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Soluble Neuropilin-1 Response to Hypoglycemia in Type 2 Diabetes: Increased Risk or Protection in SARS-CoV-2 Infection? (2021)
Journal Article
Moin, A. S. M., Al-Qaissi, A., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2021). Soluble Neuropilin-1 Response to Hypoglycemia in Type 2 Diabetes: Increased Risk or Protection in SARS-CoV-2 Infection?. Frontiers in endocrinology, 12, Article 665134. https://doi.org/10.3389/fendo.2021.665134

Introduction: Neuropilin-1(NRP1) is a cofactor that enhances SARS-CoV-2 coronavirus cell infectivity when co-expressed with angiotensin-converting enzyme 2(ACE2). The Renin-Angiotensin System (RAS) is activated in type 2 diabetes (T2D); therefore, th... Read More about Soluble Neuropilin-1 Response to Hypoglycemia in Type 2 Diabetes: Increased Risk or Protection in SARS-CoV-2 Infection?.

Predictors of diabetes-related distress before and after FreeStyle Libre-1 use: Lessons from the Association of British Clinical Diabetologists nationwide study (2021)
Journal Article
Deshmukh, H., Wilmot, E. G., Gregory, R., Barnes, D., Narendran, P., Saunders, S., Furlong, N., Kamaruddin, S., Banatwalla, R., Herring, R., Kilvert, A., Patmore, J., Walton, C., Ryder, R. E., & Sathyapalan, T. (2021). Predictors of diabetes-related distress before and after FreeStyle Libre-1 use: Lessons from the Association of British Clinical Diabetologists nationwide study. Diabetes, Obesity and Metabolism, 23(10), 2261-2268. https://doi.org/10.1111/dom.14467

Aim: To identify the baseline demographic and clinical characteristics associated with diabetes-related distress (DRD) and factors associated with improvement in DRD after initiating use of the FreeStyle Libre (FSL) in people living with type 1 diabe... Read More about Predictors of diabetes-related distress before and after FreeStyle Libre-1 use: Lessons from the Association of British Clinical Diabetologists nationwide study.

Roux-en-Y gastric bypass-induced bacterial perturbation contributes to altered host-bacterial co-metabolic phenotype (2021)
Journal Article
Li, J. V., Ashrafian, H., Sarafian, M., Homola, D., Rushton, L., Barker, G., Cabrera, P. M., Lewis, M. R., Darzi, A., Lin, E., Gletsu-Miller, N. A., Atkin, S. L., Sathyapalan, T., Gooderham, N. J., Nicholson, J. K., Marchesi, J. R., Athanasiou, T., & Holmes, E. (2021). Roux-en-Y gastric bypass-induced bacterial perturbation contributes to altered host-bacterial co-metabolic phenotype. Microbiome, 9(1), Article 139. https://doi.org/10.1186/s40168-021-01086-x

Background: Bariatric surgery, used to achieve effective weight loss in individuals with severe obesity, modifies the gut microbiota and systemic metabolism in both humans and animal models. The aim of the current study was to understand better the m... Read More about Roux-en-Y gastric bypass-induced bacterial perturbation contributes to altered host-bacterial co-metabolic phenotype.

Eliapixant (BAY 1817080), a P2X3 receptor antagonist, in refractory chronic cough: A randomised, placebo-controlled, crossover phase 2a study (2021)
Journal Article
Morice, A., Smith, J. A., McGarvey, L., Birring, S. S., Parker, S. M., Turner, A., Hummel, T., Gashaw, I., Fels, L., Klein, S., Francke, K., & Friedrich, C. (2021). Eliapixant (BAY 1817080), a P2X3 receptor antagonist, in refractory chronic cough: A randomised, placebo-controlled, crossover phase 2a study. European respiratory journal, 58(5), Article 2004240. https://doi.org/10.1183/13993003.04240-2020

Background. ATP acting via P2X3 receptors is an important mediator of refractory chronic cough (RCC). This phase 2a double-blinded crossover study assessed the safety, tolerability and efficacy of eliapixant (BAY 1817080), a selective P2X3 receptor a... Read More about Eliapixant (BAY 1817080), a P2X3 receptor antagonist, in refractory chronic cough: A randomised, placebo-controlled, crossover phase 2a study.

Astaxanthin and Nrf2 signaling pathway: a novel target for new therapeutic approaches (2021)
Journal Article
Ashrafizadeh, M., Ahmadi, Z., Yaribeygi, H., Sathyapalan, T., & Sahebkar, A. (in press). Astaxanthin and Nrf2 signaling pathway: a novel target for new therapeutic approaches. Mini-Reviews in Medicinal Chemistry, 22(2), 312-321. https://doi.org/10.2174/1389557521666210505112834

Astaxanthin (AST) is a naturally occurring compound isolated from various sources such as fungi, plants, salmon, and crab. However, Haematococcus Pluvialis, a green alga, is the primary source of this beta carotenoid compound. AST has several favoura... Read More about Astaxanthin and Nrf2 signaling pathway: a novel target for new therapeutic approaches.

