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Long non-coding RNA expression in non-obese women with polycystic ovary syndrome and weight-matched controls (2020)
Journal Article
Butler, A. E., Hayat, S., Dargham, S. R., Malek, J. A., Abdullah, S. A., Mahmoud, Y. A., Sathyapalan, T., & Atkin, S. L. (2020). Long non-coding RNA expression in non-obese women with polycystic ovary syndrome and weight-matched controls. Reproductive BioMedicine Online, 41(4), 579-583. https://doi.org/10.1016/j.rbmo.2020.06.018

Research question: Long non-coding RNA (lncRNA) do not show protein translation but do have gene regulatory functions in several disease states. Studies have shown that lncRNA differ in overweight women with polycystic ovary syndrome (PCOS), increase... Read More about Long non-coding RNA expression in non-obese women with polycystic ovary syndrome and weight-matched controls.

A proposal for multidisciplinary tele-rehabilitation in the assessment and rehabilitation of COVID-19 survivors (2020)
Journal Article
Salawu, A., Green, A., Crooks, M. G., Brixey, N., Ross, D. H., & Sivan, M. (2020). A proposal for multidisciplinary tele-rehabilitation in the assessment and rehabilitation of COVID-19 survivors. International Journal of Environmental Research and Public Health, 17(13), 1-13. https://doi.org/10.3390/ijerph17134890

A global pandemic of a new highly contagious disease called COVID-19 resulting from coronavirus (severe acute respiratory syndrome (SARS)-Cov-2) infection was declared in February 2020. Though primarily transmitted through the respiratory system, oth... Read More about A proposal for multidisciplinary tele-rehabilitation in the assessment and rehabilitation of COVID-19 survivors.

The effects of empagliflozin vs metformin on endothelial microparticles in overweight/obese women with polycystic ovary syndrome (2020)
Journal Article
Javed, Z., Papageorgiou, M., Madden, L. A., Rigby, A. S., Kilpatrick, E. S., Atkin, S. L., & Sathyapalan, T. (2020). The effects of empagliflozin vs metformin on endothelial microparticles in overweight/obese women with polycystic ovary syndrome. Endocrine Connections, 9(6), 563-569. https://doi.org/10.1530/EC-20-0173

Context: Endothelial microparticles (EMPs) are novel, surrogate biomarkers of endothelial function and have been shown to be elevated in women with polycystic ovary syndrome (PCOS). It remains poorly understood how pharmacological options for managin... Read More about The effects of empagliflozin vs metformin on endothelial microparticles in overweight/obese women with polycystic ovary syndrome.

Author Correction: Effect of induced hypoglycemia on inflammation and oxidative stress in type 2 diabetes and control subjects (Scientific Reports, (2020), 10, 1, (4750), 10.1038/s41598-020-61531-z) (2020)
Journal Article
Kahal, H., Halama, A., Aburima, A., Bhagwat, A. M., Butler, A. E., Graumann, J., Suhre, K., Sathyapalan, T., & Atkin, S. L. (2020). Author Correction: Effect of induced hypoglycemia on inflammation and oxidative stress in type 2 diabetes and control subjects (Scientific Reports, (2020), 10, 1, (4750), 10.1038/s41598-020-61531-z). Scientific reports, 10(1), Article 10233. https://doi.org/10.1038/s41598-020-66189-1

© 2020, The Author(s). The original version of this Article contained a typographical error in the spelling of the author Johannes Graumann, which was incorrectly given as Johannes Grauman. This has now been corrected in the PDF and HTML versions of... Read More about Author Correction: Effect of induced hypoglycemia on inflammation and oxidative stress in type 2 diabetes and control subjects (Scientific Reports, (2020), 10, 1, (4750), 10.1038/s41598-020-61531-z).

Counteracting arsenic toxicity: Curcumin to the rescue? (2020)
Journal Article
Bahrami, A., Sathyapalan, T., Moallem, S. A., & Sahebkar, A. (2020). Counteracting arsenic toxicity: Curcumin to the rescue?. Journal of hazardous materials, 400, Article 123160. https://doi.org/10.1016/j.jhazmat.2020.123160

Arsenicosis leads to various irreversible damages in several organs and is considered to be a carcinogen. The effects of chronic arsenic poisoning are a result of an imbalance between pro- and antioxidant homeostasis, oxidative stress, as well as DNA... Read More about Counteracting arsenic toxicity: Curcumin to the rescue?.

Incretin-based therapies and renin-angiotensin system: Looking for new therapeutic potentials in the diabetic milieu (2020)
Journal Article
Yaribeygi, H., Maleki, M., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2020). Incretin-based therapies and renin-angiotensin system: Looking for new therapeutic potentials in the diabetic milieu. Life Sciences, 256, Article 117916. https://doi.org/10.1016/j.lfs.2020.117916

Incretin-based therapies include pharmacologic agents such as glucagon like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors which exert potent anti-hyperglycemic effects in the diabetic milieu. They are also shown to have extra-panc... Read More about Incretin-based therapies and renin-angiotensin system: Looking for new therapeutic potentials in the diabetic milieu.

