All Outputs (776)

Cancer stem cells: An overview of the pathophysiological and prognostic roles in colorectal cancer (2022)
Journal Article
Pashirzad, M., Sathyapalan, T., Sheikh, A., Kesharwani, P., & Sahebkar, A. (2022). Cancer stem cells: An overview of the pathophysiological and prognostic roles in colorectal cancer. Process Biochemistry, 115, 19-29. https://doi.org/10.1016/j.procbio.2022.02.006

Colorectal cancer (CRC) is one of the most common types of cancer globally. A subpopulation of tumour cells, cancer stem cells (CSC), is speculated to be responsible for tumor initiation, development, maintenance, metastasis, and recurrence. Colorect... Read More about Cancer stem cells: An overview of the pathophysiological and prognostic roles in colorectal cancer.

The Edinburgh Claudication Questionnaire has poor diagnostic accuracy in people with intermittent claudication (2022)
Journal Article
Ibeggazene, S., Cai, P. L., Smith, G. E., Ibbegazene, S., Stirrup, A., Pymer, S., …Chetter, I. C. (in press). The Edinburgh Claudication Questionnaire has poor diagnostic accuracy in people with intermittent claudication. Vascular, https://doi.org/10.1177/17085381211059665

Background: The screening and diagnosis of intermittent claudication is a challenging process and often relies on the expertise of specialist vascular clinicians. We sought to investigate the diagnostic performance of the Edinburgh Claudication Quest... Read More about The Edinburgh Claudication Questionnaire has poor diagnostic accuracy in people with intermittent claudication.

The therapeutic potential of regulatory T cells in reducing cardiovascular complications in patients with severe COVID-19 (2022)
Journal Article
Saghafi, N., Rezaee, S. A., Momtazi-Borojeni, A. A., Tavasolian, F., Sathyapalan, T., Abdollahi, E., & Sahebkar, A. (2022). The therapeutic potential of regulatory T cells in reducing cardiovascular complications in patients with severe COVID-19. Life Sciences, 294, Article 120392. https://doi.org/10.1016/j.lfs.2022.120392

The SARS coronavirus 2 (SARS CoV-2) causes Coronavirus Disease (COVID-19), is an emerging viral infection. SARS CoV-2 infects target cells by attaching to Angiotensin-Converting Enzyme (ACE2). SARS CoV-2 could cause cardiac damage in patients with se... Read More about The therapeutic potential of regulatory T cells in reducing cardiovascular complications in patients with severe COVID-19.

PLGA-Based Curcumin Delivery System: An Interesting Therapeutic Approach in the Treatment of Alzheimer’s Disease (2022)
Journal Article
Shahbaz, S. K., Koushki, K., Sathyapalan, T., Majeed, M., & Sahebkar, A. (2022). PLGA-Based Curcumin Delivery System: An Interesting Therapeutic Approach in the Treatment of Alzheimer’s Disease. Current Neuropharmacology, 20(2), 309-323. https://doi.org/10.2174/1570159X19666210823103020

Progressive degeneration and dysfunction of the nervous system because of oxidative stress, aggregations of misfolded proteins, and neuroinflammation are the key pathological features of neurodegenerative diseases. Alzheimer's disease is a chronic ne... Read More about PLGA-Based Curcumin Delivery System: An Interesting Therapeutic Approach in the Treatment of Alzheimer’s Disease.

A systematic review of exercise intervention reporting quality and dose in studies of intermittent claudication (2022)
Journal Article
Ibeggazene, S., Pymer, S., Birkett, S. T., Caldow, E., & Harwood, A. E. (in press). A systematic review of exercise intervention reporting quality and dose in studies of intermittent claudication. Vascular, https://doi.org/10.1177/17085381211070700

Background: Exercise therapy is an important treatment option for people with intermittent claudication (IC). Appropriate reporting of exercise interventions in populations with IC within randomised controlled trials (RCTs) is important to ensure tha... Read More about A systematic review of exercise intervention reporting quality and dose in studies of intermittent claudication.

