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Variant IRF4/MUM1 associates with CD38 status and treatment-free survival in chronic lymphocytic leukaemia (2010)
Journal Article
Allan, J. M., Sunter, N. J., Bailey, J. R., Pettitt, A. R., Harris, R. J., Pepper, C., Fegan, C., Hall, A. G., Deignan, L., Bacon, C. M., Pointon, J. C., Houlston, R. S., Broderick, P., Mainou-Fowler, T., Jackson, G. H., Summerfield, G., Evans, P. A., Strefford, J. C., Parker, A., Oscier, D., …Allsup, D. J. (2010). Variant IRF4/MUM1 associates with CD38 status and treatment-free survival in chronic lymphocytic leukaemia. Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 24(4), 877-881. https://doi.org/10.1038/leu.2009.298

KSHV-encoded miRNAs target MAF to induce endothelial cell reprogramming (2010)
Journal Article
Hansen, A., Henderson, S., Lagos, D., Nikitenko, L., Coulter, E., Roberts, S., Gratrix, F., Plaisance, K., Renne, R., Bower, M., Kellam, P., & Boshoff, C. (2010). KSHV-encoded miRNAs target MAF to induce endothelial cell reprogramming. Genes & development, 24(2), 195-205. https://doi.org/10.1101/gad.553410

Kaposi sarcoma herpesvirus (KSHV) induces transcriptional reprogramming of endothelial cells. In particular, KSHV-infected lymphatic endothelial cells (LECs) show an up-regulation of genes associated with blood vessel endothelial cells (BECs). Conseq... Read More about KSHV-encoded miRNAs target MAF to induce endothelial cell reprogramming.

Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk (2010)
Journal Article
Crowther-Swanepoel, D., Broderick, P., Di Bernardo, M. C., Dobbins, S. E., Torres, M., Mansouri, M., Ruiz-Ponte, C., Enjuanes, A., Rosenquist, R., Carracedo, A., Jurlander, J., Campo, E., Juliusson, G., Montserrat, E., Smedby, K. E., Dyer, M. J., Matutes, E., Dearden, C., Sunter, N. J., Hall, A. G., …Houlston, R. S. (2010). Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk. Nature genetics, 42(2), 132-136. https://doi.org/10.1038/ng.510

To identify new risk variants for chronic lymphocytic leukemia (CLL), we conducted a genome-wide association study of 299,983 tagging SNPs, with validation in four additional series totaling 2,503 cases and 5,789 controls. We identified four new risk... Read More about Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk.

Amino acid metabolism of bovine blastocysts: A biomarker of sex and viability (2010)
Journal Article
Sturmey, R. G., Bermejo-Alvarez, P., Gutierrez-Adan, A., Rizos, D., Leese, H. J., & Lonergan, P. (2010). Amino acid metabolism of bovine blastocysts: A biomarker of sex and viability. Molecular Reproduction and Development, 77(3), 285-296. https://doi.org/10.1002/mrd.21145

The ratio of male/female embryos may be modified by environmental factors such as maternal diet in vivo and the composition of embryo culture media in vitro. We have used amino acid profiling, a noninvasive marker of developmental potential to compar... Read More about Amino acid metabolism of bovine blastocysts: A biomarker of sex and viability.

Alterations in the Th1/Th2 balance in breast cancer patients using reflexology and scalp massage (2010)
Journal Article
Green, V. L., Alexandropoulou, A., Walker, M. B., Walker, A. A., Sharp, D. M., Walker, L. G., & Greenman, J. (2010). Alterations in the Th1/Th2 balance in breast cancer patients using reflexology and scalp massage. Experimental and Therapeutic Medicine, 1(1), 97-108. https://doi.org/10.3892/etm_00000018

The diagnosis and treatment of breast cancer can adversely affect quality of life Here the aim was to determine the effects of reflexology on host defences and endocrine function in women with early breast cancer Six weeks after surgery for early bre... Read More about Alterations in the Th1/Th2 balance in breast cancer patients using reflexology and scalp massage.

Coordination chemistry of macrocyclic ligands (2009)
Journal Article
Archibald, S. J. (2009). Coordination chemistry of macrocyclic ligands. Annual Reports Section A :Inorganic Chemistry, 105, 297 - 322. https://doi.org/10.1039/b818281g

This chapter reviews the literature published during 2008 on macrocyclic coordination chemistry. Porphyrin ligands and supramolecular chemistry are not covered in this review which primarily focuses on complexes formed with transition metals and lant... Read More about Coordination chemistry of macrocyclic ligands.

Development of a high throughput screening tool for biotransformations utilising a thermophilic L-aminoacylase enzyme (2009)
Journal Article
Ngamsom, B., Hickey, A. M., Greenway, G. M., Littlechild, J. A., Watts, P., & Wiles, C. (2010). Development of a high throughput screening tool for biotransformations utilising a thermophilic L-aminoacylase enzyme. Journal of Molecular Catalysis B: Enzymatic, 63(1-2), 81-86. https://doi.org/10.1016/j.molcatb.2009.12.013

Micro-reactors containing a monolith-immobilised thermophilic l-aminoacylase, from Thermococcus litoralis, have been developed for use in biotransformation reactions and a study has been carried out to investigate the stereospecificity and stability... Read More about Development of a high throughput screening tool for biotransformations utilising a thermophilic L-aminoacylase enzyme.

