), Article 28006. https://doi.org/10.1038/srep28006

Systemic inflammation in humans may be triggered by infection, termed sepsis, or non-infective processes, termed non-infective systemic inflammatory response syndrome (SIRS). MicroRNAs regulate cellular processes including inflammation and may be det... Read More about Circulating plasma microRNAs can differentiate Human Sepsis and Systemic Inflammatory Response Syndrome (SIRS).

Whole exome sequencing identifies genetic variants in inherited thrombocytopenia with secondary qualitative function defects (2016)
Journal Article
Johnson, B., Lowe, G. C., Futterer, J., Lordkipanidzé, M., Macdonald, D., Simpson, M. A., Sanchez-Guiú, I., Drake, S., Bem, D., Leo, V., Fletcher, S. J., Dawood, B., Rivera, J., Allsup, D., Biss, T., Bolton-Maggs, P. H. B., Collins, P., Curry, N., Grimley, C., James, B., …on behalf of the UK GAPP Study Group. (2016). Whole exome sequencing identifies genetic variants in inherited thrombocytopenia with secondary qualitative function defects. Haematologica, 101(10), 1170-1179. https://doi.org/10.3324/haematol.2016.146316

© 2016 Ferrata Storti Foundation. Inherited thrombocytopenias are a heterogeneous group of disorders characterized by abnormally low platelet counts which can be associated with abnormal bleeding. Next-generation sequencing has previously been employ... Read More about Whole exome sequencing identifies genetic variants in inherited thrombocytopenia with secondary qualitative function defects.

Atypical Rho GTPases of the RhoBTB Subfamily: Roles in vesicle trafficking and tumorigenesis (2016)
Journal Article
Ji, W., & Rivero, F. (2016). Atypical Rho GTPases of the RhoBTB Subfamily: Roles in vesicle trafficking and tumorigenesis. Cells, 5(2), 28. https://doi.org/10.3390/cells5020028

RhoBTB proteins constitute a subfamily of atypical Rho GTPases represented in mammals by RhoBTB1, RhoBTB2, and RhoBTB3. Their characteristic feature is a carboxyl terminal extension that harbors two BTB domains capable of assembling cullin 3-dependen... Read More about Atypical Rho GTPases of the RhoBTB Subfamily: Roles in vesicle trafficking and tumorigenesis.

Congenital macrothrombocytopenia is a heterogeneous disorder in India (2016)
Journal Article
Ali, S., Ghosh, K., Daly, M. E., Hampshire, D. J., Makris, M., Ghosh, M., Mukherjee, L., Bhattacharya, M., & Shetty, S. (2016). Congenital macrothrombocytopenia is a heterogeneous disorder in India. Haemophilia, 22(4), 570-582. https://doi.org/10.1111/hae.12917

Introduction: Inherited macrothrombocytopenia represents a heterogeneous group of disorders which are characterized by the presence of a reduced number of abnormally large platelets in the circulation, which may or may not be associated with a bleedi... Read More about Congenital macrothrombocytopenia is a heterogeneous disorder in India.

Harvesting human prostate tissue material and culturing primary prostate epithelial cells (2016)
Book Chapter
Frame, F. M., Pellacani, D., Collins, A. T., & Maitland, N. J. (2016). Harvesting human prostate tissue material and culturing primary prostate epithelial cells. In I. J. McEwan (Ed.), The nuclear receptor superfamily: methods and protocols (181-201). Humana Press. https://doi.org/10.1007/978-1-4939-3724-0_12

In order to fully explore the biology of a complex solid tumor such as prostate cancer, it is desirable to work with patient tissue. Only by working with cells from a tissue can we take into account patient variability and tumor heterogeneity. Cell l... Read More about Harvesting human prostate tissue material and culturing primary prostate epithelial cells.

Microcrystalline testing used in combination with Raman micro-spectroscopy for absolute identification of novel psychoactive substances: Microcrystalline testing used in combination with Raman micro-spectroscopy (2016)
Journal Article
Elie, L., Elie, M., Cave, G., Vetter, M., Croxton, R., & Baron, M. (2016). Microcrystalline testing used in combination with Raman micro-spectroscopy for absolute identification of novel psychoactive substances: Microcrystalline testing used in combination with Raman micro-spectroscopy. Journal of Raman Spectroscopy, 47(11), 1343-1350. https://doi.org/10.1002/jrs.4957

Two new psychoactive substances, namely 4-methylmethcathinone (mephedrone) and 5,6-methylenedioxy-2-aminoindane (MDAI) were analysed with a novel combination of microcrystalline tests followed by Raman micro-spectroscopy to facilitate their absolute... Read More about Microcrystalline testing used in combination with Raman micro-spectroscopy for absolute identification of novel psychoactive substances: Microcrystalline testing used in combination with Raman micro-spectroscopy.

Release of infectious hepatitis C virus from huh7 cells occurs via a trans-golgi network-to-endosome pathway independent of very-low-density lipoprotein secretion (2016)
Journal Article
Mankouri, J., Walter, C., Stewart, H., Bentham, M., Park, W. S., Heo, W. D., Fukuda, M., Griffin, S., & Harris, M. (2016). Release of infectious hepatitis C virus from huh7 cells occurs via a trans-golgi network-to-endosome pathway independent of very-low-density lipoprotein secretion. Journal of virology, 90(16), 7159-7170. https://doi.org/10.1128/jvi.00826-16

© 2016 Mankouri et al. The release of infectious hepatitis C virus (HCV) particles from infected cells remains poorly characterized. We previously demonstrated that virus release is dependent on the endosomal sorting complex required for transport (E... Read More about Release of infectious hepatitis C virus from huh7 cells occurs via a trans-golgi network-to-endosome pathway independent of very-low-density lipoprotein secretion.

