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Increase of Direct C-C Coupling Reaction Yield by Identifying Structural and Electronic Properties of High-Spin Iron Tetra-azamacrocyclic Complexes (2018)
Journal Article
Brewer, S. M., Wilson, K. R., Jones, D. G., Reinheimer, E. W., Archibald, S. J., Prior, T. J., …Green, K. N. (2018). Increase of Direct C-C Coupling Reaction Yield by Identifying Structural and Electronic Properties of High-Spin Iron Tetra-azamacrocyclic Complexes. Inorganic chemistry, 57(15), 8890-8902. https://doi.org/10.1021/acs.inorgchem.8b00777

Macrocyclic ligands have been explored extensively as scaffolds for transition metal catalysts for oxygen and hydrogen atom transfer reactions. C–C reactions facilitated using earth abundant metals bound to macrocyclic ligands have not been well-unde... Read More about Increase of Direct C-C Coupling Reaction Yield by Identifying Structural and Electronic Properties of High-Spin Iron Tetra-azamacrocyclic Complexes.

The membrane-associated fraction of cyclase associate protein 1 translocates to the cytosol upon platelet stimulation (2018)
Journal Article
Joshi, P., Riley, D. R., Khalil, J. S., Xiong, H., Ji, W., & Rivero, F. (2018). The membrane-associated fraction of cyclase associate protein 1 translocates to the cytosol upon platelet stimulation. Scientific reports, 8(1), Article 10804. https://doi.org/10.1038/s41598-018-29151-w

Platelets undergo profound shape changes upon adhesion to damaged blood vessel walls that are mediated by reorganisation of the actin cytoskeleton in response to receptor-mediated signalling cascades. The highly conserved 56 kDa multidomain cyclase a... Read More about The membrane-associated fraction of cyclase associate protein 1 translocates to the cytosol upon platelet stimulation.

The membrane-associated fraction of cyclase associated protein 1 translocates to the cytosol upon platelet stimulation (2018)
Journal Article
Joshi, P., Riley, D. R., Khalil, J. S., Xiong, H., Ji, W., & Rivero, F. (2018). The membrane-associated fraction of cyclase associated protein 1 translocates to the cytosol upon platelet stimulation. Scientific reports, 8, Article 10804. https://doi.org/10.1038/s41598-018-29151-w

Platelets undergo profound shape changes upon adhesion to damaged blood vessel walls that are mediated by reorganisation of the actin cytoskeleton in response to receptor-mediated signalling cascades. The highly conserved 56 kDa multidomain cyclase a... Read More about The membrane-associated fraction of cyclase associated protein 1 translocates to the cytosol upon platelet stimulation.

Plastic scintillator-based microfluidic devices for miniaturized detection of Positron Emission Tomography radiopharmaceuticals (2018)
Journal Article
Tarn, M. D., Kızılyer, N. Y., Esfahani, M. M. N., Joshi, P., Brown, N. J., Pamme, N., …Archibald, S. J. (2018). Plastic scintillator-based microfluidic devices for miniaturized detection of Positron Emission Tomography radiopharmaceuticals. Chemistry: a European journal, 24(52), 13749-13753. https://doi.org/10.1002/chem.201802395

A miniaturized radio-HPLC detector has been developed comprising a microfluidic device fabricated from plastic scintillator in combination with a silicon photomultiplier light sensor, and tested with samples containing a positron-emitting radionuclid... Read More about Plastic scintillator-based microfluidic devices for miniaturized detection of Positron Emission Tomography radiopharmaceuticals.

The common VWF single nucleotide variants c.2365A>G and c.2385T>C modify VWF biosynthesis and clearance (2018)
Journal Article
Mufti, A. H., Ogiwara, K., Swystun, L. L., Eikenboom, J. C. J., Budde, U., Hopman, W. M., … on behalf of the European Group on von Willebrand disease (EU-VWD) and Zimmerman Program for the Molecular and Clinical Biology of von Willebrand disease (ZPMCB-VWD) Study Groups. (2018). The common VWF single nucleotide variants c.2365A>G and c.2385T>C modify VWF biosynthesis and clearance. Blood Advances, 2(13), 1585-1594. https://doi.org/10.1182/bloodadvances.2017011643

Plasma levels of von Willebrand factor (VWF) vary considerably in the general population and this variation has been linked to several genetic and environmental factors. Genetic factors include 2 common single nucleotide variants (SNVs) located in VW... Read More about The common VWF single nucleotide variants c.2365A>G and c.2385T>C modify VWF biosynthesis and clearance.

