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Professor Matthew Hardman's Outputs (33)

Elevated local senescence in diabetic wound healing is linked to pathological repair via CXCR2. (2019)
Journal Article
Wilkinson, H. N., Clowes, C., Banyard, K. L., Matteuci, P., Mace, K., & Hardman, M. J. (2019). Elevated local senescence in diabetic wound healing is linked to pathological repair via CXCR2. Journal of Investigative Dermatology, 139(5), 1171-1181.e6. https://doi.org/10.1016/j.jid.2019.01.005

© 2019 The Authors Cellular senescence can be broadly defined as a stable, but essentially irreversible, loss of proliferative capacity. Historically, senescence has been described as a negative outcome of advanced cellular age. It is now clear, howe... Read More about Elevated local senescence in diabetic wound healing is linked to pathological repair via CXCR2..

Amplified antimicrobial action of chlorhexidine encapsulated in PDAC-functionalized acrylate copolymer nanogel carriers (2018)
Journal Article
Al-Awady, M. J., Weldrick, P. J., Hardman, M. J., Greenway, G. M., & Paunov, V. N. (2018). Amplified antimicrobial action of chlorhexidine encapsulated in PDAC-functionalized acrylate copolymer nanogel carriers. Materials Chemistry Frontiers, 2(11), 2032-2044. https://doi.org/10.1039/c8qm00343b

We have developed and tested a novel functionalised nanocarrier for chlorhexidine (CHX) which provides a very strong enhancement of its antimicrobial action. The nanocarrier was based on lightly-cross-linked acrylate copolymer nanogel particles loade... Read More about Amplified antimicrobial action of chlorhexidine encapsulated in PDAC-functionalized acrylate copolymer nanogel carriers.

A novel silver bioactive glass elicits antimicrobial efficacy against Pseudomonas aeruginosa and Staphylococcus aureus in an ex vivo skin wound biofilm model (2018)
Journal Article
Wilkinson, H. N., Iveson, S., Catherall, P., & Hardman, M. J. (2018). A novel silver bioactive glass elicits antimicrobial efficacy against Pseudomonas aeruginosa and Staphylococcus aureus in an ex vivo skin wound biofilm model. Frontiers in Microbiology, 9(JUL), Article 1450. https://doi.org/10.3389/fmicb.2018.01450

Biofilm infection is now understood to be a potent contributor to the recalcitrant nature of chronic wounds. Bacterial biofilms evade the host immune response and show increased resistance to antibiotics. Along with improvements in antibiotic steward... Read More about A novel silver bioactive glass elicits antimicrobial efficacy against Pseudomonas aeruginosa and Staphylococcus aureus in an ex vivo skin wound biofilm model.

Microbial host interactions and impaired wound healing in mice and humans: defining a role for BD14 and NOD2 (2018)
Journal Article
Williams, H., Campbell, L., Crompton, R. A., Singh, G., McHugh, B. J., Davidson, D. J., McBain, A. J., Cruickshank, S. M., & Hardman, M. J. (2018). Microbial host interactions and impaired wound healing in mice and humans: defining a role for BD14 and NOD2. Journal of Investigative Dermatology, 138(10), 2264-2274. https://doi.org/10.1016/j.jid.2018.04.014

Chronic wounds cause significant patient morbidity and mortality. A key factor in their etiology is microbial infection, yet skin host-microbiota interactions during wound repair remain poorly understood. Microbiome profiles of non-infected human chr... Read More about Microbial host interactions and impaired wound healing in mice and humans: defining a role for BD14 and NOD2.

The role of estrogen in cutaneous ageing and repair (2017)
Journal Article
Wilkinson, H. N., & Hardman, M. J. (2017). The role of estrogen in cutaneous ageing and repair. Maturitas, 103, 60-64. https://doi.org/10.1016/j.maturitas.2017.06.026

© 2017 Elsevier B.V. Combined advances in modern medical practice and increased human longevity are driving an ever-expanding elderly population. Females are particularly at risk of age-associated pathology, spending more of their lives in a post-men... Read More about The role of estrogen in cutaneous ageing and repair.

Cutaneous Nod2 expression regulates the skin microbiome and wound healing in a murine model (2017)
Journal Article
Williams, H., Crompton, R. A., Thomason, H. A., Campbell, L., Singh, G., McBain, A. J., Cruickshank, S. M., & Hardman, M. J. (2017). Cutaneous Nod2 expression regulates the skin microbiome and wound healing in a murine model. Journal of Investigative Dermatology, 137(11), 2427-2436. https://doi.org/10.1016/j.jid.2017.05.029

The skin microbiome exists in dynamic equilibrium with the host but when the skin is compromised, bacteria can colonise the wound and impair wound healing. Thus the interplay between normal skin-microbial interactions versus pathogenic-microbial inte... Read More about Cutaneous Nod2 expression regulates the skin microbiome and wound healing in a murine model.

