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All Outputs (35)

Association of Differing Qatari Genotypes with Vitamin D Metabolites (2020)
Thesis
Dakroury, Y. (2020). Association of Differing Qatari Genotypes with Vitamin D Metabolites. (Thesis). Hull York Medical School, The University of Hull and The University of York. Retrieved from https://hull-repository.worktribe.com/output/4192858

This work aimed to determine the possible association between Qatari genotypes and vitamin-D deficiency and diabetes complications. Through next-generation exome sequencing three major genetic Qatari genotypes were determined, Q1 - Bedouin, Q2 - Pers... Read More about Association of Differing Qatari Genotypes with Vitamin D Metabolites.

The effect of variation of fatty substances found in the blood on patients with type 2 diabetes. ISRCTN27314990 (2020)
Other
Sathyapalan, T. (2020). The effect of variation of fatty substances found in the blood on patients with type 2 diabetes. ISRCTN27314990

Background and study aims
High blood sugar and fat content are well-recognised risk factors for causing the formation of obstructive plaques in arteries which lead to cardiovascular disease, for example heart attacks. From earlier studies, we know t... Read More about The effect of variation of fatty substances found in the blood on patients with type 2 diabetes. ISRCTN27314990.

Metabolic comparison of polycystic ovarian syndrome and control women in Middle Eastern and UK Caucasian populations (2020)
Journal Article
Butler, A. E., Abouseif, A., Dargham, S. R., Sathyapalan, T., & Atkin, S. L. (2020). Metabolic comparison of polycystic ovarian syndrome and control women in Middle Eastern and UK Caucasian populations. Scientific reports, 10(1), Article 18895. https://doi.org/10.1038/s41598-020-75109-2

© 2020, The Author(s). To determine if metabolic characteristics differed in women with and without polycystic ovary syndrome (PCOS) between a Caucasian and Middle East population. Comparative cross-sectional analysis. Demographic and metabolic data... Read More about Metabolic comparison of polycystic ovarian syndrome and control women in Middle Eastern and UK Caucasian populations.

Recent advances in drug discovery for diabetic kidney disease (2020)
Journal Article
Danta, C. C., Boa, A. N., Bhandari, S., Sathyapalan, T., & Xu, S. Z. (2021). Recent advances in drug discovery for diabetic kidney disease. Expert Opinion on Drug Discovery, 16(4), 447-461. https://doi.org/10.1080/17460441.2021.1832077

Introduction: Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease (ESRD), and 40% of patients with diabetes develop DKD. Although some pathophysiological mechanisms and drug targets of DKD have been described, the effectivenes... Read More about Recent advances in drug discovery for diabetic kidney disease.

Curcumin for the management of periodontal diseases: a review (2020)
Journal Article
Forouzanfar, F., Forouzanfar, A., Sathyapalan, T., Orafai, H. M., & Sahebkar, A. (2020). Curcumin for the management of periodontal diseases: a review. Current Pharmaceutical Design, 26(34), 4277-4284. https://doi.org/10.2174/1381612826666200513112607

Periodontal disease is one of the most common causes of tooth loss among adults. Research shows that inflammation is one of the crucial components in the initiation and progression of periodontitis. Various herbal medicines have recently been receivi... Read More about Curcumin for the management of periodontal diseases: a review.

Hypoglycaemia in type 2 diabetes exacerbates amyloid-related proteins associated with dementia (2020)
Journal Article
Moin, A. S. M., Al-Qaissi, A., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (in press). Hypoglycaemia in type 2 diabetes exacerbates amyloid-related proteins associated with dementia. Diabetes, Obesity and Metabolism, https://doi.org/10.1111/dom.14220

Objective
Hypoglycemia in diabetes (T2D) may increase the risk for Alzheimer's disease (AD). We hypothesized that hypoglycemia‐induced amyloid‐related protein changes would be exacerbated in T2D.

