All Outputs (54)

Nutrigenetics—Personalized Nutrition in the Genetic Age (2017)
Journal Article
Beckett, E., Jones, P., Veysey, M., & Lucock, M. (2017). Nutrigenetics—Personalized Nutrition in the Genetic Age. Exploratory research and hypothesis in medicine, 2(4), 109-116. https://doi.org/10.14218/ERHM.2017.00027

Diet is an important modifiable determinant of disease, and it is becoming clear that diet and genetic risk factors are interactive in determining risk for diseases such as cardiovascular disease, diabetes and cancers. Advances in technology have imp... Read More about Nutrigenetics—Personalized Nutrition in the Genetic Age.

ORAI channels are critical for receptor-mediated endocytosis of albumin (2017)
Journal Article
Zeng, B., Chen, G.-L., Garcia-Vaz, E., Bhandari, S., Daskoulidou, N., Berglund, L. M., Jiang, H., Hallett, T., Zhou, L.-P., Huang, L., Xu, Z.-H., Nair, V., Nelson, R. G., Ju, W., Kretzler, M., Atkin, S. L., Gomez, M. F., & Xu, S.-Z. (2017). ORAI channels are critical for receptor-mediated endocytosis of albumin. Nature communications, 8(1), Article 1920. https://doi.org/10.1038/s41467-017-02094-y

Impaired albumin reabsorption by proximal tubular epithelial cells (PTECs) has been highlighted in diabetic nephropathy (DN), but little is known about the underlying molecular mechanisms. Here we find that ORAI1-3, are preferentially expressed in PT... Read More about ORAI channels are critical for receptor-mediated endocytosis of albumin.

Categorisation of Mobile EEG: A Researcher's Perspective (2017)
Journal Article
Bateson, A. D., Baseler, H. A., Paulson, K. S., Ahmed, F., & Asghar, A. U. (2017). Categorisation of Mobile EEG: A Researcher's Perspective. Biomed research international, 2017, 1-15. https://doi.org/10.1155/2017/5496196

© 2017 Anthony D. Bateson et al. Researchers are increasingly attempting to undertake electroencephalography (EEG) recordings in novel environments and contexts outside of the traditional static laboratory setting. The term "mobile EEG," although com... Read More about Categorisation of Mobile EEG: A Researcher's Perspective.

Interventions to improve the uptake of cervical cancer screening among lower socioeconomic groups: A systematic review (2017)
Journal Article
Rees, I., Jones, D., Chen, H., & Macleod, U. (2018). Interventions to improve the uptake of cervical cancer screening among lower socioeconomic groups: A systematic review. Preventive Medicine, 111, 323-335. https://doi.org/10.1016/j.ypmed.2017.11.019

© 2017 Elsevier Inc. Cervical cancer is the fourth most common cancer in women worldwide. Screening can reduce both the incidence and mortality of the disease but is often not utilized by lower socioeconomic groups. A systematic review, including stu... Read More about Interventions to improve the uptake of cervical cancer screening among lower socioeconomic groups: A systematic review.

Asthma phenotypes: Do cough and wheeze predict exacerbations in persistent asthma? (2017)
Journal Article
Morjaria, J. B., Rigby, A. S., & Morice, A. H. (2017). Asthma phenotypes: Do cough and wheeze predict exacerbations in persistent asthma?. European respiratory journal, 50(6), Article 1701366. https://doi.org/10.1183/13993003.01366-2017

Copyright © ERS 2017. Little is known of the long-term symptom profile in uncontrolled asthma and whether symptoms can predict distinct phenotypes. The primary objective of these analyses was to assess diurnal profile of cough and wheeze in an uncont... Read More about Asthma phenotypes: Do cough and wheeze predict exacerbations in persistent asthma?.

