Professor John Saxton's Outputs (22)

Optimisation of the preparation phase for orthopaedic surgery: Study protocol for a student-led multimodal prehabilitation feasibility trial (BoneFit) (2025)
Journal Article
Ingle, L., Snook, J., Smith, L., Oliver, B., Bray, J., Wells, L., Moorhouse, J., Dixon, L., Simpson, P., Osman, S., Saxton, J., Rajendran, A., Gopalakrishnan, G., & Symes, T. (2025). Optimisation of the preparation phase for orthopaedic surgery: Study protocol for a student-led multimodal prehabilitation feasibility trial (BoneFit). PLoS ONE, 20(2), Article e0314680. https://doi.org/10.1371/journal.pone.0314680

Background
Since the Covid-19 pandemic, a surgical backlog for total hip replacement (THR) and total knee replacement (TKR) surgery remains in the United Kingdom. Multimodal prehabilitation pathways (encompassing exercise, nutritional support and ps... Read More about Optimisation of the preparation phase for orthopaedic surgery: Study protocol for a student-led multimodal prehabilitation feasibility trial (BoneFit).

Nutrition Modulation of Cardiotoxicity in Breast Cancer: A Scoping Review (2024)
Journal Article
Stephenson, E., Mclaughlin, M., Bray, J. W., Saxton, J. M., & Vince, R. V. (2024). Nutrition Modulation of Cardiotoxicity in Breast Cancer: A Scoping Review. Nutrients, 16(21), Article 3777. https://doi.org/10.3390/nu16213777

Background/Objectives: Advancements in breast cancer therapeutics, such as anthracyclines, are improving cancer survival rates but can have side effects that limit their use. Cardiotoxicity, defined as damage to the heart caused by cancer therapeutic... Read More about Nutrition Modulation of Cardiotoxicity in Breast Cancer: A Scoping Review.

Effect of exercise before and/or during taxane-containing chemotherapy treatment on chemotherapy-induced peripheral neuropathy symptoms in women with breast cancer: systematic review and meta-analysis (2023)
Journal Article
Brownson-Smith, R., Orange, S. T., Cresti, N., Hunt, K., Saxton, J., & Temesi, J. (in press). Effect of exercise before and/or during taxane-containing chemotherapy treatment on chemotherapy-induced peripheral neuropathy symptoms in women with breast cancer: systematic review and meta-analysis. Journal of cancer survivorship : research and practice, https://doi.org/10.1007/s11764-023-01450-w

Purpose To systematically review and meta-analyse the efficacy of exercise interventions delivered before and/or during taxane-containing chemotherapy regimens on chemotherapy-induced peripheral neuropathy (CIPN), fatigue, and health-related quality... Read More about Effect of exercise before and/or during taxane-containing chemotherapy treatment on chemotherapy-induced peripheral neuropathy symptoms in women with breast cancer: systematic review and meta-analysis.

Co-designed weight management intervention for women recovering from oestrogen-receptor positive breast cancer (2022)
Journal Article
Saxton, J. M., Pickering, K., Wane, S., Humphreys, H., Crank, H., Anderson, A. S., Cain, H., Cohen, J., Copeland, R. J., Gray, J., Hargreaves, J., McNally, R. J., & Wilson, C. (2022). Co-designed weight management intervention for women recovering from oestrogen-receptor positive breast cancer. BMC Cancer, 22(1), Article 1202. https://doi.org/10.1186/s12885-022-10287-y

Background: Weight gain is commonly observed during and after breast cancer treatment and is associated with poorer survival outcomes, particularly in women with oestrogen receptor-positive (ER +) disease. The aim of this study was to co-design (with... Read More about Co-designed weight management intervention for women recovering from oestrogen-receptor positive breast cancer.

The experiences and perceptions of female breast cancer patients regarding weight management during and after treatment for oestrogen-receptor positive disease: a qualitative study (2022)
Journal Article
Saxton, J., Pickering, K., Wane, S., Crank, H., Anderson, A., Cain, H., Cohen, J., Copeland, R., Gray, J., Hargreaves, J., McNally, R., & Wilson, C. (2022). The experiences and perceptions of female breast cancer patients regarding weight management during and after treatment for oestrogen-receptor positive disease: a qualitative study. BMC Cancer, 22(1), Article 1189. https://doi.org/10.1186/s12885-022-10238-7

Background: Weight gain is commonly observed during and after breast cancer treatment and is associated with poorer survival outcomes, notably in women with oestrogen-receptor positive disease. The aim of this qualitative study was to investigate the... Read More about The experiences and perceptions of female breast cancer patients regarding weight management during and after treatment for oestrogen-receptor positive disease: a qualitative study.

