All Outputs (917)

Evaluation of the dimethylaminocinnemaldehyde contact transfer process and its application to fingerprint development on thermal papers (2009)
Journal Article
Croxton, R., Lee, J., Bleay, S., Sears, V., & Mehmet, S. (2009). Evaluation of the dimethylaminocinnemaldehyde contact transfer process and its application to fingerprint development on thermal papers. Journal of Forensic Identification, 59(5), 545-568

The use of dimethylaminocinnemaldehyde (DMAC) as a fingerprint development reagent was first proposed in the 1970s as a solution-dipping technique to target the urea constituent of fingerprints. However, in operational trials, the quality of develope... Read More about Evaluation of the dimethylaminocinnemaldehyde contact transfer process and its application to fingerprint development on thermal papers.

Immobilized anthraquinone for redox mediation of horseradish peroxidase for hydrogen peroxide sensing (2009)
Journal Article
Dou, Y., Haswell, S., Greenman, J., & Wadhawan, J. (2009). Immobilized anthraquinone for redox mediation of horseradish peroxidase for hydrogen peroxide sensing. Electrochemistry communications, 11(10), 1976-1981. https://doi.org/10.1016/j.elecom.2009.08.032

The detection of hydrogen peroxide is detailed using horseradish peroxidase and anthraquinone. Both species are immobilized on a glassy carbon electrode substrate. This dual immobilization gives rise to lower detection limits compared with the situat... Read More about Immobilized anthraquinone for redox mediation of horseradish peroxidase for hydrogen peroxide sensing.

Development of a gel-to-gel electro-kinetic pinched injection method for an integrated micro-fluidic based DNA analyser (2009)
Journal Article
Oakley, J. A., Robinson, S., Dyer, C. E., Greenman, J., Greenway, G. M., & Haswell, S. J. (2009). Development of a gel-to-gel electro-kinetic pinched injection method for an integrated micro-fluidic based DNA analyser. Analytica Chimica Acta, 652(1-2), 239-244. https://doi.org/10.1016/j.aca.2009.07.063

An integrated gel supported micro-fluidic system is reported, in which PCR products can be efficiently injected into a capillary electrophoresis device. The gel supported system is designed to provide greater stability to reagents during long periods... Read More about Development of a gel-to-gel electro-kinetic pinched injection method for an integrated micro-fluidic based DNA analyser.

Development of enzyme immobilized monolith micro-reactors integrated with microfluidic electrochemical cell for the evaluation of enzyme kinetics (2009)
Journal Article
Greenway, G., Haswell, S. J., & He, P. (2010). Development of enzyme immobilized monolith micro-reactors integrated with microfluidic electrochemical cell for the evaluation of enzyme kinetics. Microfluidics and Nanofluidics, 8(5), 565-573. https://doi.org/10.1007/s10404-009-0476-8

This paper describes a simple and efficient method for producing an on-chip enzyme immobilized monolith micro-reactor that integrates a microfluidic electrochemical cell for rapid characterization of enzymatic kinetics. The monolith was generated usi... Read More about Development of enzyme immobilized monolith micro-reactors integrated with microfluidic electrochemical cell for the evaluation of enzyme kinetics.

Response of the microbial community to water table variation and nutrient addition and its implications for in situ preservation of organic archaeological remains in wetland soils (2009)
Journal Article
Douterelo, I., Goulder, R., & Lillie, M. (2009). Response of the microbial community to water table variation and nutrient addition and its implications for in situ preservation of organic archaeological remains in wetland soils. International Biodeterioration and Biodegradation, 63(6), 795-805. https://doi.org/10.1016/j.ibiod.2009.06.010

Wetland environments can preserve organic archaeological remains because of their anaerobic nature. The ongoing discovery of archaeological sites in wetlands is associated with a lack of funds for excavation and preservation. This situation has led t... Read More about Response of the microbial community to water table variation and nutrient addition and its implications for in situ preservation of organic archaeological remains in wetland soils.

