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Recent Advancements in Hematology: Knowledge, Methods and Dissemination, Part 2 (2021)
Journal Article
Corre, J., Sabbah, M., Schjesvold, F., Zeidan, A. M., Buccisano, F., Sallman, D., Mazzucato, M., Madden, L. A., Martini, M., Van Breda, E., Dolcetti, R., Busca, A., Cook, G., Onida, F., Versari, A., Kiladjian, J. J., Walter, R. B., Garderet, L., Robin, M., & Signore, A. (2021). Recent Advancements in Hematology: Knowledge, Methods and Dissemination, Part 2. Hemato, 2(1), 79-88. https://doi.org/10.3390/hemato2010004

Revascularisation of type 2 diabetics with coronary artery disease: Insights and therapeutic targeting of O-GlcNAcylation (2021)
Journal Article
Bolanle, I. O., Riches-Suman, K., Loubani, M., Williamson, R., & Palmer, T. M. (2021). Revascularisation of type 2 diabetics with coronary artery disease: Insights and therapeutic targeting of O-GlcNAcylation. Nutrition, metabolism, and cardiovascular diseases : NMCD, https://doi.org/10.1016/j.numecd.2021.01.017

Background and Aim: Coronary artery bypass graft (CABG) using autologous saphenous vein continues to be a gold standard procedure to restore the supply of oxygen-rich blood to the heart muscles in coronary artery disease (CAD) patients with or with... Read More about Revascularisation of type 2 diabetics with coronary artery disease: Insights and therapeutic targeting of O-GlcNAcylation.

Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia (2021)
Journal Article
Lin, W. Y., Fordham, S. E., Sunter, N., Elstob, C., Rahman, T., Willmore, E., Shepherd, C., Strathdee, G., Mainou-Fowler, T., Piddock, R., Mearns, H., Barrow, T., Houlston, R. S., Marr, H., Wallis, J., Summerfield, G., Marshall, S., Pettitt, A., Pepper, C., Fegan, C., …Allan, J. M. (2021). Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia. Nature communications, 12(1), Article 665. https://doi.org/10.1038/s41467-020-20822-9

© 2021, The Author(s). Prognostication in patients with chronic lymphocytic leukemia (CLL) is challenging due to heterogeneity in clinical course. We hypothesize that constitutional genetic variation affects disease progression and could aid prognost... Read More about Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia.

Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles (2021)
Journal Article
Baghdadi, N. E., Burke, B. P., Alresheedi, T., Nigam, S., Saeed, A., Almutairi, F., Domarkas, J., Khan, A., & Archibald, S. J. (2021). Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles. Dalton Transactions : an international journal of inorganic chemistry, 50(5), 1599-1603. https://doi.org/10.1039/d0dt02626c

The CXCR4 chemokine receptor is an important biomolecular target in cancer diagnostics and therapeutics. In a new multivalent approach, iron oxide nanoparticles were conjugated with multiple binding units of a low affinity azamacrocylic CXCR4 antagon... Read More about Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles.

Platelet releasate normalises the compromised muscle regeneration in a mouse model of hyperlipidaemia (2021)
Journal Article
Barlow, J., Sfyri, P. P., Mitchell, R., Verpoorten, S., Scully, D., Andreou, C., Papadopoulos, P., Patel, K., & Matsakas, A. (2021). Platelet releasate normalises the compromised muscle regeneration in a mouse model of hyperlipidaemia. Experimental Physiology, 106(3), 700-713. https://doi.org/10.1113/ep088937

Muscle satellite cells are important stem cells for skeletal muscle regeneration and repair after injury. ApoE‐deficient mice, an established mouse model of hyperlipidaemia and atherosclerosis, show evidence of oxidative stress‐induced lesions and fa... Read More about Platelet releasate normalises the compromised muscle regeneration in a mouse model of hyperlipidaemia.

PI3K inhibition as a novel therapeutic strategy for neoadjuvant chemoradiotherapy resistant oesophageal adenocarcinoma (2021)
Journal Article
Edge, S. D., Renard, I., Pyne, E., Li, C., Moody, H., Roy, R., Beavis, A. W., Archibald, S. J., Cawthorne, C. J., Maher, S. J., & Pires, I. M. (2021). PI3K inhibition as a novel therapeutic strategy for neoadjuvant chemoradiotherapy resistant oesophageal adenocarcinoma. British Journal of Radiology, 94(1119), Article 20201191. https://doi.org/10.1259/bjr.20201191

OBJECTIVE: Neoadjuvant chemoradiotherapy (neo-CRT) prior to surgery is the standard of care for oesophageal adenocarcinoma (OAC) patients. Unfortunately, most patients fail to respond to treatment. MiR-187 was previously shown to be downregulated in... Read More about PI3K inhibition as a novel therapeutic strategy for neoadjuvant chemoradiotherapy resistant oesophageal adenocarcinoma.

Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function (2021)
Journal Article
Huang, J., Peng, J., Pearson, J. A., Efthimiou, G., Hu, Y., Tai, N., Xing, Y., Zhang, L., Gu, J., Jiang, J., Zhao, H., Zhou, Z., Wong, F. S., & Wen, L. (2021). Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function. Cellular and Molecular Immunology, 18(2), 328-338. https://doi.org/10.1038/s41423-020-00590-8

Innate immunity mediated by Toll-like receptors (TLRs), which can recognize pathogen molecular patterns, plays a critical role in type 1 diabetes development. TLR7 is a pattern recognition receptor that senses single-stranded RNAs from viruses and ho... Read More about Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function.

Arginine methylation: the promise of a ‘silver bullet’ for brain tumours? (2021)
Journal Article
Samuel, S. F., Barry, A., Greenman, J., & Beltran-Alvarez, P. (2021). Arginine methylation: the promise of a ‘silver bullet’ for brain tumours?. Amino acids, 53(4), 489-506. https://doi.org/10.1007/s00726-020-02937-x

Despite intense research efforts, our pharmaceutical repertoire against high-grade brain tumours has not been able to increase patient survival for a decade and life expectancy remains at less than 16months after diagnosis, on average. Inhibitors of... Read More about Arginine methylation: the promise of a ‘silver bullet’ for brain tumours?.

Cellular benefits of single-use negative pressure wound therapy demonstrated in a novel ex vivo human skin wound model (2020)
Journal Article
Wilkinson, H. N., Longhorne, F. L., Roberts, E. R., Brownhill, V. R., & Hardman, M. J. (in press). Cellular benefits of single-use negative pressure wound therapy demonstrated in a novel ex vivo human skin wound model. Wound Repair and Regeneration, https://doi.org/10.1111/wrr.12888

Negative pressure wound therapy is a widely used treatment for chronic, nonhealing wounds. Surprisingly, few studies have systematically evaluated the cellular and molecular effects of negative pressure treatment on human skin. In addition, no study... Read More about Cellular benefits of single-use negative pressure wound therapy demonstrated in a novel ex vivo human skin wound model.

Association Between Breastfeeding and the Development of Childhood Diabetes Mellitus Type I (DM I): The Effect of Prolonged Exclusive Breastfeeding on Gut Microbiome and the Link with DM I (2020)
Journal Article
Karagkouni, I., Sideridou, M., Stoupi, S., & Efthimiou, G. (2021). Association Between Breastfeeding and the Development of Childhood Diabetes Mellitus Type I (DM I): The Effect of Prolonged Exclusive Breastfeeding on Gut Microbiome and the Link with DM I. Acta scientific paediatrics, 4(1), 28-32

The role of breastfeeding and dietary habits was studied in 10 children with DM I (case group) and compared with 10 healthy controls. Our results showed that the case group had significantly shorter exclusive breastfeeding duration compared with the... Read More about Association Between Breastfeeding and the Development of Childhood Diabetes Mellitus Type I (DM I): The Effect of Prolonged Exclusive Breastfeeding on Gut Microbiome and the Link with DM I.

Distinct immune regulatory receptor profiles linked to altered monocyte subsets in sarcoidosis (2020)
Journal Article
Fraser, S. D., Crooks, M. G., Kaye, P. M., & Hart, S. P. (2021). Distinct immune regulatory receptor profiles linked to altered monocyte subsets in sarcoidosis. ERJ Open Research, 7(1), https://doi.org/10.1183/23120541.00804-2020

Background: In sarcoidosis, blood monocytes, circulating precursors of granuloma macrophages, display enhanced inflammatory cytokine production, reduced expression of the regulatory (inhibitory) receptor CD200R, and altered subsets defined by CD14 an... Read More about Distinct immune regulatory receptor profiles linked to altered monocyte subsets in sarcoidosis.

Towards dual SPECT/optical bioimaging with a mitochondrial targeting, 99mTc(i) radiolabelled 1,8-naphthalimide conjugate (2020)
Journal Article
Day, A. H., Domarkas, J., Nigam, S., Renard, I., Cawthorne, C., Burke, B. P., Bahra, G. S., Oyston, P. C. F., Fallis, I. A., Archibald, S. J., & Pope, S. J. A. (in press). Towards dual SPECT/optical bioimaging with a mitochondrial targeting, 99mTc(i) radiolabelled 1,8-naphthalimide conjugate. Dalton Transactions : an international journal of inorganic chemistry, 49(2), 511-523. https://doi.org/10.1039/c9dt04024b

A series of six different 1,8-naphthalimide conjugated dipicolylamine ligands (L1-6) have been synthesised and characterised. The ligands possess a range of different linker units between the napthalimide fluorophore and dipcolylamine chelator which... Read More about Towards dual SPECT/optical bioimaging with a mitochondrial targeting, 99mTc(i) radiolabelled 1,8-naphthalimide conjugate.

