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A microfluidic system for testing the responses of head and neck squamous cell carcinoma tissue biopsies to treatment with chemotherapy drugs (2011)
Journal Article
Hattersley, S. M., Sylvester, D. C., Dyer, C. E., Stafford, N. D., Haswell, S. J., & Greenman, J. (2012). A microfluidic system for testing the responses of head and neck squamous cell carcinoma tissue biopsies to treatment with chemotherapy drugs. Annals of biomedical engineering, 40(6), 1277-1288. https://doi.org/10.1007/s10439-011-0428-9

Tumors are heterogeneous masses of cells characterized pathologically by their size and spread. Their chaotic biology makes treatment of malignancies hard to generalize. We present a robust and reproducible glass microfluidic system, for the maintena... Read More about A microfluidic system for testing the responses of head and neck squamous cell carcinoma tissue biopsies to treatment with chemotherapy drugs.

Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure (2011)
Journal Article
Xu, S.-Z., Zeng, B., Atkin, S. L., Daskoulidou, N., Chen, G.-L., & Lukhele, B. (2012). Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure. Toxicological Sciences, 125(1), 56 - 68. https://doi.org/10.1093/toxsci/kfr268

Mercury is an established worldwide environmental pollutant with well-known toxicity affecting neurodevelopment in humans, but the molecular basis of cytotoxicity and the detoxification procedure are still unclear. Here we examined the involvement of... Read More about Activation of TRPC cationic channels by mercurial compounds confers the cytotoxicity of mercury exposure.

Keeping it in the Family: Conducting Research Interviews with your own Family Members (2011)
Book Chapter
Seymour, J. (2011). Keeping it in the Family: Conducting Research Interviews with your own Family Members. In Researching Families and Relationships: Reflections on Process (90 - 92). Palgrave Macmillan

As a family researcher I am writing about a project which came literally close to home; one that involved interviewing members of my own family.  I focus mostly on the process of interviewing them and the issues that emerged from this.  I also talk b... Read More about Keeping it in the Family: Conducting Research Interviews with your own Family Members.

Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study (2011)
Journal Article
Faruqi, S., Molyneux, I. D., Fathi, H., Wright, C., Thompson, R., & Morice, A. H. (2011). Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study. Respirology : official journal of the Asian Pacific Society of Respirology, 16(7), 1150-1156. https://doi.org/10.1111/j.1440-1843.2011.02014.x

Background and objective: Gastro-oesophageal reflux has been implicated in the pathogenesis of chronic cough. Guidelines on management suggest a therapeutic trial of anti-reflux medication. Esomeprazole is a proton pump inhibitor licensed for the lon... Read More about Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study.

Prevalence of scarred and dysfunctional myocardium in patients with heart failure of ischaemic origin: A cardiovascular magnetic resonance study (2011)
Journal Article
Bourantas, C. V., Nikitin, N. P., Loh, H. P., Lukaschuk, E. I., Sherwi, N., de Silva, R., Tweddel, A. C., Alamgir, M. F., Wong, K., Gupta, S., Clark, A. L., & Cleland, J. G. (2011). Prevalence of scarred and dysfunctional myocardium in patients with heart failure of ischaemic origin: A cardiovascular magnetic resonance study. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 13(53), Article ARTN 53. https://doi.org/10.1186/1532-429x-13-53

BackgroundCardiovascular magnetic resonance (CMR) with late gadolinium enhancement (LGE) can provide unique data on the transmural extent of scar/viability. We assessed the prevalence of dysfunctional myocardium, including partial thickness scar, whi... Read More about Prevalence of scarred and dysfunctional myocardium in patients with heart failure of ischaemic origin: A cardiovascular magnetic resonance study.

Limited role for ivabradine in the treatment of chronic heart failure (2011)
Journal Article
Cullington, D., Goode, K. M., Cleland, J. G. F., & Clark, A. L. (2011). Limited role for ivabradine in the treatment of chronic heart failure. Heart, 97(23), 1961-1966. https://doi.org/10.1136/heartjnl-2011-300041

ObjectiveTo quantify the proportion of patients attending a community heart failure clinic with left ventricular systolic impairment who might be suitable for ivabradine therapy.BackgroundHigh resting heart rate is an important and potentially modifi... Read More about Limited role for ivabradine in the treatment of chronic heart failure.

Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis (2011)
Journal Article
Botham, A., Guo, X., Xiao, Y. P., Morice, A. H., Compton, S., & Sadofsky, L. R. (2011). Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis. Biochemical Journal, 438(2), 359-367. https://doi.org/10.1042/BJ20101958

hPAR2 (human proteinase-activated receptor-2) is a member of the novel family of proteolytically activated GPCRs (G-protein-coupled receptors) termed PARs (proteinase-activated receptors). Previous pharmacological studies have found that activation o... Read More about Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis.

Differential proteomics in the search for biomarkers of radiotherapy resistance (2011)
Journal Article
Scaife, L., Hodgkinson, V. C., Drew, P. J., Lind, M. J., & Cawkwell, L. (2011). Differential proteomics in the search for biomarkers of radiotherapy resistance. Expert Review of Proteomics, 8(4), 535-552. https://doi.org/10.1586/EPR.11.32

The individualization of radiotherapy treatment would be beneficial for cancer patients; however, there are no predictive biomarkers of radiotherapy resistance in routine clinical use. This article describes the body of work in this field where compa... Read More about Differential proteomics in the search for biomarkers of radiotherapy resistance.

Displaying Families: A New Concept for the Sociology of Family Life (2011)
Book
Dermott, E., & Seymour, J. (2011). Displaying Families: A New Concept for the Sociology of Family Life. Palgrave Macmillan

This volume assesses how the concept of 'displaying families' can contribute to a better understanding of contemporary family and personal life. Using this concept, contributors discuss how family life must not only be 'done' but also be 'seen to be... Read More about Displaying Families: A New Concept for the Sociology of Family Life.

Family Hold Back:Displaying Families in the Single-Location Home/Workplace (2011)
Book Chapter
Seymour, J. (2011). Family Hold Back:Displaying Families in the Single-Location Home/Workplace. In Displaying families: a new concept for the sociology of family life (160 - 174). Palgrave Macmillan

This chapter, in keeping with the overall aim of this volume, takes up Finch?s invitation to assess and develop the new concept of „Displaying Families? (Finch 2007). It aims particularly, as proposed in the original article, to use empirical data to... Read More about Family Hold Back:Displaying Families in the Single-Location Home/Workplace.

Patients' perspective of functional outcome after elective abdominal aortic aneurysm repair: a questionnaire survey (2011)
Journal Article
Khan, J. A., Mazari, F. A., Abdul Rahman, M., Mockford, K., Chetter, I. C., & McCollum, P. T. (2011). Patients' perspective of functional outcome after elective abdominal aortic aneurysm repair: a questionnaire survey. Annals of vascular surgery, 25(7), 878-886. https://doi.org/10.1016/j.avsg.2011.05.013

BackgroundTo evaluate patients' awareness, functional outcome, and satisfaction after abdominal aortic aneurysm (AAA) repair.MethodsA study-specific questionnaire was developed with collaboration of a multidisciplinary team. Lists of patients who und... Read More about Patients' perspective of functional outcome after elective abdominal aortic aneurysm repair: a questionnaire survey.

Sacral neuromodulation for the management of severe constipation: development of a constipation treatment protocol (2011)
Journal Article
Sharma, A., Liu, B., Waudby, P., & Duthie, G. S. (2011). Sacral neuromodulation for the management of severe constipation: development of a constipation treatment protocol. International Journal of Colorectal Disease, 26(12), 1583-1587. https://doi.org/10.1007/s00384-011-1257-x

Background
Constipation is a common multifactorial gastrointestinal symptom with quality of life implications. Sacral neuromodulation has been used in the management of severe constipation with mixed results. The aim of this study was to review our... Read More about Sacral neuromodulation for the management of severe constipation: development of a constipation treatment protocol.

Targeted duplex ultrasound in a one-stop dialysis vascular access assessment clinic (2011)
Journal Article
Smith, G. E., Samuel, N., Khan, J., Johnson, B. F., & Chetter, I. C. (2011). Targeted duplex ultrasound in a one-stop dialysis vascular access assessment clinic. Annals of vascular surgery, 25(8), 1099-1103. https://doi.org/10.1016/j.avsg.2011.02.043

BackgroundMany duplex detectable factors have been shown to correlate with upper limb arteriovenous fistula (AVF) outcomes, and many practitioners now request preoperative duplex vessel mapping routinely before AVF surgery. We report outcomes from a... Read More about Targeted duplex ultrasound in a one-stop dialysis vascular access assessment clinic.