Stem cells and the role of ETS transcription factors in the differentiation hierarchy of normal and malignant prostate epithelium (2016)
Journal Article
Archer, L. K., Frame, F. M., & Maitland, N. J. (2017). Stem cells and the role of ETS transcription factors in the differentiation hierarchy of normal and malignant prostate epithelium. Journal of Steroid Biochemistry and Molecular Biology, 166, 68-83. https://doi.org/10.1016/j.jsbmb.2016.05.006

Prostate cancer is the most common cancer of men in the UK and accounts for a quarter of all new cases. Although treatment of localised cancer can be successful, there is no cure for patients presenting with invasive prostate cancer and there are les... Read More about Stem cells and the role of ETS transcription factors in the differentiation hierarchy of normal and malignant prostate epithelium.

Skin Microbiology☆ (2016)
Book
McBain, A., O’Neill, C., & Oates, A. (2016). Skin Microbiology☆. Elsevier. https://doi.org/10.1016/b978-0-12-801238-3.99217-1

In recent years the application of high throughput DNA sequencing for analyzing the composition of the skin microbiota has identified a highly diverse group of microorganisms. Although the factors determining the composition of the skin microbiota ar... Read More about Skin Microbiology☆.

Sigma-1 receptors modulate neonatal Nav1.5 ion channels in breast cancer cell lines (2016)
Journal Article
Aydar, E., Stratton, D., Fraser, S. P., Djamgoz, M. B., & Palmer, C. (2016). Sigma-1 receptors modulate neonatal Nav1.5 ion channels in breast cancer cell lines. European Biophysics Journal, 45(7), 671-683. https://doi.org/10.1007/s00249-016-1135-0

The main aim of this study was to investigate a possible functional connection between sigma-1 receptors and voltage-gated sodium channels (VGSCs) in human breast cancer cells. The hypothesis was that sigma-1 drugs could alter the metastatic properti... Read More about Sigma-1 receptors modulate neonatal Nav1.5 ion channels in breast cancer cell lines.

RHOBTB3 (Rho-related BTB domain containing 3) (2016)
Journal Article
Cai, S., & Rivero, F. (2016). RHOBTB3 (Rho-related BTB domain containing 3). Atlas of genetics and cytogenetics in oncology and haematology, 20(12), https://doi.org/10.4267/2042/66947

RHOBTB3 is one of the three members of the RhoBTB family. All RhoBTB proteins are characterized by a GTPase domain followed by a proline-rich region, a tandem of two BTB domains and a C-terminal putative RING finger domain. In RHOBTB3 the GTPase doma... Read More about RHOBTB3 (Rho-related BTB domain containing 3).

Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells (2016)
Journal Article
Nigam, S., Burke, B. P., Davies, L. H., Domarkas, J., Wallis, J. F., Waddell, P. G., Waby, J. S., Benoit, D. M., Seymour, A. M., Cawthorne, C., Higham, L. J., & Archibald, S. J. (2016). Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells. Chemical communications : Chem comm / the Royal Society of Chemistry, 52(44), 7114-7117. https://doi.org/10.1039/c5cc08325g

The structural features required for mitochondrial uptake of BODIPY-based optical imaging agents have been explored. The first derivatives of this class of dyes shown to have mitochondrial membrane potential-dependent uptake in both cancer and heart... Read More about Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells.

Comparing the effectiveness of polymer debriding devices using a porcine wound biofilm model (2016)
Journal Article
Wilkinson, H. N., McBain, A. J., Stephenson, C., & Hardman, M. J. (2016). Comparing the effectiveness of polymer debriding devices using a porcine wound biofilm model. Advances in wound care, 5(11), 475-485. https://doi.org/10.1089/wound.2015.0683

Objective: Debridement to remove necrotic and/or infected tissue and promote active healing remains a cornerstone of contemporary chronic wound management. While there has been a recent shift toward less invasive polymer-based debriding devices, thei... Read More about Comparing the effectiveness of polymer debriding devices using a porcine wound biofilm model.

A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders (2016)
Journal Article
Simeoni, I., Stephens, J. C., Hu, F., Deevi, S. V. V., Megy, K., Bariana, T. K., Lentaigne, C., Schulman, S., Sivapalaratnam, S., Vries, M. J. A., Westbury, S. K., Greene, D., Papadia, S., Alessi, M. C., Attwood, A. P., Ballmaier, M., Baynam, G., Bermejo, E., Bertoli, M., Bray, P. F., …Turro, E. (2016). A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders. Blood, 127(23), 2791-2803. https://doi.org/10.1182/blood-2015-12-688267

Inherited bleeding, thrombotic, and platelet disorders (BPDs) are diseases that affect ∼300 individuals per million births. With the exception of hemophilia and von Willebrand disease patients, a molecular analysis for patients with a BPD is often un... Read More about A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders.

Development of radiodetection systems towards miniaturised quality control of PET and SPECT radiopharmaceuticals (2016)
Journal Article
Taggart, M. P., Tarn, M. D., Esfahani, M. M. N., Schofield, D. M., Brown, N. J., Archibald, S. J., Deakin, T., Pamme, N., & Thompson, L. F. (2016). Development of radiodetection systems towards miniaturised quality control of PET and SPECT radiopharmaceuticals. Lab on a chip, 16(9), 1605-1616. https://doi.org/10.1039/c6lc00099a

The ability to detect radiation in microfluidic devices is important for the on-chip analysis of radiopharmaceuticals, but previously reported systems have largely suffered from various limitations including cost, complexity of fabrication, and insuf... Read More about Development of radiodetection systems towards miniaturised quality control of PET and SPECT radiopharmaceuticals.