Defining priorities in vascular access research (2022)
Journal Article
De Siqueira, J., Fielding, C., Pettigrew, G., Robson, M., Rogers, S., Steiner, K., …Smith, G. (2022). Defining priorities in vascular access research. Journal of Vascular Societies Great Britain and Ireland, 1(2), 30-33. https://doi.org/10.54522/jvsgbi.2022.013

Introduction: There is increasing need for renal replacement therapy associated with the aging population and dramatic increases in diabetes prevalence. Despite an increasing clinical vascular access workload, there are significant unanswered researc... Read More about Defining priorities in vascular access research.

Research priorities for patients with peripheral arterial disease: A James Lind Alliance Priority Setting Partnership (2022)
Journal Article
Pymer, S., Harwood, A., Long, J., Chetter, I., Saratzis, A., & Coughlin, P. (2022). Research priorities for patients with peripheral arterial disease: A James Lind Alliance Priority Setting Partnership. Journal of Vascular Societies Great Britain and Ireland, 1(2), 23-29. https://doi.org/10.54522/jvsgbi.2022.011

Introduction: Peripheral arterial disease (PAD) is a common health problem associated with reduced mobility, functional capacity and quality of life. Significant research exists in the field of vascular surgery, but its relevance to the research prio... Read More about Research priorities for patients with peripheral arterial disease: A James Lind Alliance Priority Setting Partnership.

Tenotomy for diabetic foot ulcers: a scoping survey of current practice (2022)
Journal Article
Hitchman, L., Nandhra, S., Gooday, C., Cowan, C., Bowling, F., Nixon, J., …Russell, D. (2022). Tenotomy for diabetic foot ulcers: a scoping survey of current practice. Journal of Vascular Societies Great Britain and Ireland, 1(2), 54-58. https://doi.org/10.54522/jvsgbi.2022.006

Background: Diabetes mellitus is one of the fastest growing health crises of our time. One of the major complications is diabetic foot ulcers, many of which fail to heal. Tenotomy – transection of tendon fibres – may help to redistribute pressure in... Read More about Tenotomy for diabetic foot ulcers: a scoping survey of current practice.

Electrochemotherapy vs radiotherapy in the treatment of primary cutaneous malignancies or cutaneous metastases from primary solid organ malignancies: A protocol for a systematic review and meta-analysis (2022)
Journal Article
McMillan, A., McElroy, L., O'Toole, L., Matteucci, P., & Totty, J. (2022). Electrochemotherapy vs radiotherapy in the treatment of primary cutaneous malignancies or cutaneous metastases from primary solid organ malignancies: A protocol for a systematic review and meta-analysis. Journal of Surgical Protocols and Research Methodologies, 2022(1), Article snac005. https://doi.org/10.1093/jsprm/snac005

Electrochemotherapy has emerged as a valuable tool in the treatment of cutaneous malignancies that are unamenable to surgical resection. Despite growing recognition and recommendation in national guidelines, to date, no Level 1 evidence exists compar... Read More about Electrochemotherapy vs radiotherapy in the treatment of primary cutaneous malignancies or cutaneous metastases from primary solid organ malignancies: A protocol for a systematic review and meta-analysis.

The effects of phytochemicals and herbal bio-active compounds on tumour necrosis factor-α in overweight and obese individuals: a clinical review (2022)
Journal Article
Bagherniya, M., Mahdavi, A., Abbasi, E., Iranshahy, M., Sathyapalan, T., & Sahebkar, A. (2022). The effects of phytochemicals and herbal bio-active compounds on tumour necrosis factor-α in overweight and obese individuals: a clinical review. Inflammopharmacology, 30(1), 91-110. https://doi.org/10.1007/s10787-021-00902-y

Obesity is abnormal fat accumulation in the body which acts as a risk factor for various cardiometabolic states. Adipose tissue in excess can release inflammatory factors, including TNF-α and IL-6, and suppress adiponectin production. TNF-α increases... Read More about The effects of phytochemicals and herbal bio-active compounds on tumour necrosis factor-α in overweight and obese individuals: a clinical review.