Methods
A prospective, parallel study in T2D (n=2... Read More about Hypoglycaemia in type 2 diabetes exacerbates amyloid-related proteins associated with dementia.

Increased MicroRNA Levels in Women With Polycystic Ovarian Syndrome but Without Insulin Resistance: A Pilot Prospective Study (2020)
Journal Article
Butler, A. E., Ramachandran, V., Cunningham, T. K., David, R., Gooderham, N. J., Benurwar, M., Dargham, S. R., Hayat, S., Sathyapalan, T., Najafi-Shoushtari, S. H., & Atkin, S. L. (2020). Increased MicroRNA Levels in Women With Polycystic Ovarian Syndrome but Without Insulin Resistance: A Pilot Prospective Study. Frontiers in endocrinology, 11, Article 571357. https://doi.org/10.3389/fendo.2020.571357

© Copyright © 2020 Butler, Ramachandran, Cunningham, David, Gooderham, Benurwar, Dargham, Hayat, Sathyapalan, Najafi-Shoushtari and Atkin. Background: Small noncoding microRNA (miRNA) have regulatory functions in polycystic ovary syndrome (PCOS) that... Read More about Increased MicroRNA Levels in Women With Polycystic Ovarian Syndrome but Without Insulin Resistance: A Pilot Prospective Study.

Dynamic Changes in Circulating Endocrine FGF19 Subfamily and Fetuin-A in Response to Intralipid and Insulin Infusions in Healthy and PCOS Women (2020)
Journal Article
Ramanjaneya, M., Bensila, M., Bettahi, I., Jerobin, J., Samra, T. A., Aye, M. M., Alkasem, M., Siveen, K. S., Sathyapalan, T., Skarulis, M., Atkin, S. L., & Abou-Samra, A. B. (2020). Dynamic Changes in Circulating Endocrine FGF19 Subfamily and Fetuin-A in Response to Intralipid and Insulin Infusions in Healthy and PCOS Women. Frontiers in endocrinology, 11, Article 568500. https://doi.org/10.3389/fendo.2020.568500

© Copyright © 2020 Ramanjaneya, Bensila, Bettahi, Jerobin, Samra, Aye, Alkasem, Siveen, Sathyapalan, Skarulis, Atkin and Abou-Samra. Background: The fibroblast growth factors (FGF) 19 subfamily, also referred to as endocrine FGFs, includes FGF19, FGF... Read More about Dynamic Changes in Circulating Endocrine FGF19 Subfamily and Fetuin-A in Response to Intralipid and Insulin Infusions in Healthy and PCOS Women.

Integrin-associated ILK and PINCH1 protein content are reduced in skeletal muscle of maintenance haemodialysis patients (2020)
Journal Article
Draicchio, F., van Vliet, S., Ancu, O., Paluska, S. A., Wilund, K. R., Mickute, M., Sathyapalan, T., Renshaw, D., Watt, P., Sylow, L., Burd, N. A., & Mackenzie, R. W. (2020). Integrin-associated ILK and PINCH1 protein content are reduced in skeletal muscle of maintenance haemodialysis patients. The Journal of physiology, 598(24), 5701-5716. https://doi.org/10.1113/JP280441

Key points: Patients with renal failure undergoing maintenance haemodialysis are associated with insulin resistance and protein metabolism dysfunction. Novel research suggests that disruption to the transmembrane protein linkage between the cytoskele... Read More about Integrin-associated ILK and PINCH1 protein content are reduced in skeletal muscle of maintenance haemodialysis patients.

Hyperthyroidism, and bone mineral density : dissecting the causal association with Mendelian randomization analysis (2020)
Journal Article
Deshmukh, H., Papageorgiou, M., Aye, M., England, J., Abdalla, M., & Sathyapalan, T. (in press). Hyperthyroidism, and bone mineral density : dissecting the causal association with Mendelian randomization analysis. Clinical Endocrinology, https://doi.org/10.1111/cen.14330

Introduction
Untreated hyperthyroidism is associated with accelerated bone turnover, low bone mineral density (BMD) and increased susceptibility to fragility fractures. Although treatment appears to improve or even reverse some of these adverse skel... Read More about Hyperthyroidism, and bone mineral density : dissecting the causal association with Mendelian randomization analysis.