Development of a monolith based immobilized lipase micro-reactor for biocatalytic reactions in a biphasic mobile system (2009)
Journal Article
He, P., Greenway, G., & Haswell, S. J. (2010). Development of a monolith based immobilized lipase micro-reactor for biocatalytic reactions in a biphasic mobile system. Process Biochemistry, 45(4), 593-597. https://doi.org/10.1016/j.procbio.2009.12.008

This paper reports a simple method for producing macroporous silica-monoliths with controllable porosity that can be used for the immobilization of lipases to generate an active and stable micro-reactor for biocatalysis. A range of commercially avail... Read More about Development of a monolith based immobilized lipase micro-reactor for biocatalytic reactions in a biphasic mobile system.

Measurement of acetylcholinesterase inhibition using bienzymes immobilized monolith micro-reactor with integrated electrochemical detection (2009)
Journal Article
He, P., Davies, J., Greenway, G., & Haswell, S. J. (2010). Measurement of acetylcholinesterase inhibition using bienzymes immobilized monolith micro-reactor with integrated electrochemical detection. Analytica Chimica Acta, 659(1-2), 9-14. https://doi.org/10.1016/j.aca.2009.11.052

This paper reports a simple μ-FIA based method for the rapid evaluation of acetylcholinesterase inhibition based on bienzymes immobilized monolith micro-reactor, with integrated electrochemical detection. The monolith was prepared inside a micro-flui... Read More about Measurement of acetylcholinesterase inhibition using bienzymes immobilized monolith micro-reactor with integrated electrochemical detection.

TRPA1 agonists evoke coughing in guinea pig and human volunteers (2009)
Journal Article
Birrell, M. A., Belvisi, M. G., Grace, M., Sadofsky, L., Faruqi, S., Hele, D. J., Maher, S. A., Freund-Michel, V., & Morice, A. H. (2009). TRPA1 agonists evoke coughing in guinea pig and human volunteers. American Journal of Respiratory and Critical Care Medicine, 180(11), 1042-1047. https://doi.org/10.1164/rccm.200905-0665OC

Rationale: Cough is the most frequent reason for consultation with a family doctor, or with a general or respiratory physician. Treatment options are limited and one meta-analysis concluded that over-the-counter remedies are ineffective. There is als... Read More about TRPA1 agonists evoke coughing in guinea pig and human volunteers.

Detection of nitric oxide in tissue samples by ESI-MS (2009)
Journal Article
Shen, Z., Webster, A., Welham, K. J., Dyer, C. E., Greenman, J., & Haswell, S. J. (2010). Detection of nitric oxide in tissue samples by ESI-MS. Analyst, 135(2), 302-305. https://doi.org/10.1039/b917643h

A novel method to determine nitric oxide (NO) in biological tissue samples with minimal interference from the cellular detritus is described. Methylpiperazinobenzenediamine, consisting of an o-phenylenediamine and a methyl piperazine group, was chose... Read More about Detection of nitric oxide in tissue samples by ESI-MS.

Proteomic identification of putative biomarkers of radiotherapy resistance: a possible role for the 26S proteasome? (2009)
Journal Article
Smith, L., Qutob, O., Watson, M. B., Beavis, A. W., Potts, D., Welham, K. J., Garimella, V., Lind, M. J., Drew, P. J., & Cawkwell, L. (2009). Proteomic identification of putative biomarkers of radiotherapy resistance: a possible role for the 26S proteasome?. Neoplasia, 11(11), 1194-1207. https://doi.org/10.1593/neo.09902

PURPOSE: We aimed to identify putative predictive protein biomarkers of radioresistance. EXPERIMENTAL DESIGN: Three breast cancer cell lines (MCF7, MDA-MB-231, and T47D) were used as in vitro models to study radioresistance. Inherent radiosensitiviti... Read More about Proteomic identification of putative biomarkers of radiotherapy resistance: a possible role for the 26S proteasome?.

IL-7 is superior to IL-2 for ex vivo expansion of tumourspecific CD4 + T cells (2009)
Journal Article
Caserta, S., Alessi, P., Basso, V., & Mondino, A. (2010). IL-7 is superior to IL-2 for ex vivo expansion of tumourspecific CD4 + T cells. European journal of immunology, 40(2), 470-479. https://doi.org/10.1002/eji.200939801

It is well established that tumours hinder both natural and vaccine-induced tumourspecific CD4 + T-cell responses. Adoptive T-cell therapy has the potential to circumvent functional tolerance and enhance anti-tumour protective responses. While proto... Read More about IL-7 is superior to IL-2 for ex vivo expansion of tumourspecific CD4 + T cells.

