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Aspartame in conjunction with carbohydrate reduces insulin levels during endurance exercise

Siegler, Jason; Howell, Keith; Vince, Rebecca; Bray, James; Towlson, Chris; Peart, Daniel; Mellor, Duane; Atkin, Stephen


Jason Siegler

Keith Howell

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Dr James Bray
Lecturer in Sport Nutrition & Physiology

Daniel Peart

Duane Mellor

Stephen Atkin


Background: As most sport drinks contain some form of non-nutritive sweetener (e.g. aspartame), and with the variation in blood glucose regulation and insulin secretion reportedly associated with aspartame, a further understanding of the effects on insulin and blood glucose regulation during exercise is warranted. Therefore, the aim of this preliminary study was to profile the insulin and blood glucose responses in healthy individuals after aspartame and carbohydrate ingestion during rest and exercise.Findings: Each participant completed four trials under the same conditions (45 min rest + 60 min self-paced intense exercise) differing only in their fluid intake: 1) carbohydrate (2% maltodextrin and 5% sucrose (C)); 2) 0.04% aspartame with 2% maltodextrin and 5% sucrose (CA)); 3) water (W); and 4) aspartame (0.04% aspartame with 2% maltodextrin (A)). Insulin levels dropped significantly for CA versus C alone (43%) between pre-exercise and 30 min, while W and A insulin levels did not differ between these time points.Conclusions: Aspartame with carbohydrate significantly lowered insulin levels during exercise versus carbohydrate alone. © 2012 Siegler et al.; licensee BioMed Central Ltd.


Siegler, J., Howell, K., Vince, R., Bray, J., Towlson, C., Peart, D., …Atkin, S. (2012). Aspartame in conjunction with carbohydrate reduces insulin levels during endurance exercise. Journal of the International Society of Sports Nutrition, 9, Article 36.

Journal Article Type Article
Acceptance Date Jun 28, 2012
Online Publication Date Aug 1, 2012
Publication Date Aug 1, 2012
Deposit Date Oct 24, 2020
Publicly Available Date Jan 21, 2021
Journal Journal of the International Society of Sports Nutrition
Electronic ISSN 1550-2783
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 9
Article Number 36
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Published article (291 Kb)

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Copyright Statement
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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