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Uremic cardiomyopathy is characterised by loss of the cardioprotective effects of insulin (2012)
Journal Article
Seymour, A., Bhandari, S., & Semple, D. (2012). Uremic cardiomyopathy is characterised by loss of the cardioprotective effects of insulin. AJP - Renal Physiology, 303(9), (F1275-F1286). doi:10.1152/ajprenal.00048.2012. ISSN 1931-857X

Chronic kidney disease is associated with a unique cardiomyopathy, characterised by a combination of structural and cellular remodelling, and an enhanced susceptibility to ischaemia-reperfusion injury. This may represent dysfunction of the reperfusio... Read More

Uremic cardiomyopathy and insulin resistance: a critical role for Akt? (2010)
Journal Article
Smith, K., Semple, D., Bhandari, S., & Seymour, A. M. L. (2011). Uremic cardiomyopathy and insulin resistance: a critical role for Akt?. Journal of the American Society of Nephrology : JASN, 22(2), 207-215. doi:10.1681/ASN.2009090900

Uremic cardiomyopathy is a classic complication of chronic renal failure whose cause is unclear and treatment remains disappointing. Insulin resistance is an independent predictor of cardiovascular mortality in chronic renal failure. Underlying insul... Read More

Functional and metabolic adaptation in uraemic cardiomyopathy (2010)
Journal Article
Seymour, A., Aksentijević, D., Bhandari, S., Semple, D., & Smith, K. (2010). Functional and metabolic adaptation in uraemic cardiomyopathy. Frontiers in bioscience (Elite edition), E2(4), 1492-1501. doi:10.2741/e208

Cardiovascular complications are the leading cause of death in patients with chronic kidney disease (CKD). The uraemic heart undergoes substantial remodelling, including left ventricular hypertrophy (LVH), an important determinant of heart failure. L... Read More

Insulin resistance and altered glucose transporter 4 expression in experimental uremia (2009)
Journal Article
Seymour, A. M. L., Aksentijević, D., & Bhandari, S. (2009). Insulin resistance and altered glucose transporter 4 expression in experimental uremia. Kidney International, 75(7), (711-718). doi:10.1038/ki.2008.691. ISSN 0085-2538

Progressive ventricular hypertrophy can lead to the development of insulin resistance, a feature of both chronic kidney disease and heart failure. Here we induced uremia in adult male Sprague-Dawley rats using a remnant kidney model and studied the e... Read More

Western diet impairs metabolic remodelling and contractile efficiency in cardiac hypertrophy (2008)
Journal Article
Seymour, A. L., & Akki, A. (2009). Western diet impairs metabolic remodelling and contractile efficiency in cardiac hypertrophy. Cardiovascular research, 81(3), 610-617. doi:10.1093/cvr/cvn316

Metabolic remodelling in cardiac hypertrophy is underscored by a reduction in fatty acid (FA) oxidation. We tested whether this decline in FA oxidation in the presence of enhanced FA supply may predispose the hypertrophied myocardium to lipid accumul... Read More

Compensated cardiac hypertrophy is characterised by a decline in palmitate oxidation (2008)
Journal Article
Smith, K., Akki, A., & Seymour, A. M. L. (2008). Compensated cardiac hypertrophy is characterised by a decline in palmitate oxidation. Molecular and Cellular Biochemistry, 311(1-2), 215-224. doi:10.1007/s11010-008-9711-y

Cardiac hypertrophy is an independent risk factor in the development of heart failure. However, the cellular mechanisms underlying the transition from compensated hypertrophy to heart failure are incompletely understood. The aim of this study was to... Read More

Metabolic remodeling in the aging heart (2005)
Journal Article
Sample, J., Cleland, J. G. F., & Seymour, A. L. (2006). Metabolic remodeling in the aging heart. Journal of Molecular and Cellular Cardiology, 40(1), (56-63). doi:10.1016/j.yjmcc.2005.09.018. ISSN 0022-2828

The aim of this study was to investigate the effects of aging on the profile of myocardial substrate utilization and cardiac function using a physiological profile of substrates. Hearts from 6-, 15- and 24-month male Wistar rats were perfused in the... Read More

Semiquantitative analysis of collagen types in the hypertrophied left ventricle (2001)
Journal Article
Seymour, A. (2001). Semiquantitative analysis of collagen types in the hypertrophied left ventricle. Journal of anatomy, 198(1), (83 - 92). ISSN 0021-8782

Cardiac fibrosis is a characteristic feature of left ventricular hypertrophy. The aim of this study was to develop a simple and accurate method to analyse collagen accumulation, taking into account the variation in cardiac muscle fibre orientation an... Read More