Outputs (28)

Investigating oxygen transport efficiencies in precision-cut liver slice-based organ-on-a-chip devices (2021)
Journal Article
Christensen, M. G., Cawthorne, C., Dyer, C. E., Greenman, J., & Pamme, N. (2021). Investigating oxygen transport efficiencies in precision-cut liver slice-based organ-on-a-chip devices. Microfluidics and Nanofluidics, 25(4), Article 35. https://doi.org/10.1007/s10404-021-02434-x

Microfluidic ‘organ-on-a-chip’ devices hold great potential for better mimicking the continuous flow microenvironment experienced by tissue and cells in vivo, thereby ensuring realistic transport of nutrients and elimination of waste products. Howeve... Read More about Investigating oxygen transport efficiencies in precision-cut liver slice-based organ-on-a-chip devices.

PI3K inhibition as a novel therapeutic strategy for neoadjuvant chemoradiotherapy resistant oesophageal adenocarcinoma (2021)
Journal Article
Edge, S. D., Renard, I., Pyne, E., Li, C., Moody, H., Roy, R., Beavis, A. W., Archibald, S. J., Cawthorne, C. J., Maher, S. J., & Pires, I. M. (2021). PI3K inhibition as a novel therapeutic strategy for neoadjuvant chemoradiotherapy resistant oesophageal adenocarcinoma. British Journal of Radiology, 94(1119), Article 20201191. https://doi.org/10.1259/bjr.20201191

OBJECTIVE: Neoadjuvant chemoradiotherapy (neo-CRT) prior to surgery is the standard of care for oesophageal adenocarcinoma (OAC) patients. Unfortunately, most patients fail to respond to treatment. MiR-187 was previously shown to be downregulated in... Read More about PI3K inhibition as a novel therapeutic strategy for neoadjuvant chemoradiotherapy resistant oesophageal adenocarcinoma.

Towards dual SPECT/optical bioimaging with a mitochondrial targeting, 99mTc(i) radiolabelled 1,8-naphthalimide conjugate (2020)
Journal Article
Day, A. H., Domarkas, J., Nigam, S., Renard, I., Cawthorne, C., Burke, B. P., Bahra, G. S., Oyston, P. C. F., Fallis, I. A., Archibald, S. J., & Pope, S. J. A. (in press). Towards dual SPECT/optical bioimaging with a mitochondrial targeting, 99mTc(i) radiolabelled 1,8-naphthalimide conjugate. Dalton Transactions : an international journal of inorganic chemistry, 49(2), 511-523. https://doi.org/10.1039/c9dt04024b

A series of six different 1,8-naphthalimide conjugated dipicolylamine ligands (L1-6) have been synthesised and characterised. The ligands possess a range of different linker units between the napthalimide fluorophore and dipcolylamine chelator which... Read More about Towards dual SPECT/optical bioimaging with a mitochondrial targeting, 99mTc(i) radiolabelled 1,8-naphthalimide conjugate.

Use of non-Gaussian time-of-flight kernels for image reconstruction of Monte Carlo simulated data of ultra-fast PET scanners (2020)
Journal Article
Efthimiou, N., Thielemans, K., Emond, E., Cawthorne, C., Archibald, S. J., & Tsoumpas, C. (in press). Use of non-Gaussian time-of-flight kernels for image reconstruction of Monte Carlo simulated data of ultra-fast PET scanners. EJNMMI Physics, 7(1), Article 42. https://doi.org/10.1186/s40658-020-00309-8

Introduction: Time-of-flight (TOF) positron emission tomography (PET) scanners can provide significant benefits by improving the noise properties of reconstructed images. In order to achieve this, the timing response of the scanner needs to be modell... Read More about Use of non-Gaussian time-of-flight kernels for image reconstruction of Monte Carlo simulated data of ultra-fast PET scanners.

Validation of in-house knowledge-based planning model for advance-stage lung cancer patients treated using VMAT radiotherapy (2020)
Journal Article
Tambe, N., Pires, I. M., Moore, C., Cawthorne, C., & Beavis, A. (2020). Validation of in-house knowledge-based planning model for advance-stage lung cancer patients treated using VMAT radiotherapy. British Journal of Radiology, 93(1106), https://doi.org/10.1259/bjr.20190535

Objectives: Radiotherapy plan quality may vary considerably depending on planner's experience and time constraints. The variability in treatment plans can be assessed by calculating the difference between achieved and the optimal dose distribution. T... Read More about Validation of in-house knowledge-based planning model for advance-stage lung cancer patients treated using VMAT radiotherapy.

