Skip to main content

Research Repository

Advanced Search

All Outputs (27)

T cell exhaustion potential of bacterial superantigens relevant in severe infections and cancer (2023)
Thesis
Tantoush, F. A. A. T cell exhaustion potential of bacterial superantigens relevant in severe infections and cancer. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4373985

Bacterial superantigens (SAgs) trigger oligoclonal activation of T cells by crosslinking MHC-class-II, on Ag-presenting cells, to the T cell receptor (TCR)/CD28, on T cells, which can be independent of Lck, a critical kinase normally involved... Read More about T cell exhaustion potential of bacterial superantigens relevant in severe infections and cancer.

Identification of the molecular pathways involved in paediatric and adult acute myeloid leukaemia (2022)
Thesis
Brown, E. (2022). Identification of the molecular pathways involved in paediatric and adult acute myeloid leukaemia. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4224412

Acute myeloid leukaemia (AML) affects 3100 people every year in the UK, around 1% of whom are under 19 years of age. Despite improvements in immunotherapeutic treatment opportunities for AML, the rates of survival particularly in adults remain poor.... Read More about Identification of the molecular pathways involved in paediatric and adult acute myeloid leukaemia.

Bruton’s tyrosine kinase inhibitors impair FcγRIIA-driven platelet responses to bacteria in chronic lymphocytic leukemia (2021)
Journal Article
Naylor-Adamson, L., Chacko, A., Booth, Z., Caserta, S., Jarvis, J., Khan, S., …Arman, M. (2021). Bruton’s tyrosine kinase inhibitors impair FcγRIIA-driven platelet responses to bacteria in chronic lymphocytic leukemia. Frontiers in immunology, 12, Article 766272. https://doi.org/10.3389/fimmu.2021.766272

Bacterial infections are a major cause of morbidity and mortality in chronic lymphocytic leukemia (CLL), and infection risk increases in patients treated with the Bruton’s tyrosine kinase (Btk) inhibitor, ibrutinib. Btk and related kinases (like Tec)... Read More about Bruton’s tyrosine kinase inhibitors impair FcγRIIA-driven platelet responses to bacteria in chronic lymphocytic leukemia.

In-Depth Profiling of T-Cell Responsiveness to Commonly Recognized CMV Antigens in Older People Reveals Important Sex Differences (2021)
Journal Article
Reus, B., Caserta, S., Larsen, M., Morrow, G., Bano, A., Hallensleben, M., …Kern, F. (2021). In-Depth Profiling of T-Cell Responsiveness to Commonly Recognized CMV Antigens in Older People Reveals Important Sex Differences. Frontiers in immunology, 12, Article 707830. https://doi.org/10.3389/fimmu.2021.707830

The impact of biological sex on T-cell immunity to Cytomegalovirus (CMV) has not been investigated in detail with only one published study comparing CMV-specific T-cell responses in men and women. Many studies, however, have shown an association betw... Read More about In-Depth Profiling of T-Cell Responsiveness to Commonly Recognized CMV Antigens in Older People Reveals Important Sex Differences.

Immune Responses to Persistent or Recurrent Antigens: Implications for Immunological Memory and Immunotherapy (2021)
Book
Pera, A., & Caserta, S. (Eds.). (2021). Immune Responses to Persistent or Recurrent Antigens: Implications for Immunological Memory and Immunotherapy. Lausanne: Frontiers Media. https://doi.org/10.3389/978-2-88966-718-5

Immunological memory is considered the hallmark of the adaptive immune response, which is essential for long-term protection against infection throughout life. From the perspective of adaptive immunity, clonally expanded antigen-specific lymphocytes... Read More about Immune Responses to Persistent or Recurrent Antigens: Implications for Immunological Memory and Immunotherapy.

Release of redox enzymes and micro-RNAs in extracellular vesicles, during infection and inflammation (2021)
Journal Article
Caserta, S., & Ghezzi, P. (2021). Release of redox enzymes and micro-RNAs in extracellular vesicles, during infection and inflammation. Free radical biology & medicine, 169, 248-257. https://doi.org/10.1016/j.freeradbiomed.2021.04.010

Many studies reported that redox enzymes, particularly thioredoxin and peroxiredoxin, can be released by cells and act as soluble mediators in immunity. Recently, it became clear that peroxiredoxins can be secreted via the exosome-release route, yet... Read More about Release of redox enzymes and micro-RNAs in extracellular vesicles, during infection and inflammation.

