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Altered Primary and Secondary Myogenesis in the Myostatin-Null Mouse (2010)
Journal Article
Matsakas, A., Otto, A., Elashry, M. I., Brown, S. C., & Patel, K. (2010). Altered Primary and Secondary Myogenesis in the Myostatin-Null Mouse. Rejuvenation Research, 13(6), 717-727. https://doi.org/10.1089/rej.2010.1065

Skeletal muscle fiber generation occurs principally in two myogenic phases: (1) Primary (embryonic) myogenesis when myoblasts proliferate and fuse to form primary myotubes and (2) secondary (fetal) myogenesis when successive waves of myoblasts fuse a... Read More about Altered Primary and Secondary Myogenesis in the Myostatin-Null Mouse.

Chronic lymphocytic leukaemia is a risk factor for venous thromboembolism (2010)
Journal Article
Whittle, A. M., Allsup, D. J., & Bailey, J. R. (2011). Chronic lymphocytic leukaemia is a risk factor for venous thromboembolism. Leukemia Research, 35(3), 419-421. https://doi.org/10.1016/j.leukres.2010.11.011

Venous thromboembolism (VTE) is a major cause of morbidity and mortality in cancer patients. The literature is sparse on the incidence in the most common lymphoid malignancy, chronic lymphocytic leukaemia (CLL). We calculated the incidence rates for... Read More about Chronic lymphocytic leukaemia is a risk factor for venous thromboembolism.

The effect of hyperbaric oxygen preconditioning on heat shock protein 72 expression following in vitro stress in human monocytes (2010)
Journal Article
Vince, R. V., Midgley, A. W., Laden, G., & Madden, L. A. (2011). The effect of hyperbaric oxygen preconditioning on heat shock protein 72 expression following in vitro stress in human monocytes. Cell Stress and Chaperones, 16(3), 339-343. https://doi.org/10.1007/s12192-010-0246-2

Hyperbaric oxygen (HBO) is thought to confer protection to cells via a cellular response to free radicals. This process may involve increased expression of heat shock proteins, in particular the highly inducible heat shock protein 72 (Hsp72). Healthy... Read More about The effect of hyperbaric oxygen preconditioning on heat shock protein 72 expression following in vitro stress in human monocytes.

The Ras related GTPase Miro is not required for mitochondrial transport in Dictyostelium discoideum (2010)
Journal Article
Vlahou, G., Eliáš, M., von Kleist-Retzow, J., Wiesner, R. J., & Rivero, F. (2011). The Ras related GTPase Miro is not required for mitochondrial transport in Dictyostelium discoideum. European journal of cell biology, 90(4), 342-355. https://doi.org/10.1016/j.ejcb.2010.10.012

Ras-related GTPases of the Miro family have been implicated in mitochondrial homeostasis and microtubule-dependent transport. They consist of two GTP-binding domains separated by calcium-binding motifs and of a C-terminal transmembrane domain that ta... Read More about The Ras related GTPase Miro is not required for mitochondrial transport in Dictyostelium discoideum.

Clinical indications for intravascular ultrasound imaging (2010)
Journal Article
Bourantas, C. V., Naka, K. K., Garg, S., Thackray, S., Papadopoulos, D., Alamgir, F. M., …Michalis, L. K. (2010). Clinical indications for intravascular ultrasound imaging. Echocardiography, 27(10), 1282-1290. https://doi.org/10.1111/j.1540-8175.2010.01259.x

Intravascular ultrasound (IVUS) is a catheter-based imaging modality, which provides high resolution cross-sectional images of the coronary arteries. Unlike angiography, which displays only the opacified luminal silhouette, IVUS permits imaging of bo... Read More about Clinical indications for intravascular ultrasound imaging.

TRPA1 is activated by direct addition of cysteine residues to the N-hydroxysuccinyl esters of acrylic and cinnamic acids (2010)
Journal Article
Sadofsky, L. R., Boa, A. N., Maher, S. A., Birrell, M. A., Belvisi, M. G., & Morice, A. H. (2011). TRPA1 is activated by direct addition of cysteine residues to the N-hydroxysuccinyl esters of acrylic and cinnamic acids. Pharmacological research : the official journal of the Italian Pharmacological Society, 63(1), 30-36. https://doi.org/10.1016/j.phrs.2010.11.004

The nociceptor TRPA1 is thought to be activated through covalent modification of specific cysteine residues on the N terminal of the channel. The precise mechanism of covalent modification with unsaturated carbonyl-containing compounds is unclear, th... Read More about TRPA1 is activated by direct addition of cysteine residues to the N-hydroxysuccinyl esters of acrylic and cinnamic acids.