Recent Advances in Lung Cancer Therapy Based on Nanomaterials: A Review (2022)
Journal Article
Gholami, L., Ivari, J. R., Nasab, N. K., Oskuee, R. K., Sathyapalan, T., & Sahebkar, A. (2023). Recent Advances in Lung Cancer Therapy Based on Nanomaterials: A Review. Current medicinal chemistry, 30(3), 335-355. https://doi.org/10.2174/0929867328666210810160901

Lung cancer is one of the commonest cancers with a significant mortality rate for both genders, particularly in men. Lung cancer is recognized as one of the leading causes of death worldwide, which threatens the lives of over 1.6 million people every... Read More about Recent Advances in Lung Cancer Therapy Based on Nanomaterials: A Review.

Antitumor and Protective Effects of Melatonin: The Potential Roles of MicroRNAs (2022)
Book Chapter
Ashrafizadeh, M., Ahmadi, Z., Yaribeygi, H., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2022). Antitumor and Protective Effects of Melatonin: The Potential Roles of MicroRNAs. In A. Sahebkar, & T. Sathyapalan (Eds.), Natural Products and Human Diseases (463-471). Cham: Springer. https://doi.org/10.1007/978-3-030-73234-9_31

MicroRNAs (miRNAs) are endogenous short noncoding RNAs with approximately 22 nucleotides. The primary function of miRNAs is the negative regulation of target gene expression via mRNA degradation or translation inhibition. During recent years, much at... Read More about Antitumor and Protective Effects of Melatonin: The Potential Roles of MicroRNAs.

A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Phase 2b Trial of P2X3 Receptor Antagonist Sivopixant for Refractory or Unexplained Chronic Cough (2022)
Journal Article
McGarvey, L., Smith, J. A., Morice, A., Birring, S. S., Chung, K. F., Dicpinigaitis, P. V., …Gomez, J. C. (2022). A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Phase 2b Trial of P2X3 Receptor Antagonist Sivopixant for Refractory or Unexplained Chronic Cough. Lung, https://doi.org/10.1007/s00408-022-00592-5

Introduction: To determine the optimal dose of sivopixant, a highly selective P2X3 receptor antagonist, for refractory or unexplained chronic cough (RCC/UCC). Methods: In this phase 2b, randomized, double-blind, placebo-controlled, parallel-group, mu... Read More about A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Phase 2b Trial of P2X3 Receptor Antagonist Sivopixant for Refractory or Unexplained Chronic Cough.

Tackling the Neuropathic Cough of Idiopathic Pulmonary Fibrosis (IPF): More Needs to be Done (2022)
Journal Article
Chung, K. F., Birring, S. S., Morice, A. H., McGarvey, L. P., Mazzone, S. B., Maher, T. M., & Dicpinigaitis, P. V. (2022). Tackling the Neuropathic Cough of Idiopathic Pulmonary Fibrosis (IPF): More Needs to be Done. Lung, https://doi.org/10.1007/s00408-022-00589-0

Preface (2021)
Book Chapter
Sahebkar, A., & Sathyapalan, T. (2021). Preface. In A. Sahebkar, & T. Sathyapalan (Eds.), Natural Products and Human Diseases : Pharmacology, Molecular Targets, and Therapeutic Benefits (v). Cham: Springer Verlag. https://doi.org/10.1007/978-3-030-73234-9

Impact of COVID-19 on vascular patients worldwide: analysis of the COVIDSurg data (2021)
Journal Article
Hitchman, L., & Machin, M. (2021). Impact of COVID-19 on vascular patients worldwide: analysis of the COVIDSurg data. Journal of Cardiovascular Surgery, 62(6), 558-70. https://doi.org/10.23736/S0021-9509.21.12024-5

BACKGROUND: The COVIDSurg collaborative was an international multicenter prospective analysis of perioperative data from 235 hospitals in 24 countries. it found that perioperative COVID-19 infection was associated with a mortality rate of 24%. at the... Read More about Impact of COVID-19 on vascular patients worldwide: analysis of the COVIDSurg data.

