Outputs (943)

Distinguishing Properties of Cells From the Myocardial Sleeves of the Pulmonary Veins: A Comparison of Normal and Abnormal Pacemakers (2008)
Journal Article
Jones, S. A., Yamamoto, M., Tellez, J. O., Billeter, R., Boyett, M. R., Honjo, H., & Lancaster, M. K. (2008). Distinguishing Properties of Cells From the Myocardial Sleeves of the Pulmonary Veins: A Comparison of Normal and Abnormal Pacemakers. Circulation. Arrhythmia and electrophysiology, 1(1), 39-48. https://doi.org/10.1161/CIRCEP.107.748467

BACKGROUND: A common source of arrhythmogenic spontaneous activity instigating atrial fibrillation is the myocardial tissue, or sleeves, at the base of the pulmonary veins. This study compared the properties of cells from the myocardial sleeves of th... Read More about Distinguishing Properties of Cells From the Myocardial Sleeves of the Pulmonary Veins: A Comparison of Normal and Abnormal Pacemakers.

Dictyostelium Sun-1 connects the centrosome to chromatin and ensures genome stability (2008)
Journal Article
Rivero, F., Xiong, H., Rivero-Crespo, F., Euteneuer, U., Mondal, S., Mana-Capelli, S., Larochelle, D., Vogel, A., Gassen, B., & Noegel, A. A. (2008). Dictyostelium Sun-1 connects the centrosome to chromatin and ensures genome stability. Traffic, 9(5), 708-724. https://doi.org/10.1111/j.1600-0854.2008.00721.x

The centrosome-nucleus attachment is a prerequisite for faithful chromosome segregation during mitosis. We addressed the function of the nuclear envelope (NE) protein Sun-1 in centrosome-nucleus connection and the maintenance of genome stability in D... Read More about Dictyostelium Sun-1 connects the centrosome to chromatin and ensures genome stability.

Investigation of the mechanisms of tissue factor-mediated evasion of tumour cells from cellular cytotoxicity (2008)
Journal Article
Li, C., Collier, M. E. W., Frentzou, G. A., Greenman, J., & Ettelaie, C. (2008). Investigation of the mechanisms of tissue factor-mediated evasion of tumour cells from cellular cytotoxicity. Cancer Immunology, Immunotherapy, 57(9), 1347-1355. https://doi.org/10.1007/s00262-008-0469-6

Aims We previously reported that overexpression of tissue factor (TF) protected HT29 tumour cells from cellular cytotoxicity through a mechanism requiring the presence of the cytoplasmic domain of TF. In this investigation the mechanism of TF-mediate... Read More about Investigation of the mechanisms of tissue factor-mediated evasion of tumour cells from cellular cytotoxicity.

Fluvastatin reduces oxidative damage in human vascular endothelial cells by upregulating Bcl-2 (2008)
Journal Article
Xu, S. Z., Zhong, W., Watson, N. M., Dickerson, E., Wake, J. D., Lindow, S. W., Newton, C. J., & Atkin, S. L. (2008). Fluvastatin reduces oxidative damage in human vascular endothelial cells by upregulating Bcl-2. Journal of thrombosis and haemostasis : JTH, 6(4), 692-700. https://doi.org/10.1111/j.1538-7836.2008.02913.x

Background: 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have been widely used in clinical practise and their efficacy in reducing cardiovascular risk has been well described. Objectives: To investigate the effect of low doses... Read More about Fluvastatin reduces oxidative damage in human vascular endothelial cells by upregulating Bcl-2.

Regulatory T cells: what role do they play in antitumor immunity in patients with head and neck cancer? (2008)
Journal Article
Alhamarneh, O., Amarnath, S. M. P., Stafford, N. D., & Greenman, J. (2008). Regulatory T cells: what role do they play in antitumor immunity in patients with head and neck cancer?. Head & neck, 30(2), 251-261. https://doi.org/10.1002/hed.20739

Advances in the treatment modalities for head and neck squamous cell carcinoma (HNSCC) over the last 20 years involving surgery, radiotherapy, chemotherapy, and immunotherapy are not fully reflected in increases in the 5-year survival rates, mainly d... Read More about Regulatory T cells: what role do they play in antitumor immunity in patients with head and neck cancer?.