Collagen remodelling by osteoblast and prostate vancer vell interactions in metastatic bone lesions (2009)
Presentation / Conference Contribution
Sturge, J. (2009, May). Collagen remodelling by osteoblast and prostate vancer vell interactions in metastatic bone lesions. Presented at BIT‘s 2nd Annual World Cancer Congess 2009, Beijing

A major clinical complication in patients with advanced prostate cancer is metastasis to bone where osteoblastic and/or osteoclastic activity results in a highly destructive tissue remodelling process.Recent in vivo studies have identified important... Read More about Collagen remodelling by osteoblast and prostate vancer vell interactions in metastatic bone lesions.

Mitochondrial carrier family inventory of Trypanosoma brucei brucei: identification, expression and subcellular localisation (2009)
Journal Article
Colasante, C., Peña Diaz, P., Clayton, C., & Voncken, F. (2009). Mitochondrial carrier family inventory of Trypanosoma brucei brucei: identification, expression and subcellular localisation. Molecular and Biochemical Parasitology, 167(2), 104-117. https://doi.org/10.1016/j.molbiopara.2009.05.004

The mitochondrial carrier family (MCF) is a group of structurally conserved proteins that mediate the transport of a wide range of metabolic intermediates across the mitochondrial inner membrane. In this paper, an overview of the mitochondrial carrie... Read More about Mitochondrial carrier family inventory of Trypanosoma brucei brucei: identification, expression and subcellular localisation.

COX-2 specific inhibitors enhance the cytotoxic effects of pemetrexed in mesothelioma cell lines (2009)
Journal Article
O'Kane, S. L., Eagle, G. L., Greenman, J., Lind, M. J., & Cawkwell, L. (2010). COX-2 specific inhibitors enhance the cytotoxic effects of pemetrexed in mesothelioma cell lines. Lung Cancer, 67(2), 160-165. https://doi.org/10.1016/j.lungcan.2009.04.008

BACKGROUND Although malignant pleural mesothelioma is a rare tumour, its incidence is increasing. The prognosis remains very poor with an average survival of 10 months from diagnosis. The choice of chemotherapy regimens for mesothelioma patients is l... Read More about COX-2 specific inhibitors enhance the cytotoxic effects of pemetrexed in mesothelioma cell lines.

CXCR4 antagonists: a new generation of configurationally restricted bis-azamacrocyclic compounds (2009)
Journal Article
Khan, A., Nicholson, G., McRobbie, G., Greenman, J., Pannecouque, C., Daelemans, D., Schols, D., De CLercq, E., Hubin, T. J., & Archibald, S. J. (2009). CXCR4 antagonists: a new generation of configurationally restricted bis-azamacrocyclic compounds. Antiviral research, 82(2), A59-A60. https://doi.org/10.1016/j.antiviral.2009.02.141

AMD3100 is a bis-azamacrocyclic compound that has been demonstrated to be a highly effective antagonist of the CXCR4 chemokine receptor. The two azamacrocyclic rings have been shown to interact with aspartate residues on the receptor via hydrogen bon... Read More about CXCR4 antagonists: a new generation of configurationally restricted bis-azamacrocyclic compounds.

Muscle hypertrophy driven by myostatin blockade does not require stem/precursor-cell activity (2009)
Journal Article
Amthor, H., Otto, A., Vulin, A., Rochat, A., Dumonceaux, J., Garcia, L., Mouisel, E., Hourdé, C., Macharia, R., Friedrichs, M., Relaix, F., Zammit, P. S., Matsakas, A., Patel, K., & Partridge, T. (2009). Muscle hypertrophy driven by myostatin blockade does not require stem/precursor-cell activity. Proceedings of the National Academy of Sciences of the United States of America, 106(18), 7479-7484. https://doi.org/10.1073/pnas.0811129106

Myostatin, a member of the TGF-β family, has been identified as a powerful inhibitor of muscle growth. Absence or blockade of myostatin induces massive skeletal muscle hypertrophy that is widely attributed to proliferation of the population of muscle... Read More about Muscle hypertrophy driven by myostatin blockade does not require stem/precursor-cell activity.

