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Adoptive transfer of Tregs: A novel strategy for cell-based immunotherapy in spontaneous abortion: Lessons from experimental models (2021)
Journal Article
Mohammadi, S., Abdollahi, E., Nezamnia, M., Esmaeili, S. A., Tavasolian, F., Sathyapalan, T., & Sahebkar, A. (2021). Adoptive transfer of Tregs: A novel strategy for cell-based immunotherapy in spontaneous abortion: Lessons from experimental models. International immunopharmacology, 90, Article 107195. https://doi.org/10.1016/j.intimp.2020.107195

Since half of the genes are inherited from the paternal side, the maternal immune system has to tolerate the presence of foreign paternal antigens. Regulatory T cells facilitate the development and maintenance of peripheral tissue tolerance of the fe... Read More about Adoptive transfer of Tregs: A novel strategy for cell-based immunotherapy in spontaneous abortion: Lessons from experimental models.

The potential role of incretin-based therapies for polycystic ovary syndrome: a narrative review of the current evidence (2021)
Journal Article
Abdalla, M. A., Deshmukh, H., Atkin, S., & Sathyapalan, T. (2021). The potential role of incretin-based therapies for polycystic ovary syndrome: a narrative review of the current evidence. Therapeutic Advances in Endocrinology and Metabolism, 12, https://doi.org/10.1177/2042018821989238

© The Author(s), 2021. Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women of reproductive age. Metabolic consequences associated with PCOS include, but are not limited to, insulin resistance (IR), type 2... Read More about The potential role of incretin-based therapies for polycystic ovary syndrome: a narrative review of the current evidence.

Author response to: Comment on: Patterns of acute surgical inflammatory processes presentation of in the COVID-19 outbreak (PIACO Study): surgery may be the best treatment option (2021)
Journal Article
Guadalajara, H., Muñoz de Nova, J. L., Fernandez Gonzalez, S., Yiasemidou, M., Recarte Rico, M., Juez, L. D., García Septiem, J., Galindo Jara, P., García Virosta, M., Lobo Martínez, E., Martín-Pérez, E., García-Olmo, D., Fernández-Cebrián, J. M., Blazquez Martin, A., Jover, J. M., Iparraguirre, M. A., Acín-Gándara, D., Perea-del-Pozo, E., Dios-Barbeito, S., Martin-Antona, E., …PIACO Collaboration Group. (2021). Author response to: Comment on: Patterns of acute surgical inflammatory processes presentation of in the COVID-19 outbreak (PIACO Study): surgery may be the best treatment option. British journal of surgery, 108(1), e42-e43. https://doi.org/10.1093/bjs/znaa022

A feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE): Study protocol (2021)
Journal Article
Northgraves, M., Cohen, J., Allgar, V., Currow, D., Hart, S., Hird, K., Hodge, A., Johnson, M., Mason, S., Swan, F., & Hutchinson, A. (2021). A feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE): Study protocol. ERJ Open Research, 7(1), Article 00955-2020. https://doi.org/10.1183/23120541.00955-2020

Introduction: Chronic breathlessness, persistent and disabling despite optimal treatment of underlying causes, is a prevalent and frightening symptom and is associated with many emergency presentations and admission to hospital. Breathlessness manage... Read More about A feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE): Study protocol.

Neurokinin-1 receptor (NK-1R) antagonists: potential targets in the treatment of glioblastoma multiforme (2021)
Journal Article
Afshari, A. R., Motamed-Sanaye, A., Sabri, H., Soltani, A., Karkon-Shayan, S., Radvar, S., Javid, H., Mollazadeh, H., Sathyapalan, T., & Sahebkar, A. (2021). Neurokinin-1 receptor (NK-1R) antagonists: potential targets in the treatment of glioblastoma multiforme. Current medicinal chemistry, 28(24), 4877-4892. https://doi.org/10.2174/0929867328666210113165805

The current standard of care in glioblastoma multiforme (GBM), as the most morbid brain tumor, is not adequate, despite substantial progress in cancer therapy. Among patients receiving current standard treatments, including surgery, irradiation, and... Read More about Neurokinin-1 receptor (NK-1R) antagonists: potential targets in the treatment of glioblastoma multiforme.

siRNA Therapeutics: Future Promise for Neurodegenerative Diseases (2021)
Journal Article
Amiri, A., Barreto, G., Sathyapalan, T., & Sahebkar, A. (2021). siRNA Therapeutics: Future Promise for Neurodegenerative Diseases. Current Neuropharmacology, 19(11), 1896-1911. https://doi.org/10.2174/1570159X19666210402104054

Neurodegenerative diseases (ND), as a group of central nervous system (CNS) disorders, are among the most prominent medical problems of the 21st century. They are often associated with considerable disability, motor dysfunction and dementia and are m... Read More about siRNA Therapeutics: Future Promise for Neurodegenerative Diseases.