Reduced functional avidity promotes central and effector memory CD4 T cell responses to tumor-associated antigens (2010)
Journal Article
Caserta, S., Kleczkowska, J., Mondino, A., & Zamoyska, R. (2010). Reduced functional avidity promotes central and effector memory CD4 T cell responses to tumor-associated antigens. Journal of Immunology, 185(11), 6545-6554. https://doi.org/10.4049/jimmunol.1001867

The effect of TCR signals on the differentiation of memory T cells is poorly defined. Conventional wisdom suggests that high-avidity interactions are best for the selection of vaccine Ag candidates or T cell specificities for adoptive T cell therapy... Read More about Reduced functional avidity promotes central and effector memory CD4 T cell responses to tumor-associated antigens.

Development of a real-world direct interface for integrated DNA extraction and amplification in a microfluidic device (2010)
Journal Article
Shaw, K. J., Joyce, D., Docker, P. T., Dyer, C. E., Greenway, G. M., Greenman, J., & Haswell, S. J. (2011). Development of a real-world direct interface for integrated DNA extraction and amplification in a microfluidic device. Lab on a chip, 11(3), 443-448. https://doi.org/10.1039/c0lc00346h

Integrated DNA extraction and amplification have been carried out in a microfluidic device using electro-osmotic pumping (EOP) for fluidic control. All the necessary reagents for performing both DNA extraction and polymerase chain reaction (PCR) ampl... Read More about Development of a real-world direct interface for integrated DNA extraction and amplification in a microfluidic device.

Viability of plant spore exine capsules for microencapsulation (2010)
Journal Article
Barrier, S., Diego-Taboada, A., Thomasson, M. J., Madden, L., Pointon, J. C., Wadhawan, J. D., …Mackenzie, G. (2011). Viability of plant spore exine capsules for microencapsulation. Journal of Materials Chemistry, 21(4), 975-981. https://doi.org/10.1039/c0jm02246b

Sporopollenin exine capsules (SECs) (outer exoskeletal wall of the spores of Lycopodium clavatum) were extracted and examined for their potential use as microcapsules. They were shown, by laser scanning confocal microscopy (LSCM), to be void of their... Read More about Viability of plant spore exine capsules for microencapsulation.

Regulation of the actin cytoskeleton by an interaction of IQGAP related protein GAPA with Filamin and Cortexillin I (2010)
Journal Article
Mondal, S., Burgute, B., Rieger, D., Müller, R., Rivero, F., Faix, J., …Noegel, A. A. (2010). Regulation of the actin cytoskeleton by an interaction of IQGAP related protein GAPA with Filamin and Cortexillin I. PLoS ONE, 5(11), Article e15440. https://doi.org/10.1371/journal.pone.0015440

Filamin and Cortexillin are F-actin crosslinking proteins in Dictyostelium discoideum allowing actin filaments to form three-dimensional networks. GAPA, an IQGAP related protein, is required for cytokinesis and localizes to the cleavage furrow during... Read More about Regulation of the actin cytoskeleton by an interaction of IQGAP related protein GAPA with Filamin and Cortexillin I.

Thalidomide enhances cyclophosphamide and dexamethasone-mediated cytotoxicity towards cultured chronic lymphocytic leukaemia cells (2010)
Journal Article
Pointon, J. C., Eagle, G., Bailey, J., Evans, P., Allsup, D., & Greenman, J. (2010). Thalidomide enhances cyclophosphamide and dexamethasone-mediated cytotoxicity towards cultured chronic lymphocytic leukaemia cells. Oncology Reports, 24(5), 1315-1321. https://doi.org/10.3892/or_00000988

Numerous chemotherapeutic regimens exist for the treatment of symptomatic or progressive chronic lymphocytic leukaemia (CLL). However, once the disease becomes refractory to nucleoside-based therapy the prognosis is poor. In this study we investigate... Read More about Thalidomide enhances cyclophosphamide and dexamethasone-mediated cytotoxicity towards cultured chronic lymphocytic leukaemia cells.

Mono- and tri-cationic porphyrin-monoclonal antibody conjugates: photodynamic activity and mechanism of action (2010)
Journal Article
Smith, K., Malatesti, N., Cauchon, N., Hunting, D., Lecomte, R., van Lier, J. E., …Boyle, R. W. (2011). Mono- and tri-cationic porphyrin-monoclonal antibody conjugates: photodynamic activity and mechanism of action. Immunology, 132(2), 256-265. https://doi.org/10.1111/j.1365-2567.2010.03359.x

Two cationic porphyrins bearing an isothiocyanate group for conjugation to monocolonal antibodies have been synthesized. The two porphyrins conjugated efficiently to three monoclonal antibodies (anti-CD104, anti-CD146 and anti-CD326), which recognize... Read More about Mono- and tri-cationic porphyrin-monoclonal antibody conjugates: photodynamic activity and mechanism of action.

