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The effects of phytochemicals and herbal bio-active compounds on tumour necrosis factor-α in overweight and obese individuals: a clinical review (2022)
Journal Article
Bagherniya, M., Mahdavi, A., Abbasi, E., Iranshahy, M., Sathyapalan, T., & Sahebkar, A. (2022). The effects of phytochemicals and herbal bio-active compounds on tumour necrosis factor-α in overweight and obese individuals: a clinical review. Inflammopharmacology, 30(1), 91-110. https://doi.org/10.1007/s10787-021-00902-y

Obesity is abnormal fat accumulation in the body which acts as a risk factor for various cardiometabolic states. Adipose tissue in excess can release inflammatory factors, including TNF-α and IL-6, and suppress adiponectin production. TNF-α increases... Read More about The effects of phytochemicals and herbal bio-active compounds on tumour necrosis factor-α in overweight and obese individuals: a clinical review.

Recent Advances in Lung Cancer Therapy Based on Nanomaterials: A Review (2022)
Journal Article
Gholami, L., Ivari, J. R., Nasab, N. K., Oskuee, R. K., Sathyapalan, T., & Sahebkar, A. (2023). Recent Advances in Lung Cancer Therapy Based on Nanomaterials: A Review. Current medicinal chemistry, 30(3), 335-355. https://doi.org/10.2174/0929867328666210810160901

Lung cancer is one of the commonest cancers with a significant mortality rate for both genders, particularly in men. Lung cancer is recognized as one of the leading causes of death worldwide, which threatens the lives of over 1.6 million people every... Read More about Recent Advances in Lung Cancer Therapy Based on Nanomaterials: A Review.

Antitumor and Protective Effects of Melatonin: The Potential Roles of MicroRNAs (2022)
Book Chapter
Ashrafizadeh, M., Ahmadi, Z., Yaribeygi, H., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2022). Antitumor and Protective Effects of Melatonin: The Potential Roles of MicroRNAs. In A. Sahebkar, & T. Sathyapalan (Eds.), Natural Products and Human Diseases (463-471). Springer. https://doi.org/10.1007/978-3-030-73234-9_31

MicroRNAs (miRNAs) are endogenous short noncoding RNAs with approximately 22 nucleotides. The primary function of miRNAs is the negative regulation of target gene expression via mRNA degradation or translation inhibition. During recent years, much at... Read More about Antitumor and Protective Effects of Melatonin: The Potential Roles of MicroRNAs.

A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Phase 2b Trial of P2X3 Receptor Antagonist Sivopixant for Refractory or Unexplained Chronic Cough (2022)
Journal Article
McGarvey, L., Smith, J. A., Morice, A., Birring, S. S., Chung, K. F., Dicpinigaitis, P. V., Niimi, A., Benninger, M. S., Sher, M., Matsunaga, Y., Miyazaki, S., Machida, M., Ishihara, H., Mahmood, A., & Gomez, J. C. (2022). A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Phase 2b Trial of P2X3 Receptor Antagonist Sivopixant for Refractory or Unexplained Chronic Cough. Lung, https://doi.org/10.1007/s00408-022-00592-5

Introduction: To determine the optimal dose of sivopixant, a highly selective P2X3 receptor antagonist, for refractory or unexplained chronic cough (RCC/UCC). Methods: In this phase 2b, randomized, double-blind, placebo-controlled, parallel-group, mu... Read More about A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Phase 2b Trial of P2X3 Receptor Antagonist Sivopixant for Refractory or Unexplained Chronic Cough.

Impact of COVID-19 on vascular patients worldwide: analysis of the COVIDSurg data (2021)
Journal Article
Hitchman, L., & Machin, M. (2021). Impact of COVID-19 on vascular patients worldwide: analysis of the COVIDSurg data. Journal of Cardiovascular Surgery, 62(6), 558-70. https://doi.org/10.23736/S0021-9509.21.12024-5

BACKGROUND: The COVIDSurg collaborative was an international multicenter prospective analysis of perioperative data from 235 hospitals in 24 countries. it found that perioperative COVID-19 infection was associated with a mortality rate of 24%. at the... Read More about Impact of COVID-19 on vascular patients worldwide: analysis of the COVIDSurg data.

Developing an evidence-based system to facilitate the predictive assessment and optimisation of older adults with cancer (2021)
Thesis
McKenzie, G. A. G. Developing an evidence-based system to facilitate the predictive assessment and optimisation of older adults with cancer. (Thesis). The University of Hull and the University of York. https://hull-repository.worktribe.com/output/4192792

Introduction: Older adults with cancer have worse outcomes than their younger counterparts, including higher postoperative complications, chemotherapy toxicity and treatment allocation to best supportive care. Oncogeriatric assessment (OGA) can provi... Read More about Developing an evidence-based system to facilitate the predictive assessment and optimisation of older adults with cancer.

