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Development of radiodetection systems towards miniaturised quality control of PET and SPECT radiopharmaceuticals (2016)
Journal Article
Taggart, M. P., Tarn, M. D., Esfahani, M. M. N., Schofield, D. M., Brown, N. J., Archibald, S. J., Deakin, T., Pamme, N., & Thompson, L. F. (2016). Development of radiodetection systems towards miniaturised quality control of PET and SPECT radiopharmaceuticals. Lab on a chip, 16(9), 1605-1616. https://doi.org/10.1039/c6lc00099a

The ability to detect radiation in microfluidic devices is important for the on-chip analysis of radiopharmaceuticals, but previously reported systems have largely suffered from various limitations including cost, complexity of fabrication, and insuf... Read More about Development of radiodetection systems towards miniaturised quality control of PET and SPECT radiopharmaceuticals.

New AMD3100 derivatives for CXCR4 chemokine receptor targeted molecular imaging studies: synthesis, anti-HIV-1 evaluation and binding affinities (2015)
Journal Article
Poty, S., Désogère, P., Goze, C., Boschetti, F., D‘huys, T., Schols, D., Cawthorne, C., Archibald, S. J., Maëcke, H. R., & Denat, F. (2015). New AMD3100 derivatives for CXCR4 chemokine receptor targeted molecular imaging studies: synthesis, anti-HIV-1 evaluation and binding affinities. Dalton Transactions : an international journal of inorganic chemistry, 44(11), 5004-5016. https://doi.org/10.1039/c4dt02972k

CXCR4 is a target of growing interest for the development of new therapeutic drugs and imaging agents as its role in multiple disease states has been demonstrated. AMD3100, a CXCR4 chemokine receptor antagonist that is in current clinical use as a ha... Read More about New AMD3100 derivatives for CXCR4 chemokine receptor targeted molecular imaging studies: synthesis, anti-HIV-1 evaluation and binding affinities.

Challenges in chelating positron emitting copper isotopes: tailored synthesis of unsymmetric chelators to form ultra stable complexes (2011)
Journal Article
Silversides, J. D., Smith, R., & Archibald, S. J. (2011). Challenges in chelating positron emitting copper isotopes: tailored synthesis of unsymmetric chelators to form ultra stable complexes. Dalton Transactions : an international journal of inorganic chemistry, 40(23), 6289-6297. https://doi.org/10.1039/c0dt01395a

The synthesis of chelators that form high stability complexes with copper(II) isotopes and do not suffer from transchelation in vivo has been a goal for many chemists. Such chelators will facilitate the exploitation of the Cu-64 isotope (t(1/2) = 12.... Read More about Challenges in chelating positron emitting copper isotopes: tailored synthesis of unsymmetric chelators to form ultra stable complexes.

PI3K inhibition as a novel therapeutic strategy for neoadjuvant chemoradiotherapy resistant oesophageal adenocarcinoma (2021)
Journal Article
Edge, S. D., Renard, I., Pyne, E., Li, C., Moody, H., Roy, R., Beavis, A. W., Archibald, S. J., Cawthorne, C. J., Maher, S. J., & Pires, I. M. (2021). PI3K inhibition as a novel therapeutic strategy for neoadjuvant chemoradiotherapy resistant oesophageal adenocarcinoma. British Journal of Radiology, 94(1119), Article 20201191. https://doi.org/10.1259/bjr.20201191

OBJECTIVE: Neoadjuvant chemoradiotherapy (neo-CRT) prior to surgery is the standard of care for oesophageal adenocarcinoma (OAC) patients. Unfortunately, most patients fail to respond to treatment. MiR-187 was previously shown to be downregulated in... Read More about PI3K inhibition as a novel therapeutic strategy for neoadjuvant chemoradiotherapy resistant oesophageal adenocarcinoma.