Changes in functional health status following open abdominal aortic aneurysm repair and the role of exercise-based rehabilitation: protocol for a systematic review and meta-analysis (2022)
Journal Article
Ravindhran, B., Lathan, R., Staniland, T., Sidapra, M., Carradice, D., Chetter, I., Smith, G., Saxton, J., & Pymer, S. (2022). Changes in functional health status following open abdominal aortic aneurysm repair and the role of exercise-based rehabilitation: protocol for a systematic review and meta-analysis. Journal of Vascular Societies Great Britain and Ireland, 2(1), 41-45. https://doi.org/10.54522/jvsgbi.2022.042

Background and objectives: The aim of this systematic review is to explore the current evidence surrounding the changes in functional status following open or endovascular abdominal aortic aneurysm (AAA) repair and the role of postoperative exercise-... Read More about Changes in functional health status following open abdominal aortic aneurysm repair and the role of exercise-based rehabilitation: protocol for a systematic review and meta-analysis.

Supervised and Non-Supervised Exercise Programs for the Management of Cancer-Related Fatigue in Women with Breast Cancer: A Systematic Review and Meta-Analysis (2022)
Journal Article
Reverte-Pagola, G., Sánchez-Trigo, H., Saxton, J., & Sañudo, B. (2022). Supervised and Non-Supervised Exercise Programs for the Management of Cancer-Related Fatigue in Women with Breast Cancer: A Systematic Review and Meta-Analysis. Cancers, 14(14), Article 3428. https://doi.org/10.3390/cancers14143428

Physical exercise is considered to be a non-pharmacological strategy for reducing symptoms of cancer-related fatigue (CRF) in women with breast cancer (BC). This systematic review and meta-analysis aims to assess the effects of non-supervised exercis... Read More about Supervised and Non-Supervised Exercise Programs for the Management of Cancer-Related Fatigue in Women with Breast Cancer: A Systematic Review and Meta-Analysis.

Evaluating the feasibility and acceptability of an exercise and behaviour change intervention in socioeconomically deprived patients with peripheral arterial disease: The textpad study protocol (2022)
Journal Article
Cucato, G., Snowden, C., McCone, E., Nesbitt, C., Nandhra, S., Fong, M., Kane, E., Rowland, M., Bhattarai, N., Court, P., Bell, O., Saxton, J. M., & Prentis, J. (2022). Evaluating the feasibility and acceptability of an exercise and behaviour change intervention in socioeconomically deprived patients with peripheral arterial disease: The textpad study protocol. PLoS ONE, 17(6), Article e0269999. https://doi.org/10.1371/journal.pone.0269999

This pilot randomised controlled trial aims to assess the feasibility and acceptability of a 12-week home-based telehealth exercise and behavioural intervention delivered in socioeconomically deprived patients with peripheral artery disease (PAD). Th... Read More about Evaluating the feasibility and acceptability of an exercise and behaviour change intervention in socioeconomically deprived patients with peripheral arterial disease: The textpad study protocol.

Acute aerobic exercise-conditioned serum reduces colon cancer cell proliferation in vitro through interleukin-6-induced regulation of DNA damage (2022)
Journal Article
Orange, S. T., Jordan, A. R., Odell, A., Kavanagh, O., Hicks, K. M., Eaglen, T., Todryk, S., & Saxton, J. M. (2022). Acute aerobic exercise-conditioned serum reduces colon cancer cell proliferation in vitro through interleukin-6-induced regulation of DNA damage. International journal of cancer. Journal international du cancer, 151(2), 265-274. https://doi.org/10.1002/ijc.33982

Epidemiological evidence shows that regular physical activity is associated with reduced risk of primary and recurrent colon cancer. However, the underlying mechanisms of action are poorly understood. We evaluated the effects of stimulating a human c... Read More about Acute aerobic exercise-conditioned serum reduces colon cancer cell proliferation in vitro through interleukin-6-induced regulation of DNA damage.

Implementing supportive exercise interventions in the colorectal cancer care pathway: a process evaluation of the PREPARE-ABC randomised controlled trial (2021)
Journal Article
Murdoch, J., Varley, A., McCulloch, J., Jones, M., Thomas, L. B., Clark, A., Stirling, S., Turner, D., Swart, A. M., Dresser, K., Howard, G., Saxton, J., & Hernon, J. (2021). Implementing supportive exercise interventions in the colorectal cancer care pathway: a process evaluation of the PREPARE-ABC randomised controlled trial. BMC Cancer, 21(1), Article 1137. https://doi.org/10.1186/s12885-021-08880-8

Background: A colorectal resection is standard treatment for patients with colorectal cancer (CRC). However, the procedure results in significant post-operative mortality and reduced quality of life. Maximising pre-operative cardiopulmonary fitness c... Read More about Implementing supportive exercise interventions in the colorectal cancer care pathway: a process evaluation of the PREPARE-ABC randomised controlled trial.

