All Outputs (665)

Mode of presentation and mortality amongst patients hospitalized with heart failure? A report from the First Euro Heart Failure Survey (2018)
Journal Article
Shoaib, A., Farag, M., Nolan, J., Rigby, A., Patwala, A., Rashid, M., Kwok, C. S., Perveen, R., Clark, A., Komajda, M., & Cleland, J. G. (2019). Mode of presentation and mortality amongst patients hospitalized with heart failure? A report from the First Euro Heart Failure Survey. Clinical Research in Cardiology, 108(5), 510-519. https://doi.org/10.1007/s00392-018-1380-6

© 2018, The Author(s). Background: Heart failure is heterogeneous in aetiology, pathophysiology, and presentation. Despite this diversity, clinical trials of patients hospitalized for HF deal with this problem as a single entity, which may be one rea... Read More about Mode of presentation and mortality amongst patients hospitalized with heart failure? A report from the First Euro Heart Failure Survey.

Inhibiting arginine methylation as a tool to investigate cross-talk with methylation and acetylation post-translational modifications in a glioblastoma cell line (2018)
Journal Article
Samuel, S. F., Marsden, A. J., Deepak, S., Rivero, F., Greenman, J., & Beltran-Alvarez, P. (2018). Inhibiting arginine methylation as a tool to investigate cross-talk with methylation and acetylation post-translational modifications in a glioblastoma cell line. Proteomes, 6(4), Article 44. https://doi.org/10.3390/proteomes6040044

Glioblastomas (GBM) are the most common grade 4 brain tumours; patients have very poor prognosis with an average survival of 15 months after diagnosis. Novel research lines have begun to explore aberrant protein arginine methylation (ArgMe) as a poss... Read More about Inhibiting arginine methylation as a tool to investigate cross-talk with methylation and acetylation post-translational modifications in a glioblastoma cell line.

Attenuation of oxidative stress-induced lesions in skeletal muscle in a mouse model of obesity-independent hyperlipidaemia and atherosclerosis through the inhibition of Nox2 activity (2018)
Journal Article
Sfyri, P. P., Yuldasheva, N. Y., Tzimou, A., Giallourou, N., Crispi, V., Aburima, A., Beltran-Alvarez, P., Patel, K., Mougios, V., Swann, J. R., Kearney, M. T., & Matsakas, A. (2018). Attenuation of oxidative stress-induced lesions in skeletal muscle in a mouse model of obesity-independent hyperlipidaemia and atherosclerosis through the inhibition of Nox2 activity. Free radical biology & medicine, 129, 504-519. https://doi.org/10.1016/j.freeradbiomed.2018.10.422

Obesity leading to hyperlipidaemia and atherosclerosis is recognised to induce morphological and metabolic changes in many tissues. However, hyperlipidaemia can occur in the absence of obesity. The impact of the latter scenario on skeletal muscle and... Read More about Attenuation of oxidative stress-induced lesions in skeletal muscle in a mouse model of obesity-independent hyperlipidaemia and atherosclerosis through the inhibition of Nox2 activity.

Environmental effects of ambient temperature and relative humidity on insulin pharmacodynamics in adults with type 1 diabetes mellitus (2018)
Journal Article
Al-Qaissi, A., Papageorgiou, M., Javed, Z., Heise, T., Rigby, A. S., Garrett, A. T., Hepburn, D., Kilpatrick, E. S., Atkin, S. L., & Sathyapalan, T. (2019). Environmental effects of ambient temperature and relative humidity on insulin pharmacodynamics in adults with type 1 diabetes mellitus. Diabetes, Obesity and Metabolism, 21(3), 569-574. https://doi.org/10.1111/dom.13555

Objective This study aimed to explore the effects of ambient temperature and relative humidity on insulin pharmacodynamics in adults with type 1 diabetes. Research Design A 3‐way, cross‐over, randomised study was performed in adults with type 1 diab... Read More about Environmental effects of ambient temperature and relative humidity on insulin pharmacodynamics in adults with type 1 diabetes mellitus.

Systematic literature review on the delays in the diagnosis and misdiagnosis of cluster headache (2018)
Journal Article
Buture, A., Ahmed, F., Dikomitis, L., & Boland, J. W. (2018). Systematic literature review on the delays in the diagnosis and misdiagnosis of cluster headache. Neurological Sciences, 40(1), 25–39. https://doi.org/10.1007/s10072-018-3598-5

Introduction Patients with cluster headache (CH), the most common trigeminal autonomic cephalalgia, often face delayed diagnosis, misdiagnosis and mismanagement. Objectives To identify, appraise and synthesise clinical studies on the delays in diagn... Read More about Systematic literature review on the delays in the diagnosis and misdiagnosis of cluster headache.

