All Outputs (23)

Bn2DT3A, a Chelator for 68Ga Positron Emission Tomography: Hydroxide Coordination Increases Biological Stability of [68Ga][Ga(Bn2DT3A)(OH)]− (2022)
Journal Article
Price, T. W., Renard, I., Prior, T. J., Kubíček, V., Benoit, D. M., Archibald, S. J., …Stasiuk, G. J. (2022). Bn2DT3A, a Chelator for 68Ga Positron Emission Tomography: Hydroxide Coordination Increases Biological Stability of [68Ga][Ga(Bn2DT3A)(OH)]−. Inorganic chemistry, 61(43), 17059–17067. https://doi.org/10.1021/acs.inorgchem.2c01992

The chelator Bn2DT3A was used to produce a novel 68Ga complex for positron emission tomography (PET). Unusually, this system is stabilized by a coordinated hydroxide in aqueous solutions above pH 5, which confers sufficient stability for it to be use... Read More about Bn2DT3A, a Chelator for 68Ga Positron Emission Tomography: Hydroxide Coordination Increases Biological Stability of [68Ga][Ga(Bn2DT3A)(OH)]−.

Measurement of Glutathione as a Tool for Oxidative Stress Studies by High Performance Liquid Chromatography (2020)
Journal Article
Nuhu, F., Gordon, A., Sturmey, R., Seymour, A. M., & Bhandari, S. (2020). Measurement of Glutathione as a Tool for Oxidative Stress Studies by High Performance Liquid Chromatography. Molecules, 25(18), Article 4196. https://doi.org/10.3390/molecules25184196

Background: Maintenance of the ratio of glutathione in the reduced (GSH) and oxidised (GSSG) state in cells is important in redox control, signal transduction and gene regulation, factors that are altered in many diseases. The accurate and reliable d... Read More about Measurement of Glutathione as a Tool for Oxidative Stress Studies by High Performance Liquid Chromatography.

Mitochondrial dysfunction in uraemic cardiomyopathy : Technetium 99m sestamibi washout as a novel marker of mitochondrial function (2018)
Thesis
Callan, P. (2018). Mitochondrial dysfunction in uraemic cardiomyopathy : Technetium 99m sestamibi washout as a novel marker of mitochondrial function. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4221517

Introduction
Cardiovascular disease is the most common cause of morbidity and mortality in patients with chronic kidney disease. Uraemic cardiomyopathy describes a classical phenotype of left ventricular hypertrophy, diastolic impairment, myocardial... Read More about Mitochondrial dysfunction in uraemic cardiomyopathy : Technetium 99m sestamibi washout as a novel marker of mitochondrial function.

Probing cardiac metabolism in uraemic cardiomyopathy (2017)
Thesis
Atkinson, R. (2017). Probing cardiac metabolism in uraemic cardiomyopathy. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4220698

Cardiovascular complications are the leading cause of death in patients with chronic kidney disease (CKD). Uraemic cardiomyopathy (UCM) is characterised by structural and cellular remodelling including left ventricular hypertrophy (LVH), metabolic re... Read More about Probing cardiac metabolism in uraemic cardiomyopathy.

Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells (2016)
Journal Article
Nigam, S., Burke, B. P., Davies, L. H., Domarkas, J., Wallis, J. F., Waddell, P. G., Waby, J. S., Benoit, D. M., Seymour, A. M., Cawthorne, C., Higham, L. J., & Archibald, S. J. (2016). Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells. Chemical communications : Chem comm / the Royal Society of Chemistry, 52(44), 7114-7117. https://doi.org/10.1039/c5cc08325g

The structural features required for mitochondrial uptake of BODIPY-based optical imaging agents have been explored. The first derivatives of this class of dyes shown to have mitochondrial membrane potential-dependent uptake in both cancer and heart... Read More about Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells.

Metal oxide nanoparticles as potential MRI contrast agents (2015)
Thesis
Jones, N. E. (2015). Metal oxide nanoparticles as potential MRI contrast agents. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4218445

Magnetic resonance imaging (MRI) is a common medical imaging modality that does not require the administration of radiopharmaceuticals, as it relies on the inherent nuclear spin of the protons in the tissues and organs. However, it lacks sensitivity... Read More about Metal oxide nanoparticles as potential MRI contrast agents.