Microfluidic synthesis of silica nanoparticles using polyethylenimine polymers (2010)
Journal Article
He, P., Greenway, G., & Haswell, S. J. (2011). Microfluidic synthesis of silica nanoparticles using polyethylenimine polymers. Chemical Engineering Journal, 167(2-3), 694-699. https://doi.org/10.1016/j.cej.2010.08.079

A microfluidic reactor system for the synthesis of silica nanoparticles has been developed from commercially available ETFE tubing (0.17-1.0 mm diameter) connected in series to support the hydrolysis, nucleation and particle growth based on a sol-gel... Read More about Microfluidic synthesis of silica nanoparticles using polyethylenimine polymers.

Contextual synthetic lethality of cancer cell kill based on the tumor microenvironment (2010)
Journal Article
Chan, N., Pires, I. M., Bencokova, Z., Coackley, C., Luoto, K. R., Bhogal, N., …Bristow, R. G. (2010). Contextual synthetic lethality of cancer cell kill based on the tumor microenvironment. Cancer Research, 70(20), 8045-8054. https://doi.org/10.1158/0008-5472.CAN-10-2352

Acute and chronic hypoxia exists within the three-dimensional microenvironment of solid tumors and drives therapy resistance, genetic instability, and metastasis. Replicating cells exposed to either severe acute hypoxia (16 hours with 0.02% O 2 ) fol... Read More about Contextual synthetic lethality of cancer cell kill based on the tumor microenvironment.

Differential induction of cellular proliferation, hypertrophy and apoptosis in H9c2 cardiomyocytes by exogenous tissue factor (2010)
Journal Article
Alkistis Frentzou, G., Collier, M. E. W., Ettelaie, C., & Seymour, A. L. (2010). Differential induction of cellular proliferation, hypertrophy and apoptosis in H9c2 cardiomyocytes by exogenous tissue factor. Molecular and Cellular Biochemistry, 345(1-2), 119-130. https://doi.org/10.1007/s11010-010-0565-8

Recent evidence has shown that prolonged exposure to exogenous tissue factor (TF) can alter the cellular functions of cardiomyocytes resulting in cardiac dysfunction. The effect of TF may arise from local inflammation within or in the vicinity of the... Read More about Differential induction of cellular proliferation, hypertrophy and apoptosis in H9c2 cardiomyocytes by exogenous tissue factor.

Development and limitations of lentivirus vectors as tools for tracking differentiation in prostate epithelial cells (2010)
Journal Article
Frame, F. M., Hager, S., Pellacani, D., Stower, M. J., Walker, H. F., Burns, J. E., …Maitland, N. J. (2010). Development and limitations of lentivirus vectors as tools for tracking differentiation in prostate epithelial cells. Experimental Cell Research, 316(19), 3161-3171. https://doi.org/10.1016/j.yexcr.2010.08.004

To investigate hierarchy in human prostate epithelial cells, we generated recombinant lentiviruses, infected primary cultures and cell lines, and followed their fate in vitro. The lentiviruses combined constitutive promoters including CMV and β-actin... Read More about Development and limitations of lentivirus vectors as tools for tracking differentiation in prostate epithelial cells.

Microfluidic perfusion system for maintaining viable heart tissue with real-time electrochemical monitoring of reactive oxygen species (2010)
Journal Article
Cheah, L., Dou, Y. H., Seymour, A. M. L., Dyer, C. E., Haswell, S. J., Wadhawan, J. D., & Greenman, J. (2010). Microfluidic perfusion system for maintaining viable heart tissue with real-time electrochemical monitoring of reactive oxygen species. Lab on a chip, 10(20), 2720-2726. https://doi.org/10.1039/c004910g

A microfluidic device has been developed to maintain viable heart tissue samples in a biomimetic microenvironment. This device allows rat or human heart tissue to be studied under pseudo in vivo conditions. Effluent levels of lactate dehydrogenase an... Read More about Microfluidic perfusion system for maintaining viable heart tissue with real-time electrochemical monitoring of reactive oxygen species.

Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents (2010)
Journal Article
Nassini, R., Materazzi, S., Andrè, E., Sartiani, L., Aldini, G., Trevisani, M., …Geppetti, P. (2010). Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents. FASEB Journal, 24(12), 4904-4916. https://doi.org/10.1096/fj.10-162438

Acetaminophen [N-acetyl-p-aminophenol (APAP)] is the most common antipyretic/analgesic medicine worldwide. If APAP is overdosed, its metabolite, N-acetyl-p-benzo-quinoneimine (NAPQI), causes liver damage. However, epidemiological evidence has associa... Read More about Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents.