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All Outputs (853)

Dopamine induces functional extracellular traps in microglia (2021)
Journal Article
Agrawal, I., Sharma, N., Saxena, S., Arvind, S., Chakraborty, D., Chakraborty, D. B., …Jha, S. (2021). Dopamine induces functional extracellular traps in microglia. iScience, 24(1), Article 101968. https://doi.org/10.1016/j.isci.2020.101968

Dopamine (DA) plays many roles in the brain, especially in movement, motivation, and reinforcement of behavior; however, its role in regulating innate immunity is not clear. Here, we show that DA can induce DNA-based extracellular traps in primary, a... Read More about Dopamine induces functional extracellular traps in microglia.

Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain (2021)
Journal Article
Bury, J. J., Chambers, A., Heath, P. R., Ince, P. G., Shaw, P. J., Matthews, F. E., …Wharton, S. B. (2021). Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain. Acta Neuropathologica Communications, 9(1), Article 5. https://doi.org/10.1186/s40478-020-01109-y

Type 2 diabetes mellitus (T2D), characterised by peripheral insulin resistance, is a risk factor for dementia. In addition to its contribution to small and large vessel disease, T2D may directly damage cells of the brain neurovascular unit. In this s... Read More about Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain.

Arginine methylation: the promise of a ‘silver bullet’ for brain tumours? (2021)
Journal Article
Samuel, S. F., Barry, A., Greenman, J., & Beltran-Alvarez, P. (2021). Arginine methylation: the promise of a ‘silver bullet’ for brain tumours?. Amino acids, 53(4), 489-506. https://doi.org/10.1007/s00726-020-02937-x

Despite intense research efforts, our pharmaceutical repertoire against high-grade brain tumours has not been able to increase patient survival for a decade and life expectancy remains at less than 16months after diagnosis, on average. Inhibitors of... Read More about Arginine methylation: the promise of a ‘silver bullet’ for brain tumours?.

Smart windows – Transmittance tuned thermochromic coatings for dynamic control of building performance (2021)
Journal Article
Aburas, M., Ebendorff-Heidepriem, H., Lei, L., Li, M., Zhao, J., Williamson, T., …Soebarto, V. (2021). Smart windows – Transmittance tuned thermochromic coatings for dynamic control of building performance. Energy and Buildings, 235, Article 110717. https://doi.org/10.1016/j.enbuild.2021.110717

Thermochromic window technologies promise energy-saving capabilities through intelligent regulation of solar irradiation indoor penetration. Although improvements have been made, nanoparticle thermochromic coated glazing technology has not yet achiev... Read More about Smart windows – Transmittance tuned thermochromic coatings for dynamic control of building performance.

A divide-and-conquer approach to neural natural language generation from structured data (2021)
Journal Article
Dethlefs, N., Schoene, A., & Cuayáhuitl, H. (2021). A divide-and-conquer approach to neural natural language generation from structured data. Neurocomputing, 433, 300-309. https://doi.org/10.1016/j.neucom.2020.12.083

Current approaches that generate text from linked data for complex real-world domains can face problems including rich and sparse vocabularies as well as learning from examples of long varied sequences. In this article, we propose a novel divide-and-... Read More about A divide-and-conquer approach to neural natural language generation from structured data.

Direct contact membrane distillation: A sensitivity analysis and an outlook on membrane effective thermal conductivity (2021)
Journal Article
Ismail, M. S., Mohamed, A. M., Poggio, D., & Pourkashanian, M. (2021). Direct contact membrane distillation: A sensitivity analysis and an outlook on membrane effective thermal conductivity. Journal of membrane science, 624, Article 119035. https://doi.org/10.1016/j.memsci.2020.119035

A rigorous and high-fidelity two-dimensional numerical model for a direct contact membrane distillation (DCMD) module has been developed. The developed model incorporates all the key physics governing the transport phenomena taking place within the m... Read More about Direct contact membrane distillation: A sensitivity analysis and an outlook on membrane effective thermal conductivity.

