Dr Harshal Deshmukh's Outputs (37)

Time to first remission and survival in patients with acromegaly: Evidence from the UK Acromegaly Register Study (UKAR) (2024)
Journal Article
Deshmukh, H., Ssemmondo, E., Adeleke, K., Mongolu, S., Aye, M., Orme, S., Flanagan, D., Abraham, P., Higham, C., & Sathyapalan, T. (2024). Time to first remission and survival in patients with acromegaly: Evidence from the UK Acromegaly Register Study (UKAR). Clinical Endocrinology, 101(3), 274-281. https://doi.org/10.1111/cen.15112

Objective: This study aimed to understand the effect of time to remission of acromegaly on survival in people living with acromegaly. Design, Patients and Measurement: This cross-sectional study used data from the UK Acromegaly Register. We considere... Read More about Time to first remission and survival in patients with acromegaly: Evidence from the UK Acromegaly Register Study (UKAR).

The Effect of Thiazolidinediones in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomised Controlled Trials (2024)
Journal Article
Abdalla, M. A., Shah, N., Deshmukh, H., Sahebkar, A., Östlundh, L., Al-Rifai, R. H., Atkin, S. L., & Sathyapalan, T. (2024). The Effect of Thiazolidinediones in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. Advances in Therapy, 41, 2168-2195. https://doi.org/10.1007/s12325-024-02848-3

Introduction: Polycystic ovary syndrome (PCOS) is a complex endocrine condition affecting women of reproductive age. It is characterised by insulin resistance and is a risk for type 2 diabetes mellitus (T2DM). The aim of this study was to review the... Read More about The Effect of Thiazolidinediones in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.

Effect of intermittently scanned continuous glucose monitoring in people with diabetes with a psychosocial indication for initiation (2024)
Journal Article
Ssemmondo, E., Deshmukh, H., Wilmot, E. G., Adeleke, K. A., Shah, N., Walton, C., Barnes, D., Ryder, R. E., & Sathyapalan, T. (2024). Effect of intermittently scanned continuous glucose monitoring in people with diabetes with a psychosocial indication for initiation. Diabetes, Obesity and Metabolism, 26(4), 1340-1345. https://doi.org/10.1111/dom.15435

Aim: To understand the effect of intermittently scanned continuous glucose monitoring (isCGM) in people with diabetes with a ‘psychosocial’ indication for access. Methods: The study utilized baseline and follow-up data from the Association of British... Read More about Effect of intermittently scanned continuous glucose monitoring in people with diabetes with a psychosocial indication for initiation.

Clinical features of type 1 diabetes in older adults and the impact of intermittently scanned continuous glucose monitoring: An Association of British Clinical Diabetologists (ABCD) study (2024)
Journal Article
Deshmukh, H., Adeleke, K., Wilmot, E. G., Folwell, A., Barnes, D., Walker, N., Saunders, S., Ssemmondo, E., Walton, C., Patmore, J., Ryder, R. E., & Sathyapalan, T. (2024). Clinical features of type 1 diabetes in older adults and the impact of intermittently scanned continuous glucose monitoring: An Association of British Clinical Diabetologists (ABCD) study. Diabetes, Obesity and Metabolism, 26(4), 1333-1339. https://doi.org/10.1111/dom.15434

Aims: To evaluate the clinical features and impact of flash glucose monitoring in older adults with type 1 diabetes (T1D) across age groups defined as young-old, middle-old, and old-old. Materials and Methods: Clinicians were invited to submit anonym... Read More about Clinical features of type 1 diabetes in older adults and the impact of intermittently scanned continuous glucose monitoring: An Association of British Clinical Diabetologists (ABCD) study.

Intermittently scanned continuous glucose monitoring and hypoglycaemia awareness in drivers with diabetes: Insights from the Association of British Clinical Diabetologists Nationwide audit (2023)
Journal Article
Mark-Wagstaff, C., Deshmukh, H., Wilmot, E. G., Walker, N., Barnes, D., Parfitt, V., Saunders, S., Gregory, R., Choudhary, P., Patmore, J., Walton, C., Ryder, R. E., & Sathyapalan, T. (2024). Intermittently scanned continuous glucose monitoring and hypoglycaemia awareness in drivers with diabetes: Insights from the Association of British Clinical Diabetologists Nationwide audit. Diabetes, Obesity and Metabolism, 26(1), 46-53. https://doi.org/10.1111/dom.15283

Aim: Frequent hypoglycaemia results in disruption to usual hypoglycaemic autonomic responses leading to impaired awareness of hypoglycaemia, which is associated with an increased risk of severe hypoglycaemia requiring third-party assistance (SH). The... Read More about Intermittently scanned continuous glucose monitoring and hypoglycaemia awareness in drivers with diabetes: Insights from the Association of British Clinical Diabetologists Nationwide audit.

