Professor Steve Archibald's Projects (15)

TARGETING THE MYOSIN LIGHT CHAIN PHOSPHATASE WITH PEPTIDE DISRUPTORS: A NOVEL ANTIPLATELET THERAPEUTIC APPROACH Jul 3, 2023 - Jul 2, 2026
Platelet activation and thrombus formation play key roles in the pathogenesis of ischaemic cardiovascular diseases, one of the major causes of death in the UK. Many antiplatelet agents have been developed to manage these conditions; however, they are... Read More about TARGETING THE MYOSIN LIGHT CHAIN PHOSPHATASE WITH PEPTIDE DISRUPTORS: A NOVEL ANTIPLATELET THERAPEUTIC APPROACH.

PreclinHUPET2: Enabling Enhanced Preclinical Nuclear Imaging For The North Of England Feb 1, 2023 - Jan 31, 2024
The grant application is to upgrade the preclinical scanning facilities for nuclear imaging of small animals (mice and rats) at the University of Hull. These facilities are used for research into disease and human health. The main areas that will be... Read More about PreclinHUPET2: Enabling Enhanced Preclinical Nuclear Imaging For The North Of England.

Radiopharmacy GMP radiotracer production Feb 1, 2023 - Dec 31, 2023

HPLC purification of GMP PET radiopharmaceuticals in the Molecular Imaging Research Centre (MIRC) Mar 1, 2022 - Feb 28, 2023
Nuclear medicine is a clinical discipline where the unique properties of ionising radiation are harnessed to diagnose and treat diseases like cancer. Positron Emission Tomography (PET) is a medical scan used in nuclear medicine, where a radioactive m... Read More about HPLC purification of GMP PET radiopharmaceuticals in the Molecular Imaging Research Centre (MIRC).

CageTag: Caged Theranostics as a Universal Platform for Nuclear Medicine Apr 1, 2022 - Mar 31, 2025
Molecular imaging in cancer allows specific features of the disease to be characterised. In particular, receptor expression levels can be prognostic and allow targeting of systemic radiotherapies. There are roadblocks in the widespread use of molecul... Read More about CageTag: Caged Theranostics as a Universal Platform for Nuclear Medicine.

Translational nanoconstructs for targeted tissue accumulation and guided surgery in cancer May 1, 2023 - Apr 30, 2026

Development of novel acyclic chelates for gallium-68 and scandium-44 radiometals used in PET Jun 14, 2021 - Jun 13, 2024
This proposal sets out to design, synthesize and validate the next generation of chelators for radiometals that are utilised in positron emission tomography. The radiometals; gallium-68 and scandium-44 that are produced on generators the size of a be... Read More about Development of novel acyclic chelates for gallium-68 and scandium-44 radiometals used in PET.

CXCR7/CXCR4 dual receptor cancer theranostics with copper 64 PET imaging Jul 1, 2020 - Jun 30, 2022
Pleural malignant mesothelioma (PMM) has one of the poorest survival rates of any cancer. We propose a new approach using the latest theranostic technologies that are driving the clinical radiopharmaceutical market and exploiting a new biological tar... Read More about CXCR7/CXCR4 dual receptor cancer theranostics with copper 64 PET imaging.

Novel dual CXCR4/CXCR7 receptor drugs: targeting secondary disease progression and resistance to immunotherapy in breast cancer Aug 1, 2019 - Jul 31, 2023
CXCR4/CXCR7-CXCL12 chemokine axis plays a pivotal role in breast cancer (BC) growth, survival, therapy evasion and metastasis. Clinically overexpression of CXCR4/CXCR7-CXCL12 correlates with aggressive BC disease and poor outcome. Evidence suggests c... Read More about Novel dual CXCR4/CXCR7 receptor drugs: targeting secondary disease progression and resistance to immunotherapy in breast cancer.

Medical Imaging Alliance: Siberia and Hull Sep 3, 2018 - Sep 2, 2019
British Council Newton Trust monies for a workshop in Novosibirsk on the topic of medical imaging. Aim is to forge good links with universities there and then apply for larger funds.

Positron Emission Tomography research Mar 1, 2016 - Feb 28, 2017

Training scientists to develop and Image materials for Tissue Engineering and Regenerative Medicine (iTERM) Oct 1, 2013 - Sep 30, 2017
With an increasingly aging population, new treatment solutions for diseased, defective, or damaged tissues need to be developed. Although human donor material would be preferable for these purposes, this is often not available and often associated wi... Read More about Training scientists to develop and Image materials for Tissue Engineering and Regenerative Medicine (iTERM).

Translational Research in the Molecular Imaging Research Centre Aug 1, 2016 - Jul 31, 2018

TRANSFORM: Reducing Inequalities in Cancer Outcomes in Yorkshire: Realising our potential for innovation in Diagnosis, Patient Management, Survivorship and Palliative Care Research Sep 1, 2017 - Dec 31, 2026
The death rate is higher in Yorkshire than the rest of England resulting in about 200 extra deaths each year of which more than half are in Hull. There are other significant cancer outcome inequalities between different groups; for example poorer pe... Read More about TRANSFORM: Reducing Inequalities in Cancer Outcomes in Yorkshire: Realising our potential for innovation in Diagnosis, Patient Management, Survivorship and Palliative Care Research.

New technology to improve capability for clinical radiopharmaceutical production Jan 1, 2019 - Feb 28, 2022
Medical imaging techniques rely on radioactive atoms that don't last for a long time and so methods need to be developed to handle them on hospital sites or close by. Essentially this is drug factory near to the patient as the material is decaying al... Read More about New technology to improve capability for clinical radiopharmaceutical production.