The use of carrier RNA to enhance DNA extraction from microfluidic-based silica monoliths (2009)
Journal Article
Shaw, K. J., Thain, L., Dyer, C., Docker, P. T., Greenman, J., Greenway, G. M., & Haswell, S. J. (2009). The use of carrier RNA to enhance DNA extraction from microfluidic-based silica monoliths. Analytica Chimica Acta, 652(1-2), 231-233. https://doi.org/10.1016/j.aca.2009.03.038

DNA extraction was carried out on silica-based monoliths within a microfluidic device. Solid-phase DNA extraction methodology was applied in which the DNA binds to silica in the presence of a chaotropic salt, such as guanidine hydrochloride, and is e... Read More about The use of carrier RNA to enhance DNA extraction from microfluidic-based silica monoliths.

Plastin 1 binds to keratin and is required for terminal web assembly in the intestinal epithelium (2009)
Journal Article
Grimm-Gunter, E. M. S., Grimm-Guenter, E.-M. S., Ferrary, E., Grimm-Günter, E.-M. S., Hurbain, I., Louvard, D., Ramos, S., Revenu, C., Rivero, F., Robine, S., & Smyth, N. (2009). Plastin 1 binds to keratin and is required for terminal web assembly in the intestinal epithelium. Molecular Biology of the Cell, 20(10), 2549-2562. https://doi.org/10.1091/mbc.e08-10-1030

Plastin 1 (I-plastin, fimbrin) along with villin and espin is a prominent actin-bundling protein of the intestinal brush border microvilli. We demonstrate here that plastin 1 accumulates in the terminal web and interacts with keratin 19, possibly con... Read More about Plastin 1 binds to keratin and is required for terminal web assembly in the intestinal epithelium.

Development of a bi-functional silica monolith for electro-osmotic pumping and DNA clean-up/extraction using gel-supported reagents in a microfluidic device (2009)
Journal Article
Oakley, J. A., Shaw, K. J., Docker, P. T., Dyer, C. E., Greenman, J., Greenway, G. M., & Haswell, S. J. (2009). Development of a bi-functional silica monolith for electro-osmotic pumping and DNA clean-up/extraction using gel-supported reagents in a microfluidic device. Lab on a chip, 9(11), 1596-1600. https://doi.org/10.1039/b820553a

A silica monolith used to support both electro-osmotic pumping (EOP) and the extraction/elution of DNA coupled with gel-supported reagents is described. The benefits of the combined EOP extraction/elution system were illustrated by combining DNA extr... Read More about Development of a bi-functional silica monolith for electro-osmotic pumping and DNA clean-up/extraction using gel-supported reagents in a microfluidic device.

T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance (2009)
Journal Article
Salmond, R. J., Filby, A., Qureshi, I., Caserta, S., & Zamoyska, R. (2009). T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance. Immunological reviews, 228(1), 9-22. https://doi.org/10.1111/j.1600-065x.2008.00745.x

T-cell development in the thymus and activation of mature T cells in secondary lymphoid organs requires the ability of cells to respond appropriately to environmental signals at multiple stages of their development. The process of thymocyte selection... Read More about T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance.

Binding Optimization through Coordination Chemistry: CXCR4 Chemokine Receptor Antagonists from Ultrarigid Metal Complexes (2009)
Journal Article
Khan, A., Nicholson, G., McRobbie, G., Pannecouque, C., De Clercq, E., Ullom, R., Maples, D. L., Maples, R. D., Silversides, J. D., Hubin, T. J., Archibald, S. J., Madden, L., & Greenman, J. (2009). Binding Optimization through Coordination Chemistry: CXCR4 Chemokine Receptor Antagonists from Ultrarigid Metal Complexes. Journal of the American Chemical Society, 131(10), 3416-3417. https://doi.org/10.1021/ja807921k

A new copper(II) containing bis-macrocyclic CXCR4 chemokine receptor antagonist is shown to have improved binding properties to the receptor protein in comparison to the drug AMD3100 (Plerixafor, Mozobil). The interaction of the metallodrug has been... Read More about Binding Optimization through Coordination Chemistry: CXCR4 Chemokine Receptor Antagonists from Ultrarigid Metal Complexes.