The Effect of a Very-Low-Calorie Diet (VLCD) vs. a Moderate Energy Deficit Diet in Obese Women with Polycystic Ovary Syndrome (PCOS)—A Randomised Controlled Trial (2023)
Journal Article
Deshmukh, H., Papageorgiou, M., Wells, L., Akbar, S., Strudwick, T., Deshmukh, K., …Sathyapalan, T. (2023). The Effect of a Very-Low-Calorie Diet (VLCD) vs. a Moderate Energy Deficit Diet in Obese Women with Polycystic Ovary Syndrome (PCOS)—A Randomised Controlled Trial. Nutrients, 15(18), Article 3872. https://doi.org/10.3390/nu15183872

We performed an open-label, randomised controlled trial to compare the effects of a very-low-calorie diet (VLCD) vs. moderate energy deficit approach on body weight, body composition, free androgen index (FAI), and metabolic markers in obese women wi... Read More about The Effect of a Very-Low-Calorie Diet (VLCD) vs. a Moderate Energy Deficit Diet in Obese Women with Polycystic Ovary Syndrome (PCOS)—A Randomised Controlled Trial.

No causal association between anti-Mullerian hormone (AMH) levels and polycystic ovary syndrome (PCOS)-a Mendelian randomization analysis (2023)
Journal Article
Deshmukh, H., & Sathyapalan, T. (2023). No causal association between anti-Mullerian hormone (AMH) levels and polycystic ovary syndrome (PCOS)-a Mendelian randomization analysis. Endocrine, 81, 388–389. https://doi.org/10.1007/s12020-023-03380-0

Ethnic disparities in people accessing FreeStyle Libre in the United Kingdom: Insights from the Association of British Clinical Diabetologists audit (2023)
Journal Article
Deshmukh, H., Adeleke, K. A., Ssemmondo, E., Wilmot, E. G., Shah, N., Pieri, B., …Sathyapalan, T. (2023). Ethnic disparities in people accessing FreeStyle Libre in the United Kingdom: Insights from the Association of British Clinical Diabetologists audit. Diabetic medicine, 40(8), Article e15095. https://doi.org/10.1111/dme.15095

Metabolic and endocrine complications of long COVID-19: A review (2023)
Journal Article
Bandara, T., Deshmukh, H. A., Abdalla, M., & Sathyapalan, T. (2023). Metabolic and endocrine complications of long COVID-19: A review. Experimental and Clinical Endocrinology and Diabetes, 131(6), 367-374. https://doi.org/10.1055/a-2063-8697

Over the past two years, the COVID-19 outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), centralized the interest of the health care systems and the scientific world. Majority of the COVID-19 infected individuals fully r... Read More about Metabolic and endocrine complications of long COVID-19: A review.

The long-term impact of glucose monitoring with the FreeStyle Libre on glycaemic control and hypoglycaemia awareness in people with type1 diabetes: Insights from the Association of British Clinical Diabetologists national audit (2023)
Journal Article
Shah, N., Deshmukh, H., Wilmot, E. G., Patmore, J., Christian, P., Barnes, D. J., Walton, C., Ryder, R. E. J., & Sathyapalan, T. (2023). The long-term impact of glucose monitoring with the FreeStyle Libre on glycaemic control and hypoglycaemia awareness in people with type1 diabetes: Insights from the Association of British Clinical Diabetologists national audit. Diabetic medicine, 40(6), Article e15070. https://doi.org/10.1111/dme.15070

Aims: To investigate the change in glycated haemoglobin (HbA1c), hypoglycaemia awareness and diabetes-related distress in people with type 1 diabetes (T1D) using FreeStyle Libre (FSL) over a 2-year follow-up period. Methods: FSL user data from U.K wi... Read More about The long-term impact of glucose monitoring with the FreeStyle Libre on glycaemic control and hypoglycaemia awareness in people with type1 diabetes: Insights from the Association of British Clinical Diabetologists national audit.