Association of endocrine active environmental compounds with body mass index and weight loss following bariatric surgery (2020)
Journal Article
Deshmukh, H., Aylward, L. L., Rose, M., Fernandes, A., Sedman, P., Thatcher, N. J., Atkin, S. L., & Sathyapalan, T. (2020). Association of endocrine active environmental compounds with body mass index and weight loss following bariatric surgery. Clinical Endocrinology, 93(3), 280-287. https://doi.org/10.1111/cen.14257

Introduction The objective of this study was to study associations of a wide range of halogenated biphenyls, dibenzo‐p‐dioxins, dibenzofurans, and diphenylethers with body mass index (BMI) and evaluate changes in their concentration following bariat... Read More about Association of endocrine active environmental compounds with body mass index and weight loss following bariatric surgery.

Relationship between markers of malnutrition and clinical outcomes in older adults with cancer: systematic review, narrative synthesis and meta-analysis (2020)
Journal Article
Bullock, A. F., Greenley, S. L., McKenzie, G. A., Paton, L. W., & Johnson, M. J. (2020). Relationship between markers of malnutrition and clinical outcomes in older adults with cancer: systematic review, narrative synthesis and meta-analysis. European journal of clinical nutrition, 74, 1519–1535. https://doi.org/10.1038/s41430-020-0629-0

© 2020, The Author(s). Malnutrition predicts poorer clinical outcomes for people with cancer. Older adults with cancer are a complex, growing population at high risk of weight-losing conditions. A number of malnutrition screening tools exist, however... Read More about Relationship between markers of malnutrition and clinical outcomes in older adults with cancer: systematic review, narrative synthesis and meta-analysis.

microRNA Expression in Women With and Without Polycystic Ovarian Syndrome Matched for Body Mass Index (2020)
Journal Article
Butler, A. E., Ramachandran, V., Sathyapalan, T., David, R., Gooderham, N. J., Benurwar, M., …Atkin, S. L. (2020). microRNA Expression in Women With and Without Polycystic Ovarian Syndrome Matched for Body Mass Index. Frontiers in endocrinology, 11, Article 206. https://doi.org/10.3389/fendo.2020.00206

Background: Despite several authors who have hypothesized that alterations of small noncoding RNAs (miR) are implicated in the etiopathogenesis of polycystic ovarian syndrome (PCOS), contrasting findings have been reported so far. Discrepancies in bo... Read More about microRNA Expression in Women With and Without Polycystic Ovarian Syndrome Matched for Body Mass Index.

The role of interleukin-18 in the development and progression of atherosclerosis (2020)
Journal Article
Bahrami, A., Sathyapalan, T., & Sahebkar, A. (2021). The role of interleukin-18 in the development and progression of atherosclerosis. Current medicinal chemistry, 28(9), 1757-1774. https://doi.org/10.2174/0929867327666200427095830

Atherosclerosis (AS), as a chronic inflammatory disorder of the cardiovascular system, is one of the leading causes of ischemic heart disease, stroke and peripheral vascular disease. There is growing evidence on the role of innate and adaptive immuni... Read More about The role of interleukin-18 in the development and progression of atherosclerosis.

Physical activity and nutrition interventions for older adults with cancer: a systematic review (2020)
Journal Article
Forbes, C. C., Swan, F., Greenley, S. L., Lind, M., & Johnson, M. J. (2020). Physical activity and nutrition interventions for older adults with cancer: a systematic review. Journal of cancer survivorship : research and practice, 14(5), 689-711. https://doi.org/10.1007/s11764-020-00883-x

Purpose: The aim of this review was to summarize the current literature for the effectiveness of activity and nutritional based interventions on health-related quality of life (HRQoL) in older adults living with and beyond cancer (LWBC). Methods: We... Read More about Physical activity and nutrition interventions for older adults with cancer: a systematic review.

Cough persistence in adults with chronic cough: a 4-year retrospective cohort study (2020)
Journal Article
Kang, S. Y., Song, W. J., Won, H. K., Chung, S. J., Kim, J. Y., Park, H. W., Morice, A. H., & Cho, S.-H. (2020). Cough persistence in adults with chronic cough: a 4-year retrospective cohort study. Allergology International, 69(4), 588-593. https://doi.org/10.1016/j.alit.2020.03.012

Background There is very limited evidence regarding long-term prognosis of chronic cough. We examined longitudinal outcomes among patients with chronic cough, and explored predictors of cough persistence. Methods A retrospective cohort was constru... Read More about Cough persistence in adults with chronic cough: a 4-year retrospective cohort study.

British Thoracic Society guideline for the use of long-term macrolides in adults with respiratory disease (2020)
Journal Article
Smith, D., Du Rand, I., Addy, C. L., Collyns, T., Hart, S. P., Mitchelmore, P. J., Rahman, N. M., & Saggu, R. (2020). British Thoracic Society guideline for the use of long-term macrolides in adults with respiratory disease. Thorax, 75(5), 370-404. https://doi.org/10.1136/thoraxjnl-2019-213929

Summary of recommendations and good practice points Asthma Recommendations Oral macrolide therapy could be considered to reduce exacerbation frequency in adults (50–70 years), with ongoing symptoms despite >80% adherence to high-dose inhaled stero... Read More about British Thoracic Society guideline for the use of long-term macrolides in adults with respiratory disease.