Clinical and technical outcomes from a randomized clinical trial of endovenous laser ablation compared with conventional surgery for great saphenous varicose veins (2011)
Journal Article
Carradice, D., Mekako, A. I., Mazari, F. A. K., Samuel, N., Hatfield, J., & Chetter, I. C. (2011). Clinical and technical outcomes from a randomized clinical trial of endovenous laser ablation compared with conventional surgery for great saphenous varicose veins. British journal of surgery, 98(8), 1117-1123. https://doi.org/10.1002/bjs.7615

Background:This report describes the clinical effectiveness and recurrence rates from a randomized trial of endovenous laser ablation (EVLA) and surgery for varicose veins.Methods:Some 280 patients were randomized equally using sealed opaque envelope... Read More about Clinical and technical outcomes from a randomized clinical trial of endovenous laser ablation compared with conventional surgery for great saphenous varicose veins.

Workshop 07. Developing approaches to professionalism in medical students (2011)
Presentation / Conference Contribution
Hammond, A., & Henderson, J. (2011, May). Workshop 07. Developing approaches to professionalism in medical students. Presented at 4th International Clinical Skills Conference - Research in Clinical Skills: Showcasing Best Practice for Students & Practitioners Prato, Tuscany 22 – 25 May 2011 Showcasing Innovation and Evidenced Based Clinical Skills Education and Practice, Prato, Italy

Since the inception of our medical school seven years ago we have noticed that despite undergraduate medical students having an awareness that doctors have expected professional behaviours they have not always appreciated how professional behaviour a... Read More about Workshop 07. Developing approaches to professionalism in medical students.

P15. Employing students' multilingualism and language diversity in teaching and learning (2011)
Presentation / Conference Contribution
Hammond, A., Collins, S., Adam, J., & Pearce, J. (2011, May). P15. Employing students' multilingualism and language diversity in teaching and learning. Poster presented at 4th International Clinical Skills Conference: Showcasing Innovation and Evidenced Based Clinical Skills Education and Practice, Prato, Italy

Before our innovative clinical skills session ‘Interpreting in Consultations’, we conducted an annual survey of languages spoken by students on admission, in 2006, 2007 and 2008. From
a response rate of 94% we noted that 28% of students are advance... Read More about P15. Employing students' multilingualism and language diversity in teaching and learning.

P16. Introducing Peer Physical Examination (2011)
Presentation / Conference Contribution
Hammond, A., Henderson, J., Asghar, A., & Collins, S. (2011, May). P16. Introducing Peer Physical Examination. Poster presented at 4th International Clinical Skills Conference: Showcasing Innovation and Evidenced Based Clinical Skills Education and Practice, Prato, Italy

We are a new medical school (now into our eighth year) and until the 2008/09 academic year our Year One and Two students acquired
physical examination skills by examining healthy volunteers. The Year One cohort in 2008/09 were the first to acquire t... Read More about P16. Introducing Peer Physical Examination.

Junction jump sign: a useful adjunct to the precise positioning of the catheter tip during endovenous thermal ablation (2011)
Journal Article
Samuel, N., Wallace, T., Smith, G. E., Shahin, Y., & Chetter, I. C. (2011). Junction jump sign: a useful adjunct to the precise positioning of the catheter tip during endovenous thermal ablation. Ultrasound, 19(2), 97-98. https://doi.org/10.1258/ult.2011.011006

Duplex ultrasound imaging plays a key role in the increasingly popular, minimally invasive endothermal treatment of varicose veins. Accurate placement of the echodense tip of endovenous catheter distal to the site of junctional incompetence is by far... Read More about Junction jump sign: a useful adjunct to the precise positioning of the catheter tip during endovenous thermal ablation.

The effect of soy phytoestrogen supplementation on thyroid status and cardiovascular risk markers in patients with subclinical hypothyroidism: A randomized, double-blind, crossover study (2011)
Journal Article
Sathyapalan, T., Manuchehri, A. M., Thatcher, N. J., Rigby, A. S., Chapman, T., Kilpatrick, E. S., & Atkin, S. L. (2011). The effect of soy phytoestrogen supplementation on thyroid status and cardiovascular risk markers in patients with subclinical hypothyroidism: A randomized, double-blind, crossover study. Journal of Clinical Endocrinology and Metabolism, 96(5), 1442-1449. https://doi.org/10.1210/jc.2010-2255

Context: There is concern whether soy phytoestrogens may affect thyroid function. If true, soy phytoestrogens may be expected to have a greater impact in subjects with subclinical hypothyroidism. Objective: The primary aim was to determine the effect... Read More about The effect of soy phytoestrogen supplementation on thyroid status and cardiovascular risk markers in patients with subclinical hypothyroidism: A randomized, double-blind, crossover study.