Pharmacogenomics of GLP-1 receptor agonists: a genome-wide analysis of observational data and large randomised controlled trials (2022)
Journal Article
Dawed, A. Y., Mari, A., Brown, A., McDonald, T. J., Li, L., Wang, S., …Jonsson, A. (2023). Pharmacogenomics of GLP-1 receptor agonists: a genome-wide analysis of observational data and large randomised controlled trials. Lancet Diabetes and Endocrinology, 11(1), 33-41. https://doi.org/10.1016/S2213-8587%2822%2900340-0

Background: In the treatment of type 2 diabetes, GLP-1 receptor agonists lower blood glucose concentrations, body weight, and have cardiovascular benefits. The efficacy and side effects of GLP-1 receptor agonists vary between people. Human pharmacoge... Read More about Pharmacogenomics of GLP-1 receptor agonists: a genome-wide analysis of observational data and large randomised controlled trials.

Assessing the androgenic and metabolic heterogeneity in polycystic ovary syndrome using cluster analysis (2022)
Journal Article
Deshmukh, H., Akbar, S., Bhaiji, A., Saeed, Y., Shah, N., Adeleke, K., …Sathyapalan, T. (2023). Assessing the androgenic and metabolic heterogeneity in polycystic ovary syndrome using cluster analysis. Clinical Endocrinology, 98(3), 400-406. https://doi.org/10.1111/cen.14847

Introduction: Some but not all women with polycystic ovary syndrome (PCOS) develop the metabolic syndrome (MS). The objective of this study was to determine if a subset of women with PCOS had higher androgen levels predisposing them to MS and whether... Read More about Assessing the androgenic and metabolic heterogeneity in polycystic ovary syndrome using cluster analysis.

Impact of metformin on the clinical and metabolic parameters of women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials (2022)
Journal Article
Abdalla, M. A., Shah, N., Deshmukh, H., Sahebkar, A., Östlundh, L., Al-Rifai, R. H., …Sathyapalan, T. (2022). Impact of metformin on the clinical and metabolic parameters of women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials. Therapeutic Advances in Endocrinology and Metabolism, 13, https://doi.org/10.1177/20420188221127142

Context: Polycystic ovary syndrome (PCOS) is one of the commonest endocrine disorders affecting women of reproductive age, and metformin is a widely used medication in managing this condition. Aim: To review the available literature comprehensively o... Read More about Impact of metformin on the clinical and metabolic parameters of women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials.

Time in range following flash glucose monitoring: Relationship with glycaemic control, diabetes-related distress and resource utilisation in the Association of British Clinical Diabetologists national audit (2022)
Journal Article
Deshmukh, H., Wilmot, E., Pieri, B., Choudhary, P., Shah, N., Gregory, R., …Sathyapalan, T. (2022). Time in range following flash glucose monitoring: Relationship with glycaemic control, diabetes-related distress and resource utilisation in the Association of British Clinical Diabetologists national audit. Diabetic medicine, Article e14942. https://doi.org/10.1111/dme.14942

Aims: The aim of this study was to understand the relationship between time in range (TIR) achieved using the isCGM with changes in glycaemic control, diabetes-related distress (DRD) and resource utilisation in people living with diabetes. Methods: C... Read More about Time in range following flash glucose monitoring: Relationship with glycaemic control, diabetes-related distress and resource utilisation in the Association of British Clinical Diabetologists national audit.

Impaired awareness of hypoglycaemia: Prevalence and associated factors before and after FreeStyle Libre use in the Association of British Clinical Diabetologists audit (2022)
Journal Article
Pieri, B., Deshmukh, H., Wilmot, E. G., Choudhary, P., Shah, N., Gregory, R., …Sathyapalan, T. (2023). Impaired awareness of hypoglycaemia: Prevalence and associated factors before and after FreeStyle Libre use in the Association of British Clinical Diabetologists audit. Diabetes, Obesity and Metabolism, 25(1), 302-305. https://doi.org/10.1111/dom.14841

Ethnic disparities in people accessing FreeStyle Libre in the UK: insights from the Association of British Clinical Diabetologists audit (2022)
Journal Article
Deshmukh, H., Adeleke, K. A., Wilmot, E., Shah, N., Patmore, J., Walton, C., Ryder, R. E. J., & Sathyapalan, T. (2022). Ethnic disparities in people accessing FreeStyle Libre in the UK: insights from the Association of British Clinical Diabetologists audit. Future Healthcare Journal, 9(Suppl 2), 11-11. https://doi.org/10.7861/fhj.9-2-s11