Dynamic change in insulin resistance induced by free fatty acids is unchanged though insulin sensitivity improves following endurance exercise in PCOS (2018)
Journal Article
Aye, M. M., Butler, A. E., Kilpatrick, E. S., Kirk, R., Vince, R., Rigby, A. S., Sandeman, D., & Atkin, S. L. (2018). Dynamic change in insulin resistance induced by free fatty acids is unchanged though insulin sensitivity improves following endurance exercise in PCOS. Frontiers in endocrinology, 9(OCT), Article 592. https://doi.org/10.3389/fendo.2018.00592

Background: Insulin resistance (IR) is the hallmark of PCOS and it is known that exercise may decrease it. What is unknown is whether exercise may mechanistically alter the underlying IR, attenuating the dynamic lipid induced IR in insulin resistant... Read More about Dynamic change in insulin resistance induced by free fatty acids is unchanged though insulin sensitivity improves following endurance exercise in PCOS.

Perspectives of patients, family caregivers and health professionals on the use of outcome measures in palliative care and lessons for implementation: a multi-method qualitative study (2018)
Journal Article
Pinto, C., Bristowe, K., Witt, J., Davies, J. M., de Wolf-Linder, S., Dawkins, M., Guo, P., Higginson, I. J., Daveson, B., & Murtagh, F. E. (2018). Perspectives of patients, family caregivers and health professionals on the use of outcome measures in palliative care and lessons for implementation: a multi-method qualitative study. Annals of palliative medicine, 7(s3), S137-S150. https://doi.org/10.21037/apm.2018.09.02

Background: Routine use of outcome measures in palliative care is recommended to demonstrate and improve quality of care. The use of outcome measures is relatively recent in UK specialist palliative care services and understanding their use in practi... Read More about Perspectives of patients, family caregivers and health professionals on the use of outcome measures in palliative care and lessons for implementation: a multi-method qualitative study.

Warm water immersion in patients with chronic heart failure: a pilot study: Shah immerse: HF (2018)
Journal Article
Shah, P., Pellicori, P., Kallvikbacka-Bennett, A., Zhang, J., Pan, D., & Clark, A. L. (2019). Warm water immersion in patients with chronic heart failure: a pilot study: Shah immerse: HF. Clinical Research in Cardiology, 108(5), 468–476. https://doi.org/10.1007/s00392-018-1376-2

Background Patients with chronic conditions, such as heart failure, swim regularly and most rehabilitation exercises are conducted in warm hydrotherapy pools. However, little is known about the acute effects of warm water immersion (WWI) on cardiac... Read More about Warm water immersion in patients with chronic heart failure: a pilot study: Shah immerse: HF.

Textural analysis demonstrates heterogeneous [18F]-fluorodeoxyglucose uptake in radiologically normal lung in patients with idiopathic pulmonary fibrosis (2018)
Journal Article
Aliyu, S. A., Avery, G., Cawthorne, C., Archibald, S. J., Kadir, T., Willaime, J. M., Morice, A. H., Hart, S. P., & Crooks, M. G. (2018). Textural analysis demonstrates heterogeneous [18F]-fluorodeoxyglucose uptake in radiologically normal lung in patients with idiopathic pulmonary fibrosis. European respiratory journal, 52(5), 1801138. https://doi.org/10.1183/13993003.01138-2018

Positron Emission Tomography (PET) scanning in idiopathic pulmonary fibrosis (IPF) has revealed increased [18F]-fluorodeoxyglucose ([18F]-FDG) uptake in areas of the lungs that appear normal on high resolution computed tomography (HRCT). We hypothesi... Read More about Textural analysis demonstrates heterogeneous [18F]-fluorodeoxyglucose uptake in radiologically normal lung in patients with idiopathic pulmonary fibrosis.