Postload glucose spike but not fasting glucose determines prognosis after myocardial infarction in patients without known or newly diagnosed diabetes (2020)
Journal Article
Chattopadhyay, S., George, A., John, J., & Sathyapalan, T. (2021). Postload glucose spike but not fasting glucose determines prognosis after myocardial infarction in patients without known or newly diagnosed diabetes. Journal of Diabetes, 13(3), 191-199. https://doi.org/10.1111/1753-0407.13111

Background: The effect of postload glucose spikes (PGS), the difference between 2 hour post-load plasma glucose (2hPLPG) and fasting plasma glucose (FPG), on post–myocardial infarction (post-MI) prognosis in nondiabetic patients is unexplored. Method... Read More about Postload glucose spike but not fasting glucose determines prognosis after myocardial infarction in patients without known or newly diagnosed diabetes.

Rationale and design of the LIBERATES trial: Protocol for a randomised controlled trial of flash glucose monitoring for optimisation of glycaemia in individuals with type 2 diabetes and recent myocardial infarction (2020)
Journal Article
Everett, C. C., Reynolds, C., Fernandez, C., Stocken, D. D., Sharples, L. D., Sathyapalan, T., Heller, S., Storey, R. F., & Ajjan, R. A. (2020). Rationale and design of the LIBERATES trial: Protocol for a randomised controlled trial of flash glucose monitoring for optimisation of glycaemia in individuals with type 2 diabetes and recent myocardial infarction. Diabetes and Vascular Disease Research, 17(5), https://doi.org/10.1177/1479164120957934

Hyperglycaemia in individuals with type 2 diabetes (T2D) and myocardial infarction (MI) is associated with guarded clinical prognosis. Studies improving glucose levels in T2D following MI relied on HbA1c as the main glycaemic marker, failing to addre... Read More about Rationale and design of the LIBERATES trial: Protocol for a randomised controlled trial of flash glucose monitoring for optimisation of glycaemia in individuals with type 2 diabetes and recent myocardial infarction.

Two-Hour Post-Load Plasma Glucose, a Biomarker to Improve the GRACE Score in Patients without Known Diabetes (2020)
Journal Article
Chattopadhyay, S., George, A., John, J., & Sathyapalan, T. (2020). Two-Hour Post-Load Plasma Glucose, a Biomarker to Improve the GRACE Score in Patients without Known Diabetes. Cardiology, 145(9), 553-561. https://doi.org/10.1159/000509180

© 2020 S. Karger AG, Basel. All rights reserved. Objective: To assess improvement in predictive performance of Global Registry of Acute Coronary Events risk score (GRS) by addition of a glucose matrix. Methods: 1,056 acute coronary syndrome (ACS) sur... Read More about Two-Hour Post-Load Plasma Glucose, a Biomarker to Improve the GRACE Score in Patients without Known Diabetes.

Obesity and Insulin Resistance: A Review of Molecular Interactions (2020)
Journal Article
Yaribeygi, H., Maleki, M., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2022). Obesity and Insulin Resistance: A Review of Molecular Interactions. Current Molecular Medicine, 21(3), 182-193. https://doi.org/10.2174/1566524020666200812221527

The prevalence of insulin resistance and diabetes mellitus is rising globally in epidemic proportions. Diabetes and its complications contribute to significant morbidity and mortality. An increase in sedentary lifestyle and consumption of a more ener... Read More about Obesity and Insulin Resistance: A Review of Molecular Interactions.

miRNAs as a novel clinical biomarker and therapeutic targets in polycystic ovary syndrome (PCOS): A review (2020)
Journal Article
Abdalla, M., Deshmukh, H., Atkin, S. L., & Sathyapalan, T. (2020). miRNAs as a novel clinical biomarker and therapeutic targets in polycystic ovary syndrome (PCOS): A review. Life Sciences, 259, https://doi.org/10.1016/j.lfs.2020.118174

© 2020 Elsevier Inc. Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in females of the reproductive age. PCOS is commonly manifested as ovulatory dysfunction, clinical and biochemical excess androgen level, and polycystic ov... Read More about miRNAs as a novel clinical biomarker and therapeutic targets in polycystic ovary syndrome (PCOS): A review.