A novel silver bioactive glass elicits antimicrobial efficacy against Pseudomonas aeruginosa and Staphylococcus aureus in an ex vivo skin wound biofilm model (2018)
Journal Article
Wilkinson, H. N., Iveson, S., Catherall, P., & Hardman, M. J. (2018). A novel silver bioactive glass elicits antimicrobial efficacy against Pseudomonas aeruginosa and Staphylococcus aureus in an ex vivo skin wound biofilm model. Frontiers in Microbiology, 9(JUL), Article 1450. https://doi.org/10.3389/fmicb.2018.01450

Biofilm infection is now understood to be a potent contributor to the recalcitrant nature of chronic wounds. Bacterial biofilms evade the host immune response and show increased resistance to antibiotics. Along with improvements in antibiotic steward... Read More about A novel silver bioactive glass elicits antimicrobial efficacy against Pseudomonas aeruginosa and Staphylococcus aureus in an ex vivo skin wound biofilm model.

Test-Retest reliability of a commercial linear position transducer (GymAware PowerTool) to measure velocity and power in the Back Squat and Bench Press (2018)
Journal Article
Orange, S. T., Metcalfe, J. W., Vince, R. V., Marshall, P., Madden, L. A., & Liefeith, A. (2020). Test-Retest reliability of a commercial linear position transducer (GymAware PowerTool) to measure velocity and power in the Back Squat and Bench Press. Journal of strength and conditioning research, 34(3), 728-737. https://doi.org/10.1519/JSC.0000000000002715

This study examined the test-retest reliability of the GymAware PowerTool (GYM) to measure velocity and power in the free-weight back squat and bench press. Twenty-nine academy rugby league players (age: 17.6 ± 1.0 years; body mass: 87.3 ± 20.8 kg) c... Read More about Test-Retest reliability of a commercial linear position transducer (GymAware PowerTool) to measure velocity and power in the Back Squat and Bench Press.

The effect of Glucose Concentration (5.6 mM vs. 17 mM) During IVM on Developmental and Metabolic Markers of Equine Cumulus-oocyte Complex Function (2018)
Journal Article
Lewis, N., Hinrichs, K., Brison, D., Sturmey, R., & McG. Argo, C. (2018). The effect of Glucose Concentration (5.6 mM vs. 17 mM) During IVM on Developmental and Metabolic Markers of Equine Cumulus-oocyte Complex Function. Journal of Equine Veterinary Science, 66, 181. https://doi.org/10.1016/j.jevs.2018.05.073

Both M199 and DMEM/F-12 support in vitro maturation (IVM) of equine oocytes and production of viable embryos after ICSI. However, these media differ markedly in glucose concentration: 5.6 mM (M199) vs. 17 mM (DMEM/F-12). Given the known impact of emb... Read More about The effect of Glucose Concentration (5.6 mM vs. 17 mM) During IVM on Developmental and Metabolic Markers of Equine Cumulus-oocyte Complex Function.

Attenuation of autophagy impacts on muscle fibre development, starvation induced stress and fibre regeneration following acute injury (2018)
Journal Article
Paolini, A., Omairi, S., Mitchell, R., Vaughan, D., Matsakas, A., Vaiyapuri, S., …Patel, K. (in press). Attenuation of autophagy impacts on muscle fibre development, starvation induced stress and fibre regeneration following acute injury. Scientific reports, 8(1), Article 9062. https://doi.org/10.1038/s41598-018-27429-7

Autophagy has been implicated as a major factor in the development of a number of diseases of skeletal muscle. However, its role in skeletal muscle homeostasis is still evolving. We examined skeletal muscle architecture in a mouse model, Atg16L1, whe... Read More about Attenuation of autophagy impacts on muscle fibre development, starvation induced stress and fibre regeneration following acute injury.

Synthesis, Crystal Structure, and Cytotoxicity Studies of titanacalix[4 and 8]arene Complexes (2018)
Journal Article
Miller-Shakesby, D. M., Nigam, S., Hughes, D. L., Lopez-Estelles, E., Elsegood, M. R., Cawthorne, C. J., …Redshaw, C. (2018). Synthesis, Crystal Structure, and Cytotoxicity Studies of titanacalix[4 and 8]arene Complexes. Dalton Transactions : an international journal of inorganic chemistry, 47(27), 8992-8999. https://doi.org/10.1039/c8dt01992d

© 2018 The Royal Society of Chemistry. Reaction of 5,11,17,23-tetra-tert-butyl-dihydroxy-26,28-bis(2-pentoxy)calix[4]arene (L(OH)2(Opentyl)2) with [TiCl4] afforded the dichlorotitanoacalix[4]arene complex [TiCl2L(O)2(Opentyl)2] (1) in good yield. Hyd... Read More about Synthesis, Crystal Structure, and Cytotoxicity Studies of titanacalix[4 and 8]arene Complexes.

Identifying patterns in signs and symptoms preceding the clinical diagnosis of Alzheimer's disease: retrospective medical record review study and a nested case -control design (2018)
Journal Article
Bature, F., Pang, D., Robinson, A., Polson, N., Pappas, Y., & Guinn, B. (2018). Identifying patterns in signs and symptoms preceding the clinical diagnosis of Alzheimer's disease: retrospective medical record review study and a nested case -control design. Current Alzheimer Research, 15(8), 723-730. https://doi.org/10.2174/1567205015666180404155358

Objective: Evidence suggests that individuals with Alzheimer’s disease (AD) are often diagnosed in the later stages of their disease with a poor prognosis. This study is aimed to identify patterns in signs and symptoms preceding the clinical diagnosi... Read More about Identifying patterns in signs and symptoms preceding the clinical diagnosis of Alzheimer's disease: retrospective medical record review study and a nested case -control design.

Validity and reliability of a wearable inertial sensor to measure velocity and power in the back squat and bench press (2018)
Journal Article
Orange, S. T., Metcalfe, J. W., Liefeith, A., Marshall, P., Madden, L. A., Fewster, C. R., & Vince, R. V. (2019). Validity and reliability of a wearable inertial sensor to measure velocity and power in the back squat and bench press. Journal of strength and conditioning research, 33(9), 2398-2408. https://doi.org/10.1519/JSC.0000000000002574

Orange, ST, Metcalfe, JW, Liefeith, A, Marshall, P, Madden, LA, Fewster, CR, and Vince, RV. Validity and reliability of a wearable inertial sensor to measure velocity and power in the back squat and bench press. J Strength Cond Res 33(9): 2398-2408,... Read More about Validity and reliability of a wearable inertial sensor to measure velocity and power in the back squat and bench press.

Modelling antisepsis using defined populations of facultative and anaerobic wound pathogens grown in a basally perfused biofilm model (2018)
Journal Article
Oates, A., Lindsay, S., Mistry, H., Ortega, F., & McBain, A. J. (2018). Modelling antisepsis using defined populations of facultative and anaerobic wound pathogens grown in a basally perfused biofilm model. Biofouling, 34(5), 507-518. https://doi.org/10.1080/08927014.2018.1466115

An in vitro model was developed to assess the effects of topical antimicrobials on taxonomically defined wound biofilms. Biofilms were exposed over seven days to povidone-iodine, silver acetate or polyhexamethylene biguanide (PHMB) at concentrations... Read More about Modelling antisepsis using defined populations of facultative and anaerobic wound pathogens grown in a basally perfused biofilm model.

Platelet function following induced hypoglycaemia in type 2 diabetes (2018)
Journal Article
Kahal, H., Aburima, A., Spurgeon, B., Wraith, K. S., Rigby, A. S., Sathyapalan, T., …Atkin, S. L. (2018). Platelet function following induced hypoglycaemia in type 2 diabetes. Diabetes & metabolism, 44(5), 431-436. https://doi.org/10.1016/j.diabet.2018.04.004

Aim Strict glycaemic control has been associated with an increased mortality rate in subjects with type 2 diabetes (T2DM). Here we examined platelet function immediately and 24 hours following induced hypoglycaemia in people with type 2 diabetes comp... Read More about Platelet function following induced hypoglycaemia in type 2 diabetes.