Impact of pharmacological interventions on biochemical hyperandrogenemia in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials (2022)
Journal Article
Abdalla, M. A., Shah, N., Deshmukh, H., Sahebkar, A., Östlundh, L., Al-Rifai, R. H., …Sathyapalan, T. (in press). Impact of pharmacological interventions on biochemical hyperandrogenemia in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials. Archives of Gynecology and Obstetrics, https://doi.org/10.1007/s00404-022-06549-6

Context: Polycystic ovary syndrome (PCOS) is a complex endocrine disease that affects women of reproductive age and is characterised by biochemical and clinical androgen excess. Aim: To evaluate the efficacy of pharmacological interventions used to d... Read More about Impact of pharmacological interventions on biochemical hyperandrogenemia in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials.

FreeStyle Libre Flash Glucose Monitoring system for people with type 1 diabetes in the UK: a budget impact analysis (2022)
Journal Article
Blissett, R., Blissett, D., Levrat-Guillen, F., Deshmukh, H., Wilmot, E. G., Ryder, R. E., …Sathyapalan, T. (2022). FreeStyle Libre Flash Glucose Monitoring system for people with type 1 diabetes in the UK: a budget impact analysis. BMJ Open Diabetes Research and Care, 10(2), Article e002580. https://doi.org/10.1136/bmjdrc-2021-002580

INTRODUCTION: This study aims to estimate the budget impact of increased uptake of the FreeStyle Libre Flash Glucose Monitoring system in people with type 1 diabetes mellitus (T1DM) in the UK. RESEARCH DESIGN AND METHODS: A budget impact model was de... Read More about FreeStyle Libre Flash Glucose Monitoring system for people with type 1 diabetes in the UK: a budget impact analysis.

Impact of pharmacological interventions on anthropometric indices in women with polycystic ovary syndrome: a systematic review and meta‐analysis of randomised controlled trials (2021)
Journal Article
Abdalla, M. A., Shah, N., Deshmukh, H., Sahebkar, A., Östlundh, L., Al‐Rifai, R. H., …Sathyapalan, T. (in press). Impact of pharmacological interventions on anthropometric indices in women with polycystic ovary syndrome: a systematic review and meta‐analysis of randomised controlled trials. Clinical Endocrinology, https://doi.org/10.1111/cen.14663

Context: Polycystic ovary syndrome (PCOS) is a heterogeneous condition affecting women of reproductive age and is associated with increased body weight. Objective: To review the literature on the effect of different pharmacological interventions on t... Read More about Impact of pharmacological interventions on anthropometric indices in women with polycystic ovary syndrome: a systematic review and meta‐analysis of randomised controlled trials.

Genetic risk for the polycystic ovary syndrome, bone mineral density and fractures in women and men: A UK Biobank Mendelian randomisation study (2021)
Journal Article
Deshmukh, H., Shah, N., Papageorgiou, M., Abdalla, M. A., Lhaf, F., Aye, M., & Sathyapalan, T. (2022). Genetic risk for the polycystic ovary syndrome, bone mineral density and fractures in women and men: A UK Biobank Mendelian randomisation study. Bone, 155, Article 116285. https://doi.org/10.1016/j.bone.2021.116285

Introduction: There is conflicting data on the effect of polycystic ovary syndrome (PCOS) on bone mineral density (BMD) and fracture risk. Recent genetic data suggest that men may also carry genetic risk factors for PCOS; the associations of these fa... Read More about Genetic risk for the polycystic ovary syndrome, bone mineral density and fractures in women and men: A UK Biobank Mendelian randomisation study.

Effect of pharmacological interventions on lipid profiles and C-reactive protein in polycystic ovary syndrome: A systematic review and meta-analysis (2021)
Journal Article
Abdalla, M. A., Shah, N., Deshmukh, H., Sahebkar, A., Östlundh, L., Al-Rifai, R. H., …Sathyapalan, T. (in press). Effect of pharmacological interventions on lipid profiles and C-reactive protein in polycystic ovary syndrome: A systematic review and meta-analysis. Clinical Endocrinology, https://doi.org/10.1111/cen.14636

Context: Polycystic ovary syndrome (PCOS) is a heterogeneous condition affecting women of reproductive age. It is associated with dyslipidaemia and elevated plasma C-reactive protein (CRP), which increase the risks of cardiovascular disease (CVD). Ob... Read More about Effect of pharmacological interventions on lipid profiles and C-reactive protein in polycystic ovary syndrome: A systematic review and meta-analysis.