Preface (2021)
Book Chapter
Sahebkar, A., & Sathyapalan, T. (2021). Preface. In A. Sahebkar, & T. Sathyapalan (Eds.), Natural Products and Human Diseases : Pharmacology, Molecular Targets, and Therapeutic Benefits (v). Springer Verlag. https://doi.org/10.1007/978-3-030-73234-9

European respiratory society guidelines on the diagnosis and treatment of chronic cough in adults and children (2021)
Journal Article
Morice, A. H., Millqvist, E., Bieksiene, K., Birring, S. S., Dicpinigaitis, P., Ribas, C. D., Boon, M. H., Kantar, A., Lai, K., McGarvey, L., Rigau, D., Satia, I., Smith, J., Song, W. J., Tonia, T., van den Berg, J. W., van Manen, M. J., & Zacharasiewicz, A. (2021). European respiratory society guidelines on the diagnosis and treatment of chronic cough in adults and children. Pulmonologiya, 31(4), 418-438. https://doi.org/10.18093/0869-0189-2021-31-4-418-438

These guidelines incorporate the recent advances in chronic cough pathophysiology, diagnosis and treatment. The concept of cough hypersensitivity has allowed an umbrella term that explains the exquisite sensitivity of patients to external stimuli suc... Read More about European respiratory society guidelines on the diagnosis and treatment of chronic cough in adults and children.

The use of perioperative prophylactic antibiotics following excision of ulcerated skin lesions in the UK – A national, multi-speciality survey of clinicians (2021)
Journal Article
Totty, J., Matin, R., Wernham, A., Ray, R., Thomas-Jones, E., & Abbott, R. (in press). The use of perioperative prophylactic antibiotics following excision of ulcerated skin lesions in the UK – A national, multi-speciality survey of clinicians. Clinical and experimental dermatology, https://doi.org/10.1111/ced.15075

Skin cancer is the most common malignancy in the UK, and up to a third of lesions are ulcerated at the time of excision. Ulceration has been shown to increase the risk of developing surgical site infection post-excision, with some studies finding inf... Read More about The use of perioperative prophylactic antibiotics following excision of ulcerated skin lesions in the UK – A national, multi-speciality survey of clinicians.

Impact of pharmacological interventions on anthropometric indices in women with polycystic ovary syndrome: a systematic review and meta‐analysis of randomised controlled trials (2021)
Journal Article
Abdalla, M. A., Shah, N., Deshmukh, H., Sahebkar, A., Östlundh, L., Al‐Rifai, R. H., Atkin, S. L., & Sathyapalan, T. (in press). Impact of pharmacological interventions on anthropometric indices in women with polycystic ovary syndrome: a systematic review and meta‐analysis of randomised controlled trials. Clinical Endocrinology, https://doi.org/10.1111/cen.14663

Context: Polycystic ovary syndrome (PCOS) is a heterogeneous condition affecting women of reproductive age and is associated with increased body weight. Objective: To review the literature on the effect of different pharmacological interventions on t... Read More about Impact of pharmacological interventions on anthropometric indices in women with polycystic ovary syndrome: a systematic review and meta‐analysis of randomised controlled trials.

Genetic risk for the polycystic ovary syndrome, bone mineral density and fractures in women and men: A UK Biobank Mendelian randomisation study (2021)
Journal Article
Deshmukh, H., Shah, N., Papageorgiou, M., Abdalla, M. A., Lhaf, F., Aye, M., & Sathyapalan, T. (2022). Genetic risk for the polycystic ovary syndrome, bone mineral density and fractures in women and men: A UK Biobank Mendelian randomisation study. Bone, 155, Article 116285. https://doi.org/10.1016/j.bone.2021.116285

Introduction: There is conflicting data on the effect of polycystic ovary syndrome (PCOS) on bone mineral density (BMD) and fracture risk. Recent genetic data suggest that men may also carry genetic risk factors for PCOS; the associations of these fa... Read More about Genetic risk for the polycystic ovary syndrome, bone mineral density and fractures in women and men: A UK Biobank Mendelian randomisation study.

Potential Biomarkers to Predict Acute Ischemic Stroke in Type 2 Diabetes (2021)
Journal Article
Moin, A. S. M., Nandakumar, M., Al-Qaissi, A., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2021). Potential Biomarkers to Predict Acute Ischemic Stroke in Type 2 Diabetes. Frontiers in Molecular Biosciences, 8, Article 744459. https://doi.org/10.3389/fmolb.2021.744459

Background and Purpose: Patients with type 2 diabetes (T2D) have increased risk of cardiovascular disease (CVD), encompassing myocardial infarction, stroke, and peripheral vascular disease. We hypothesized that those biomarkers indicative of acute is... Read More about Potential Biomarkers to Predict Acute Ischemic Stroke in Type 2 Diabetes.