Differing mechanisms of thrombin generation in live haematological and solid cancer cells determined by calibrated automated thrombography (2017)
Journal Article
Adesanya, M. A., Maraveyas, A., & Madden, L. (2017). Differing mechanisms of thrombin generation in live haematological and solid cancer cells determined by calibrated automated thrombography. Blood Coagulation and Fibrinolysis, 28(8), 602-611. https://doi.org/10.1097/mbc.0000000000000644

© 2017 Wolters Kluwer Health, Inc. All rights reserved. Calibrated automated thrombography (CAT) is emerging as a reliable tool for real-Time estimation of thrombin generation potential. There is a clinical need for knowledge about the pathways under... Read More about Differing mechanisms of thrombin generation in live haematological and solid cancer cells determined by calibrated automated thrombography.

Does FeNO Predict Clinical Characteristics in Chronic Cough? (2017)
Journal Article
Sadeghi, M. H., Wright, C. E., Hart, S., Crooks, M., & Morice, A. H. (2018). Does FeNO Predict Clinical Characteristics in Chronic Cough?. Lung, 196(1), 59-64. https://doi.org/10.1007/s00408-017-0074-6

© 2017, The Author(s). Purpose: To evaluate whether exhaled nitric oxide measurement can facilitate in the assessment of chronic cough patients based on their airway inflammatory phenotype. Methods: We have studied consecutive patients attending a sp... Read More about Does FeNO Predict Clinical Characteristics in Chronic Cough?.

Social and clinical determinants of preferences and their achievement at the end of life: Prospective cohort study of older adults receiving palliative care in three countries (2017)
Journal Article
Higginson, I. J., Bennett, E., Daveson, B. A., Cooper, F., Morrison, R. S., Yi, D., de Wolf-Linder, S., Meier, D., Dzingina, M., Smith, M., Ellis-Smith, C., Ryan, K., Evans, C., McQuillan, R., Ferguson, T., Normand, C., Henson, L., Johnston, B. M., Murtagh, F. E., Kaler, P., …Wei, G. (2017). Social and clinical determinants of preferences and their achievement at the end of life: Prospective cohort study of older adults receiving palliative care in three countries. BMC Geriatrics, 17(1), https://doi.org/10.1186/s12877-017-0648-4

© 2017 The Author(s). Background: Achieving choice is proposed as a quality marker. But little is known about what influences preferences especially among older adults. We aimed to determine and compare, across three countries, factors associated wit... Read More about Social and clinical determinants of preferences and their achievement at the end of life: Prospective cohort study of older adults receiving palliative care in three countries.

Frequency of folate-related polymorphisms varies by skin pigmentation (2017)
Journal Article
Jones, P., Lucock, M., Veysey, M., Jablonski, N., Chaplin, G., & Beckett, E. (2018). Frequency of folate-related polymorphisms varies by skin pigmentation. American Journal of Human Biology, 30(2), Article e23079. https://doi.org/10.1002/ajhb.23079

© 2017 Wiley Periodicals, Inc. Objectives: Folate-mediated 1-carbon transfer processes are vital in human health but are susceptible to independent and interactive influences of genetic variance and environmental exposures. Evidence suggests folate l... Read More about Frequency of folate-related polymorphisms varies by skin pigmentation.

Effect of soy on bone turn-over markers in men with type 2 diabetes and hypogonadism - A randomised controlled study (2017)
Journal Article
Sathyapalan, T., Aye, M., Rigby, A. S., Fraser, W. D., Kilpatrick, E. S., & Atkin, S. L. (2017). Effect of soy on bone turn-over markers in men with type 2 diabetes and hypogonadism - A randomised controlled study. Scientific reports, 7(1), Article ARTN 15366. https://doi.org/10.1038/s41598-017-15402-9

© 2017 The Author(s). Type 2 diabetes (T2DM) is associated with increased risk of fractures. Soy supplementation has been shown to have a beneficial effect on bone turnover markers (BTM) in postmenopausal women. However, the effect of soy supplementa... Read More about Effect of soy on bone turn-over markers in men with type 2 diabetes and hypogonadism - A randomised controlled study.

