All Outputs (77)

Expression of microRNA in follicular fluid in women with and without PCOS (2019)
Journal Article
Butler, A. E., Ramachandran, V., Hayat, S., Dargham, S. R., Cunningham, T. K., Benurwar, M., Sathyapalan, T., Najafi-Shoushtari, S. H., & Atkin, S. L. (2019). Expression of microRNA in follicular fluid in women with and without PCOS. Scientific reports, 9(1), Article 16306. https://doi.org/10.1038/s41598-019-52856-5

© 2019, The Author(s). Several studies have shown the expression of small non-coding microRNA (miRNA) changes in PCOS and their expression in follicular fluid has been described, though the number of studies remains small. In this prospective cohort... Read More about Expression of microRNA in follicular fluid in women with and without PCOS.

The CD105:CD106 microparticle ratio is CD106 dominant in polycystic ovary syndrome compared to type 2 diabetes and healthy subjects (2019)
Journal Article
Al-Qaissi, A., Alqarni, S., Javed, Z., Atkin, S. L., Sathyapalan, T., Vince, R., & Madden, L. A. (2019). The CD105:CD106 microparticle ratio is CD106 dominant in polycystic ovary syndrome compared to type 2 diabetes and healthy subjects. Endocrine, https://doi.org/10.1007/s12020-019-02059-9

© 2019, The Author(s). Background: A retrospective analysis was carried out from patients and controls during the past 5 years from a series of studies investigating endothelial microparticles (MP). Methods: In total, 319 samples from 207 individuals... Read More about The CD105:CD106 microparticle ratio is CD106 dominant in polycystic ovary syndrome compared to type 2 diabetes and healthy subjects.

The effect of atorvastatin (and subsequent metformin) on adipose tissue acylation-stimulatory-protein concentration and inflammatory biomarkers in overweight/obese women with polycystic ovary syndrome (2019)
Journal Article
Sathyapalan, T., Hobkirk, J. P., Javed, Z., Carroll, S., Coady, A. M., Pemberton, P., Smith, A., Cianflone, K., & Atkin, S. L. (2019). The effect of atorvastatin (and subsequent metformin) on adipose tissue acylation-stimulatory-protein concentration and inflammatory biomarkers in overweight/obese women with polycystic ovary syndrome. Frontiers in endocrinology, 10(JUN), Article 394. https://doi.org/10.3389/fendo.2019.00394

Copyright © 2019 Sathyapalan, Hobkirk, Javed, Carroll, Coady, Pemberton, Smith, Cianflone and Atkin. Background: Atorvastatin has been shown to improve cardiovascular risk (CVR) indices in women with polycystic ovary syndrome (PCOS). Low-grade chroni... Read More about The effect of atorvastatin (and subsequent metformin) on adipose tissue acylation-stimulatory-protein concentration and inflammatory biomarkers in overweight/obese women with polycystic ovary syndrome.

The effects of soy protein and cocoa with or without isoflavones on glycemic control in type 2 diabetes. A double-blind, randomized, placebo-controlled study (2019)
Journal Article
Konya, J., Sathyapalan, T., Kilpatrick, E. S., & Atkin, S. L. (2019). The effects of soy protein and cocoa with or without isoflavones on glycemic control in type 2 diabetes. A double-blind, randomized, placebo-controlled study. Frontiers in endocrinology, 10(MAY), Article 296. https://doi.org/10.3389/fendo.2019.00296

Objective: Soy and cocoa have been suggested to be beneficial for diabetes. The aim of this study was to identify the effects of soy protein, isoflavones, and cocoa on glycemic control parameters.

Research design and methods: The study was a paral... Read More about The effects of soy protein and cocoa with or without isoflavones on glycemic control in type 2 diabetes. A double-blind, randomized, placebo-controlled study.

Lipids and insulin regulate mitochondrial-derived peptide (MOTS-c) in PCOS and healthy subjects (2019)
Journal Article
Ramanjaneya, M., Jerobin, J., Bettahi, I., Bensila, M., Aye, M., Siveen, K. S., Sathyapalan, T., Skarulis, M., Abou‐Samra, A., & Atkin, S. L. (2019). Lipids and insulin regulate mitochondrial-derived peptide (MOTS-c) in PCOS and healthy subjects. Clinical Endocrinology, 91(2), 278-287. https://doi.org/10.1111/cen.14007

Objective: Polycystic ovarian syndrome (PCOS) is a heterogeneous endocrine disorder associated with mitochondrial dysfunction and insulin resistance (IR). MOTS-c, a mitochondrial peptide, promotes insulin sensitivity (IS) through activating AKT and A... Read More about Lipids and insulin regulate mitochondrial-derived peptide (MOTS-c) in PCOS and healthy subjects.