Nitric oxide inhibits von Willebrand factor-mediated platelet adhesion and spreading through regulation of integrin α IIbβ 3 and myosin light chain (2009)
Journal Article
Roberts, W., Michno, A., Aburima, A., & Naseem, K. M. (2009). Nitric oxide inhibits von Willebrand factor-mediated platelet adhesion and spreading through regulation of integrin α IIbβ 3 and myosin light chain. Journal of thrombosis and haemostasis : JTH, 7(12), 2106-2115. https://doi.org/10.1111/j.1538-7836.2009.03619.x

Background: von Willebrand factor (VWF)-mediated platelet adhesion and spreading at sites of vascular injury is a critical step in hemostasis. This process requires two individual receptors: glycoprotein Ib (GPIb)-V-IX and integrin αIIbβ3. However, l... Read More about Nitric oxide inhibits von Willebrand factor-mediated platelet adhesion and spreading through regulation of integrin α IIbβ 3 and myosin light chain.

Single and multiple CH (calponin homology) domain containing multidomain proteins in Dictyostelium discoideum: An inventory (2009)
Journal Article
Friedberg, F., & Rivero, F. (2010). Single and multiple CH (calponin homology) domain containing multidomain proteins in Dictyostelium discoideum: An inventory. Molecular biology reports, 37(6), 2853-2862. https://doi.org/10.1007/s11033-009-9839-1

We present an inventory of single or multiple calponin homology (CH) domain containing proteins of Dictyostelium discoideum. A multiple alignment and a phylogenetic tree of all 60 CH domains found in 36 proteins showed that most CH domains can be ass... Read More about Single and multiple CH (calponin homology) domain containing multidomain proteins in Dictyostelium discoideum: An inventory.

Evaluation of the dimethylaminocinnemaldehyde contact transfer process and its application to fingerprint development on thermal papers (2009)
Journal Article
Croxton, R., Lee, J., Bleay, S., Sears, V., & Mehmet, S. (2009). Evaluation of the dimethylaminocinnemaldehyde contact transfer process and its application to fingerprint development on thermal papers. Journal of Forensic Identification, 59(5), 545-568

The use of dimethylaminocinnemaldehyde (DMAC) as a fingerprint development reagent was first proposed in the 1970s as a solution-dipping technique to target the urea constituent of fingerprints. However, in operational trials, the quality of develope... Read More about Evaluation of the dimethylaminocinnemaldehyde contact transfer process and its application to fingerprint development on thermal papers.

Immobilized anthraquinone for redox mediation of horseradish peroxidase for hydrogen peroxide sensing (2009)
Journal Article
Dou, Y., Haswell, S., Greenman, J., & Wadhawan, J. (2009). Immobilized anthraquinone for redox mediation of horseradish peroxidase for hydrogen peroxide sensing. Electrochemistry communications, 11(10), 1976-1981. https://doi.org/10.1016/j.elecom.2009.08.032

The detection of hydrogen peroxide is detailed using horseradish peroxidase and anthraquinone. Both species are immobilized on a glassy carbon electrode substrate. This dual immobilization gives rise to lower detection limits compared with the situat... Read More about Immobilized anthraquinone for redox mediation of horseradish peroxidase for hydrogen peroxide sensing.

Development of a gel-to-gel electro-kinetic pinched injection method for an integrated micro-fluidic based DNA analyser (2009)
Journal Article
Oakley, J. A., Robinson, S., Dyer, C. E., Greenman, J., Greenway, G. M., & Haswell, S. J. (2009). Development of a gel-to-gel electro-kinetic pinched injection method for an integrated micro-fluidic based DNA analyser. Analytica Chimica Acta, 652(1-2), 239-244. https://doi.org/10.1016/j.aca.2009.07.063

An integrated gel supported micro-fluidic system is reported, in which PCR products can be efficiently injected into a capillary electrophoresis device. The gel supported system is designed to provide greater stability to reagents during long periods... Read More about Development of a gel-to-gel electro-kinetic pinched injection method for an integrated micro-fluidic based DNA analyser.

Development of enzyme immobilized monolith micro-reactors integrated with microfluidic electrochemical cell for the evaluation of enzyme kinetics (2009)
Journal Article
Greenway, G., Haswell, S. J., & He, P. (2010). Development of enzyme immobilized monolith micro-reactors integrated with microfluidic electrochemical cell for the evaluation of enzyme kinetics. Microfluidics and Nanofluidics, 8(5), 565-573. https://doi.org/10.1007/s10404-009-0476-8

This paper describes a simple and efficient method for producing an on-chip enzyme immobilized monolith micro-reactor that integrates a microfluidic electrochemical cell for rapid characterization of enzymatic kinetics. The monolith was generated usi... Read More about Development of enzyme immobilized monolith micro-reactors integrated with microfluidic electrochemical cell for the evaluation of enzyme kinetics.