Natural Insulin Sensitizers for the Management of Diabetes Mellitus: A Review of Possible Molecular Mechanisms (2021)
Book Chapter
Yaribeygi, H., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2021). Natural Insulin Sensitizers for the Management of Diabetes Mellitus: A Review of Possible Molecular Mechanisms. In A. Sahebkar, & T. Sathyapalan (Eds.), Natural Products and Human Diseases (401-410). Cham: Springer. https://doi.org/10.1007/978-3-030-73234-9_26

Diabetes mellitus is a growing health challenge globally which is increasing in epidemic proportion. Naturally occurring pharmacological agents are more likely to provide beneficial therapeutic effects without undesirable side effects compared to the... Read More about Natural Insulin Sensitizers for the Management of Diabetes Mellitus: A Review of Possible Molecular Mechanisms.

Therapeutics for type-2 diabetes mellitus: a glance at the recent inclusions and novel agents under development for use in clinical practice (2021)
Journal Article
Shah, N., Abdalla, M. A., Deshmukh, H., & Sathyapalan, T. (2021). Therapeutics for type-2 diabetes mellitus: a glance at the recent inclusions and novel agents under development for use in clinical practice. Therapeutic Advances in Endocrinology and Metabolism, 12, https://doi.org/10.1177/20420188211042145

Diabetes mellitus (DM) is a chronic, progressive, and multifaceted illness resulting in significant physical and psychological detriment to patients. As of 2019, 463 million people are estimated to be living with DM worldwide, out of which 90% have t... Read More about Therapeutics for type-2 diabetes mellitus: a glance at the recent inclusions and novel agents under development for use in clinical practice.

Cardiac Injury in COVID-19: A Systematic Review (2021)
Book Chapter
Moayed, M. S., Rahimi-Bashar, F., Vahedian-Azimi, A., Sathyapalan, T., Guest, P. C., Jamialahmadi, T., & Sahebkar, A. (2021). Cardiac Injury in COVID-19: A Systematic Review. In P. C. Guest (Ed.), Clinical, Biological and Molecular Aspects of COVID-19 (325-333). Springer. https://doi.org/10.1007/978-3-030-59261-5_29

© 2021, The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG. Coronavirus 2019 (COVID-19) is responsible for the current pandemic which has already resulted in considerable mortality worldwide. Th... Read More about Cardiac Injury in COVID-19: A Systematic Review.

Patient-specific mental rehearsal with three-dimensional models before low anterior resection: randomized clinical trial (2020)
Journal Article
Yiasemidou, M., Mushtaq, F., Basheer, M., Galli, R., Panagiotou, D., Stock, S., Preston, N., Mon-Williams, M., Jayne, D. G., & Miskovic, D. (2021). Patient-specific mental rehearsal with three-dimensional models before low anterior resection: randomized clinical trial. BJS Open, 5(2), Article zraa004. https://doi.org/10.1093/bjsopen/zraa004

Background It was hypothesized that preparing for a surgical procedure, taking into account individual patient characteristics, may facilitate the procedure and improve surgical quality. The aim of this study was to compare different case-specific,... Read More about Patient-specific mental rehearsal with three-dimensional models before low anterior resection: randomized clinical trial.

Distinct immune regulatory receptor profiles linked to altered monocyte subsets in sarcoidosis (2020)
Journal Article
Fraser, S. D., Crooks, M. G., Kaye, P. M., & Hart, S. P. (2021). Distinct immune regulatory receptor profiles linked to altered monocyte subsets in sarcoidosis. ERJ Open Research, 7(1), https://doi.org/10.1183/23120541.00804-2020

Background: In sarcoidosis, blood monocytes, circulating precursors of granuloma macrophages, display enhanced inflammatory cytokine production, reduced expression of the regulatory (inhibitory) receptor CD200R, and altered subsets defined by CD14 an... Read More about Distinct immune regulatory receptor profiles linked to altered monocyte subsets in sarcoidosis.