Community Occupational Therapy for people with dementia and family carers (COTiD-UK) versus treatment as usual (Valuing Active Life in Dementia [VALID]) study: A single-blind, randomised controlled trial (2021)
Journal Article
Wenborn, J., O’Keeffe, A. G., Mountain, G., Moniz-Cook, E., King, M., Omar, R. Z., …Orrell, M. (2021). Community Occupational Therapy for people with dementia and family carers (COTiD-UK) versus treatment as usual (Valuing Active Life in Dementia [VALID]) study: A single-blind, randomised controlled trial. PLoS Medicine, 18(1), Article e1003433. https://doi.org/10.1371/journal.pmed.1003433

© 2021 Wenborn et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cr... Read More about Community Occupational Therapy for people with dementia and family carers (COTiD-UK) versus treatment as usual (Valuing Active Life in Dementia [VALID]) study: A single-blind, randomised controlled trial.

Equilibrating ripple effect, disturbing information cascade effect and regional disparity – A perspective from China's tiered housing markets (2021)
Journal Article
Xiao, Q. (2023). Equilibrating ripple effect, disturbing information cascade effect and regional disparity – A perspective from China's tiered housing markets. International journal of finance & economics : IJFE, 28(1), 858-875. https://doi.org/10.1002/ijfe.2453

The current study investigates the role of the tier-one cities of China in affecting regional disparities within and across its five mega-city clusters, through the lens of housing market. For that purpose, an equilibrating ripple effect is different... Read More about Equilibrating ripple effect, disturbing information cascade effect and regional disparity – A perspective from China's tiered housing markets.

Order book price impact in the Chinese soybean futures market (2021)
Journal Article
Jin, M., Kearney, F., Li, Y., & Yang, Y. C. (in press). Order book price impact in the Chinese soybean futures market. International journal of finance & economics : IJFE, https://doi.org/10.1002/ijfe.2439

We study the price impact of order flow in the world's largest soybean meal futures markets. Our intraday results indicate that incoming orders can be used to explain and predict future price changes. Our results are shown to be robust to various ord... Read More about Order book price impact in the Chinese soybean futures market.

Sustainable product development in a circular economy: Implications for products, actors, decision-making support and lifecycle information management (2021)
Journal Article
Diaz, A., Schöggl, J.-P., Reyes, T., & Baumgartner, R. J. (2021). Sustainable product development in a circular economy: Implications for products, actors, decision-making support and lifecycle information management. Sustainable Production and Consumption, 26, 1031-1045. https://doi.org/10.1016/j.spc.2020.12.044

The concept of circular economy (CE) is of great interest for manufacturing companies since it provides a framework which allows them to align organisational objectives with the Sustainable Development Goals (SDGs). Corporate CE entails the adoption... Read More about Sustainable product development in a circular economy: Implications for products, actors, decision-making support and lifecycle information management.

A call to evaluate Plastic's impacts on marine benthic ecosystem interaction networks (2021)
Journal Article
Ladewig, S. M., Bianchi, T. S., Coco, G., Hope, J. A., & Thrush, S. F. (2021). A call to evaluate Plastic's impacts on marine benthic ecosystem interaction networks. Environmental pollution, 273, Article 116423. https://doi.org/10.1016/j.envpol.2021.116423

Plastic pollution continues to seep into natural and pristine habitats. Emerging laboratory-based research has evoked concern regarding plastic’s impact on ecosystem structure and function, the essence of the ecosystem services that supports our life... Read More about A call to evaluate Plastic's impacts on marine benthic ecosystem interaction networks.

Adversarial Reconstruction Loss for Domain Generalization (2021)
Journal Article
Bekkouch, I. E. I., Nicolae, D. C., Khan, A., Kazmi, S. M., Khattak, A. M., & Ibragimov, B. (2021). Adversarial Reconstruction Loss for Domain Generalization. IEEE Access, 9, 42424-42437. https://doi.org/10.1109/ACCESS.2021.3066041

The biggest fear when deploying machine learning models to the real world is their ability to handle the new data. This problem is significant especially in medicine, where models trained on rich high-quality data extracted from large hospitals do no... Read More about Adversarial Reconstruction Loss for Domain Generalization.