InsuTAG: A novel physiologically relevant predictor for insulin resistance and metabolic syndrome (2017)
Journal Article
Thota, R. N., Abbott, K. A., Ferguson, J. J. A., Veysey, M., Lucock, M., Niblett, S., King, K., & Garg, M. L. (2017). InsuTAG: A novel physiologically relevant predictor for insulin resistance and metabolic syndrome. Scientific reports, 7(1), https://doi.org/10.1038/s41598-017-15460-z

© 2017 The Author(s). The aim of this study was to investigate whether a novel physiologically relevant marker, InsuTAG (fasting insulin × fasting triglycerides) can predict insulin resistance (IR) and metabolic syndrome (MetS). Data of 618 participa... Read More about InsuTAG: A novel physiologically relevant predictor for insulin resistance and metabolic syndrome.

Relationship between Adiponectin and apoB in individuals with diabetes in the Atlantic PATH Cohort (2017)
Journal Article
DeClercq, V., Cui, Y., Dummer, T. J. B., Forbes, C., Grandy, S. A., Keats, M., Parker, L., Sweeney, E., Yu, Z. M., & McLeod, R. S. (2017). Relationship between Adiponectin and apoB in individuals with diabetes in the Atlantic PATH Cohort. Journal of the Endocrine Society, 1(12), 1477-1487. https://doi.org/10.1210/js.2017-00339

Context: The increasing prevalence of obesity and diabetes greatly influences the risk for cardiovascular (CV) comorbidities and affects the quality of life of many people. However, the relationship among diabetes, obesity, and cardiovascular risk is... Read More about Relationship between Adiponectin and apoB in individuals with diabetes in the Atlantic PATH Cohort.

Is swimming safe in heart failure? : a systematic review (2017)
Journal Article
Shah, P. M., Pellicori, P., Macnamara, A., Urbinati, A., & Clark, A. L. (2017). Is swimming safe in heart failure? : a systematic review. Cardiology in review, 25(6), 321-325. https://doi.org/10.1097/CRD.0000000000000154

It is not clear whether swimming is safe in patients with chronic heart failure. Ten studies examining the hemodynamic effects of acute water immersion (WI) (155 patients; average age 60 years; 86% male; mean left ventricular ejection fraction (LVEF)... Read More about Is swimming safe in heart failure? : a systematic review.

Adiposity Measures and Plasma Adipokines in Females with Rheumatoid and Osteoarthritis (2017)
Journal Article
DeClercq, V., Cui, Y., Forbes, C., Grandy, S. A., Keats, M., Parker, L., Sweeney, E., Yu, Z. M., & Dummer, T. J. (2017). Adiposity Measures and Plasma Adipokines in Females with Rheumatoid and Osteoarthritis. Mediators of Inflammation, 2017, 1-9. https://doi.org/10.1155/2017/4302412

The objective of this study was to examine the relationship between adipokines and adiposity in individuals with rheumatoid and osteoarthritis in the Atlantic PATH cohort. Using a nested case-control analysis, participants in the Atlantic PATH cohort... Read More about Adiposity Measures and Plasma Adipokines in Females with Rheumatoid and Osteoarthritis.

Association between diet quality and adiposity in the Atlantic PATH cohort (2017)
Journal Article
DeClercq, V., Cui, Y., Forbes, C., Grandy, S. A., Keats, M., Parker, L., Sweeney, E., Yu, Z. M., & Dummer, T. J. (2017). Association between diet quality and adiposity in the Atlantic PATH cohort. Nutrients, 9(10), 1155. https://doi.org/10.3390/nu9101155

The aim of this study was to examine diet quality among participants in the Atlantic Partnership for Tomorrow’s Health (PATH) cohort and to assess the association with adiposity. Data were collected from participants (n = 23,768) aged 35–69 years tha... Read More about Association between diet quality and adiposity in the Atlantic PATH cohort.

Life after prostate cancer: A systematic literature review and thematic synthesis of the post-treatment experiences of Black African and Black Caribbean men (2017)
Journal Article
Bamidele, O., McGarvey, H., Lagan, B. M., Ali, N., Chinegwundoh MBE, F., Parahoo, K., & McCaughan, E. (2018). Life after prostate cancer: A systematic literature review and thematic synthesis of the post-treatment experiences of Black African and Black Caribbean men. European Journal of Cancer Care, 27(1), Article e12784. https://doi.org/10.1111/ecc.12784

© 2017 John Wiley & Sons Ltd Evidence shows that there are significant ethnic variations in prostate cancer prevalence and outcomes. Specifically, Black African and Black Caribbean men may encounter different post-treatment experiences than Caucasi... Read More about Life after prostate cancer: A systematic literature review and thematic synthesis of the post-treatment experiences of Black African and Black Caribbean men.