Synthesis of a porphyrin with histidine-like chelate: an efficient path towards molecular PDT/SPECT theranostics (2020)
Journal Article
Yap, S. Y., Savoie, H., Renard, I., Burke, B. P., Sample, H. C., Michue-Seijas, S., Archibald, S. J., Boyle, R. W., & Stasiuk, G. J. (2020). Synthesis of a porphyrin with histidine-like chelate: an efficient path towards molecular PDT/SPECT theranostics. Chemical communications : Chem comm / the Royal Society of Chemistry, 56(75), 11090-11093. https://doi.org/10.1039/d0cc03958f

© The Royal Society of Chemistry 2020. The goal of “personalised” medicine has seen a growing interest in the development of theranostic agents. Bifunctional, and targeted-trifunctional, theranostic water-soluble porphyrins with a histidine-like chel... Read More about Synthesis of a porphyrin with histidine-like chelate: an efficient path towards molecular PDT/SPECT theranostics.

CXCR4 chemokine receptor antagonists: nickel(II) complexes of configurationally restricted macrocycles (2012)
Journal Article
Smith, R., Huskens, D., Daelemans, D., Mewis, R. E., Garcia, C. D., Cain, A. N., Freeman, T. N. C., Pannecouque, C., Clercq, E. D., Schols, D., Hubin, T. J., & Archibald, S. J. (2012). CXCR4 chemokine receptor antagonists: nickel(II) complexes of configurationally restricted macrocycles. Dalton Transactions : an international journal of inorganic chemistry, 41(37), 11369-11377. https://doi.org/10.1039/c2dt31137b

Tetraazamacrocyclic complexes of transition metals provide useful units for incorporating multiple coordination interactions into a single protein binding molecule. They can be designed with available sites for protein interactions via donor atom-con... Read More about CXCR4 chemokine receptor antagonists: nickel(II) complexes of configurationally restricted macrocycles.

MRI contrast agent delivery using spore capsules: controlled release in blood plasma (2009)
Journal Article
Lorch, M., Thomasson, M. J., Diego-Taboada, A., Barrier, S., Atkin, S. L., Mackenzie, G., & Archibald, S. J. (2009). MRI contrast agent delivery using spore capsules: controlled release in blood plasma. Chemical communications : Chem comm / the Royal Society of Chemistry, 6442-6444. https://doi.org/10.1039/b909551a

The exine coatings of spores can be used to encapsulate drug molecules. We have demonstrated that these microcapsules can be filled with a commercial gadolinium(III) MRI contrast agent (in this proof of concept study Gd-DTPA-BMA was used) which is sl... Read More about MRI contrast agent delivery using spore capsules: controlled release in blood plasma.

Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells (2016)
Journal Article
Nigam, S., Burke, B. P., Davies, L. H., Domarkas, J., Wallis, J. F., Waddell, P. G., Waby, J. S., Benoit, D. M., Seymour, A. M., Cawthorne, C., Higham, L. J., & Archibald, S. J. (2016). Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells. Chemical communications : Chem comm / the Royal Society of Chemistry, 52(44), 7114-7117. https://doi.org/10.1039/c5cc08325g

The structural features required for mitochondrial uptake of BODIPY-based optical imaging agents have been explored. The first derivatives of this class of dyes shown to have mitochondrial membrane potential-dependent uptake in both cancer and heart... Read More about Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells.

Multimodal nanoparticle imaging agents: Design and applications (2017)
Journal Article
Burke, B. P., Cawthorne, C., & Archibald, S. J. (2017). Multimodal nanoparticle imaging agents: Design and applications. Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 375(2107), 20170261. https://doi.org/10.1098/rsta.2017.0261

Molecular imaging, where the location of molecules or nanoscale constructs can be tracked in the body to report on disease or biochemical processes, is rapidly expanding to include combined modality or multimodal imaging. No single imaging technique... Read More about Multimodal nanoparticle imaging agents: Design and applications.

Synthesis, characterization and in vivo evaluation of a magnetic cisplatin delivery nanosystem based on PMAA-graft-PEG copolymers (2016)
Journal Article
Voulgari, E., Bakandritsos, A., Galtsidis, S., Zoumpourlis, V., Burke, B. P., Clemente, G. S., Cawthorne, C., Archibald, S. J., Tuček, J., Zbořil, R., Kantarelou, V., Karydas, A. G., & Avgoustakis, K. (2016). Synthesis, characterization and in vivo evaluation of a magnetic cisplatin delivery nanosystem based on PMAA-graft-PEG copolymers. Journal of controlled release : official journal of the Controlled Release Society, 243, 342-356. https://doi.org/10.1016/j.jconrel.2016.10.021

© 2016 Elsevier B.V. The development of anticancer drug delivery systems which retain or enhance the cytotoxic properties of the drug to tumorous tissues, while reducing toxicity to other organs is of key importance. We investigated different poly(me... Read More about Synthesis, characterization and in vivo evaluation of a magnetic cisplatin delivery nanosystem based on PMAA-graft-PEG copolymers.