Chronic cough: new insights and future prospects (2021)
Journal Article
Morice, A., Dicpinigaitis, P., McGarvey, L., & Birring, S. S. (2021). Chronic cough: new insights and future prospects. European Respiratory Review, 30(162), Article 210127. https://doi.org/10.1183/16000617.0127-2021

Chronic cough is defined in adults as a cough that lasts for ≥8 weeks. When it proves intractable to standard-of-care treatment, it can be referred to as refractory chronic cough (RCC). Chronic cough is now understood to be a condition of neural dysr... Read More about Chronic cough: new insights and future prospects.

Chlorhexidine versus Povidone-Iodine Skin Antisepsis Prior to Upper Limb Surgery (CIPHUR): An International Multicentre Prospective Cohort Study (2021)
Journal Article
Wade, R., Bourke, G., Wormald, J., Totty, J., Stanley, G., Lewandowski, A., Rakhra, S., Gardiner, M., & The CIPHUR Collaborative. (2021). Chlorhexidine versus Povidone-Iodine Skin Antisepsis Prior to Upper Limb Surgery (CIPHUR): An International Multicentre Prospective Cohort Study. BJS Open, 5(6), Article zrab117. https://doi.org/10.1093/bjsopen/zrab117

Introduction: Surgical site infection (SSI) is the most common and costly complication of surgery. International guidelines recommend topical alcoholic chlorhexidine (CHX) prior to surgery but upper limb surgeons continue to use other antiseptics, ci... Read More about Chlorhexidine versus Povidone-Iodine Skin Antisepsis Prior to Upper Limb Surgery (CIPHUR): An International Multicentre Prospective Cohort Study.

Bruton’s tyrosine kinase inhibitors impair FcγRIIA-driven platelet responses to bacteria in chronic lymphocytic leukemia (2021)
Journal Article
Naylor-Adamson, L., Chacko, A., Booth, Z., Caserta, S., Jarvis, J., Khan, S., Hart, S. P., Rivero, F., Allsup, D. J., & Arman, M. (2021). Bruton’s tyrosine kinase inhibitors impair FcγRIIA-driven platelet responses to bacteria in chronic lymphocytic leukemia. Frontiers in immunology, 12, Article 766272. https://doi.org/10.3389/fimmu.2021.766272

Bacterial infections are a major cause of morbidity and mortality in chronic lymphocytic leukemia (CLL), and infection risk increases in patients treated with the Bruton’s tyrosine kinase (Btk) inhibitor, ibrutinib. Btk and related kinases (like Tec)... Read More about Bruton’s tyrosine kinase inhibitors impair FcγRIIA-driven platelet responses to bacteria in chronic lymphocytic leukemia.

Hypoglycemia-induced changes in complement pathways in type 2 diabetes (2021)
Journal Article
Moin, A. S. M., Nandakumar, M., Diboun, I., Al-Qaissi, A., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2021). Hypoglycemia-induced changes in complement pathways in type 2 diabetes. Atherosclerosis, 46, 35-45. https://doi.org/10.1016/j.athplu.2021.11.002

Background and aims: An association between hypoglycaemia and adverse cardiovascular events has been suggested from longitudinal and retrospective cohort studies. The complement pathway proteins in hypoglycemia are not well studied. Here, we hypothes... Read More about Hypoglycemia-induced changes in complement pathways in type 2 diabetes.

Effect of pharmacological interventions on lipid profiles and C-reactive protein in polycystic ovary syndrome: A systematic review and meta-analysis (2021)
Journal Article
Abdalla, M. A., Shah, N., Deshmukh, H., Sahebkar, A., Östlundh, L., Al-Rifai, R. H., Atkin, S. L., & Sathyapalan, T. (in press). Effect of pharmacological interventions on lipid profiles and C-reactive protein in polycystic ovary syndrome: A systematic review and meta-analysis. Clinical Endocrinology, https://doi.org/10.1111/cen.14636

Context: Polycystic ovary syndrome (PCOS) is a heterogeneous condition affecting women of reproductive age. It is associated with dyslipidaemia and elevated plasma C-reactive protein (CRP), which increase the risks of cardiovascular disease (CVD). Ob... Read More about Effect of pharmacological interventions on lipid profiles and C-reactive protein in polycystic ovary syndrome: A systematic review and meta-analysis.

Heat shock-related protein responses and inflammatory protein changes are associated with mild prolonged hypoglycemia (2021)
Journal Article
Moin, A. S. M., Nandakumar, M., Kahal, H., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2021). Heat shock-related protein responses and inflammatory protein changes are associated with mild prolonged hypoglycemia. Cells, 10(11), Article 3109. https://doi.org/10.3390/cells10113109

Mild hypoglycemia is common in clinical practice. Severe hypoglycemia results in heat shock protein and associate co-chaperone changes. Whether mild prolonged hypoglycemia elic-its a similar response with inflammatory and oxidative-stress responses c... Read More about Heat shock-related protein responses and inflammatory protein changes are associated with mild prolonged hypoglycemia.