Development of an anatomically correct mouse phantom for dosimetry measurement in small animal radiotherapy research (2019)
Journal Article
Soultanidis, G., Subiel, A., Renard, I., Reinhart, A. M., Green, V. L., Oelfke, U., Archibald, S. J., Greenman, J., Tulk, A., Walker, A., Schettino, G., & Cawthorne, C. J. (2019). Development of an anatomically correct mouse phantom for dosimetry measurement in small animal radiotherapy research. Physics in Medicine and Biology, 64(12), Article 12NT02. https://doi.org/10.1088/1361-6560/ab215b

Significant improvements in radiotherapy are likely to come from biological rather than technical optimization, for example increasing tumour radiosensitivity via combination with targeted therapies. Such paradigms must first be evaluated in preclini... Read More about Development of an anatomically correct mouse phantom for dosimetry measurement in small animal radiotherapy research.

64Cu PET Imaging of the CXCR4 Chemokine Receptor Using a Cross-Bridged Cyclam Bis-Tetraazamacrocyclic Antagonist (2019)
Journal Article
Burke, B. P., Miranda, C., Lee, R., Renard, I., Nigam, S., Clemente, G., D'Huys, T., Ruest, T., Domarkas, J., Thompson, J., Hubin, T., Schols, D., Cawthorne, C., & Archibald, S. J. (2020). 64Cu PET Imaging of the CXCR4 Chemokine Receptor Using a Cross-Bridged Cyclam Bis-Tetraazamacrocyclic Antagonist. Journal of nuclear medicine, 61(1), 123-128. https://doi.org/10.2967/jnumed.118.218008

© 2020 by the Society of Nuclear Medicine and Molecular Imaging. Expression of the chemokine receptor chemokine C-X-C motif receptor 4 (CXCR4) plays an important role in cancer metastasis, in autoimmune diseases, and during stem cell-based repair pro... Read More about 64Cu PET Imaging of the CXCR4 Chemokine Receptor Using a Cross-Bridged Cyclam Bis-Tetraazamacrocyclic Antagonist.

Evaluation of new PET tracers for receptor tumour imaging (2018)
Thesis
Miranda, C. Evaluation of new PET tracers for receptor tumour imaging. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4193339

PET imaging can be used to non-invasively characterise biological processes at the molecular and cellular levels. The oestrogen receptor (ER) and progesterone receptor (PR) are important biomarkers in the diagnosis, prognosis and follow-up of the the... Read More about Evaluation of new PET tracers for receptor tumour imaging.

Visualizing kinetically robust CoIII4L6 assemblies in Vivo: SPECT imaging of the encapsulated [99mTc]TcO4- Anion (2018)
Journal Article
Burke, B. P., Grantham, W., Burke, M. J., Nichol, G. S., Roberts, D., Renard, I., Hargreaves, R., Cawthorne, C., Archibald, S. J., & Lusby, P. J. (2018). Visualizing kinetically robust CoIII4L6 assemblies in Vivo: SPECT imaging of the encapsulated [99mTc]TcO4- Anion. Journal of the American Chemical Society, 140(49), 16877-16881. https://doi.org/10.1021/jacs.8b09582

© 2018 American Chemical Society. Noncovalent encapsulation is an attractive approach for modifying the efficacy and physiochemical properties of both therapeutic and diagnostic species. Abiotic self-assembled constructs have shown promise, yet many... Read More about Visualizing kinetically robust CoIII4L6 assemblies in Vivo: SPECT imaging of the encapsulated [99mTc]TcO4- Anion.

Characterisation of targeted imaging and theranostic agents for cancer and fibrosis (2018)
Thesis
Thompson, J. A. Characterisation of targeted imaging and theranostic agents for cancer and fibrosis. (Thesis). Hull York Medical School, the University of Hull and the University of York. https://hull-repository.worktribe.com/output/4221539

Positron emission tomography (PET) imaging is a non-invasive modality that permits the characterisation of biological processes at the molecular level. Integrin αvβ6 and the chemokine receptor CXCR4 are important receptors in the pathogenesis of vari... Read More about Characterisation of targeted imaging and theranostic agents for cancer and fibrosis.