Synthesis, characterisation and ROP catalytic evaluation of Cu(II) complexes bearing 2,2ʹ-diphenylglycine-derived moieties (2020)
Journal Article
Alshamrani, A. F. A., Santoro, O., Ounsworth, S., Prior, T. J., Stasiuk, G. J., & Redshaw, C. (2021). Synthesis, characterisation and ROP catalytic evaluation of Cu(II) complexes bearing 2,2ʹ-diphenylglycine-derived moieties. Polyhedron, 195, Article 114977. https://doi.org/10.1016/j.poly.2020.114977

The treatment of CuX2 (X = Cl, Br) with an equimolar amount of 2-2ʹ-diphenylglycine (DpgH) in EtOH at reflux afforded, after work up, the complexes [CuCl(Dpg)(EtOH)]2 (1) and [(CuBr2)2(Dpg)2Cu(EtOH)4] (2), respectively. The compounds were obtained mi... Read More about Synthesis, characterisation and ROP catalytic evaluation of Cu(II) complexes bearing 2,2ʹ-diphenylglycine-derived moieties.

Antibiofilm activity of heather and manuka honeys and antivirulence potential of some of their constituents on the DsbA1 enzyme of pseudomonas aeruginosa (2020)
Journal Article
Shirlaw, O., Billah, Z., Attar, B., Hughes, L., Qasaymeh, R. M., Seidel, V., & Efthimiou, G. (2020). Antibiofilm activity of heather and manuka honeys and antivirulence potential of some of their constituents on the DsbA1 enzyme of pseudomonas aeruginosa. Antibiotics, 9(12), 1-12. https://doi.org/10.3390/antibiotics9120911

Heather honey was tested for its effect on the formation of biofilms by Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterococcus faecalis, Salmonella Enteriditis and Acinetobacter baumanii in comparison wit... Read More about Antibiofilm activity of heather and manuka honeys and antivirulence potential of some of their constituents on the DsbA1 enzyme of pseudomonas aeruginosa.

Smart active antibiotic nanocarriers with protease surface functionality can overcome biofilms of resistant bacteria (2020)
Journal Article
Weldrick, P. J., Hardman, M. J., & Paunov, V. N. (2021). Smart active antibiotic nanocarriers with protease surface functionality can overcome biofilms of resistant bacteria. Materials Chemistry Frontiers, 5(2), 961-972. https://doi.org/10.1039/d0qm00874e

Treating bacterial infections with species demonstrating antibiotic resistance to the chosen antibiotic is often hindered due to the ability of certain bacteria to grow biofilms where they can effectively hide and resist the antibiotic action. We rep... Read More about Smart active antibiotic nanocarriers with protease surface functionality can overcome biofilms of resistant bacteria.

Microbes Against Humanity, a workshop game for horrible students: using a creative card game in higher education microbiology teaching (2020)
Journal Article
Efthimiou, G., & Tucker, N. P. (2020). Microbes Against Humanity, a workshop game for horrible students: using a creative card game in higher education microbiology teaching. Access Microbiology, https://doi.org/10.1099/acmi.0.000186

Introducing creative workshops in higher education curricula, in addition to formal lectures, is an excellent way of reinforcing knowledge and encouraging creative thinking. In particular, the use of card games as a tool for inducing student engageme... Read More about Microbes Against Humanity, a workshop game for horrible students: using a creative card game in higher education microbiology teaching.

Activation of PAR2 by tissue factor induces the release of the PTEN from MAGI proteins and regulates PTEN and Akt activities (2020)
Journal Article
Mohammad, M. A., Greenman, J., Maraveyas, A., & Ettelaie, C. (2020). Activation of PAR2 by tissue factor induces the release of the PTEN from MAGI proteins and regulates PTEN and Akt activities. Scientific reports, 10(1), Article 20908. https://doi.org/10.1038/s41598-020-77963-6

Tissue factor (TF) signalling has been associated with alterations in Akt activity influencing cellular survival and proliferation. TF is also shown to induce signalling through activation of the protease activated receptor (PAR)2. Seven cell lines w... Read More about Activation of PAR2 by tissue factor induces the release of the PTEN from MAGI proteins and regulates PTEN and Akt activities.

High-throughput fabrication of hepatic cell clusteroids with enhanced growth and functionality for tissue engineering applications (2020)
Journal Article
Wang, A., Madden, L. A., & Paunov, V. N. (2020). High-throughput fabrication of hepatic cell clusteroids with enhanced growth and functionality for tissue engineering applications. Materials Advances, 1(8), 3022-3032. https://doi.org/10.1039/d0ma00635a

Culturing of cells as three-dimensional (3D) clusters can enhance in vitro tests for basic biological research as well as for therapeutics development. Such 3D culture models, however, are often more complicated, cumbersome and expensive than two-dim... Read More about High-throughput fabrication of hepatic cell clusteroids with enhanced growth and functionality for tissue engineering applications.

Advanced biomedical applications based on emerging 3D cell culturing platforms (2020)
Journal Article
Wang, A., Madden, L. A., & Paunov, V. N. (2020). Advanced biomedical applications based on emerging 3D cell culturing platforms. Journal of Materials Chemistry B, 8(46), 10487-10501. https://doi.org/10.1039/d0tb01658f

It is of great value to develop reliable in vitro models for cell biology and toxicology. However, ethical issues and the decreasing number of donors restrict the further use of traditional animal models in various fields, including the emerging fiel... Read More about Advanced biomedical applications based on emerging 3D cell culturing platforms.