BiCyCLE NMES—neuromuscular electrical stimulation in the perioperative treatment of sarcopenia and myosteatosis in advanced rectal cancer patients: design and methodology of a phase II randomised controlled trial (2021)
Journal Article
Pring, E. T., Gould, L. E., Malietzis, G., Lung, P., Bharal, M., Fadodun, T., Bassett, P., Naghibi, M., Taylor, C., Drami, I., Chauhan, D., Street, T., Francis, N. K., Athanasiou, T., Saxton, J. M., & Jenkins, J. T. (2021). BiCyCLE NMES—neuromuscular electrical stimulation in the perioperative treatment of sarcopenia and myosteatosis in advanced rectal cancer patients: design and methodology of a phase II randomised controlled trial. Trials, 22(1), Article 621. https://doi.org/10.1186/s13063-021-05573-2

Background: Colorectal cancer is associated with secondary sarcopenia (muscle loss) and myosteatosis (fatty infiltration of muscle) and patients who exhibit these host characteristics have poorer outcomes following surgery. Furthermore, patients, who... Read More about BiCyCLE NMES—neuromuscular electrical stimulation in the perioperative treatment of sarcopenia and myosteatosis in advanced rectal cancer patients: design and methodology of a phase II randomised controlled trial.

SupPoRtive Exercise Programmes for Accelerating REcovery after major ABdominal Cancer surgery trial (PREPARE-ABC): Pilot phase of a multicentre randomised controlled trial (2021)
Journal Article
Hernon, J., Saxton, J., Jones, M., Howard, G., Swart, A. M., Clark, A., Stirling, S., Turner, D., Murdoch, J., Nortje, J., Bach, S., Fearnhead, N., Din, F., Stephens, A., Lund, J., Tou, S., Kelly, S., Ziprin, P., Dennis, R., Smart, N., …Dresser, K. (2021). SupPoRtive Exercise Programmes for Accelerating REcovery after major ABdominal Cancer surgery trial (PREPARE-ABC): Pilot phase of a multicentre randomised controlled trial. Colorectal Disease, 23(11), 3008-3022. https://doi.org/10.1111/codi.15856

Aim: PREPARE-ABC is a pragmatic multicentre randomised controlled trial including an internal pilot designed to assess the clinical and cost-effectiveness of pre- and postoperative exercise in relation to short- and longer-term postoperative recovery... Read More about SupPoRtive Exercise Programmes for Accelerating REcovery after major ABdominal Cancer surgery trial (PREPARE-ABC): Pilot phase of a multicentre randomised controlled trial.

Patient activation and patient-reported outcomes of men from a community pharmacy lifestyle intervention after prostate cancer treatment (2021)
Journal Article
Lemanska, A., Poole, K., Manders, R., Marshall, J., Nazar, Z., Noble, K., Saxton, J. M., Turner, L., Warner, G., Griffin, B. A., & Faithfull, S. (2022). Patient activation and patient-reported outcomes of men from a community pharmacy lifestyle intervention after prostate cancer treatment. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 30(1), 347-358. https://doi.org/10.1007/s00520-021-06404-5

Purpose: To report patient activation, which is the knowledge, skills, and confidence in self-managing health conditions, and patient-reported outcomes of men after prostate cancer treatment from a community pharmacy lifestyle intervention. Methods:... Read More about Patient activation and patient-reported outcomes of men from a community pharmacy lifestyle intervention after prostate cancer treatment.

Obesity and low levels of physical activity impact on cardiopulmonary fitness in older men after treatment for prostate cancer (2021)
Journal Article
Faithfull, S., Lemanska, A., Poole, K., Aning, J., Manders, R., Marshall, J., Saxton, J., Turner, L., & Griffin, B. (2021). Obesity and low levels of physical activity impact on cardiopulmonary fitness in older men after treatment for prostate cancer. European Journal of Cancer Care, 30(6), Article e13476. https://doi.org/10.1111/ecc.13476

The purpose of this study was to compare fitness parameters and cardiovascular disease risk of older and younger men with prostate cancer (PCa) and explore how men's fitness scores compared to normative age values. 83 men were recruited post-treatmen... Read More about Obesity and low levels of physical activity impact on cardiopulmonary fitness in older men after treatment for prostate cancer.

