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All Outputs (17)

Recent Advancements in the Use of Olive Products for Biotechnological Processes (2024)
Book Chapter
Efthimiou, G. (2024). Recent Advancements in the Use of Olive Products for Biotechnological Processes. In V. Lagouri (Ed.), Olives and Olive Related Products - Innovations in Production and Processing (1-8). IntechOpen. https://doi.org/10.5772/intechopen.1007424

This chapter discusses the most recent applications of olive-derived materials in biotechnology, agriculture and food technology. Although the high-quality olive oil is usually destined for human consumption, lower oil grades or waste materials from... Read More about Recent Advancements in the Use of Olive Products for Biotechnological Processes.

Embryo Metabolism and What Does the Embryo Need? (2021)
Book Chapter
Vergaro, P., & Sturmey, R. G. (2021). Embryo Metabolism and What Does the Embryo Need?. In K. Lundin, & A. Ahlström (Eds.), Manual of Embryo Culture in Human Assisted Reproduction (30-41). Cambridge University Press. https://doi.org/10.1017/9781108874014.005

The embryo is a dynamic structure that can be affected by the interaction with the surrounding environment. During its journey through the female reproductive tract from fertilization to implantation, the embryo undergoes numerous biochemical and phy... Read More about Embryo Metabolism and What Does the Embryo Need?.

Culture Media and Embryo Culture (2021)
Book Chapter
Sunde, A., & Sturmey, R. G. (2021). Culture Media and Embryo Culture. In K. Lundin, & A. Ahlström (Eds.), Manual of Embryo Culture in Human Assisted Reproduction (42-52). Cambridge University Press. https://doi.org/10.1017/9781108874014.006

Before considering the basis of embryo culture medium, it is worthwhile reflecting on its function. A detailed overview of embryo metabolism is given in Chapter 4; however, in brief, the embryo must satisfy changing demands for energy by consumption... Read More about Culture Media and Embryo Culture.

Investigation of novel cavin-1/suppressor of cytokine signaling 3 (SOCS3) interactions by coimmunoprecipitation, peptide pull-down, and peptide array overlay approaches (2020)
Book Chapter
Williams, J. J. L., Baillie, G. S., & Palmer, T. M. (2020). Investigation of novel cavin-1/suppressor of cytokine signaling 3 (SOCS3) interactions by coimmunoprecipitation, peptide pull-down, and peptide array overlay approaches. In C. M. Blouin (Ed.), Caveolae: methods and protocols (105-118). Springer. https://doi.org/10.1007/978-1-0716-0732-9_10

The ability of inducible regulator suppressor of cytokine signaling 3 (SOCS3) to inhibit Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling requires interaction with specific cytokine receptors, JAKs, and components of... Read More about Investigation of novel cavin-1/suppressor of cytokine signaling 3 (SOCS3) interactions by coimmunoprecipitation, peptide pull-down, and peptide array overlay approaches.

Metabolomic Screening of Embryos to Enhance Successful Selection and Transfer (2019)
Book Chapter
McKeegan, P. J., & Sturmey, R. G. (2019). Metabolomic Screening of Embryos to Enhance Successful Selection and Transfer. In G. Kovacs, A. Rutherford, & D. K. Gardner (Eds.), How to prepare the egg and embryo to maximize IVF success (295-304). Cambridge University Press. https://doi.org/10.1017/9781316756744.025

A key role of cellular metabolism is the provision of energy, in the form of adenosine triphosphate (ATP). In the case of the embryo, energy demand is dynamic and highly regulated to facilitate developmental milestones such as fertilization, cleavage... Read More about Metabolomic Screening of Embryos to Enhance Successful Selection and Transfer.

Assaying Rho GTPase–dependent processes in Dictyostelium discoideum (2018)
Book Chapter
Marinovic, M., Xiong, H., Rivero Crespo, F., & Weber, I. (2018). Assaying Rho GTPase–dependent processes in Dictyostelium discoideum. In F. Rivero (Ed.), Rho GTPases: Methods and Protocols (371-392). https://doi.org/10.1007/978-1-4939-8612-5_25

The model organism D. discoideum is well-suited to investigate basic questions of molecular and cell biology, particularly those related to the structure, regulation and dynamics of the cytoskeleton, signal transduction, cell-cell adhesion and develo... Read More about Assaying Rho GTPase–dependent processes in Dictyostelium discoideum.

Methods to study the roles of Rho GTPases in platelet function (2018)
Book Chapter
Rivero, F., & Calaminus, S. (2018). Methods to study the roles of Rho GTPases in platelet function. In F. Rivero (Ed.), Rho GTPases: Methods and Protocols (199-217). Humana Press. https://doi.org/10.1007/978-1-4939-8612-5_14

Platelets are a critical cell for prevention of bleeding. Part of the response to the formation of the thrombus is the activation of the actin cytoskeleton, with an inability to effectively activate the cytoskeleton linked to thrombus formation defec... Read More about Methods to study the roles of Rho GTPases in platelet function.