Age-associated changes to calcium handling proteins across the whole heart (2012)
Thesis
Hatch, F. S. (2012). Age-associated changes to calcium handling proteins across the whole heart. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4215591

Age is a major risk factor for the development of cardiac problems. The ageing process causes significant changes to cardiac structure and function. These are linked with the elderly heart’s diminished ability to respond to cardiac demand and associa... Read More about Age-associated changes to calcium handling proteins across the whole heart.

Uremic cardiomyopathy is characterised by loss of the cardioprotective effects of insulin (2012)
Journal Article
Semple, D. J., Bhandari, S., & Seymour, A.-M. L. (2012). Uremic cardiomyopathy is characterised by loss of the cardioprotective effects of insulin. AJP - Renal Physiology, 303(9), F1275-F1286. https://doi.org/10.1152/ajprenal.00048.2012

Chronic kidney disease is associated with a unique cardiomyopathy, characterised by a combination of structural and cellular remodelling, and an enhanced susceptibility to ischaemia-reperfusion injury. This may represent dysfunction of the reperfusio... Read More about Uremic cardiomyopathy is characterised by loss of the cardioprotective effects of insulin.

Development of microfluidic devices for analysis of cardiac tissue ex vivo (2012)
Thesis
Cheah, L. T. (2012). Development of microfluidic devices for analysis of cardiac tissue ex vivo. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4227445

Polydimethylsiloxane (PDMS)–based (Generation 1) and glass–based (Generation 2) microfluidic devices for heart tissue maintenance have been developed. Rat and human heart biopsies were electrically–paced in a 37 oC environment constantly perfused wit... Read More about Development of microfluidic devices for analysis of cardiac tissue ex vivo.

Impact of dietary manipulation on cardiac hypertrophy (2012)
Thesis
Butler, T. J. P. (2012). Impact of dietary manipulation on cardiac hypertrophy. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4219424

Left ventricular hypertrophy (LVH) is a significant risk factor for the development of heart failure (HF), the incidence of which is increased by obesity. Diets high in fat and sugar have been linked with the development of the metabolic syndrome and... Read More about Impact of dietary manipulation on cardiac hypertrophy.

Differential induction of cellular proliferation, hypertrophy and apoptosis in H9c2 cardiomyocytes by exogenous tissue factor (2010)
Journal Article
Alkistis Frentzou, G., Collier, M. E. W., Ettelaie, C., & Seymour, A.-M. L. (2010). Differential induction of cellular proliferation, hypertrophy and apoptosis in H9c2 cardiomyocytes by exogenous tissue factor. Molecular and Cellular Biochemistry, 345(1-2), 119-130. https://doi.org/10.1007/s11010-010-0565-8

Recent evidence has shown that prolonged exposure to exogenous tissue factor (TF) can alter the cellular functions of cardiomyocytes resulting in cardiac dysfunction. The effect of TF may arise from local inflammation within or in the vicinity of the... Read More about Differential induction of cellular proliferation, hypertrophy and apoptosis in H9c2 cardiomyocytes by exogenous tissue factor.

Microfluidic perfusion system for maintaining viable heart tissue with real-time electrochemical monitoring of reactive oxygen species (2010)
Journal Article
Cheah, L.-T., Dou, Y. H., Seymour, A. M. L., Dyer, C. E., Haswell, S. J., Wadhawan, J. D., & Greenman, J. (2010). Microfluidic perfusion system for maintaining viable heart tissue with real-time electrochemical monitoring of reactive oxygen species. Lab on a chip, 10(20), 2720-2726. https://doi.org/10.1039/c004910g

A microfluidic device has been developed to maintain viable heart tissue samples in a biomimetic microenvironment. This device allows rat or human heart tissue to be studied under pseudo in vivo conditions. Effluent levels of lactate dehydrogenase an... Read More about Microfluidic perfusion system for maintaining viable heart tissue with real-time electrochemical monitoring of reactive oxygen species.

Uremic cardiomyopathy and insulin resistance: a critical role for Akt? (2010)
Journal Article
Semple, D., Smith, K., Bhandari, S., & Seymour, A. M. L. (2011). Uremic cardiomyopathy and insulin resistance: a critical role for Akt?. Journal of the American Society of Nephrology : JASN, 22(2), 207-215. https://doi.org/10.1681/ASN.2009090900

Uremic cardiomyopathy is a classic complication of chronic renal failure whose cause is unclear and treatment remains disappointing. Insulin resistance is an independent predictor of cardiovascular mortality in chronic renal failure. Underlying insul... Read More about Uremic cardiomyopathy and insulin resistance: a critical role for Akt?.

Functional and metabolic adaptation in uraemic cardiomyopathy (2010)
Journal Article
Smith, K., Semple, D., Aksentijević, D., Bhandari, S., & Seymour, A. L. (2010). Functional and metabolic adaptation in uraemic cardiomyopathy. Frontiers in bioscience (Elite edition), E2(4), 1492-1501. https://doi.org/10.2741/e208

Cardiovascular complications are the leading cause of death in patients with chronic kidney disease (CKD). The uraemic heart undergoes substantial remodelling, including left ventricular hypertrophy (LVH), an important determinant of heart failure. L... Read More about Functional and metabolic adaptation in uraemic cardiomyopathy.

Insulin resistance and altered glucose transporter 4 expression in experimental uremia (2009)
Journal Article
Aksentijević, D., Bhandari, S., & Seymour, A. M. L. (2009). Insulin resistance and altered glucose transporter 4 expression in experimental uremia. Kidney International, 75(7), 711-718. https://doi.org/10.1038/ki.2008.691

Progressive ventricular hypertrophy can lead to the development of insulin resistance, a feature of both chronic kidney disease and heart failure. Here we induced uremia in adult male Sprague-Dawley rats using a remnant kidney model and studied the e... Read More about Insulin resistance and altered glucose transporter 4 expression in experimental uremia.

Western diet impairs metabolic remodelling and contractile efficiency in cardiac hypertrophy (2008)
Journal Article
Akki, A., & Seymour, A. L. (2009). Western diet impairs metabolic remodelling and contractile efficiency in cardiac hypertrophy. Cardiovascular research, 81(3), 610-617. https://doi.org/10.1093/cvr/cvn316

Metabolic remodelling in cardiac hypertrophy is underscored by a reduction in fatty acid (FA) oxidation. We tested whether this decline in FA oxidation in the presence of enhanced FA supply may predispose the hypertrophied myocardium to lipid accumul... Read More about Western diet impairs metabolic remodelling and contractile efficiency in cardiac hypertrophy.

Compensated cardiac hypertrophy is characterised by a decline in palmitate oxidation (2008)
Journal Article
Akki, A., Smith, K., & Seymour, A. M. L. (2008). Compensated cardiac hypertrophy is characterised by a decline in palmitate oxidation. Molecular and Cellular Biochemistry, 311(1-2), 215-224. https://doi.org/10.1007/s11010-008-9711-y

Cardiac hypertrophy is an independent risk factor in the development of heart failure. However, the cellular mechanisms underlying the transition from compensated hypertrophy to heart failure are incompletely understood. The aim of this study was to... Read More about Compensated cardiac hypertrophy is characterised by a decline in palmitate oxidation.

The preparation of lanthanide macrocyclic complexes for use as MRI and luminescence contrast agents (2008)
Thesis
Sparke, A. E. (2008). The preparation of lanthanide macrocyclic complexes for use as MRI and luminescence contrast agents. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4212783

Multimodality imaging agents have the potential to be detected in both MRI and optical imaging experiments allowing for visualisation of biological systems from the cellular level up to the whole body. Lanthanide complexes have shown great promise as... Read More about The preparation of lanthanide macrocyclic complexes for use as MRI and luminescence contrast agents.

Investigations into the influence and role of tissue factor in the pathogenesis of myocardial hypertrophy (2007)
Thesis
Frentzou, G. A. (2007). Investigations into the influence and role of tissue factor in the pathogenesis of myocardial hypertrophy. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4215164

Recently it has been demonstrated that tissue factor (TF) plays an important role in the induction and/or progression of cardiac hypertrophy. The aim of this thesis was to examine the relationship between TF and the onset of cardiac hypertrophy. Card... Read More about Investigations into the influence and role of tissue factor in the pathogenesis of myocardial hypertrophy.

Metabolic remodeling in the aging heart (2005)
Journal Article
Sample, J., Cleland, J. G. F., & Seymour, A. L. (2006). Metabolic remodeling in the aging heart. Journal of Molecular and Cellular Cardiology, 40(1), 56-63. https://doi.org/10.1016/j.yjmcc.2005.09.018

The aim of this study was to investigate the effects of aging on the profile of myocardial substrate utilization and cardiac function using a physiological profile of substrates. Hearts from 6-, 15- and 24-month male Wistar rats were perfused in the... Read More about Metabolic remodeling in the aging heart.