Interactions between bitter taste, diet and dysbiosis: Consequences for appetite and obesity (2018)
Journal Article
Turner, A., Veysey, M., Keely, S., Scarlett, C., Lucock, M., & Beckett, E. (2018). Interactions between bitter taste, diet and dysbiosis: Consequences for appetite and obesity. Nutrients, 10(10), Article 1336. https://doi.org/10.3390/nu10101336

The type 2 family of taste receptors (T2Rs) detect and respond to bitter tastants. These receptors are expressed throughout the gastrointestinal (GI) tract, with location dependant roles. In the oral cavity, T2Rs are involved in the conscious percept... Read More about Interactions between bitter taste, diet and dysbiosis: Consequences for appetite and obesity.

The effect of phytoestrogen on thyroid in subclinical hypothyroidism: Randomized, double blind, crossover study (2018)
Journal Article
Sathyapalan, T., Dawson, A. J., Rigby, A. S., Thatcher, N. J., Kilpatrick, E. S., & Atkin, S. L. (2018). The effect of phytoestrogen on thyroid in subclinical hypothyroidism: Randomized, double blind, crossover study. Frontiers in endocrinology, 9(SEP), Article 531. https://doi.org/10.3389/fendo.2018.00531

Objective: Soy phytoestrogens are suggested to impair thyroid function but the effects of pharmacological doses of soy phytoestrogens are unknown; therefore, this study was performed to determine the effect of high dose soy phytoestrogens (66 mg) on... Read More about The effect of phytoestrogen on thyroid in subclinical hypothyroidism: Randomized, double blind, crossover study.

Effect of vitamin D supplementation on free and total vitamin D: A comparison of Asians and Caucasians (2018)
Journal Article
Gopal-Kothandapani, J. S., Evans, L. F., Walsh, J. S., Gossiel, F., Rigby, A. S., Eastell, R., & Bishop, N. J. (2019). Effect of vitamin D supplementation on free and total vitamin D: A comparison of Asians and Caucasians. Clinical Endocrinology, 90(1), 222-231. https://doi.org/10.1111/cen.13825

Objectives It is well established that UK Asians typically have lower vitamin D levels than Caucasians. It is also known that vitamin D binding protein (DBP) is lower in some races than Caucasians. To investigate how ethnicity, skin colour and geneti... Read More about Effect of vitamin D supplementation on free and total vitamin D: A comparison of Asians and Caucasians.

Vitamin D and folate: A reciprocal environmental association based on seasonality and genetic disposition (2018)
Journal Article
Lucock, M., Thota, R., Garg, M., Martin, C., Jones, P., Furst, J., Yates, Z., Jablonski, N., Chaplin, G., Veysey, M., Sutherland, J., & Beckett, E. (2018). Vitamin D and folate: A reciprocal environmental association based on seasonality and genetic disposition. American journal of human biology : the official journal of the Human Biology Council, 30(5), Article e23166. https://doi.org/10.1002/ajhb.23166

Objectives: The purpose of this study was (1) to elucidate any reciprocal seasonal relationship that might exist between red cell folate (RCF) and serum vitamin D3 Levels; (2) to explore whether folate-related gene variants that influence/alter DNA-t... Read More about Vitamin D and folate: A reciprocal environmental association based on seasonality and genetic disposition.

Development and applications of a smartphone-based mobile electroencephalography (EEG) system (2018)
Thesis
Bateson, A. D. (2018). Development and applications of a smartphone-based mobile electroencephalography (EEG) system. (Thesis). University of Hull and University of York. Retrieved from https://hull-repository.worktribe.com/output/4567418

Electroencephalography (EEG) is a clinical and research technique used to non-invasively acquire brain activity. EEG is performed using static systems in specialist laboratories where participant mobility is constrained. It is desirable to have EEG s... Read More about Development and applications of a smartphone-based mobile electroencephalography (EEG) system.

Glucose metabolism and metabolic flexibility in blood platelets (2018)
Journal Article
Aibibula, M., Naseem, K. M., & Sturmey, R. (2018). Glucose metabolism and metabolic flexibility in blood platelets. Journal of thrombosis and haemostasis : JTH, 16(11), 2300-2314. https://doi.org/10.1111/jth.14274

The metabolic integration processes required for platelet activation are unclear. The metabolic plasticity of human platelets were investigated. Activated platelets exhibit a glycolytic phenotype while preserving mitochondrial function. Platelets can... Read More about Glucose metabolism and metabolic flexibility in blood platelets.