Exercise prehabilitation in elective intra-cavity surgery: A role within the ERAS pathway? A narrative review (2018)
Journal Article
Orange, S. T., Northgraves, M. J., Marshall, P., Madden, L. A., & Vince, R. V. (2018). Exercise prehabilitation in elective intra-cavity surgery: A role within the ERAS pathway? A narrative review. International journal of surgery, 56, 328-333. https://doi.org/10.1016/j.ijsu.2018.04.054

The Enhanced Recovery after Surgery (ERAS) model integrates several elements of perioperative care into a standardised clinical pathway for surgical patients. ERAS programmes aim to reduce the rate of complications, improve surgical recovery, and lim... Read More about Exercise prehabilitation in elective intra-cavity surgery: A role within the ERAS pathway? A narrative review.

Microbial host interactions and impaired wound healing in mice and humans: defining a role for BD14 and NOD2 (2018)
Journal Article
Williams, H., Campbell, L., Crompton, R. A., Singh, G., McHugh, B. J., Davidson, D. J., …Hardman, M. J. (2018). Microbial host interactions and impaired wound healing in mice and humans: defining a role for BD14 and NOD2. Journal of Investigative Dermatology, 138(10), 2264-2274. https://doi.org/10.1016/j.jid.2018.04.014

Chronic wounds cause significant patient morbidity and mortality. A key factor in their etiology is microbial infection, yet skin host-microbiota interactions during wound repair remain poorly understood. Microbiome profiles of non-infected human chr... Read More about Microbial host interactions and impaired wound healing in mice and humans: defining a role for BD14 and NOD2.

Hyaluronan-Based Nanohydrogels for Targeting Intracellular S. Aureus in Human Keratinocytes (2018)
Journal Article
Montanari, E., Oates, A., Di Meo, C., Meade, J., Cerrone, R., Francioso, A., …Matricardi, P. (2018). Hyaluronan-Based Nanohydrogels for Targeting Intracellular S. Aureus in Human Keratinocytes. Advanced Healthcare Materials, 7(12), Article 1701483. https://doi.org/10.1002/adhm.201701483

© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Staphylococcus aureus is one of the most significant human pathogens that is frequently isolated in a wide range of superficial and systemic infections. The ability of S. aureus to invade and surviv... Read More about Hyaluronan-Based Nanohydrogels for Targeting Intracellular S. Aureus in Human Keratinocytes.

Platelet biology in regenerative medicine of skeletal muscle (2018)
Journal Article
Scully, D., Naseem, K. M., & Matsakas, A. (2018). Platelet biology in regenerative medicine of skeletal muscle. Acta Physiologica, 223(3), Article e13071. https://doi.org/10.1111/apha.13071

Platelet‐based applications such as platelet‐rich plasma (PRP) and platelet releasate have gained unprecedented attention in regenerative medicine across a variety of tissues as of late. The rationale behind utilizing PRP originates in the delivery o... Read More about Platelet biology in regenerative medicine of skeletal muscle.

Pursuing intracellular pathogens with hyaluronan. From a 'pro-infection' polymer to a biomaterial for 'trojan horse' systems (2018)
Journal Article
Montanari, E., Di Meo, C., Oates, A., Coviello, T., & Matricardi, P. (2018). Pursuing intracellular pathogens with hyaluronan. From a 'pro-infection' polymer to a biomaterial for 'trojan horse' systems. Molecules, 23(4), 939. https://doi.org/10.3390/molecules23040939

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Hyaluronan (HA) is among the most important bioactive polymers in mammals, playing a key role in a number of biological functions. In the last decades, it has been increasingly studied as a bi... Read More about Pursuing intracellular pathogens with hyaluronan. From a 'pro-infection' polymer to a biomaterial for 'trojan horse' systems.