Hematological malignancies in pregnancy (2017)
Book Chapter
Allsup, D., Ali, S., & Robinson, S. (2017). Hematological malignancies in pregnancy. In D. James, P. Steer, C. Weiner, B. Gonik, & S. Robson (Eds.), High-Risk Pregnancy: Management Options (1006-1043). Cambridge University Press

The diagnosis of a hematological malignancy during pregnancy poses a major challenge to the pregnant woman, her family, and the medical team. Treatment of a pregnant woman with chemotherapy poses a risk to the fetus and raises therapeutic, ethical, a... Read More about Hematological malignancies in pregnancy.

Harvesting human prostate tissue material and culturing primary prostate epithelial cells (2016)
Book Chapter
Frame, F. M., Pellacani, D., Collins, A. T., & Maitland, N. J. (2016). Harvesting human prostate tissue material and culturing primary prostate epithelial cells. In I. J. McEwan (Ed.), The nuclear receptor superfamily: methods and protocols (181-201). Humana Press. https://doi.org/10.1007/978-1-4939-3724-0_12

In order to fully explore the biology of a complex solid tumor such as prostate cancer, it is desirable to work with patient tissue. Only by working with cells from a tissue can we take into account patient variability and tumor heterogeneity. Cell l... Read More about Harvesting human prostate tissue material and culturing primary prostate epithelial cells.

Induction of human regulatory T cells with bacterial superantigens (2015)
Book Chapter
Caserta, S., Taylor, A. L., Terrazzini, N., & Llewelyn, M. J. (2016). Induction of human regulatory T cells with bacterial superantigens. In Superantigens; Methods in Molecular Biology (181-206). https://doi.org/10.1007/978-1-4939-3344-0_16

© Springer Science+Business Media New York 2016. Regulatory T cells (Tregs) that suppress the activation of immune effector cells limit immunopathology and are fast emerging as therapeutic targets for autoimmune and cancer disease. Tools enabling Tre... Read More about Induction of human regulatory T cells with bacterial superantigens.

Regulation of adenosine receptor desensitisation and function (2015)
Book Chapter
Rutherford, C., & Palmer, T. M. (2015). Regulation of adenosine receptor desensitisation and function. In V. Ramkumar, & R. Paes de Carvalho (Eds.), Adenosine Signaling Mechanisms: Pharmacology, Functions and Therapeutic Aspects (35-53). Nova Science Publishers

© 2015 by Nova Science Publishers, Inc. All rights reserved. The ability of cells to respond to changes in extracellular concentrations of the nucleoside adenosine is determined by their complement of cell surface adenosine receptors. Four receptor s... Read More about Regulation of adenosine receptor desensitisation and function.

Secondary bone tumors in prostate cancer: New treatments on the horizon (2013)
Book Chapter
Sturge, J. (2013). Secondary bone tumors in prostate cancer: New treatments on the horizon. In M. Berhouma (Ed.), Bone tumors: Symptoms, diagnosis and treatment (145-175). Nova Science Publishers

Secondary bone tumors associated with the advancement of solid tumors of the prostate and other tissue sites result in the increased risk of intractable bone pain, pathological skeletal fracture and spinal-cord compression. In addition to increasing... Read More about Secondary bone tumors in prostate cancer: New treatments on the horizon.

Use of the xCELLigence system for real-time analysis of changes in cellular motility and adhesion in physiological conditions (2013)
Book Chapter
Scrace, S., O'Neill, E., Hammond, E. M., & Pires, I. M. (2013). Use of the xCELLigence system for real-time analysis of changes in cellular motility and adhesion in physiological conditions. In A. S. Coutts (Ed.), Adhesion Protein Protocols (295-306). Humana Press. https://doi.org/10.1007/978-1-62703-538-5_17

Investigation of the mechanisms behind the regulation of cellular motility and adhesion is key to understanding metastasis and the biology of tumor spreading. There are many technologies available for these studies, but the majority of them are eithe... Read More about Use of the xCELLigence system for real-time analysis of changes in cellular motility and adhesion in physiological conditions.

Cancer Stem Cells, Models of Study and Implications of Therapy Resistance Mechanisms (2011)
Book Chapter
Frame, F. M., & Maitland, N. J. (2011). Cancer Stem Cells, Models of Study and Implications of Therapy Resistance Mechanisms. In J. S. Rhim, & R. Kremer (Eds.), Human cell transformation (105-118). Springer. https://doi.org/10.1007/978-1-4614-0254-1_9

There is now compelling evidence for tumour initiating or cancer stem cells (CSCs) in human cancers. The current evidence of this CSC hypothesis, the CSC phenotype and methods of identification, culture and in vitro modelling will be presented, with... Read More about Cancer Stem Cells, Models of Study and Implications of Therapy Resistance Mechanisms.

Endothelial cells and cancer (2006)
Book Chapter
Nikitenko, L., & Boshoff, C. (2006). Endothelial cells and cancer. In S. Moncada, & A. Higgs (Eds.), The Vascular Endothelium II (307-334). Springer Verlag. https://doi.org/10.1007/3-540-36028-X_10

Endothelial cells play a key role in the development and function of blood and lymph vessels. Excessive proliferation and transformation of endothelial cells lead to pathological angiogenesis/ lymphangiogenesis or vascular malfunctions which are hall... Read More about Endothelial cells and cancer.