Cytomegalovirus infection is associated with an increase in aortic stiffness in older men which may be mediated in part by CD4 memory T-cells (2021)
Journal Article
Kirkham, F., Pera, A., Simanek, A. M., Bano, A., Morrow, G., Reus, B., …Kern, F. (in press). Cytomegalovirus infection is associated with an increase in aortic stiffness in older men which may be mediated in part by CD4 memory T-cells. Theranostics, 11(12), 5728-5741. https://doi.org/10.7150/thno.58356

Human Cytomegalovirus (CMV) infection is associated with atherosclerosis, higher cardiovascular disease (CVD) risk, and an increase in memory T-cells (Tmem). T-cells have also been implicated in CVD, independently of CMV infection. To better understa... Read More about Cytomegalovirus infection is associated with an increase in aortic stiffness in older men which may be mediated in part by CD4 memory T-cells.

CD28null pro-atherogenic CD4 T-cells explain the link between CMV infection and an increased risk of cardiovascular death (2018)
Journal Article
Pera, A., Caserta, S., Albanese, F., Blowers, P., Morrow, G., Terrazzini, N., Smith, H. E., Rajkumar, C., Reus, B., Msonda, J. R., Verboom, M., Hallensleben, M., Blasczyk, R., Davies, K. A., & Kern, F. (2018). CD28null pro-atherogenic CD4 T-cells explain the link between CMV infection and an increased risk of cardiovascular death. Theranostics, 8(16), 4509-4519. https://doi.org/10.7150/thno.27428

An increased risk of cardiovascular death in Cytomegalovirus (CMV)-infected individuals remains unexplained, although it might partly result from the fact that CMV infection is closely associated with the accumulation of CD28null T-cells, in particul... Read More about CD28null pro-atherogenic CD4 T-cells explain the link between CMV infection and an increased risk of cardiovascular death.

Interleukin-7 unveils Pathogen-Specific T Cells by enhancing Antigen-Recall responses (2018)
Journal Article
Terrazzini, N., Mantegani, P., Kern, F., Fortis, C., Mondino, A., & Caserta, S. (2018). Interleukin-7 unveils Pathogen-Specific T Cells by enhancing Antigen-Recall responses. The journal of infectious diseases : official publication of the Infectious Diseases Society of America, 217(12), 1997-2007. https://doi.org/10.1093/infdis/jiy096

© 2018 The Author(s). Background Interleukin (IL)-7 promotes the generation, expansion, and survival of memory T cells. Previous mouse and human studies showed that IL-7 can support immune cell reconstitution in lymphopenic conditions, expand tumor-r... Read More about Interleukin-7 unveils Pathogen-Specific T Cells by enhancing Antigen-Recall responses.

Severity of Systemic Inflammatory Response Syndrome Affects the Blood Levels of Circulating Inflammatory-Relevant MicroRNAs (2018)
Journal Article
Caserta, S., Mengozzi, M., Kern, F., Newbury, S. F., Ghezzi, P., & Llewelyn, M. J. (2018). Severity of Systemic Inflammatory Response Syndrome Affects the Blood Levels of Circulating Inflammatory-Relevant MicroRNAs. Frontiers in immunology, 8, Article ARTN 1977. https://doi.org/10.3389/fimmu.2017.01977

The systemic inflammatory response syndrome (SIRS) is a potentially lethal response triggered by diverse forms of tissue injury and infection. When systemic inflammation is triggered by infection, the term sepsis is used. Understanding how inflammati... Read More about Severity of Systemic Inflammatory Response Syndrome Affects the Blood Levels of Circulating Inflammatory-Relevant MicroRNAs.

Heterogeneity of phenotype and function reflects the multistage development of t follicular helper cells (2017)
Journal Article
Trüb, M., Barr, T. A., Morrison, V. L., Brown, S., Caserta, S., Rixon, J., Ivens, A., & Gray, D. (2017). Heterogeneity of phenotype and function reflects the multistage development of t follicular helper cells. Frontiers in immunology, 8(APR), 489. https://doi.org/10.3389/fimmu.2017.00489

T follicular helper cells (Tfh) provide crucial signals for germinal center (GC) formation, but Tfh populations are heterogeneous. While PD1 hi Tfh are important in the GC response, the function of the PD1 lo Tfh-like subset is unknown. We show that... