Centre for Biomedicine

A single arm, open-label exploratory clinical trial of azithromycin in pulmonary sarcoidosis Mar 1, 2019 - Sep 30, 2020
Patients with sarcoidosis need treatment options that improve their disease without causing unacceptable side effects. Currently, steroids tablets are offered for severe sarcoidosis, but side effects can be dangerous and personally distressing, and s... Read More about A single arm, open-label exploratory clinical trial of azithromycin in pulmonary sarcoidosis.

Is zinc a critical modulator of cyclic nucleotide signalling? Oct 1, 2019 - Dec 31, 2022
inc (Zn2+) deficiency is present in multiple conditions from obesity to cancer. However importantly Zn2+ deficiency can lead to a bleeding phenotype.In this proposal we investigate how Zn2+ is important for the control of platelet cyclic nucleotide... Read More about Is zinc a critical modulator of cyclic nucleotide signalling?.

Development of an immune-responsive 3D skin model May 1, 2019 - Jul 31, 2019
The immune system is an essential regulator of normal physiologic and wound repair processes within the skin, and it contributes to the progression of many different skin diseases. The nature of the interactions between circulating immune cells and r... Read More about Development of an immune-responsive 3D skin model.

Novel dual CXCR4/CXCR7 receptor drugs: targeting secondary disease progression and resistance to immunotherapy in breast cancer Aug 1, 2019 - Jul 31, 2023
CXCR4/CXCR7-CXCL12 chemokine axis plays a pivotal role in breast cancer (BC) growth, survival, therapy evasion and metastasis. Clinically overexpression of CXCR4/CXCR7-CXCL12 correlates with aggressive BC disease and poor outcome. Evidence suggests c... Read More about Novel dual CXCR4/CXCR7 receptor drugs: targeting secondary disease progression and resistance to immunotherapy in breast cancer.

Utilising tissue-on-a-chip technology as an ex vivo model of breast cancer metastatic colonisation Jul 1, 2019 - Mar 31, 2021
Breast cancer kills over 11,000 women each year in the UK. Virtually all of these women die because their breast cancer cells travel to other organs within the body such as the liver, lungs, bones and brain, where they grow into new tumours and stop... Read More about Utilising tissue-on-a-chip technology as an ex vivo model of breast cancer metastatic colonisation.

Dissecting the role of neuropeptide CGRP in human lymphatic endothelial cells Jun 10, 2019 - Aug 2, 2019
Calcitonin receptor-like receptor (CLR) is a key G-protein-coupled receptor (GPCR) that mediates the signalling of three peptides - adrenomedullin (AM), calcitonin gene-related peptide (CGRP; neuropeptide) and intermedin (IMD/AM-2). Animal models rev... Read More about Dissecting the role of neuropeptide CGRP in human lymphatic endothelial cells.

The characterisation of G-protein coupled receptor CLR in human endothelial cells Jun 10, 2019 - Aug 2, 2019
Calcitonin receptor-like receptor (CLR) is a key G-protein-coupled receptor (GPCR) mediating the effects of three peptide agonists - adrenomedullin (AM), calcitonin gene-related peptide (CGRP) and intermedin (IMD/AM-2) in ectopic expression studies.... Read More about The characterisation of G-protein coupled receptor CLR in human endothelial cells.

THYME: Machine learning and metabolic modelling of key bacteria growing in biofilm mode in the human gut Aug 1, 2019 - May 31, 2021
The commensal bacteria of the human intestine have been found to significantly affect human health. They produce Vitamins B and K, important amino acids and essential enzymes for carbohydrate fermentation that help improving digestion. In addition, t... Read More about THYME: Machine learning and metabolic modelling of key bacteria growing in biofilm mode in the human gut.

Impact of CO2 on antigen expression: new ways to induce immune responses against cancer?’ Jul 1, 2019 - Jun 30, 2020
Summer studentship to investigate the impact of CO2 levels on antigens expression in cancer. The study uses state-of-the-art 3D models to replace whole organism studies of hypoxia.

Monitoring the secretome of advanced thyroid cancers for metastatic markers May 20, 2019 - Sep 18, 2019
Aim
To identify potential biomarkers of thyroid cancer aggressiveness and metastasis.

Background
Despite differentiated thyroid cancer (DTC) typically presenting as a localised and highly treatable disease with an excellent 10-year survival rate... Read More about Monitoring the secretome of advanced thyroid cancers for metastatic markers.

Maternal Health and Reproductive Success (MHaRS) Forum Sep 1, 2019 - Aug 31, 2021
We want to establish a PPI to collaborate in the next phase of our research which seeks to understand the extent to which a wide range of maternal health factors affect reproductive outcomes. Our aim is to recruit patients locally from the Hull IVF... Read More about Maternal Health and Reproductive Success (MHaRS) Forum.

Development of point-of-care and wearable sensors for Hepatitis C diagnostics Sep 1, 2020 - Aug 31, 2023
PhD studentship application for full PhD studentship as part of Netwon Mosharafa Fund, allows for £25k per annum for registration and bench fees.

CXCR7/CXCR4 dual receptor cancer theranostics with copper 64 PET imaging Jul 1, 2020 - Jun 30, 2022
Pleural malignant mesothelioma (PMM) has one of the poorest survival rates of any cancer. We propose a new approach using the latest theranostic technologies that are driving the clinical radiopharmaceutical market and exploiting a new biological tar... Read More about CXCR7/CXCR4 dual receptor cancer theranostics with copper 64 PET imaging.

Essential equipment: The biochemistry of the human embryo Nov 10, 2019 - Nov 30, 2020
The Hull IVF Unit and Hull York Medical School work together closely to conduct research on human embryos in accordance with a HFEA Research licence. Together we have established good evidence of a link between prenatal obesity, especially in the mo... Read More about Essential equipment: The biochemistry of the human embryo.

Projects (160)