Impact of pharmacological interventions on insulin resistance in women with polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials (2021)
Journal Article
Abdalla, M. A., Shah, N., Deshmukh, H., Sahebkar, A., Östlundh, L., Al-Rifai, R. H., …Sathyapalan, T. (in press). Impact of pharmacological interventions on insulin resistance in women with polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials. Clinical Endocrinology, https://doi.org/10.1111/cen.14623

Objective: Polycystic ovary syndrome (PCOS) is a complex endocrine condition affecting women of reproductive age. It is characterized by insulin resistance and is a major risk factor for type 2 diabetes mellitus (T2DM). The objective was to review th... Read More about Impact of pharmacological interventions on insulin resistance in women with polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials.

Previous structured education attendance and the relationship with HbA1c and hypoglycaemia awareness in people living with type 1 diabetes mellitus using FreeStyle Libre: insights from the Association of British Clinical Diabetologists (ABCD) Nationwide Audit (2021)
Journal Article
Shah, N., Deshmukh, H., Wilmot, E. G., Patmore, J., Choudhary, P., Christian, P., …Sathyapalan, T. (in press). Previous structured education attendance and the relationship with HbA1c and hypoglycaemia awareness in people living with type 1 diabetes mellitus using FreeStyle Libre: insights from the Association of British Clinical Diabetologists (ABCD) Nationwide Audit. British Journal of Diabetes, https://doi.org/10.15277/bjd.2021.308

Impaired Awareness of Hypoglycemia and Severe Hypoglycemia in Drivers With Diabetes: Insights From the Association of British Clinical Diabetologists Nationwide Audit (2021)
Journal Article
Deshmukh, H., Wilmot, E. G., Choudhary, P., Narendran, P., Shah, N., Barnes, D., …Sathyapalan, T. (2021). Impaired Awareness of Hypoglycemia and Severe Hypoglycemia in Drivers With Diabetes: Insights From the Association of British Clinical Diabetologists Nationwide Audit. Diabetes Care, 44(11), e190-e191. https://doi.org/10.2337/dc21-1181

Predictors of diabetes-related distress before and after FreeStyle Libre-1 use: Lessons from the Association of British Clinical Diabetologists nationwide study (2021)
Journal Article
Deshmukh, H., Wilmot, E. G., Gregory, R., Barnes, D., Narendran, P., Saunders, S., …Sathyapalan, T. (2021). Predictors of diabetes-related distress before and after FreeStyle Libre-1 use: Lessons from the Association of British Clinical Diabetologists nationwide study. Diabetes, Obesity and Metabolism, 23(10), 2261-2268. https://doi.org/10.1111/dom.14467

Aim: To identify the baseline demographic and clinical characteristics associated with diabetes-related distress (DRD) and factors associated with improvement in DRD after initiating use of the FreeStyle Libre (FSL) in people living with type 1 diabe... Read More about Predictors of diabetes-related distress before and after FreeStyle Libre-1 use: Lessons from the Association of British Clinical Diabetologists nationwide study.

The Effect of Free Androgen Index on the Quality of Life of Women With Polycystic Ovary Syndrome: A Cross-Sectional Study (2021)
Journal Article
Abdalla, M. A., Deshmukh, H., Mohammed, I., Atkin, S., Reid, M., & Sathyapalan, T. (2021). The Effect of Free Androgen Index on the Quality of Life of Women With Polycystic Ovary Syndrome: A Cross-Sectional Study. Frontiers in Physiology, 12, Article 652559. https://doi.org/10.3389/fphys.2021.652559

Purpose: Free androgen index (FAI) and anti-Mullerian hormone (AMH) are independently associated with polycystic ovary syndrome (PCOS). This study aimed to describe the relationship between these two markers and health-related quality of life (HR-QoL... Read More about The Effect of Free Androgen Index on the Quality of Life of Women With Polycystic Ovary Syndrome: A Cross-Sectional Study.