Comparing the effectiveness of polymer debriding devices using a porcine wound biofilm model (2016)
Journal Article
Wilkinson, H. N., McBain, A. J., Stephenson, C., & Hardman, M. J. (2016). Comparing the effectiveness of polymer debriding devices using a porcine wound biofilm model. Advances in wound care, 5(11), 475-485. https://doi.org/10.1089/wound.2015.0683

Objective: Debridement to remove necrotic and/or infected tissue and promote active healing remains a cornerstone of contemporary chronic wound management. While there has been a recent shift toward less invasive polymer-based debriding devices, thei... Read More about Comparing the effectiveness of polymer debriding devices using a porcine wound biofilm model.

Oestrogen promotes healing in a bacterial LPS model of delayed cutaneous wound repair (2016)
Journal Article
Crompton, R., Williams, H., Ansell, D., Campbell, L., Holden, K., Cruickshank, S., & Hardman, M. J. (2016). Oestrogen promotes healing in a bacterial LPS model of delayed cutaneous wound repair. Laboratory investigation, 96(4), 439-449. https://doi.org/10.1038/labinvest.2015.160

Wound infection is a major clinical problem, yet understanding of bacterial host interactions in the skin remains limited. Microbe-derived molecules, known as pathogen-associated molecular patterns, are recognised in barrier tissues by pattern-recogn... Read More about Oestrogen promotes healing in a bacterial LPS model of delayed cutaneous wound repair.

Ectodysplasin A Pathway Contributes to Human and Murine Skin Repair (2016)
Journal Article
Garcin, C. L., Huttner, K. M., Kirby, N., Schneider, P., & Hardman, M. J. (2016). Ectodysplasin A Pathway Contributes to Human and Murine Skin Repair. Journal of Investigative Dermatology, 136(5), 1022-1030. https://doi.org/10.1016/j.jid.2015.09.002

The highly conserved ectodysplasin A (EDA)/EDA receptor signaling pathway is critical during development for the formation of skin appendages. Mutations in genes encoding components of the EDA pathway disrupt normal appendage development, leading to... Read More about Ectodysplasin A Pathway Contributes to Human and Murine Skin Repair.

Hair Follicle Bulge Stem Cells Appear Dispensable for the Acute Phase of Wound Re-epithelialization (2016)
Journal Article
Garcin, C. L., Ansell, D. M., Headon, D. J., Paus, R., & Hardman, M. J. (2016). Hair Follicle Bulge Stem Cells Appear Dispensable for the Acute Phase of Wound Re-epithelialization. STEM CELLS, 34(5), 1377-1385. https://doi.org/10.1002/stem.2289

The cutaneous healing response has evolved to occur rapidly, in order to minimize infection and to re-establish epithelial homeostasis. Rapid healing is achieved through complex coordination of multiple cell types, which importantly includes specific... Read More about Hair Follicle Bulge Stem Cells Appear Dispensable for the Acute Phase of Wound Re-epithelialization.

Global Gene Expression Analysis in PKCalpha-/- Mouse Skin Reveals Structural Changes in the Dermis and Defective Wound Granulation Tissue (2015)
Journal Article
Cooper, N. H., Balachandra, J. P., & Hardman, M. J. (2015). Global Gene Expression Analysis in PKCalpha-/- Mouse Skin Reveals Structural Changes in the Dermis and Defective Wound Granulation Tissue. Journal of Investigative Dermatology, 135(12), 3173-3182. https://doi.org/10.1038/jid.2015.338

The skin's mechanical integrity is maintained by an organized and robust dermal extracellular matrix (ECM). Resistance to mechanical disruption hinges primarily on homeostasis of the dermal collagen fibril architecture, which is regulated, at least i... Read More about Global Gene Expression Analysis in PKCalpha-/- Mouse Skin Reveals Structural Changes in the Dermis and Defective Wound Granulation Tissue.

Estrogen receptor-alpha promotes alternative macrophage activation during cutaneous repair (2014)
Journal Article
Campbell, L., Emmerson, E., Williams, H., Saville, C. R., Krust, A., Chambon, P., Mace, K. A., & Hardman, M. J. (2014). Estrogen receptor-alpha promotes alternative macrophage activation during cutaneous repair. Journal of Investigative Dermatology, 134(9), 2447-2457. https://doi.org/10.1038/jid.2014.175

Efficient local monocyte/macrophage recruitment is critical for tissue repair. Recruited macrophages are polarized toward classical (proinflammatory) or alternative (prohealing) activation in response to cytokines, with tight temporal regulation cruc... Read More about Estrogen receptor-alpha promotes alternative macrophage activation during cutaneous repair.