Objectively-assessed physical activity and self-reported activity pacing in adults with multiple sclerosis: A pilot study (2021)
Journal Article
Abonie, U. S., Saxton, J., Baker, K., & Hettinga, F. J. (2021). Objectively-assessed physical activity and self-reported activity pacing in adults with multiple sclerosis: A pilot study. Clinical Rehabilitation, 35(12), 1781-1788. https://doi.org/10.1177/02692155211024135

Objective: To examine the association between self-reported activity pacing (a strategy to manage fatigue symptoms) and objectively-measured physical activity behaviours in adults with multiple sclerosis. Design: Single cross-sectional study Setting:... Read More about Objectively-assessed physical activity and self-reported activity pacing in adults with multiple sclerosis: A pilot study.

Neurostructural and Neurophysiological Correlates of Multiple Sclerosis Physical Fatigue: Systematic Review and Meta-Analysis of Cross-Sectional Studies (2021)
Journal Article
Ellison, P. M., Goodall, S., Kennedy, N., Dawes, H., Clark, A., Pomeroy, V., Duddy, M., Baker, M. R., & Saxton, J. M. (2022). Neurostructural and Neurophysiological Correlates of Multiple Sclerosis Physical Fatigue: Systematic Review and Meta-Analysis of Cross-Sectional Studies. Neuropsychology Review, 32(3), 506-519. https://doi.org/10.1007/s11065-021-09508-1

Fatigue is one of the most debilitating symptoms for people with multiple sclerosis (PwMS). By consolidating a diverse and conflicting evidence-base, this systematic review and meta-analysis aimed to gain new insights into the neurobiology of MS fati... Read More about Neurostructural and Neurophysiological Correlates of Multiple Sclerosis Physical Fatigue: Systematic Review and Meta-Analysis of Cross-Sectional Studies.

Recall, perceptions and determinants of receiving physical activity advice amongst cancer survivors: a mixed-methods survey (2021)
Journal Article
Orange, S. T., Gilbert, S. E., Brown, M. C., & Saxton, J. M. (2021). Recall, perceptions and determinants of receiving physical activity advice amongst cancer survivors: a mixed-methods survey. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 29(11), 6369-6378. https://doi.org/10.1007/s00520-021-06221-w

Purpose: This study explored cancer survivors’ views and experiences of receiving physical activity advice post-diagnosis. We also determined the influence of sociodemographic characteristics on the recall of physical activity advice and whether rece... Read More about Recall, perceptions and determinants of receiving physical activity advice amongst cancer survivors: a mixed-methods survey.

Prehabilitation with wearables versus standard of care before major abdominal cancer surgery: a randomised controlled pilot study (trial registration: NCT04047524) (2021)
Journal Article
Waller, E., Sutton, P., Rahman, S., Allen, J., Saxton, J., & Aziz, O. (2022). Prehabilitation with wearables versus standard of care before major abdominal cancer surgery: a randomised controlled pilot study (trial registration: NCT04047524). Surgical Endoscopy, 36(2), 1008-1017. https://doi.org/10.1007/s00464-021-08365-6

Background: Prehabilitation aims to improve post-operative outcomes by enhancing pre-operative fitness but is labour-intensive. This pilot study aimed to assess the efficacy of a tri-modal prehabilitation programme delivered by smartwatches for impro... Read More about Prehabilitation with wearables versus standard of care before major abdominal cancer surgery: a randomised controlled pilot study (trial registration: NCT04047524).

Supported progressive resistance exercise training to counter the adverse side effects of robot-assisted radical prostatectomy: a randomised controlled trial (2021)
Journal Article
Ashton, R. E., Aning, J. J., Tew, G. A., Robson, W. A., & Saxton, J. M. (2021). Supported progressive resistance exercise training to counter the adverse side effects of robot-assisted radical prostatectomy: a randomised controlled trial. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 29(8), 4595-4605. https://doi.org/10.1007/s00520-021-06002-5

Purpose: To investigate the effects of a supported home-based progressive resistance exercise training (RET) programme on indices of cardiovascular health, muscular strength and health-related quality of life (HR-QoL) in prostate cancer (PCa) patient... Read More about Supported progressive resistance exercise training to counter the adverse side effects of robot-assisted radical prostatectomy: a randomised controlled trial.

Cancer prevention through weight control—where are we in 2020? (2020)
Journal Article
Anderson, A. S., Renehan, A. G., Saxton, J. M., Bell, J., Cade, J., Cross, A. J., King, A., Riboli, E., Sniehotta, F., Treweek, S., & Martin, R. M. (2021). Cancer prevention through weight control—where are we in 2020?. The British Journal of Cancer, 124(6), 1049-1056. https://doi.org/10.1038/s41416-020-01154-3

Growing data from epidemiological studies highlight the association between excess body fat and cancer incidence, but good indicative evidence demonstrates that intentional weight loss, as well as increasing physical activity, offers much promise as... Read More about Cancer prevention through weight control—where are we in 2020?.