Amyloid-related protein changes associated with dementia differ according to severity of hypoglycemia (2021)
Journal Article
Moin, A. S. M., Kahal, H., Al-Qaissi, A., Kumar, N., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2021). Amyloid-related protein changes associated with dementia differ according to severity of hypoglycemia. BMJ Open Diabetes Research and Care, 9(1), Article e002211. https://doi.org/10.1136/bmjdrc-2021-002211

Introduction Hypoglycemia in type 2 diabetes (T2D) may increase risk for Alzheimer’s disease (AD), but no data on changes in AD-related proteins with differing degrees of hypoglycemia exist. We hypothesized that milder prolonged hypoglycemia would ca... Read More about Amyloid-related protein changes associated with dementia differ according to severity of hypoglycemia.

Effect of curcumin on proinflammatory cytokines: A meta-analysis of randomized controlled trials (2021)
Journal Article
Gorabi, A. M., Razi, B., Aslani, S., Abbasifard, M., Imani, D., Sathyapalan, T., & Sahebkar, A. (2021). Effect of curcumin on proinflammatory cytokines: A meta-analysis of randomized controlled trials. Cytokine, 143, Article 155541. https://doi.org/10.1016/j.cyto.2021.155541

It has been suggested that curcumin has the potential for lowering inflammation. In the current meta-analysis, we attempted to clarify the efficacy of curcumin/turmeric supplementation in reducing concentrations of interleukin (IL)-1, IL-6, IL-8, and... Read More about Effect of curcumin on proinflammatory cytokines: A meta-analysis of randomized controlled trials.

Antioxidative Potentials of Incretin-Based Medications: A Review of Molecular Mechanisms (2021)
Journal Article
Yaribeygi, H., Maleki, M., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2021). Antioxidative Potentials of Incretin-Based Medications: A Review of Molecular Mechanisms. Oxidative Medicine and Cellular Longevity, 2021, Article 9959320. https://doi.org/10.1155/2021/9959320

Glucagon-like peptide 1 receptor agonists and dipeptidyl-peptidase 4 inhibitors are medications used for managing diabetes, mimicking the metabolic effects of incretin hormones. Recent evidence suggests that these medications have antioxidative poten... Read More about Antioxidative Potentials of Incretin-Based Medications: A Review of Molecular Mechanisms.

Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis (2021)
Journal Article
Aalami, A. H., Abdeahad, H., Mesgari, M., Sathyapalan, T., & Sahebkar, A. (2021). Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis. Biomed research international, 2021, Article 5557309. https://doi.org/10.1155/2021/5557309

Aims. Bladder cancer (BCa) is a common cancer in North America and Europe that carries considerable morbidity and mortality. A reliable biomarker for early detection of the bladder is crucial for improving the prognosis of BCA. In this meta-analysis,... Read More about Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis.

Plasma heat shock protein response to euglycemia in type 2 diabetes (2021)
Journal Article
Atkin, A. S., Moin, A. S., Al-Qaissi, A., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2021). Plasma heat shock protein response to euglycemia in type 2 diabetes. BMJ Open Diabetes Research and Care, 9(1), Article e002057. https://doi.org/10.1136/bmjdrc-2020-002057

Introduction Glucose variability is associated with mortality and macrovascular diabetes complications. The mechanisms through which glucose variability mediates tissue damage are not well understood, although cellular oxidative stress is likely invo... Read More about Plasma heat shock protein response to euglycemia in type 2 diabetes.

Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15 by intralipids and insulin in healthy control and polycystic ovary syndrome women following chronic exercise training (2021)
Journal Article
Jerobin, J., Ramanjaneya, M., Bettahi, I., Parammal, R., Siveen, K. S., Alkasem, M., Aye, M., Sathyapalan, T., Skarulis, M., Atkin, S. L., & Abou-Samra, A. B. (2021). Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15 by intralipids and insulin in healthy control and polycystic ovary syndrome women following chronic exercise training. Lipids in Health and Disease, 20(1), Article 34. https://doi.org/10.1186/s12944-021-01463-3

Background: Polycystic ovary syndrome (PCOS) is associated with obesity, diabetes, and insulin resistance. The circulating C1Q/TNF-related proteins (CTRP-2, CTRP-9) and growth differentiation factors (GDF-8, GDF-15) contribute to glucose and lipid ho... Read More about Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15 by intralipids and insulin in healthy control and polycystic ovary syndrome women following chronic exercise training.

Impact of curcumin on fatty acid metabolism (2021)
Journal Article
Nosrati-Oskouie, M., Aghili-Moghaddam, N. S., Sathyapalan, T., & Sahebkar, A. (in press). Impact of curcumin on fatty acid metabolism. Phytotherapy Research, https://doi.org/10.1002/ptr.7105

Free fatty acids (FFAs) and fatty acid synthesis (FAS) activity have significantly contributed to disease states such as insulin resistance, obesity, type 2 diabetes, myocardial infarction, blood pressure, and several types of cancer. Currently, seve... Read More about Impact of curcumin on fatty acid metabolism.