The effect of aromatherapy with rose and lavender on anxiety, surgical site pain, and extubation time after open-heart surgery: A double-center randomized controlled trial (2020)
Journal Article
Babatabar Darzi, H., Vahedian-Azimi, A., Ghasemi, S., Ebadi, A., Sathyapalan, T., & Sahebkar, A. (2020). The effect of aromatherapy with rose and lavender on anxiety, surgical site pain, and extubation time after open-heart surgery: A double-center randomized controlled trial. Phytotherapy Research, 34(10), 2675-2684. https://doi.org/10.1002/ptr.6698

To determine the effect of aromatherapy with rose and lavender on the patient outcomes after open‐heart surgery (OHS). In the clinical trial, patients were randomized to four groups. One group received routine care, the placebo group received a cotto... Read More about The effect of aromatherapy with rose and lavender on anxiety, surgical site pain, and extubation time after open-heart surgery: A double-center randomized controlled trial.

A positron emission tomography imaging study to confirm target engagement in the lungs of patients with idiopathic pulmonary fibrosis following a single dose of a novel inhaled αvβ6 integrin inhibitor (2020)
Journal Article
Maher, T. M., Simpson, J. K., Porter, J. C., Wilson, F. J., Chan, R., Eames, R., Cui, Y., Siederer, S., Parry, S., Kenny, J., Slack, R. J., Sahota, J., Paul, L., Saunders, P., Molyneaux, P. L., Lukey, P. T., Rizzo, G., Searle, G. E., Marshall, R. P., Saleem, A., …Vahdati-Bolouri, M. (2020). A positron emission tomography imaging study to confirm target engagement in the lungs of patients with idiopathic pulmonary fibrosis following a single dose of a novel inhaled αvβ6 integrin inhibitor. Respiratory Research, 21(1), Article 75. https://doi.org/10.1186/s12931-020-01339-7

© 2020 The Author(s). Background: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease with poor prognosis and a significant unmet medical need. This study evaluated the safety, pharmacokinetics (PK) and target engagement in the... Read More about A positron emission tomography imaging study to confirm target engagement in the lungs of patients with idiopathic pulmonary fibrosis following a single dose of a novel inhaled αvβ6 integrin inhibitor.

Effect of induced hypoglycemia on inflammation and oxidative stress in type 2 diabetes and control subjects (2020)
Journal Article
Kahal, H., Halama, A., Aburima, A., Bhagwat, A. M., Butler, A. E., Grauman, J., Suhre, K., Sathyapalan, T., & Atkin, S. L. (2020). Effect of induced hypoglycemia on inflammation and oxidative stress in type 2 diabetes and control subjects. Scientific reports, 10(1), Article 4750. https://doi.org/10.1038/s41598-020-61531-z

Intensive diabetes control has been associated with increased mortality in type 2 diabetes (T2DM); this has been suggested to be due to increased hypoglycemia. We measured hypoglycemia-induced changes in endothelial parameters, oxidative stress marke... Read More about Effect of induced hypoglycemia on inflammation and oxidative stress in type 2 diabetes and control subjects.

Drug-induced cough (2020)
Journal Article
Shim, J. S., Song, W. J., & Morice, A. H. (2020). Drug-induced cough. Physiological Research, 69(S1), S81-S92. https://doi.org/10.33549/physiolres.934406

© 2020, Czech Academy of Sciences. Since the recognition of angiotensin-converting enzyme inhibitors (ACEIs)-induced cough, drug has been considered as a potential cause of chronic cough. This review presents recent knowledge on drug-induced coughs i... Read More about Drug-induced cough.

Gefapixant, a P2X3 receptor antagonist, for the treatment of refractory or unexplained chronic cough: a randomised, double-blind, controlled, parallel-group, phase 2b trial (2020)
Journal Article
Smith, J. A., Kitt, M. M., Morice, A., Birring, S. S., McGarvey, L. P., Sher, M. R., Li, Y. P., Wu, W. C., Xu, Z. J., Muccino, D. R., Ford, A. P., Hull, J., Carr, W. W., Goldsobel, A. B., Gross, G. N., Holcomb, J. R., Hussain, I., Spangenthal, S., Storms, W., Elkayam, D., …Iyer, V. (2020). Gefapixant, a P2X3 receptor antagonist, for the treatment of refractory or unexplained chronic cough: a randomised, double-blind, controlled, parallel-group, phase 2b trial. The lancet. Respiratory medicine, 8(8), 775-785. https://doi.org/10.1016/S2213-2600%2819%2930471-0

Background: Gefapixant is a P2X3 receptor antagonist that has shown promise for the treatment of refractory and unexplained chronic cough. The aim of this study was to evaluate the efficacy of gefapixant compared with placebo after 12 weeks of treatm... Read More about Gefapixant, a P2X3 receptor antagonist, for the treatment of refractory or unexplained chronic cough: a randomised, double-blind, controlled, parallel-group, phase 2b trial.