The potential role of incretin-based therapies for polycystic ovary syndrome: a narrative review of the current evidence (2021)
Journal Article
Abdalla, M. A., Deshmukh, H., Atkin, S., & Sathyapalan, T. (2021). The potential role of incretin-based therapies for polycystic ovary syndrome: a narrative review of the current evidence. Therapeutic Advances in Endocrinology and Metabolism, 12, https://doi.org/10.1177/2042018821989238

© The Author(s), 2021. Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects women of reproductive age. Metabolic consequences associated with PCOS include, but are not limited to, insulin resistance (IR), type 2... Read More about The potential role of incretin-based therapies for polycystic ovary syndrome: a narrative review of the current evidence.

Therapeutics for type-2 diabetes mellitus: a glance at the recent inclusions and novel agents under development for use in clinical practice (2021)
Journal Article
Shah, N., Abdalla, M. A., Deshmukh, H., & Sathyapalan, T. (2021). Therapeutics for type-2 diabetes mellitus: a glance at the recent inclusions and novel agents under development for use in clinical practice. Therapeutic Advances in Endocrinology and Metabolism, 12, https://doi.org/10.1177/20420188211042145

Diabetes mellitus (DM) is a chronic, progressive, and multifaceted illness resulting in significant physical and psychological detriment to patients. As of 2019, 463 million people are estimated to be living with DM worldwide, out of which 90% have t... Read More about Therapeutics for type-2 diabetes mellitus: a glance at the recent inclusions and novel agents under development for use in clinical practice.

Hyperthyroidism, and bone mineral density : dissecting the causal association with Mendelian randomization analysis (2020)
Journal Article
Deshmukh, H., Papageorgiou, M., Aye, M., England, J., Abdalla, M., & Sathyapalan, T. (in press). Hyperthyroidism, and bone mineral density : dissecting the causal association with Mendelian randomization analysis. Clinical Endocrinology, https://doi.org/10.1111/cen.14330

Introduction
Untreated hyperthyroidism is associated with accelerated bone turnover, low bone mineral density (BMD) and increased susceptibility to fragility fractures. Although treatment appears to improve or even reverse some of these adverse skel... Read More about Hyperthyroidism, and bone mineral density : dissecting the causal association with Mendelian randomization analysis.

miRNAs as a novel clinical biomarker and therapeutic targets in polycystic ovary syndrome (PCOS): A review (2020)
Journal Article
Abdalla, M., Deshmukh, H., Atkin, S. L., & Sathyapalan, T. (2020). miRNAs as a novel clinical biomarker and therapeutic targets in polycystic ovary syndrome (PCOS): A review. Life Sciences, 259, https://doi.org/10.1016/j.lfs.2020.118174

© 2020 Elsevier Inc. Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in females of the reproductive age. PCOS is commonly manifested as ovulatory dysfunction, clinical and biochemical excess androgen level, and polycystic ov... Read More about miRNAs as a novel clinical biomarker and therapeutic targets in polycystic ovary syndrome (PCOS): A review.

Effect of flash glucose monitoring on glycemic control, hypoglycemia, diabetes-related distress, and resource utilization in the association of british clinical diabetologists (Abcd) nationwide audit (2020)
Journal Article
Deshmukh, H., Wilmot, E. G., Gregory, R., Barnes, D., Narendran, P., Saunders, S., Furlong, N., Kamaruddin, S., Banatwalla, R., Herring, R., Kilvert, A., Patmore, J., Walton, C., Ryder, R. E., & Sathyapalan, T. (2020). Effect of flash glucose monitoring on glycemic control, hypoglycemia, diabetes-related distress, and resource utilization in the association of british clinical diabetologists (Abcd) nationwide audit. Diabetes Care, 43(9), 2153-2160. https://doi.org/10.2337/dc20-0738

OBJECTIVE The FreeStyle Libre (FSL) flash glucose-monitoring device was made available on the U.K. National Health Service (NHS) drug tariff in 2017. This study aims to explore the U.K. real-world experience of FSL and the impact on glycemic control,... Read More about Effect of flash glucose monitoring on glycemic control, hypoglycemia, diabetes-related distress, and resource utilization in the association of british clinical diabetologists (Abcd) nationwide audit.

Association of endocrine active environmental compounds with body mass index and weight loss following bariatric surgery (2020)
Journal Article
Deshmukh, H., Aylward, L. L., Rose, M., Fernandes, A., Sedman, P., Thatcher, N. J., Atkin, S. L., & Sathyapalan, T. (2020). Association of endocrine active environmental compounds with body mass index and weight loss following bariatric surgery. Clinical Endocrinology, 93(3), 280-287. https://doi.org/10.1111/cen.14257

Introduction
The objective of this study was to study associations of a wide range of halogenated biphenyls, dibenzo‐p‐dioxins, dibenzofurans, and diphenylethers with body mass index (BMI) and evaluate changes in their concentration following bariat... Read More about Association of endocrine active environmental compounds with body mass index and weight loss following bariatric surgery.