European respiratory society guidelines on the diagnosis and treatment of chronic cough in adults and children (2021)
Journal Article
Morice, A. H., Millqvist, E., Bieksiene, K., Birring, S. S., Dicpinigaitis, P., Ribas, C. D., …Zacharasiewicz, A. (2021). European respiratory society guidelines on the diagnosis and treatment of chronic cough in adults and children. Pulmonologiya, 31(4), 418-438. https://doi.org/10.18093/0869-0189-2021-31-4-418-438

These guidelines incorporate the recent advances in chronic cough pathophysiology, diagnosis and treatment. The concept of cough hypersensitivity has allowed an umbrella term that explains the exquisite sensitivity of patients to external stimuli suc... Read More about European respiratory society guidelines on the diagnosis and treatment of chronic cough in adults and children.

The use of perioperative prophylactic antibiotics following excision of ulcerated skin lesions in the UK – A national, multi-speciality survey of clinicians (2021)
Journal Article
Totty, J., Matin, R., Wernham, A., Ray, R., Thomas-Jones, E., & Abbott, R. (in press). The use of perioperative prophylactic antibiotics following excision of ulcerated skin lesions in the UK – A national, multi-speciality survey of clinicians. Clinical and experimental dermatology, https://doi.org/10.1111/ced.15075

Skin cancer is the most common malignancy in the UK, and up to a third of lesions are ulcerated at the time of excision. Ulceration has been shown to increase the risk of developing surgical site infection post-excision, with some studies finding inf... Read More about The use of perioperative prophylactic antibiotics following excision of ulcerated skin lesions in the UK – A national, multi-speciality survey of clinicians.

Impact of pharmacological interventions on anthropometric indices in women with polycystic ovary syndrome: a systematic review and meta‐analysis of randomised controlled trials (2021)
Journal Article
Abdalla, M. A., Shah, N., Deshmukh, H., Sahebkar, A., Östlundh, L., Al‐Rifai, R. H., …Sathyapalan, T. (in press). Impact of pharmacological interventions on anthropometric indices in women with polycystic ovary syndrome: a systematic review and meta‐analysis of randomised controlled trials. Clinical Endocrinology, https://doi.org/10.1111/cen.14663

Context: Polycystic ovary syndrome (PCOS) is a heterogeneous condition affecting women of reproductive age and is associated with increased body weight. Objective: To review the literature on the effect of different pharmacological interventions on t... Read More about Impact of pharmacological interventions on anthropometric indices in women with polycystic ovary syndrome: a systematic review and meta‐analysis of randomised controlled trials.

Genetic risk for the polycystic ovary syndrome, bone mineral density and fractures in women and men: A UK Biobank Mendelian randomisation study (2021)
Journal Article
Deshmukh, H., Shah, N., Papageorgiou, M., Abdalla, M. A., Lhaf, F., Aye, M., & Sathyapalan, T. (2022). Genetic risk for the polycystic ovary syndrome, bone mineral density and fractures in women and men: A UK Biobank Mendelian randomisation study. Bone, 155, Article 116285. https://doi.org/10.1016/j.bone.2021.116285

Introduction: There is conflicting data on the effect of polycystic ovary syndrome (PCOS) on bone mineral density (BMD) and fracture risk. Recent genetic data suggest that men may also carry genetic risk factors for PCOS; the associations of these fa... Read More about Genetic risk for the polycystic ovary syndrome, bone mineral density and fractures in women and men: A UK Biobank Mendelian randomisation study.