Mono- and bis-alkylation of glyoxal-bridged tetraazamacrocycles using mechanochemistry (2016)
Journal Article
Abdulwahaab, B. H., Burke, B. P., Domarkas, J., Silversides, J. D., Prior, T. J., & Archibald, S. J. (2016). Mono- and bis-alkylation of glyoxal-bridged tetraazamacrocycles using mechanochemistry. Journal of Organic Chemistry, 81(3), 890-898. https://doi.org/10.1021/acs.joc.5b02464

Glyoxal-bridged bisaminal tetraazamacrocyclic derivatives of 1,4,7,10-tetraazacyclododecane (cyclen) and 1,4,8,11-tetraazacyclotetradecane (cyclam) can be N-functionalized to incorporate coordinating groups or for conjugation to biomolecules. Herein,... Read More about Mono- and bis-alkylation of glyoxal-bridged tetraazamacrocycles using mechanochemistry.

Aspartate-Based CXCR4 Chemokine Receptor Binding of Cross-Bridged Tetraazamacrocyclic Copper(II) and Zinc(II) Complexes (2016)
Journal Article
Maples, R. D., Cain, A. N., Burke, B. P., Silversides, J. D., Mewis, R. E., D'huys, T., Schols, D., Linder, D. P., Archibald, S. J., & Hubin, T. J. (2016). Aspartate-Based CXCR4 Chemokine Receptor Binding of Cross-Bridged Tetraazamacrocyclic Copper(II) and Zinc(II) Complexes. Chemistry: a European journal, 22(36), 12916-12930. https://doi.org/10.1002/chem.201601468

© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim The CXCR4 chemokine receptor is implicated in a number of diseases including HIV infection and cancer development and metastasis. Previous studies have demonstrated that configurationally restricted... Read More about Aspartate-Based CXCR4 Chemokine Receptor Binding of Cross-Bridged Tetraazamacrocyclic Copper(II) and Zinc(II) Complexes.

Synthesis, structural studies, kinetic stability, and oxidation catalysis of the late first row transition metal complexes of 4,10-dimethyl-1,4,7,10-tetraazabicyclo[6.5.2]pentadecane (2015)
Journal Article
Matz, D. L., Jones, D. G., Roewe, K. D., Gorbet, M.-J., Zhang, Z., Chen, Z., Prior, T. J., Archibald, S. J., Yin, G., & Hubin, T. J. (2015). Synthesis, structural studies, kinetic stability, and oxidation catalysis of the late first row transition metal complexes of 4,10-dimethyl-1,4,7,10-tetraazabicyclo[6.5.2]pentadecane. Dalton Transactions : an international journal of inorganic chemistry, 44(27), 12210-12224. https://doi.org/10.1039/c5dt00742a

© The Royal Society of Chemistry 2015. Synthetic details for 4,11-dimethyl-1,4,8,11-tetraazabicyclo[6.5.2]pentadecane, the dimethyl ethylene cross-bridged homocyclen ligand are presented for the first time. Its novel Mn 2+ , Fe 2+ , Mn 3+ , and Fe 3+... Read More about Synthesis, structural studies, kinetic stability, and oxidation catalysis of the late first row transition metal complexes of 4,10-dimethyl-1,4,7,10-tetraazabicyclo[6.5.2]pentadecane.

IL-24 Inhibits lung cancer cell migration and invasion by disrupting the SDF-1/CXCR4 signaling axis (2015)
Journal Article
Panneerselvam, J., Jin, J., Shanker, M., Lauderdale, J., Bates, J., Wang, Q., Zhao, Y. D., Archibald, S. J., Hubin, T. J., & Ramesh, R. (2015). IL-24 Inhibits lung cancer cell migration and invasion by disrupting the SDF-1/CXCR4 signaling axis. PLoS ONE, 10(3), Article e0122439. https://doi.org/10.1371/journal.pone.0122439

© 2015 Panneerselvam et al. Background The stromal cell derived factor (SDF)-1/chemokine receptor (CXCR)-4 signaling pathway plays a key role in lung cancer metastasis and is molecular target for therapy. In the present study we investigated whether... Read More about IL-24 Inhibits lung cancer cell migration and invasion by disrupting the SDF-1/CXCR4 signaling axis.