Deathly triangle for pancreatic β-cells: Hippo pathway-MTORC1-autophagy (2021)
Journal Article
Ardestani, A., & Maedler, K. (2021). Deathly triangle for pancreatic β-cells: Hippo pathway-MTORC1-autophagy. Autophagy, 17(12), 4494-4496. https://doi.org/10.1080/15548627.2021.1972404

A progressive decline in the macroautophagic/autophagic flux is a hallmark of pancreatic β-cell failure in type 2 diabetes (T2D) but the responsible intrinsic factors and underlying molecular mechanisms are incompletely understood. A stress-sensitive... Read More about Deathly triangle for pancreatic β-cells: Hippo pathway-MTORC1-autophagy.

Breast cancer chemotherapy vascular toxicity: a review of mediating mechanisms and exercise as a potential therapeutic (2021)
Journal Article
Mclaughlin, M., Florida-James, G., & Ross, M. (2021). Breast cancer chemotherapy vascular toxicity: a review of mediating mechanisms and exercise as a potential therapeutic. Vascular Biology, 3(1), R106-R120. https://doi.org/10.1530/vb-21-0013

Breast cancer chemotherapy, although very potent against tumour tissue, results in significant cardiovascular toxicity. The focus of research in this area has been predominantly towards cardiotoxicity. There is limited evidence detailing the impact o... Read More about Breast cancer chemotherapy vascular toxicity: a review of mediating mechanisms and exercise as a potential therapeutic.

Finding the most navigable path in road networks (2021)
Journal Article
Kaur, R., Goyal, V., & Gunturi, V. M. (2021). Finding the most navigable path in road networks. GeoInformatica, 25(1), 207-240. https://doi.org/10.1007/s10707-020-00428-5

Input to the Most Navigable Path (MNP) problem consists of the following: (a) a road network represented as a directed graph, where each edge is associated with numeric attributes of cost and “navigability score” values; (b) a source and a destinatio... Read More about Finding the most navigable path in road networks.

siRNA Therapeutics: Future Promise for Neurodegenerative Diseases (2021)
Journal Article
Amiri, A., Barreto, G., Sathyapalan, T., & Sahebkar, A. (2021). siRNA Therapeutics: Future Promise for Neurodegenerative Diseases. Current Neuropharmacology, 19(11), 1896-1911. https://doi.org/10.2174/1570159X19666210402104054

Neurodegenerative diseases (ND), as a group of central nervous system (CNS) disorders, are among the most prominent medical problems of the 21st century. They are often associated with considerable disability, motor dysfunction and dementia and are m... Read More about siRNA Therapeutics: Future Promise for Neurodegenerative Diseases.

Prostate cancer: unmet supportive and palliative care needs: national survey of patients and family carers (2021)
Journal Article
Johnson, M. J., Huang, C., Chen, H., Jones, L., & Twiddy, M. (2021). Prostate cancer: unmet supportive and palliative care needs: national survey of patients and family carers. BMJ supportive & palliative care, https://doi.org/10.1136/bmjspcare-2021-003438

Objectives: Men living with prostate cancer have supportive and palliative needs. However, few studies detail unmet needs (vs quality of life measurement) or include data from those with advanced disease. We aimed to identify unmet needs of people li... Read More about Prostate cancer: unmet supportive and palliative care needs: national survey of patients and family carers.

The role of alliance management, big data analytics and information visibility on new-product development capability (2021)
Journal Article
Dubey, R., Bryde, D. J., Graham, G., Foropon, C., Kumari, S., & Gupta, O. (2021). The role of alliance management, big data analytics and information visibility on new-product development capability. Annals of Operations Research, https://doi.org/10.1007/s10479-021-04390-9

Many organizations are increasingly investing in building dynamic capabilities to gain competitive advantage. New products play an important role in gaining competitive advantage and can significantly boost organizational performance. Although new pr... Read More about The role of alliance management, big data analytics and information visibility on new-product development capability.

Optimising planned medical education strategies to develop learners' person-centredness: A realist review (2021)
Journal Article
Bansal, A., Greenley, S., Mitchell, C., Park, S., Shearn, K., & Reeve, J. (2021). Optimising planned medical education strategies to develop learners' person-centredness: A realist review. Medical Education, https://doi.org/10.1111/medu.14707

Context: Person-centeredness is a stated aim for medical education; however, studies suggest this is not being achieved. There is a gap in our understanding of how, why and in what circumstances medical education interventions that aim to develop per... Read More about Optimising planned medical education strategies to develop learners' person-centredness: A realist review.