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Endovenous laser ablation in the treatment of small saphenous varicose veins: does site of access influence early outcomes? (2012)
Journal Article
Samuel, N., Wallace, T., Carradice, D., Shahin, Y., Mazari, F. A. K., & Chetter, I. C. (2012). Endovenous laser ablation in the treatment of small saphenous varicose veins: does site of access influence early outcomes?. Vascular and endovascular surgery, 46(4), 310-314. https://doi.org/10.1177/1538574412443316

Objective: The study was performed to evaluate the clinical and technical efficacy of endovenous laser ablation (EVLA) of small saphenous varicosities, particularly in relation to the site of endovenous access. Methods: Totally 59 patients with unila... Read More about Endovenous laser ablation in the treatment of small saphenous varicose veins: does site of access influence early outcomes?.

Pilot and feasibility study: comparative proteomic analysis by 2-DE MALDI TOF/TOF MS reveals 14-3-3 proteins as putative biomarkers of response to neoadjuvant chemotherapy in ER-positive breast cancer (2012)
Journal Article
Hodgkinson, V. C., Agarwal, V., ElFadl, D., Fox, J. N., McManus, P. L., Mahapatra, T. K., Kneeshaw, P. J., Drew, P. J., Lind, M., & Cawkwell, L. (2012). Pilot and feasibility study: comparative proteomic analysis by 2-DE MALDI TOF/TOF MS reveals 14-3-3 proteins as putative biomarkers of response to neoadjuvant chemotherapy in ER-positive breast cancer. Journal of Proteomics, 75(9), 2745-2752. https://doi.org/10.1016/j.jprot.2012.03.049

Neoadjuvant chemotherapy is used to treat oestrogen receptor-positive breast cancer however chemo-resistance is a major obstacle in this molecular subtype. The ability to predict tumour response would allow chemotherapy administration to be directed... Read More about Pilot and feasibility study: comparative proteomic analysis by 2-DE MALDI TOF/TOF MS reveals 14-3-3 proteins as putative biomarkers of response to neoadjuvant chemotherapy in ER-positive breast cancer.

Evolution of an endovenous laser ablation practice for varicose veins (2012)
Journal Article
Samuel, N., Wallace, T., Carradice, D., Smith, G., Mazari, F., & Chetter, I. (2013). Evolution of an endovenous laser ablation practice for varicose veins. Phlebology, 28(5), 248-256. https://doi.org/10.1258/phleb.2011.011103

Objective We aimed to assess the evolution of an endovenous laser ablation (EVLA) practice in the management of varicose veins in a university teaching hospital vascular surgical unit, over five years. Methods This was a retrospective review of a pro... Read More about Evolution of an endovenous laser ablation practice for varicose veins.

Proteomic identification of predictive biomarkers of resistance to neoadjuvant chemotherapy in luminal breast cancer: a possible role for 14-3-3 theta/tau and tBID? (2012)
Journal Article
Hodgkinson, V. C., ELFadl, D., Agarwal, V., Garimella, V., Russell, C., Long, E. D., Fox, J. N., McManus, P. L., Mahapatra, T. K., Kneeshaw, P. J., Drew, P. J., Lind, M. J., & Cawkwell, L. (2012). Proteomic identification of predictive biomarkers of resistance to neoadjuvant chemotherapy in luminal breast cancer: a possible role for 14-3-3 theta/tau and tBID?. Journal of Proteomics, 75(4), 1276-1283. https://doi.org/10.1016/j.jprot.2011.11.005

Introduction: Chemotherapy resistance is a major obstacle in effective neoadjuvant treatment for estrogen receptor-positive breast cancer. The ability to predict tumour response would allow chemotherapy administration to be directed towards only thos... Read More about Proteomic identification of predictive biomarkers of resistance to neoadjuvant chemotherapy in luminal breast cancer: a possible role for 14-3-3 theta/tau and tBID?.

Procedure-based assessments: an evaluation of their role in reflective learning (2012)
Journal Article
Green, L., & Chetter, I. (2012). Procedure-based assessments: an evaluation of their role in reflective learning. Bulletin of the Royal College of Surgeons of England, 94(1), 28-30. https://doi.org/10.1308/147363512x13189526437838

Procedure-based assessment (PBA) has, together with other common workplace assessments, become the cornerstone of a surgical trainee's evaluation process, the annual review of competency progression.

Evaluation of heart tissue viability under redox-magnetohydrodynamics conditions: Toward fine-tuning flow in biological microfluidics applications (2012)
Journal Article
Cheah, L. T., Fritsch, I., Haswell, S. J., & Greenman, J. (2012). Evaluation of heart tissue viability under redox-magnetohydrodynamics conditions: Toward fine-tuning flow in biological microfluidics applications. Biotechnology and bioengineering, 109(7), 1827-1834. https://doi.org/10.1002/bit.24426

A microfluidic system containing a chamber for heart tissue biopsies, perfused with Krebs–Henseleit buffer containing glucose and antibiotic (KHGB) using peristaltic pumps and continuously stimulated, was used to evaluate tissue viability under redox... Read More about Evaluation of heart tissue viability under redox-magnetohydrodynamics conditions: Toward fine-tuning flow in biological microfluidics applications.