Advances in processes for PET radiotracer synthesis: Separation of [18F]fluoride from enriched [18O]water (2014)
Journal Article
He, P., Haswell, S. J., Pamme, N., & Archibald, S. J. (2014). Advances in processes for PET radiotracer synthesis: Separation of [18F]fluoride from enriched [18O]water. Applied radiation and isotopes : including data, instrumentation, and methods for use in agriculture, industry, and medicine, 91, 64-70. https://doi.org/10.1016/j.apradiso.2014.04.021

Positron emission tomography (PET) is a powerful scientific and clinical tool for the study and visualization of human physiology that can provide important information about metabolism and diseases such as cancer. At present, [ 18 F]fluorodeoxygluco... Read More about Advances in processes for PET radiotracer synthesis: Separation of [18F]fluoride from enriched [18O]water.

Integrated microfluidic lab-on-a-chip systems for F-18 radiotracer synthesis, purification and quality control (2015)
Journal Article
Archibald, S., Pamme, N., Brown, N., & Tarn, M. (2015). Integrated microfluidic lab-on-a-chip systems for F-18 radiotracer synthesis, purification and quality control. Journal of nuclear medicine, 56(Supplement 3), Article 167

Objectives Dose-on-demand radiotracer production, whereby a single dose is generated using a compact synthesis unit with radioisotope from a mini-cyclotron or external supply is an interesting prospect for widening the availabilty of radiotracers. We... Read More about Integrated microfluidic lab-on-a-chip systems for F-18 radiotracer synthesis, purification and quality control.

Evaluation of configurationally restricted copper-64 labelled bis tetraazamacrocyclic as potential PET agents for CXCR4 expression in oncology imaging (2015)
Journal Article
Clemente, G. S., Burke, B. P., Nigam, S., Cawthorne, C., & Archibald, S. J. (2015). Evaluation of configurationally restricted copper-64 labelled bis tetraazamacrocyclic as potential PET agents for CXCR4 expression in oncology imaging. European journal of nuclear medicine and molecular imaging, 42(S1), S42. https://doi.org/10.1007/s00259-015-3198-z

Conference abstract

Development of an anatomically correct mouse phantom for dosimetry measurement in small animal radiotherapy research (2019)
Journal Article
Soultanidis, G., Subiel, A., Renard, I., Reinhart, A. M., Green, V. L., Oelfke, U., Archibald, S. J., Greenman, J., Tulk, A., Walker, A., Schettino, G., & Cawthorne, C. J. (2019). Development of an anatomically correct mouse phantom for dosimetry measurement in small animal radiotherapy research. Physics in Medicine and Biology, 64(12), Article 12NT02. https://doi.org/10.1088/1361-6560/ab215b

Significant improvements in radiotherapy are likely to come from biological rather than technical optimization, for example increasing tumour radiosensitivity via combination with targeted therapies. Such paradigms must first be evaluated in preclini... Read More about Development of an anatomically correct mouse phantom for dosimetry measurement in small animal radiotherapy research.

Fluoride doped γ-Fe2O3 nanoparticles with increased MRI relaxivity (2018)
Journal Article
Jones, N. E., Burnett, C. A., Salamon, S., Landers, J., Wende, H., Lazzarini, L., Gibbs, P., Pickles, M., Johnson, B. R., Evans, D. J., Archibald, S. J., & Francesconi, M. G. (2018). Fluoride doped γ-Fe2O3 nanoparticles with increased MRI relaxivity. Journal of Materials Chemistry B, 6(22), 3665-3673. https://doi.org/10.1039/c8tb00360b

Iron oxide nanoparticles (IONs) are being actively researched and experimented with as contrast agents for Magnetic Resonance Imaging (MRI), as well as image-directed delivery of therapeutics. The efficiency of an MRI contrast agent can be described... Read More about Fluoride doped γ-Fe2O3 nanoparticles with increased MRI relaxivity.