Positron detection in silica monoliths for miniaturised quality control of PET radiotracers

Tarn, Mark D.; Maneuski, Dzmitry; Alexander, Richard; Brown, Nathaniel J.; O’Shea, Val; Pimlott, Sally L.; Pamme, Nicole; Archibald, Stephen J.

Abstract

We demonstrate the use of the miniaturised Medipix positron sensor for detection of the clinical PET radiotracer, [⁶⁸Ga]gallium-citrate, on a silica-based monolith, towards microfluidic quality control. The system achieved a far superior signal-to-noise ratio compared to conventional sodium iodide-based radio-HPLC detection and allowed real-time visualisation of positrons in the monolith.

Citation

Tarn, M. D., Maneuski, D., Alexander, R., Brown, N. J., O’Shea, V., Pimlott, S. L., Pamme, N., & Archibald, S. J. (2016). Positron detection in silica monoliths for miniaturised quality control of PET radiotracers. Chemical communications : Chem comm / the Royal Society of Chemistry, 52(45), 7221-7224. https://doi.org/10.1039/c6cc00660d

• Journal Article Type: Article
• Acceptance Date: Mar 16, 2016
• Online Publication Date: Mar 16, 2016
• Publication Date: 2016
• Deposit Date: Apr 11, 2016
• Publicly Available Date: Apr 11, 2016
• Journal: Chemical communications
• Print ISSN: 1359-7345
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 52
• Issue: 45
• Pages: 7221-7224
• DOI: https://doi.org/10.1039/c6cc00660d
• Keywords: PET radiotracers; Positron detection
• Public URL: https://hull-repository.worktribe.com/output/435529
• Publisher URL: http://pubs.rsc.org/en/content/articlelanding/2016/cc/c6cc00660d#!divAbstract
• Contract Date: Apr 11, 2016