Caffeine and Placebo Improved Maximal Exercise Performance Despite Unchanged Motor Cortex Activation and Greater Prefrontal Cortex Deoxygenation (2018)
Journal Article
Pires, F. O., dos Anjos, C. A. S., Covolan, R. J. M., Fontes, E. B., Noakes, T. D., St Clair Gibson, A., Magalhães, F. H., & Ugrinowitsch, C. (in press). Caffeine and Placebo Improved Maximal Exercise Performance Despite Unchanged Motor Cortex Activation and Greater Prefrontal Cortex Deoxygenation. Frontiers in Physiology, 9, Article 01144. https://doi.org/10.3389/fphys.2018.01144

Caffeine (CAF) is an ergogenic aid used to improve exercise performance. Independent studies have suggested that caffeine may have the ability to increase corticospinal excitability, thereby decreasing the motor cortex activation required to generate... Read More about Caffeine and Placebo Improved Maximal Exercise Performance Despite Unchanged Motor Cortex Activation and Greater Prefrontal Cortex Deoxygenation.

“…It might not have occurred to my husband that this woman, his wife who is taking care of him has some emotional needs as well…”: the unheard voices of partners of Black African and Black Caribbean men with prostate cancer (2018)
Journal Article
Bamidele, O., Lagan, B. M., McGarvey, H., Wittmann, D., & McCaughan, E. (2019). “…It might not have occurred to my husband that this woman, his wife who is taking care of him has some emotional needs as well…”: the unheard voices of partners of Black African and Black Caribbean men with prostate cancer. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 27(3), 1089-1097. https://doi.org/10.1007/s00520-018-4398-4

© 2018, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: Evidence suggests that partners of men with prostate cancer (CaP) experience greater psychosocial distress compared with men themselves. However, the experiences of partners of h... Read More about “…It might not have occurred to my husband that this woman, his wife who is taking care of him has some emotional needs as well…”: the unheard voices of partners of Black African and Black Caribbean men with prostate cancer.

The impact of heart failure and chronic obstructive pulmonary disease on mortality in patients presenting with breathlessness (2018)
Journal Article
Cuthbert, J. J., Kearsley, J. W., Kazmi, S., Kallvikbakka-Bennett, A., Weston, J., Davis, J., Rimmer, S., & Clark, A. L. (2019). The impact of heart failure and chronic obstructive pulmonary disease on mortality in patients presenting with breathlessness. Clinical Research in Cardiology, 108(2), 185–193. https://doi.org/10.1007/s00392-018-1342-z

© 2018, The Author(s). Background: Differentiating heart failure from chronic obstructive pulmonary disease (COPD) in a patient presenting with breathlessness is difficult but may have implications for outcome. We investigated the prognostic impact o... Read More about The impact of heart failure and chronic obstructive pulmonary disease on mortality in patients presenting with breathlessness.

Psychometric Properties of the Needs Assessment Tool—Progressive Disease Cancer in U.K. Primary Care (2018)
Journal Article
Allgar, V. L., Chen, H., Richfield, E., Currow, D., Macleod, U., & Johnson, M. J. (2018). Psychometric Properties of the Needs Assessment Tool—Progressive Disease Cancer in U.K. Primary Care. Journal of pain and symptom management, 56(4), 602-612. https://doi.org/10.1016/j.jpainsymman.2018.07.002

Background. The assessment of patients' needs for care is a critical step in achieving patient-centered cancer care. Tools can be used to assess needs and inform care planning. The Needs Assessment Tool:Progressive DiseaseeCancer (NAT:PD-C) is an Aus... Read More about Psychometric Properties of the Needs Assessment Tool—Progressive Disease Cancer in U.K. Primary Care.

Mortality after admission for heart failure in the UK compared with Japan (2018)
Journal Article
Nagai, T., Sundaram, V., Rothnie, K., Quint, J. K., Shoaib, A., Shiraishi, Y., Kohsaka, S., Piper, S., McDonagh, T. A., Hardman, S. M. C., Goda, A., Mizuno, A., Kohno, T., Rigby, A. S., Yoshikawa, T., Clark, A. L., Anzai, T., & Cleland, J. G. (2018). Mortality after admission for heart failure in the UK compared with Japan. Open heart, 5(2), e000811. https://doi.org/10.1136/openhrt-2018-000811

Objective Mortality amongst patients hospitalised for heart failure (HHF) in Western and Asian countries may differ, but this has not been investigated using individual patient-level data (IPLD). We sought to remedy this through rigorous statistical... Read More about Mortality after admission for heart failure in the UK compared with Japan.