The Role of Chemokines in Thyroid Carcinoma (2017)
Journal Article
Yapa, S., Mulla, O., Green, V., England, J., & Greenman, J. (2017). The Role of Chemokines in Thyroid Carcinoma. Thyroid : official journal of the American Thyroid Association, 27(11), 1347-1359. https://doi.org/10.1089/thy.2016.0660

© Copyright 2017, Mary Ann Liebert, Inc. 2017. The global incidence of thyroid cancer is increasing, and metastatic spread to the lymph nodes is common in papillary thyroid carcinoma. The metastatic course of thyroid carcinoma is an intricate process... Read More about The Role of Chemokines in Thyroid Carcinoma.

Undiagnosed pancreatic exocrine insufficiency and chronic pancreatitis in functional GI disorder patients with diarrhea or abdominal pain (2017)
Journal Article
Talley, N., Holtmann, G., Nguyen, Q., Gibson, P., Bampton, P., Veysey, M., Wong, J., Philcox, S., Koloski, N., Bunby, L., & Jones, M. (2017). Undiagnosed pancreatic exocrine insufficiency and chronic pancreatitis in functional GI disorder patients with diarrhea or abdominal pain. Journal of Gastroenterology and Hepatology, 32(11), 1813-1817. https://doi.org/10.1111/jgh.13791

© 2017 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd Background and Aim: A previous UK study showed that 6.1% of patients with diarrhea-predominant irritable bowel syndrome (IBS-D) had evidence of severe... Read More about Undiagnosed pancreatic exocrine insufficiency and chronic pancreatitis in functional GI disorder patients with diarrhea or abdominal pain.

Beta-blockers for heart failure with reduced, mid-range, and preserved ejection fraction: An individual patient-level analysis of double-blind randomized trials (2017)
Journal Article
Cleland, J. G., Bunting, K. V., Flather, M., Altman, D. G., Holmes, J., Coats, A. J., Manzano, L., McMurray, J. J., Ruschitzka, F., van Veldhuisen, D. J., Von Lueder, T. G., Böhm, M., Andersson, B., Kjekshus, J., Packer, M., Rigby, A. S., Rosano, G., Wedel, H., Hjalmarson, Å., Wikstrand, J., …Beta-blockers in Heart Failure Collaborative Group. (2018). Beta-blockers for heart failure with reduced, mid-range, and preserved ejection fraction: An individual patient-level analysis of double-blind randomized trials. European Heart Journal, 39(1), 26-35. https://doi.org/10.1093/eurheartj/ehx564

Aims: Recent guidelines recommend that patients with heart failure and left ventricular ejection fraction (LVEF) 40-49% should be managed similar to LVEF ≥50%. We investigated the effect of beta-blockers according to LVEF in double-blind, randomised,... Read More about Beta-blockers for heart failure with reduced, mid-range, and preserved ejection fraction: An individual patient-level analysis of double-blind randomized trials.

Multimorbidity in Atlantic Canada and association with low levels of physical activity (2017)
Journal Article
Keats, M. R., Cui, Y., DeClercq, V., Dummer, T. J., Forbes, C., Grandy, S. A., Hicks, J., Sweeney, E., Yu, Z. M., & Parker, L. (2017). Multimorbidity in Atlantic Canada and association with low levels of physical activity. Preventive Medicine, 105, 326-331. https://doi.org/10.1016/j.ypmed.2017.10.013

Owing to an aging population and medical advances, the anticipated growth and prevalence of multimorbidity has been recognized as a significant challenge and priority in health care settings. Although physical activity has been shown to play a vital... Read More about Multimorbidity in Atlantic Canada and association with low levels of physical activity.