The effect of parathyroidectomy on neuropsychological symptoms and biochemical parameters in patients with asymptomatic primary hyperparathyroidism: pHPT neuropsychological symptoms (2012)
Journal Article
Kahal, H., Aye, M., Rigby, A. S., Sathyapalan, T., England, R. J. A., & Atkin, S. L. (2012). The effect of parathyroidectomy on neuropsychological symptoms and biochemical parameters in patients with asymptomatic primary hyperparathyroidism: pHPT neuropsychological symptoms. Clinical Endocrinology, 76(2), 196-200. https://doi.org/10.1111/j.1365-2265.2011.04197.x

Background With increased biochemical screening, primary hyperparathyroidism (pHPT) is often discovered incidentally whilst patients are asymptomatic. Objective To assess the impact of parathyroidectomy on neuropsychological symptoms and biochemical... Read More about The effect of parathyroidectomy on neuropsychological symptoms and biochemical parameters in patients with asymptomatic primary hyperparathyroidism: pHPT neuropsychological symptoms.

Does the physical examination still have a role in patients with suspected heart failure? (2011)
Journal Article
Damy, T., Kallvikbacka-Bennett, A., Zhang, J., Goode, K., Buga, L., Hobkirk, J., Yassin, A., Dubois-Randé, J.-L., Hittinger, L., Cleland, J. G. F., & Clark, A. L. (2011). Does the physical examination still have a role in patients with suspected heart failure?. European journal of heart failure, 13(12), 1340-1348. https://doi.org/10.1093/eurjhf/hfr128

AIMS: The prognostic value of signs of congestion in patients suspected of having chronic heart failure (CHF) is unknown. Our objectives were to define their prevalence and specificity in diagnosing CHF and to determine their prognostic value in pati... Read More about Does the physical examination still have a role in patients with suspected heart failure?.

Angiotensin converting enzyme inhibitors effect on arterial stiffness and wave reflections: a meta-analysis and meta-regression of randomised controlled trials (2011)
Journal Article
Shahin, Y., Khan, J. A., & Chetter, I. (2012). Angiotensin converting enzyme inhibitors effect on arterial stiffness and wave reflections: a meta-analysis and meta-regression of randomised controlled trials. Atherosclerosis, 221(1), 18-33. https://doi.org/10.1016/j.atherosclerosis.2011.12.005

ObjectiveSeveral studies have assessed the effect of angiotensin converting enzyme inhibitors (ACEIs) on arterial stiffness and wave reflections as measured by pulse wave velocity (PWV) and augmentation index (AIx), respectively. We conducted a meta-... Read More about Angiotensin converting enzyme inhibitors effect on arterial stiffness and wave reflections: a meta-analysis and meta-regression of randomised controlled trials.

A microfluidic system for testing the responses of head and neck squamous cell carcinoma tissue biopsies to treatment with chemotherapy drugs (2011)
Journal Article
Hattersley, S. M., Sylvester, D. C., Dyer, C. E., Stafford, N. D., Haswell, S. J., & Greenman, J. (2012). A microfluidic system for testing the responses of head and neck squamous cell carcinoma tissue biopsies to treatment with chemotherapy drugs. Annals of biomedical engineering, 40(6), 1277-1288. https://doi.org/10.1007/s10439-011-0428-9

Tumors are heterogeneous masses of cells characterized pathologically by their size and spread. Their chaotic biology makes treatment of malignancies hard to generalize. We present a robust and reproducible glass microfluidic system, for the maintena... Read More about A microfluidic system for testing the responses of head and neck squamous cell carcinoma tissue biopsies to treatment with chemotherapy drugs.

Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure (2011)
Journal Article
Xu, S.-Z., Zeng, B., Atkin, S. L., Daskoulidou, N., Chen, G.-L., & Lukhele, B. (2012). Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure. Toxicological Sciences, 125(1), 56 - 68. https://doi.org/10.1093/toxsci/kfr268

Mercury is an established worldwide environmental pollutant with well-known toxicity affecting neurodevelopment in humans, but the molecular basis of cytotoxicity and the detoxification procedure are still unclear. Here we examined the involvement of... Read More about Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure.