A review of therapeutic options for managing the metabolic aspects of polycystic ovary syndrome (2020)
Journal Article
Abdalla, M. A., Deshmukh, H., Atkin, S., & Sathyapalan, T. (2020). A review of therapeutic options for managing the metabolic aspects of polycystic ovary syndrome. Therapeutic Advances in Endocrinology and Metabolism, 11, https://doi.org/10.1177/2042018820938305

Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. Metabolic sequelae associated with PCOS range from insulin resistance to type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). Insulin resistanc... Read More about A review of therapeutic options for managing the metabolic aspects of polycystic ovary syndrome.

Effects of empagliflozin on metabolic parameters in polycystic ovary syndrome: a randomized controlled study (2019)
Journal Article
Javed, Z., Papageorgiou, M., Deshmukh, H., Rigby, A. S., Qamar, U., Abbas, J., Khan, A. Y., Kilpatrick, E. S., Atkin, S. L., & Sathyapalan, T. (2019). Effects of empagliflozin on metabolic parameters in polycystic ovary syndrome: a randomized controlled study. Clinical Endocrinology, 90(6), 805-813. https://doi.org/10.1111/cen.13968

Background: Empagliflozin is a sodium-glucose-cotransporter-2 inhibitor that improves cardiovascular risk and promotes weight loss in patients with type 2 diabetes. Polycystic ovary syndrome (PCOS) is associated with obesity and increased cardiovascu... Read More about Effects of empagliflozin on metabolic parameters in polycystic ovary syndrome: a randomized controlled study.

A randomized, controlled trial of vitamin D supplementation on cardiovascular risk factors, hormones, and liver markers in women with polycystic ovary syndrome (2019)
Journal Article
Javed, Z., Papageorgiou, M., Deshmukh, H., Kilpatrick, E., Mann, V., Corless, L., Abouda, G., Rigby, A. S., Atkin, S., & Sathyapalan, T. (2019). A randomized, controlled trial of vitamin D supplementation on cardiovascular risk factors, hormones, and liver markers in women with polycystic ovary syndrome. Nutrients, 11(1), 188. https://doi.org/10.3390/nu11010188

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Polycystic ovary syndrome (PCOS) increases the risk of metabolic syndrome and non-alcoholic-fatty-liver disease (NAFLD). Vitamin D supplementation may exert positive effects on liver biochemis... Read More about A randomized, controlled trial of vitamin D supplementation on cardiovascular risk factors, hormones, and liver markers in women with polycystic ovary syndrome.

Development of a novel risk prediction and risk stratification score for polycystic ovary syndrome (PCOS) (2018)
Journal Article
Deshmukh, H., Papageorgiou, M., Kilpatrick, E. S., Atkin, S. L., & Sathyapalan, T. (in press). Development of a novel risk prediction and risk stratification score for polycystic ovary syndrome (PCOS). Clinical Endocrinology, 90(1), 162-169. https://doi.org/10.1111/cen.13879

Objective
The aim of this study was to develop a simple phenotypic algorithm that can capture the underlying clinical and hormonal abnormalities to help in the diagnosis and risk stratification of polycystic ovary syndrome (PCOS).

Methods
The study... Read More about Development of a novel risk prediction and risk stratification score for polycystic ovary syndrome (PCOS).

Effects of acute insulin-induced hypoglycaemia on endothelial microparticles in adults with and without type 2 diabetes (2018)
Journal Article
Al-Qaissi, A., Papageorgiou, M., Deshmukh, H., Madden, L. A., Rigby, A., Kilpatrick, E. S., Atkin, S. L., & Sathyapalan, T. (2019). Effects of acute insulin-induced hypoglycaemia on endothelial microparticles in adults with and without type 2 diabetes. Diabetes, Obesity and Metabolism, 21(3), 533-540. https://doi.org/10.1111/dom.13548

Aims
Endothelial microparticles (EMPs) are novel surrogate markers of endothelial injury and dysfunction that may be differentially produced in response to acute insulin‐induced hypoglycaemia in adults with and without type 2 diabetes.