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An electrodeposited Au nanoparticle/porous graphene nanoribbon composite for electrochemical detection of alpha-fetoprotein

Jothi, Lavanya; Jaganathan, Saravana Kumar; Nageswaran, Gomathi


Lavanya Jothi

Saravana Kumar Jaganathan

Gomathi Nageswaran


In this work, a novel label-free electrochemical immunosensor for the detection of alpha-fetoprotein (AFP) is fabricated for early diagnosis and prognostics of liver cancer. A porous graphene nanoribbon (PGNR) was synthesized via chemical reduction method and it was electrodeposited with gold nanoparticles (AuNPs) to obtain AuNPs/PGNR hybrid nanomaterial. Anti-AFP was immobilized onto AuNPs/PGNR/glassy carbon electrode and anti-AFP/AuNPs/PGNR/GCE was further studied to demonstrate its electrocatalytic activity towards AFP antigen. PGNR enhances the electroactive surface area and the electron transfer ability between the electrode and redox probe while the AuNPs deposited on PGNR are used to immobilize biomolecules and to facilitate the electron transport. The superior biosensing performance towards AFP under physiological pH condition is demonstrated by a corresponding decreased peak current in differential pulse voltammetry for a wide linear range (5–60 ng/mL) with a low detection limit of 1 ng/mL. Detection of AFP in serum samples by this label-free electrochemical immunosensor without fouling or significant interference implies that the anti-AFP/AuNPs/PGNR modified GCE has a great application potential for clinical diagnosis of AFP.


Jothi, L., Jaganathan, S. K., & Nageswaran, G. (2020). An electrodeposited Au nanoparticle/porous graphene nanoribbon composite for electrochemical detection of alpha-fetoprotein. Materials Chemistry and Physics, 242, Article 122514.

Journal Article Type Article
Acceptance Date Nov 30, 2019
Online Publication Date Dec 2, 2019
Publication Date Feb 15, 2020
Deposit Date Feb 24, 2020
Publicly Available Date Dec 3, 2020
Journal Materials Chemistry and Physics
Print ISSN 0254-0584
Electronic ISSN 0254-0584
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 242
Article Number 122514
Keywords Porous graphene nanoribbons; Gold nanoparticles; Alpha fetoprotein; Differential pulse voltammetry
Public URL
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