Pre-diabetes mellitus newly diagnosed after myocardial infarction adversely affects prognosis in patients without known diabetes (2019)
Journal Article
Chattopadhyay, S., George, A., John, J., & Sathyapalan, T. (2019). Pre-diabetes mellitus newly diagnosed after myocardial infarction adversely affects prognosis in patients without known diabetes. Diabetes and Vascular Disease Research, 16(6), 489-497. https://doi.org/10.1177/1479164119845561

© The Author(s) 2019. Background: Effect of pre-diabetes mellitus on post-myocardial infarction prognosis is unclear. Methods: Retrospective cohort analysis of 1056 myocardial infarction survivors with fasting plasma glucose and 2-h post-load plasma... Read More about Pre-diabetes mellitus newly diagnosed after myocardial infarction adversely affects prognosis in patients without known diabetes.

The effect of exenatide on cardiovascular risk markers in women with polycystic ovary syndrome (2019)
Journal Article
Dawson, A. J., Sathyapalan, T., Vince, R., Coady, A. M., Ajjan, R. A., Kilpatrick, E. S., & Atkin, S. L. (2019). The effect of exenatide on cardiovascular risk markers in women with polycystic ovary syndrome. Frontiers in endocrinology, 10(APR), Article 189. https://doi.org/10.3389/fendo.2019.00189

Background: Polycystic ovary syndrome (PCOS) is associated with an adverse cardiovascular risk profile including a prothrombotic state. Exenatide has been shown to be effective at improving insulin sensitivity and weight loss in PCOS; therefore this... Read More about The effect of exenatide on cardiovascular risk markers in women with polycystic ovary syndrome.

Effects of empagliflozin on metabolic parameters in polycystic ovary syndrome: a randomized controlled study (2019)
Journal Article
Javed, Z., Papageorgiou, M., Deshmukh, H., Rigby, A. S., Qamar, U., Abbas, J., Khan, A. Y., Kilpatrick, E. S., Atkin, S. L., & Sathyapalan, T. (2019). Effects of empagliflozin on metabolic parameters in polycystic ovary syndrome: a randomized controlled study. Clinical Endocrinology, 90(6), 805-813. https://doi.org/10.1111/cen.13968

Background: Empagliflozin is a sodium-glucose-cotransporter-2 inhibitor that improves cardiovascular risk and promotes weight loss in patients with type 2 diabetes. Polycystic ovary syndrome (PCOS) is associated with obesity and increased cardiovascu... Read More about Effects of empagliflozin on metabolic parameters in polycystic ovary syndrome: a randomized controlled study.

Association of vitamin D metabolites with embryo development and fertilization in women with and without PCOS undergoing subfertility treatment (2019)
Journal Article
Cunningham, T. K., Allgar, V., Dargham, S. R., Kilpatrick, E., Sathyapalan, T., Maguiness, S., Mokhtar Rudin, H. R., Abdul Ghani, N. M., Latiff, A., & Atkin, S. L. (2019). Association of vitamin D metabolites with embryo development and fertilization in women with and without PCOS undergoing subfertility treatment. Frontiers in endocrinology, 10(JAN), Article 13. https://doi.org/10.3389/fendo.2019.00013

Objective: The relationship between fertilization rates and 1,25-dihydroxyvitamin D (1,25(OH)2D3), 25-hydroxyvitamin D2 (25(OH)D2), 25-hydroxyvitamin D3 (25(OH)D3), 24,25-dihydroxyvitamin D (24,25(OH)2D3), and 25-hydroxy-3epi-Vitamin D3 (3epi25(OH)D3... Read More about Association of vitamin D metabolites with embryo development and fertilization in women with and without PCOS undergoing subfertility treatment.

A randomized, controlled trial of vitamin D supplementation on cardiovascular risk factors, hormones, and liver markers in women with polycystic ovary syndrome (2019)
Journal Article
Javed, Z., Papageorgiou, M., Deshmukh, H., Kilpatrick, E., Mann, V., Corless, L., Abouda, G., Rigby, A. S., Atkin, S., & Sathyapalan, T. (2019). A randomized, controlled trial of vitamin D supplementation on cardiovascular risk factors, hormones, and liver markers in women with polycystic ovary syndrome. Nutrients, 11(1), 188. https://doi.org/10.3390/nu11010188

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Polycystic ovary syndrome (PCOS) increases the risk of metabolic syndrome and non-alcoholic-fatty-liver disease (NAFLD). Vitamin D supplementation may exert positive effects on liver biochemis... Read More about A randomized, controlled trial of vitamin D supplementation on cardiovascular risk factors, hormones, and liver markers in women with polycystic ovary syndrome.

Metabolic and proteomic signatures of hypoglycaemia in type 2 diabetes (2018)
Journal Article
Halama, A., Kahal, H., Bhagwat, A. M., Zierer, J., Sathyapalan, T., Grauman, J., Suhre, K., & Atkin, S. (2019). Metabolic and proteomic signatures of hypoglycaemia in type 2 diabetes. Diabetes, Obesity and Metabolism, 21(4), 909-919. https://doi.org/10.1111/dom.13602

Aims: To determine the biochemical changes that underlie hypoglycaemia in a healthy control group and in people with type 2 diabetes (T2D). Materials and methods: We report a hypoglycaemic clamp study in seven healthy controls and 10 people with T2D.... Read More about Metabolic and proteomic signatures of hypoglycaemia in type 2 diabetes.

The effect of high dose isoflavone supplementation on serum reverse T3 in euthyroid men with Type 2 Diabetes and post-menopausal women (2018)
Journal Article
Sathyapalan, T., Köhrle, J., Rijntjes, E., Rigby, A. S., Dargham, S. R., Kilpatrick, E. S., & Atkin, S. L. (2018). The effect of high dose isoflavone supplementation on serum reverse T3 in euthyroid men with Type 2 Diabetes and post-menopausal women. Frontiers in endocrinology, 9, Article 698. https://doi.org/10.3389/fendo.2018.00698

Background: The health benefits of soy are widely reported but there are queries on the effect of soy isoflavones on thyroid function and the underlying mechanism of action.

Materials and Methods: We examined the effect of soy isoflavones on rever... Read More about The effect of high dose isoflavone supplementation on serum reverse T3 in euthyroid men with Type 2 Diabetes and post-menopausal women.

Development of a novel risk prediction and risk stratification score for polycystic ovary syndrome (PCOS) (2018)
Journal Article
Deshmukh, H., Papageorgiou, M., Kilpatrick, E. S., Atkin, S. L., & Sathyapalan, T. (in press). Development of a novel risk prediction and risk stratification score for polycystic ovary syndrome (PCOS). Clinical Endocrinology, 90(1), 162-169. https://doi.org/10.1111/cen.13879

Objective
The aim of this study was to develop a simple phenotypic algorithm that can capture the underlying clinical and hormonal abnormalities to help in the diagnosis and risk stratification of polycystic ovary syndrome (PCOS).

Methods
The study... Read More about Development of a novel risk prediction and risk stratification score for polycystic ovary syndrome (PCOS).

Effects of acute insulin-induced hypoglycaemia on endothelial microparticles in adults with and without type 2 diabetes (2018)
Journal Article
Al-Qaissi, A., Papageorgiou, M., Deshmukh, H., Madden, L. A., Rigby, A., Kilpatrick, E. S., Atkin, S. L., & Sathyapalan, T. (2019). Effects of acute insulin-induced hypoglycaemia on endothelial microparticles in adults with and without type 2 diabetes. Diabetes, Obesity and Metabolism, 21(3), 533-540. https://doi.org/10.1111/dom.13548

Aims
Endothelial microparticles (EMPs) are novel surrogate markers of endothelial injury and dysfunction that may be differentially produced in response to acute insulin‐induced hypoglycaemia in adults with and without type 2 diabetes.

Environmental effects of ambient temperature and relative humidity on insulin pharmacodynamics in adults with type 1 diabetes mellitus (2018)
Journal Article
Al-Qaissi, A., Papageorgiou, M., Javed, Z., Heise, T., Rigby, A. S., Garrett, A. T., Hepburn, D., Kilpatrick, E. S., Atkin, S. L., & Sathyapalan, T. (2019). Environmental effects of ambient temperature and relative humidity on insulin pharmacodynamics in adults with type 1 diabetes mellitus. Diabetes, Obesity and Metabolism, 21(3), 569-574. https://doi.org/10.1111/dom.13555

Objective
This study aimed to explore the effects of ambient temperature and relative humidity on insulin pharmacodynamics in adults with type 1 diabetes.

Research Design
A 3‐way, cross‐over, randomised study was performed in adults with type 1 diab... Read More about Environmental effects of ambient temperature and relative humidity on insulin pharmacodynamics in adults with type 1 diabetes mellitus.

