Projects (156)

Dissecting the role of neuropeptide CGRP in human lymphatic endothelial cells Jun 10, 2019 - Aug 2, 2019
Calcitonin receptor-like receptor (CLR) is a key G-protein-coupled receptor (GPCR) that mediates the signalling of three peptides - adrenomedullin (AM), calcitonin gene-related peptide (CGRP; neuropeptide) and intermedin (IMD/AM-2). Animal models rev... Read More about Dissecting the role of neuropeptide CGRP in human lymphatic endothelial cells.

The characterisation of G-protein coupled receptor CLR in human endothelial cells Jun 10, 2019 - Aug 2, 2019
Calcitonin receptor-like receptor (CLR) is a key G-protein-coupled receptor (GPCR) mediating the effects of three peptide agonists - adrenomedullin (AM), calcitonin gene-related peptide (CGRP) and intermedin (IMD/AM-2) in ectopic expression studies.... Read More about The characterisation of G-protein coupled receptor CLR in human endothelial cells.

THYME: Machine learning and metabolic modelling of key bacteria growing in biofilm mode in the human gut Aug 1, 2019 - May 31, 2021
The commensal bacteria of the human intestine have been found to significantly affect human health. They produce Vitamins B and K, important amino acids and essential enzymes for carbohydrate fermentation that help improving digestion. In addition, t... Read More about THYME: Machine learning and metabolic modelling of key bacteria growing in biofilm mode in the human gut.

Impact of CO2 on antigen expression: new ways to induce immune responses against cancer?’ Jul 1, 2019 - Jun 30, 2020
Summer studentship to investigate the impact of CO2 levels on antigens expression in cancer. The study uses state-of-the-art 3D models to replace whole organism studies of hypoxia.

Development of fully humanised ex vivo human skin wound and infection model Jul 1, 2019 - Sep 2, 2019
Summer Studentship Project 2019

Monitoring the secretome of advanced thyroid cancers for metastatic markers May 20, 2019 - Sep 18, 2019
Aim
To identify potential biomarkers of thyroid cancer aggressiveness and metastasis.

Background
Despite differentiated thyroid cancer (DTC) typically presenting as a localised and highly treatable disease with an excellent 10-year survival rate... Read More about Monitoring the secretome of advanced thyroid cancers for metastatic markers.

Maternal Health and Reproductive Success (MHaRS) Forum Sep 1, 2019 - Aug 31, 2021
We want to establish a PPI to collaborate in the next phase of our research which seeks to understand the extent to which a wide range of maternal health factors affect reproductive outcomes. Our aim is to recruit patients locally from the Hull IVF... Read More about Maternal Health and Reproductive Success (MHaRS) Forum.

Development of point-of-care and wearable sensors for Hepatitis C diagnostics Sep 1, 2020 - Aug 31, 2023
PhD studentship application for full PhD studentship as part of Netwon Mosharafa Fund, allows for £25k per annum for registration and bench fees.

Global analysis of molecular changes in head and neck squamous cell carcinoma (HNSCC) tissue maintained and treated on microfluidic devices Feb 1, 2020 - Sep 30, 2021
We have developed a microfluidic platform in which small pieces of human tissue from tumours are maintained in an in vivo-like state. These laboratory-maintained samples appear to respond to treatment in the same way as patients do clinically, but th... Read More about Global analysis of molecular changes in head and neck squamous cell carcinoma (HNSCC) tissue maintained and treated on microfluidic devices.

CXCR7/CXCR4 dual receptor cancer theranostics with copper 64 PET imaging Jul 1, 2020 - Jun 30, 2022
Pleural malignant mesothelioma (PMM) has one of the poorest survival rates of any cancer. We propose a new approach using the latest theranostic technologies that are driving the clinical radiopharmaceutical market and exploiting a new biological tar... Read More about CXCR7/CXCR4 dual receptor cancer theranostics with copper 64 PET imaging.

SOCS VASC - Stabilising suppressor of cytokine signalling 3 (SOCS3) to limit vascular re-modelling in vein graft failure and in-stent restenosis Dec 1, 2019 - May 31, 2022

Essential equipment: The biochemistry of the human embryo Nov 10, 2019 - Nov 30, 2020
The Hull IVF Unit and Hull York Medical School work together closely to conduct research on human embryos in accordance with a HFEA Research licence. Together we have established good evidence of a link between prenatal obesity, especially in the mo... Read More about Essential equipment: The biochemistry of the human embryo.

B-More: A 24-month prospective, non-interventional, international, multicentre study to describe the real-world effectiveness and usage of Alprolix in patients with haemophilia B in selected European and Middle Eastern countries Sep 1, 2019 - Dec 31, 2022
A phase IV multicentre, international study investigating the real-world efficacy of Alprolix, an extended half-life factor IX concentrate, in the management of haemophilia B.

Development of an in-vitro model for Parkinson's disease Jan 1, 2020 - Dec 31, 2021
Parkinson’s disease affects 6.1 million people globally. The number of cases has more than doubled in the last 15 years and this cannot fully be attributed to an increase in life expectancy. The social and economic costs are in excess of £3 billion a... Read More about Development of an in-vitro model for Parkinson's disease.

Establishing the sperm and seminal plasma specific mechanisms of paternal programming Jan 1, 2022 - Dec 31, 2024

Development of novel acyclic chelates for gallium-68 and scandium-44 radiometals used in PET Jun 14, 2021 - Jun 13, 2024
This proposal sets out to design, synthesize and validate the next generation of chelators for radiometals that are utilised in positron emission tomography. The radiometals; gallium-68 and scandium-44 that are produced on generators the size of a be... Read More about Development of novel acyclic chelates for gallium-68 and scandium-44 radiometals used in PET.

THYME: Summer Internship Jun 15, 2020 - Sep 15, 2020
The students will carry out a computer-based project that will focus on the metabolism of the probiotic bacterium Lactobacillus reuterii and the proteins that affect attachment to surfaces and colonisation. This work will help us to better understand... Read More about THYME: Summer Internship.

Targeting ADAM10 as a novel strategy for radiotherapy enhancement in hypoxic colorectal cancer Sep 19, 2021 - Aug 18, 2024
Radiotherapy remains one of the most effective non-invasive treatments for solid cancers, including bowel cancer. However, specific aspects of the biology of tumours, particularly the presence of low oxygen regions, remain a key limitation for its su... Read More about Targeting ADAM10 as a novel strategy for radiotherapy enhancement in hypoxic colorectal cancer.

The Biomarker Driven Antifungal Stewardship in AML: The BioDriveAFS Trial Sep 1, 2021 - Feb 28, 2026
NIHR commisioned bid for Antifungal Stewardship in Haemato-oncology.

https://www.nihr.ac.uk/documents/2026-antifungal-stewardship-in-haemato-oncology/24460

Safe and efficient adaptive radiotherapy through evidential machine learning Sep 1, 2020 - Aug 31, 2023