Keeping it in the Family: Conducting Research Interviews with your own Family Members (2011)
Book Chapter
Seymour, J. (2011). Keeping it in the Family: Conducting Research Interviews with your own Family Members. In Researching Families and Relationships: Reflections on Process (90 - 92). Palgrave Macmillan

As a family researcher I am writing about a project which came literally close to home; one that involved interviewing members of my own family.  I focus mostly on the process of interviewing them and the issues that emerged from this.  I also talk b... Read More about Keeping it in the Family: Conducting Research Interviews with your own Family Members.

Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study (2011)
Journal Article
Faruqi, S., Molyneux, I. D., Fathi, H., Wright, C., Thompson, R., & Morice, A. H. (2011). Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study. Respirology : official journal of the Asian Pacific Society of Respirology, 16(7), 1150-1156. https://doi.org/10.1111/j.1440-1843.2011.02014.x

Background and objective: Gastro-oesophageal reflux has been implicated in the pathogenesis of chronic cough. Guidelines on management suggest a therapeutic trial of anti-reflux medication. Esomeprazole is a proton pump inhibitor licensed for the lon... Read More about Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study.

Prevalence of scarred and dysfunctional myocardium in patients with heart failure of ischaemic origin: A cardiovascular magnetic resonance study (2011)
Journal Article
Bourantas, C. V., Nikitin, N. P., Loh, H. P., Lukaschuk, E. I., Sherwi, N., de Silva, R., Tweddel, A. C., Alamgir, M. F., Wong, K., Gupta, S., Clark, A. L., & Cleland, J. G. (2011). Prevalence of scarred and dysfunctional myocardium in patients with heart failure of ischaemic origin: A cardiovascular magnetic resonance study. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 13(53), Article ARTN 53. https://doi.org/10.1186/1532-429x-13-53

BackgroundCardiovascular magnetic resonance (CMR) with late gadolinium enhancement (LGE) can provide unique data on the transmural extent of scar/viability. We assessed the prevalence of dysfunctional myocardium, including partial thickness scar, whi... Read More about Prevalence of scarred and dysfunctional myocardium in patients with heart failure of ischaemic origin: A cardiovascular magnetic resonance study.

Limited role for ivabradine in the treatment of chronic heart failure (2011)
Journal Article
Cullington, D., Goode, K. M., Cleland, J. G. F., & Clark, A. L. (2011). Limited role for ivabradine in the treatment of chronic heart failure. Heart, 97(23), 1961-1966. https://doi.org/10.1136/heartjnl-2011-300041

ObjectiveTo quantify the proportion of patients attending a community heart failure clinic with left ventricular systolic impairment who might be suitable for ivabradine therapy.BackgroundHigh resting heart rate is an important and potentially modifi... Read More about Limited role for ivabradine in the treatment of chronic heart failure.

Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis (2011)
Journal Article
Botham, A., Guo, X., Xiao, Y. P., Morice, A. H., Compton, S., & Sadofsky, L. R. (2011). Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis. Biochemical Journal, 438(2), 359-367. https://doi.org/10.1042/BJ20101958

hPAR2 (human proteinase-activated receptor-2) is a member of the novel family of proteolytically activated GPCRs (G-protein-coupled receptors) termed PARs (proteinase-activated receptors). Previous pharmacological studies have found that activation o... Read More about Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis.

Differential proteomics in the search for biomarkers of radiotherapy resistance (2011)
Journal Article
Scaife, L., Hodgkinson, V. C., Drew, P. J., Lind, M. J., & Cawkwell, L. (2011). Differential proteomics in the search for biomarkers of radiotherapy resistance. Expert Review of Proteomics, 8(4), 535-552. https://doi.org/10.1586/EPR.11.32

The individualization of radiotherapy treatment would be beneficial for cancer patients; however, there are no predictive biomarkers of radiotherapy resistance in routine clinical use. This article describes the body of work in this field where compa... Read More about Differential proteomics in the search for biomarkers of radiotherapy resistance.

Displaying Families: A New Concept for the Sociology of Family Life (2011)
Book
Dermott, E., & Seymour, J. (2011). Displaying Families: A New Concept for the Sociology of Family Life. Palgrave Macmillan

This volume assesses how the concept of 'displaying families' can contribute to a better understanding of contemporary family and personal life. Using this concept, contributors discuss how family life must not only be 'done' but also be 'seen to be... Read More about Displaying Families: A New Concept for the Sociology of Family Life.

Family Hold Back:Displaying Families in the Single-Location Home/Workplace (2011)
Book Chapter
Seymour, J. (2011). Family Hold Back:Displaying Families in the Single-Location Home/Workplace. In Displaying families: a new concept for the sociology of family life (160 - 174). Palgrave Macmillan

This chapter, in keeping with the overall aim of this volume, takes up Finch?s invitation to assess and develop the new concept of „Displaying Families? (Finch 2007). It aims particularly, as proposed in the original article, to use empirical data to... Read More about Family Hold Back:Displaying Families in the Single-Location Home/Workplace.