Synthesis, structures and cytotoxicity studies of p-sulfonatocalix[4]arene lanthanide complexes

Miller-Shakesby, David M.; Burke, Benjamin P.; Nigam, Shubhanchi; Stasiuk, Graeme J.; Prior, Timothy J.; Archibald, Stephen J.; Redshaw, Carl

Abstract

A number of p-sulfonatocalix[4]arene complexes of the lanthanides (Tb, Gd, and Eu) have been prepared, some in the presence of tetraazamacrocycle 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (DO3A), and fully characterised. Crystal structure determinations reveal lanthanide coordination at the sulfonate group, bridging several calixarene units, giving coordination polymers. All complexes in this study have been determined to be relatively non-toxic using in vitro cell assays with CC₅₀ values in the range 30–170 μM.

Citation

Miller-Shakesby, D. M., Burke, B. P., Nigam, S., Stasiuk, G. J., Prior, T. J., Archibald, S. J., & Redshaw, C. (2016). Synthesis, structures and cytotoxicity studies of p-sulfonatocalix[4]arene lanthanide complexes. CrystEngComm RSC, 18(26), 4977-4987. https://doi.org/10.1039/c6ce00209a

• Journal Article Type: Article
• Acceptance Date: Mar 11, 2016
• Publication Date: Mar 16, 2016
• Deposit Date: Mar 29, 2016
• Publicly Available Date: Mar 29, 2016
• Journal: CrystEngComm
• Print ISSN: 1466-8033
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 18
• Issue: 26
• Pages: 4977-4987
• DOI: https://doi.org/10.1039/c6ce00209a
• Keywords: p-sulfonatocalix[4]arene lanthanide complexes
• Public URL: https://hull-repository.worktribe.com/output/434200
• Publisher URL: http://pubs.rsc.org/en/Content/ArticleLanding/2016/CE/C6CE00209A#!divAbstract
• Additional Information: : This document is CrossCheck deposited; : Supplementary Information; : Crystal Structure Data; : The Royal Society of Chemistry has an exclusive publication licence for this journal; : Received 26 January 2016; Accepted 11 March 2016; Accepted Manuscript published 16 March 2016; Advance Article published 29 March 2016; Version of Record published 28 June 2016
• Contract Date: Mar 29, 2016