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Synthesis, structures and cytotoxicity studies of p-sulfonatocalix[4]arene lanthanide complexes

Miller-Shakesby, David M.; Burke, Benjamin P.; Nigam, Shubhanchi; Stasiuk, Graeme J.; Prior, Timothy J.; Archibald, Stephen J.; Redshaw, Carl


David M. Miller-Shakesby

Benjamin P. Burke

Shubhanchi Nigam

Graeme J. Stasiuk

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Dr Tim Prior
Senior Lecturer in Inorganic Chemistry

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Professor Carl Redshaw
Professor of Inorganic Materials Chemistry and REF Lead for Chemistry


A number of p-sulfonatocalix[4]arene complexes of the lanthanides (Tb, Gd, and Eu) have been prepared, some in the presence of tetraazamacrocycle 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (DO3A), and fully characterised. Crystal structure determinations reveal lanthanide coordination at the sulfonate group, bridging several calixarene units, giving coordination polymers. All complexes in this study have been determined to be relatively non-toxic using in vitro cell assays with CC₅₀ values in the range 30–170 μM.


Miller-Shakesby, D. M., Burke, B. P., Nigam, S., Stasiuk, G. J., Prior, T. J., Archibald, S. J., & Redshaw, C. (2016). Synthesis, structures and cytotoxicity studies of p-sulfonatocalix[4]arene lanthanide complexes. CrystEngComm RSC, 18(26), 4977-4987.

Journal Article Type Article
Acceptance Date Mar 11, 2016
Publication Date Mar 16, 2016
Deposit Date Mar 29, 2016
Publicly Available Date Mar 29, 2016
Journal CrystEngComm
Print ISSN 1466-8033
Electronic ISSN 1466-8033
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 18
Issue 26
Pages 4977-4987
Keywords p-sulfonatocalix[4]arene lanthanide complexes
Public URL
Publisher URL!divAbstract
Additional Information : This document is CrossCheck deposited; : Supplementary Information; : Crystal Structure Data; : The Royal Society of Chemistry has an exclusive publication licence for this journal; : Received 26 January 2016; Accepted 11 March 2016; Accepted Manuscript published 16 March 2016; Advance Article published 29 March 2016; Version of Record published 28 June 2016


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