Removal of red light minimizes methylene blue-stimulated DNA damage in oesophageal cells: implications for chromoendoscopy (2009)
Journal Article
Sturmey, R. G., Wild, C. P., & Hardie, L. J. (2009). Removal of red light minimizes methylene blue-stimulated DNA damage in oesophageal cells: implications for chromoendoscopy. Mutagenesis, 24(3), 253-258. https://doi.org/10.1093/mutage/gep004

Barrett's oesophagus (BO) carries an increased risk of progression to oesophageal adenocarcinoma. Chromoendoscopy with methylene blue (MB) can be used to facilitate identification of BO and target areas for biopsy. If photoexcited, MB can generate re... Read More about Removal of red light minimizes methylene blue-stimulated DNA damage in oesophageal cells: implications for chromoendoscopy.

Reductive Amination-A convenient method for generating diverse, mono-functionalised 5,10,15,20-tetraphenyl porphyrins (2009)
Journal Article
Welch, C., Archibald, S. J., & Boyle, R. (2009). Reductive Amination-A convenient method for generating diverse, mono-functionalised 5,10,15,20-tetraphenyl porphyrins. SYNTHESIS, 2009(4), 551-556. https://doi.org/10.1055/s-0028-1083335

Formylation followed by reductive amination of 5,10,15,20-tetraphenyl porphyrin (TPP) is shown to be a versatile synthetic procedure for monosubstitution of the porphyrin core re-giospecifically at one β-position. A diverse range of substituents can... Read More about Reductive Amination-A convenient method for generating diverse, mono-functionalised 5,10,15,20-tetraphenyl porphyrins.

pH testing for detecting the position of nasogastric tubes in adults and children (2009)
Journal Article
Kalia, S., Hall, J., El-Habbal, M., Imrie, C., Arabiat, D. H., Shields, L., Allgar, V., Wadhawan, J., Greenman, J., & Elliott, B. (2009). pH testing for detecting the position of nasogastric tubes in adults and children. Cochrane Database of Systematic Reviews, 28126. https://doi.org/10.1002/14651858.cd007660

This is the protocol for a review and there is no abstract. The objectives are as follows: Our objective is to determine if there is sufficient evidence to recommend the use of pH testing (the intervention under scrutiny) for verification of correct... Read More about pH testing for detecting the position of nasogastric tubes in adults and children.

Simple practical approach for sample loading prior to DNA extraction using a silica monolith in a microfluidic device (2009)
Journal Article
Shaw, K. J., Docker, P. T., Haswell, S. J., Joyce, D. A., Dyer, C. E., Greenman, J., & Greenway, G. M. (2009). Simple practical approach for sample loading prior to DNA extraction using a silica monolith in a microfluidic device. Lab on a chip, 9(23), 3430-3432. https://doi.org/10.1039/b913309g

A novel DNA loading methodology is presented for performing DNA extraction on a microfluidic system. DNA in a chaotropic salt solution was manually loaded onto a silica monolith orthogonal to the subsequent flow of wash and elution solutions. DNA was... Read More about Simple practical approach for sample loading prior to DNA extraction using a silica monolith in a microfluidic device.

Transient receptor potential vanilloid-1-mediated calcium responses are inhibited by the alkylamine antihistamines dexbrompheniramine and chlorpheniramine (2008)
Journal Article
Sadofsky, L. R., Campi, B., Trevisani, M., Compton, S. J., & Morice, A. H. (2008). Transient receptor potential vanilloid-1-mediated calcium responses are inhibited by the alkylamine antihistamines dexbrompheniramine and chlorpheniramine. Experimental Lung Research, 34(10), 681-693. https://doi.org/10.1080/01902140802339623

American guidelines, unlike European guidelines, support the use of antihistamines as a first line of treatment for some causes of chronic cough. Transient receptor potential vanilloid-1 (TRPV1) is an ion channel activated by the tussive agents capsa... Read More about Transient receptor potential vanilloid-1-mediated calcium responses are inhibited by the alkylamine antihistamines dexbrompheniramine and chlorpheniramine.