Characterization of Patients With Refractory or Unexplained Chronic Cough Participating in a Phase 2 Clinical Trial of the P2X3-Receptor Antagonist Gefapixant (2021)
Journal Article
Morice, A. H., Birring, S. S., Smith, J. A., McGarvey, L. P., Schelfhout, J., Martin Nguyen, A., Xu, Z. J., Wu, W. C., Muccino, D. R., & Sher, M. R. (2021). Characterization of Patients With Refractory or Unexplained Chronic Cough Participating in a Phase 2 Clinical Trial of the P2X3-Receptor Antagonist Gefapixant. Lung, 199(2), 121-129. https://doi.org/10.1007/s00408-021-00437-7

Purpose: This analysis assesses clinical characteristics of patients with refractory chronic cough (RCC) or unexplained chronic cough (UCC) enrolled in a phase 2 study to better understand this patient population. Methods: Patients with RCC/UCC lasti... Read More about Characterization of Patients With Refractory or Unexplained Chronic Cough Participating in a Phase 2 Clinical Trial of the P2X3-Receptor Antagonist Gefapixant.

Platelet Protein-Related Abnormalities in Response to Acute Hypoglycemia in Type 2 Diabetes (2021)
Journal Article
Moin, A. S. M., Al-Qaissi, A., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2021). Platelet Protein-Related Abnormalities in Response to Acute Hypoglycemia in Type 2 Diabetes. Frontiers in endocrinology, 12, Article 651009. https://doi.org/10.3389/fendo.2021.651009

Introduction: Patients with severe COVID-19 infections have coagulation abnormalities indicative of a hypercoagulable state, with thromboembolic complications and increased mortality. Platelets are recognized as mediators of inflammation, releasing p... Read More about Platelet Protein-Related Abnormalities in Response to Acute Hypoglycemia in Type 2 Diabetes.

Identification of macrophage activation-related biomarkers in obese type 2 diabetes that may be indicative of enhanced respiratory risk in COVID-19 (2021)
Journal Article
Moin, A. S. M., Sathyapalan, T., Diboun, I., Atkin, S. L., & Butler, A. E. (in press). Identification of macrophage activation-related biomarkers in obese type 2 diabetes that may be indicative of enhanced respiratory risk in COVID-19. Scientific reports, 11(1), Article 6428. https://doi.org/10.1038/s41598-021-85760-y

Hyperactivation of the immune system through obesity and diabetes may enhance infection severity complicated by Acute Respiratory Distress Syndrome (ARDS). The objective was to determine the circulatory biomarkers for macrophage activation at baselin... Read More about Identification of macrophage activation-related biomarkers in obese type 2 diabetes that may be indicative of enhanced respiratory risk in COVID-19.

Effect of COVID-19 on Mortality of Pregnant and Postpartum Women: A Systematic Review and Meta-Analysis (2021)
Journal Article
Karimi, L., Makvandi, S., Vahedian-Azimi, A., Sathyapalan, T., & Sahebkar, A. (2021). Effect of COVID-19 on Mortality of Pregnant and Postpartum Women: A Systematic Review and Meta-Analysis. Journal of Pregnancy, 2021, 1-33. https://doi.org/10.1155/2021/8870129

Background. Based on what is known at this time, pregnant women are at an increased risk of severe illness from COVID-19 compared to nonpregnant women. Additionally, pregnant women with COVID-19 might have an increased risk of adverse pregnancy outco... Read More about Effect of COVID-19 on Mortality of Pregnant and Postpartum Women: A Systematic Review and Meta-Analysis.

Metabolic consequences of obesity on the hypercoagulable state of polycystic ovary syndrome (2021)
Journal Article
Moin, A. S. M., Sathyapalan, T., Diboun, I., Elrayess, M. A., Butler, A. E., & Atkin, S. L. (in press). Metabolic consequences of obesity on the hypercoagulable state of polycystic ovary syndrome. Scientific reports, 11(1), Article 5320. https://doi.org/10.1038/s41598-021-84586-y

© 2021, The Author(s). Polycystic ovary syndrome (PCOS) women have a hypercoagulable state; however, whether this is intrinsically due to PCOS or, alternatively, a consequence of its metabolic complications is unclear. We determined plasma coagulatio... Read More about Metabolic consequences of obesity on the hypercoagulable state of polycystic ovary syndrome.

The Immune Response and Effectiveness of COVID-19 Therapies (2021)
Book Chapter
Tavasolian, F., Hatam, G. R., Mosawi, S. H., Saadi, M. I., Abdollahi, E., Jamialahmadi, T., Sathyapalan, T., & Sahebkar, A. (2021). The Immune Response and Effectiveness of COVID-19 Therapies. In P. C. Guest (Ed.), Clinical, Biological and Molecular Aspects of COVID-19 (115-126). Springer. https://doi.org/10.1007/978-3-030-59261-5_10

© 2021, The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG. Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly pathogenic with r... Read More about The Immune Response and Effectiveness of COVID-19 Therapies.