Centre for Biomedicine

Development of a cell line that represents early stage ovarian cancer Jan 1, 2022 - Jun 30, 2023
We want to develop an early stage model of OC and determine whether SSX2 is a driver for this disease. To do this we wish to purchase fallopian tube cells that have been immortalised. This process of acquiring fallopian tube cells, immortalising them... Read More about Development of a cell line that represents early stage ovarian cancer.

HPLC purification of GMP PET radiopharmaceuticals in the Molecular Imaging Research Centre (MIRC) Mar 1, 2022 - Feb 28, 2023
Nuclear medicine is a clinical discipline where the unique properties of ionising radiation are harnessed to diagnose and treat diseases like cancer. Positron Emission Tomography (PET) is a medical scan used in nuclear medicine, where a radioactive m... Read More about HPLC purification of GMP PET radiopharmaceuticals in the Molecular Imaging Research Centre (MIRC).

Identification of biomarkers for the earlier detection and targets for the immunotherapy of endometriosis Jan 1, 2022 - Dec 31, 2023
The wait for a diagnosis of endometriosis in the UK has not reduced in a decade. The causes are multifactorial with the non-specific nature of symptoms, waiting lists and the need for invasive laparoscopy contributing to the average 8-year delay to... Read More about Identification of biomarkers for the earlier detection and targets for the immunotherapy of endometriosis.

Identification of exosomal miRNA biomarkers in thyroid disease using microfluidics Sep 1, 2021 - Aug 31, 2022
Invasive tissue biopsies remain the gold standard for diagnosis of diseases within solid tissues. However, for some diseases, accessibility of the tissue prevents a diagnostic biopsy and for those that are sampled, the biopsy only takes a small frac... Read More about Identification of exosomal miRNA biomarkers in thyroid disease using microfluidics.

Identification of exosomal miRNA biomarkers in thyroid disease using microfluidics Jan 3, 2022 - Aug 31, 2023
Invasive tissue biopsies remain the gold standard for diagnosis of diseases within solid tissues. However, for some diseases, accessibility of the tissue prevents a diagnostic biopsy and for those that are sampled, the biopsy only takes a small frac... Read More about Identification of exosomal miRNA biomarkers in thyroid disease using microfluidics.

Effect of preservative on urine analysis Dec 1, 2021 - Nov 30, 2022
I have asked Novosanis whether they would provide consumables money to a MSc by Research students for a project we have discussed this morning (15.10.21). Novosanis want to see the effects of preservatives they are developing on urine samples from pa... Read More about Effect of preservative on urine analysis.

The epigenetic regulatory protein CBX2 as a novel therapeutic target for glioblastoma multiform Sep 19, 2022 - Sep 18, 2025
PhD Studentship:

Glioblastoma (GBM) is the deadliest form of brain tumour, affecting 2-3 per 100,000 people each year. The average length of survival for GBM remain low at only 12-15 months following diagnosis, in part, due to a lack of targeted t... Read More about The epigenetic regulatory protein CBX2 as a novel therapeutic target for glioblastoma multiform.

Updating (Reviewing and Printing) the Patient's Guide to Pulmonary Fibrosis. Nov 1, 2022 - Oct 31, 2023
This is an annual follow up/annual review for the Project 3632727: Development And Publication Of The Booklet For The Pulmonary Fibrosis (disease With A Degree Of Similarity To Coronavirus Disease).

Chronic diseases associated with fibrosis pres... Read More about Updating (Reviewing and Printing) the Patient's Guide to Pulmonary Fibrosis..

Using novel endolysins to selectively target antimicrobial resistant S. aureus in chronic wound biofilms Jan 1, 2023 - Dec 31, 2026
This cutting-edge PhD project will bring together a world-leading team spanning industry and academia, providing an interdisciplinary framework to explore the selectivity and efficacy of endolysin against clinically meaningful S. aureus wound biofilm... Read More about Using novel endolysins to selectively target antimicrobial resistant S. aureus in chronic wound biofilms.

Identification of targets for the therapy of epithelial ovarian cancer Mar 1, 2022 - Feb 28, 2023
Finding provided by the INSPIRE grant generously awarded to the Hull York Medical School by the Academy of Medical Sciences through the Wellcome Trust [Ref: IR5\1018]

Effect of hypoxia on prostacyclin-mediated inhibition of platelet function Jan 1, 2023 - Dec 31, 2025
Tissue hypoxia occurs in multiple cardiovascular and pulmonary conditions that have platelet activation or hyperreactivity, including myocardial infarction, stroke, chronic obstructive pulmonary disease (COPD) and sleep apnoea. However, knowledge on... Read More about Effect of hypoxia on prostacyclin-mediated inhibition of platelet function.

Quantitative proteomic analysis of pancreatic cyst fluid for early detection of cancer using University of Hull HPC Viper Apr 1, 2022 - Feb 28, 2023
The timely diagnosis of pancreatic ductal adenocarcinoma (PDAC) is challenging due to a lack of disease-specific symptoms, resulting in the majority of patients presenting with advanced disease and poor prognosis. Detection of PDAC, ideally at a prem... Read More about Quantitative proteomic analysis of pancreatic cyst fluid for early detection of cancer using University of Hull HPC Viper.

Projects (156)