Positron detection in silica monoliths for miniaturised quality control of PET radiotracers

Tarn, Mark D.; Maneuski, Dzmitry; Alexander, Richard; Brown, Nathaniel J.; O’Shea, Val; Pimlott, Sally L.; Pamme, Nicole; Archibald, Stephen J.

Abstract

We demonstrate the use of the miniaturised Medipix positron sensor for detection of the clinical PET radiotracer, [⁶⁸Ga]gallium-citrate, on a silica-based monolith, towards microfluidic quality control. The system achieved a far superior signal-to-noise ratio compared to conventional sodium iodide-based radio-HPLC detection and allowed real-time visualisation of positrons in the monolith.

Citation

Tarn, M. D., Maneuski, D., Alexander, R., Brown, N. J., O’Shea, V., Pimlott, S. L., …Archibald, S. J. (2016). Positron detection in silica monoliths for miniaturised quality control of PET radiotracers. Chemical communications : Chem comm / the Royal Society of Chemistry, 52(45), 7221-7224. https://doi.org/10.1039/c6cc00660d

• Journal Article Type: Article
• Acceptance Date: Mar 16, 2016
• Online Publication Date: Mar 16, 2016
• Publication Date: 2016
• Deposit Date: Apr 11, 2016
• Publicly Available Date: Apr 11, 2016
• Journal: Chemical communications
• Print ISSN: 1359-7345
• Electronic ISSN: 1364-548X
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 52
• Issue: 45
• Pages: 7221-7224
• DOI: https://doi.org/10.1039/c6cc00660d
• Keywords: PET radiotracers; Positron detection
• Public URL: https://hull-repository.worktribe.com/output/435529
• Publisher URL: http://pubs.rsc.org/en/content/articlelanding/2016/cc/c6cc00660d#!divAbstract