The impact of surgical site infection on hospitalisation, treatment costs, and health-related quality of life after vascular surgery (2020)
Journal Article
Totty, J., Moss, J. W. E., Barker, E., Mealing, S., Posnett, J., Chetter, I. C., & Smith, G. E. (in press). The impact of surgical site infection on hospitalisation, treatment costs, and health-related quality of life after vascular surgery. International wound journal, https://doi.org/10.1111/iwj.13526

Surgical site infections (SSI) substantially increase costs for healthcare providers because of additional treatments and extended patient recovery. The objective of this study was to assess the cost and health‐related quality of life impact of SSI,... Read More about The impact of surgical site infection on hospitalisation, treatment costs, and health-related quality of life after vascular surgery.

Patient, family and carer experiences of nutritional screening: a systematic review (2020)
Journal Article
Bullock, A., Greenley, S. L., Patterson, M. J., McKenzie, G. A. G., & Johnson, M. J. (2021). Patient, family and carer experiences of nutritional screening: a systematic review. Journal of Human Nutrition and Dietetics, 34(3), 595-603. https://doi.org/10.1111/jhn.12849

Background: Despite recommendations for nutritional risk screening of all inpatients, outpatients and care home residents, as well as work to assess clinician's experiences and the validity of tools, little attention has been paid to the experiences... Read More about Patient, family and carer experiences of nutritional screening: a systematic review.

Specificity of translocator protein-targeted positron emission tomography in inflammatory joint disease (2020)
Journal Article
Helo, Y., Searle, G. E., Borghese, F., Abraham, S., & Saleem, A. (2020). Specificity of translocator protein-targeted positron emission tomography in inflammatory joint disease. EJNMMI Research, 10(1), Article 147. https://doi.org/10.1186/s13550-020-00736-9

© 2020, The Author(s). Objective: Expression of the translocator protein (TSPO) on inflammatory cells has facilitated imaging of synovitis with TSPO-targeted positron emission tomography (PET). We aimed to quantitatively assess the specificity of the... Read More about Specificity of translocator protein-targeted positron emission tomography in inflammatory joint disease.

The surgical management of cutaneous abscesses: A UK cross-sectional survey (2020)
Journal Article
Thomas, O., Ramsay, A., Yiasemidou, M., Hardie, C., Ashmore, D., Macklin, C., Bandyopadhyay, D., Patel, B., Burke, J. R., & Jayne, D. (2020). The surgical management of cutaneous abscesses: A UK cross-sectional survey. Annals of Medicine and Surgery, 60, 654-659. https://doi.org/10.1016/j.amsu.2020.11.068

Aim Cutaneous abscesses are one of the most common acute general surgery presentations. This study aimed to understand the current practice in the management of cutaneous abscesses in the United Kingdom (UK), once the decision has been made that acu... Read More about The surgical management of cutaneous abscesses: A UK cross-sectional survey.

Advanced imaging for quantification of abnormalities in the salivary glands of patients with primary Sjögren's syndrome (2020)
Journal Article
Jimenez-Royo, P., Bombardieri, M., Ciurtin, C., Kostapanos, M., Tappuni, A. R., Jordan, N., Saleem, A., Fuller, T., Port, K., Pontarini, E., Lucchesi, D., Janiczek, R., Galette, P., Searle, G., Patel, N., Kershaw, L., Gray, C., Ratia, N., van Maurik, A., de Groot, M., …Tarzi, R. (2021). Advanced imaging for quantification of abnormalities in the salivary glands of patients with primary Sjögren's syndrome. Rheumatology, 60(5), 2396-2408. https://doi.org/10.1093/rheumatology/keaa624

OBJECTIVES: To assess non-invasive imaging for detection and quantification of gland structure, inflammation and function in patients with primary Sjogren's syndrome (pSS) using PET-CT with 11C-Methionine (11C-MET; radiolabelled amino acid), and 18F-... Read More about Advanced imaging for quantification of abnormalities in the salivary glands of patients with primary Sjögren's syndrome.

Considering the feasibility, tolerability and safety of high intensity interval training as a novel treatment for patients with intermittent claudication (2020)
Journal Article
Pymer, S., Ibeggazene, S., Palmer, J., Smith, G. E., Carroll, S., Ingle, L., Harwood, A., & Chetter, I. C. (2021). Considering the feasibility, tolerability and safety of high intensity interval training as a novel treatment for patients with intermittent claudication. Journal of Cardiopulmonary Rehabilitation and Prevention, 41(3), 188-193. https://doi.org/10.1097/HCR.0000000000000551

Considering the Feasibility, Tolerability and Safety of High-Intensity Interval Training as a Novel Treatment for Patients with Intermittent Claudication. Structured Abstract Purpose: This study assessed the feasibility, tolerability, safety and... Read More about Considering the feasibility, tolerability and safety of high intensity interval training as a novel treatment for patients with intermittent claudication.