The effect of phytoestrogen on thyroid in subclinical hypothyroidism: Randomized, double blind, crossover study (2018)
Journal Article
Sathyapalan, T., Dawson, A. J., Rigby, A. S., Thatcher, N. J., Kilpatrick, E. S., & Atkin, S. L. (2018). The effect of phytoestrogen on thyroid in subclinical hypothyroidism: Randomized, double blind, crossover study. Frontiers in endocrinology, 9(SEP), Article 531. https://doi.org/10.3389/fendo.2018.00531

Objective: Soy phytoestrogens are suggested to impair thyroid function but the effects of pharmacological doses of soy phytoestrogens are unknown; therefore, this study was performed to determine the effect of high dose soy phytoestrogens (66 mg) on... Read More about The effect of phytoestrogen on thyroid in subclinical hypothyroidism: Randomized, double blind, crossover study.

Perfluorinated alkyl acids in the serum and follicular fluid of UK women with and without polycystic ovarian syndrome undergoing fertility treatment and associations with hormonal and metabolic parameters (2018)
Journal Article
Heffernan, A., Cunningham, T., Drage, D., Aylward, L., Thompson, K., Vijayasarathy, S., Mueller, J., Atkin, S., & Sathyapalan, T. (2018). Perfluorinated alkyl acids in the serum and follicular fluid of UK women with and without polycystic ovarian syndrome undergoing fertility treatment and associations with hormonal and metabolic parameters. International Journal of Hygiene and Environmental Health, 221(7), 1068-1075. https://doi.org/10.1016/j.ijheh.2018.07.009

© 2018 Women with polycystic ovarian syndrome (PCOS) undergoing treatment for infertility could be a sensitive subpopulation for endocrine effects of exposure to perfluorinated alkyl acids (PFAAs), persistent organic pollutants with potential endocri... Read More about Perfluorinated alkyl acids in the serum and follicular fluid of UK women with and without polycystic ovarian syndrome undergoing fertility treatment and associations with hormonal and metabolic parameters.

Platelet function following induced hypoglycaemia in type 2 diabetes (2018)
Journal Article
Kahal, H., Aburima, A., Spurgeon, B., Wraith, K. S., Rigby, A. S., Sathyapalan, T., Kilpatrick, E. S., Naseem, K. M., & Atkin, S. L. (2018). Platelet function following induced hypoglycaemia in type 2 diabetes. Diabetes & metabolism, 44(5), 431-436. https://doi.org/10.1016/j.diabet.2018.04.004

Aim
Strict glycaemic control has been associated with an increased mortality rate in subjects with type 2 diabetes (T2DM). Here we examined platelet function immediately and 24 hours following induced hypoglycaemia in people with type 2 diabetes comp... Read More about Platelet function following induced hypoglycaemia in type 2 diabetes.

Adjustment of the GRACE score by 2-hour post-load glucose improves prediction of long-term major adverse cardiac events in acute coronary syndrome in patients without known diabetes (2018)
Journal Article
George, A., John, J., Sathyapalan, T., & Chattopadhyay, S. (2018). Adjustment of the GRACE score by 2-hour post-load glucose improves prediction of long-term major adverse cardiac events in acute coronary syndrome in patients without known diabetes. European Heart Journal, 39(29), 2740-2745. https://doi.org/10.1093/eurheartj/ehy233

Aims Global Registry of Acute Coronary Events (GRACE) risk score (GRS), a powerful predictor of prognosis after ACE, does not include a glucometabolic measure. We investigate whether 2 hour post-load plasma glucose (2h-PG) could improve GRS based pro... Read More about Adjustment of the GRACE score by 2-hour post-load glucose improves prediction of long-term major adverse cardiac events in acute coronary syndrome in patients without known diabetes.

Soy isoflavones improve cardiovascular disease risk markers in women during 1 the early menopause 2 1 (2018)
Journal Article
Sathyapalan, T., Aye, M., Rigby, A. S., Thatcher, N. J., Dargham, S. R., Kilpatrick, E. S., & Atkin, S. L. (2018). Soy isoflavones improve cardiovascular disease risk markers in women during 1 the early menopause 2 1. Nutrition, metabolism, and cardiovascular diseases : NMCD, 28(7), 691-697. https://doi.org/10.1016/j.numecd.2018.03.007

Background
Hormone replacement therapy may be beneficial for cardiovascular disease risk (CVR) in post-menopausal women. Soy isoflavones may act as selective estrogen receptor modulators. The aim of this study was to evaluate whether soy isoflavones... Read More about Soy isoflavones improve cardiovascular disease risk markers in women during 1 the early menopause 2 1.