Corrigendum: microRNA Expression in Women With and Without Polycystic Ovarian Syndrome Matched for Body Mass Index (Frontiers in Endocrinology, (2020), 11, 10.3389/fendo.2020.00206) (2020)
Journal Article
Butler, A. E., Ramachandran, V., Sathyapalan, T., David, R., Gooderham, N. J., Benurwar, M., Dargham, S. R., Hayat, S., Hani Najafi-Shoushtari, S., & Atkin, S. L. (2020). Corrigendum: microRNA Expression in Women With and Without Polycystic Ovarian Syndrome Matched for Body Mass Index (Frontiers in Endocrinology, (2020), 11, 10.3389/fendo.2020.00206). Frontiers in endocrinology, 11, Article 00515. https://doi.org/10.3389/fendo.2020.00515

Copyright © 2020 Butler, Ramachandran, Sathyapalan, David, Gooderham, Benurwar, Dargham, Hayat, Hani Najafi-Shoushtari and Atkin. An author name was incorrectly spelled as Sathypalan. The correct spelling is Sathyapalan. The authors apologize for thi... Read More about Corrigendum: microRNA Expression in Women With and Without Polycystic Ovarian Syndrome Matched for Body Mass Index (Frontiers in Endocrinology, (2020), 11, 10.3389/fendo.2020.00206).

Effect of flash glucose monitoring on glycemic control, hypoglycemia, diabetes-related distress, and resource utilization in the association of british clinical diabetologists (Abcd) nationwide audit (2020)
Journal Article
Deshmukh, H., Wilmot, E. G., Gregory, R., Barnes, D., Narendran, P., Saunders, S., Furlong, N., Kamaruddin, S., Banatwalla, R., Herring, R., Kilvert, A., Patmore, J., Walton, C., Ryder, R. E., & Sathyapalan, T. (2020). Effect of flash glucose monitoring on glycemic control, hypoglycemia, diabetes-related distress, and resource utilization in the association of british clinical diabetologists (Abcd) nationwide audit. Diabetes Care, 43(9), 2153-2160. https://doi.org/10.2337/dc20-0738

OBJECTIVE The FreeStyle Libre (FSL) flash glucose-monitoring device was made available on the U.K. National Health Service (NHS) drug tariff in 2017. This study aims to explore the U.K. real-world experience of FSL and the impact on glycemic control,... Read More about Effect of flash glucose monitoring on glycemic control, hypoglycemia, diabetes-related distress, and resource utilization in the association of british clinical diabetologists (Abcd) nationwide audit.

Long non-coding RNA expression in non-obese women with polycystic ovary syndrome and weight-matched controls (2020)
Journal Article
Butler, A. E., Hayat, S., Dargham, S. R., Malek, J. A., Abdullah, S. A., Mahmoud, Y. A., Sathyapalan, T., & Atkin, S. L. (2020). Long non-coding RNA expression in non-obese women with polycystic ovary syndrome and weight-matched controls. Reproductive BioMedicine Online, 41(4), 579-583. https://doi.org/10.1016/j.rbmo.2020.06.018

Research question: Long non-coding RNA (lncRNA) do not show protein translation but do have gene regulatory functions in several disease states. Studies have shown that lncRNA differ in overweight women with polycystic ovary syndrome (PCOS), increase... Read More about Long non-coding RNA expression in non-obese women with polycystic ovary syndrome and weight-matched controls.