TRPC channel activation by extracellular thioredoxin (2008)
Journal Article
Xu, S.-Z., Sukumar, P., Zeng, F., Li, J., Jairaman, A., English, A., Naylor, J., Ciurtin, C., Majeed, Y., Milligan, C. J., Bahnasi, Y. M., Al-Shawaf, E., Porter, K. E., Jiang, L.-H., Emery, P., Sivaprasadarao, A., & Beech, D. J. (2008). TRPC channel activation by extracellular thioredoxin. Nature, 451(7174), 69-72. https://doi.org/10.1038/nature06414

Mammalian homologues of Drosophila melanogaster transient receptor potential (TRP) are a large family of multimeric cation channels that act, or putatively act, as sensors of one or more chemical factor. Major research objectives are the identificati... Read More about TRPC channel activation by extracellular thioredoxin.

Development of a microfluidic device for the maintenance and interrogation of viable tissue biopsies (2008)
Journal Article
Dyer, C. E., Greenman, J., Haswell, S. J., & Hattersley, S. M. (2008). Development of a microfluidic device for the maintenance and interrogation of viable tissue biopsies. Lab on a chip, 8(11), 1842-1846. https://doi.org/10.1039/b809345h

A microfluidic based experimental methodology has been developed that offers a biomimetic microenvironment in which pseudo in vivo tissue studies can be carried out under in vitro conditions. Using this innovative technique, which utilizes the inhere... Read More about Development of a microfluidic device for the maintenance and interrogation of viable tissue biopsies.

The collagen receptor Endo180 (CD280) is expressed on basal-like breast tumor cells and promotes tumor growth in vivo (2007)
Journal Article
Wienke, D., Davies, G. C., Johnson, D. A., Sturge, J., Lambros, M. B., Savage, K., Elsheikh, S. E., Green, A. R., Ellis, I. O., Robertson, D., Reis-Filho, J. S., & Isacke, C. M. (2007). The collagen receptor Endo180 (CD280) is expressed on basal-like breast tumor cells and promotes tumor growth in vivo. Cancer Research, 67(21), 10230-10240. https://doi.org/10.1158/0008-5472.CAN-06-3496

Tumor cell invasion into the surrounding stroma requires increased cell motility and extensive remodeling of the extracellular matrix. Endo180 (CD280, MRC2, urokinase-type plasminogen activator receptor-associated protein) is a recycling endocytic re... Read More about The collagen receptor Endo180 (CD280) is expressed on basal-like breast tumor cells and promotes tumor growth in vivo.

The design and synthesis of pyrazine amide ligands suitable for the "tiles" approach to molecular weaving with octahedral metal ions (2007)
Journal Article
Cockriel, D. L., McClain, J. M., Patel, K. C., Ullom, R., Hasley, T. R., Archibald, S. J., & Hubin, T. J. (2008). The design and synthesis of pyrazine amide ligands suitable for the "tiles" approach to molecular weaving with octahedral metal ions. Inorganic Chemistry Communications, 11(1), 1-4. https://doi.org/10.1016/j.inoche.2007.10.006

The pyrazine-containing ligands 1 (pyrazine-2-carboxylic acid (pyridine-2-ylmethyl)-amide) and 2 (pyrazine-2,5-dicarboxylic acid bis[(pyridine-2-yimethyl)-amide]) have been synthesized and characterized in order to probe their ability to form polynuc... Read More about The design and synthesis of pyrazine amide ligands suitable for the "tiles" approach to molecular weaving with octahedral metal ions.

The influence of exogenous tissue factor on the regulators of proliferation and apoptosis in endothelial cells (2007)
Journal Article
Pradier, A., & Ettelaie, C. (2007). The influence of exogenous tissue factor on the regulators of proliferation and apoptosis in endothelial cells. Journal of vascular research, 45(1), 19-32. https://doi.org/10.1159/000109074

Background: The exposure of tissue factor (TF) at the site of injury or trauma is a rapid process that leads to the initiation of blood coagulation as well as homeostatic processes giving rise to vascular repair. Aims and Methods: By exposing human e... Read More about The influence of exogenous tissue factor on the regulators of proliferation and apoptosis in endothelial cells.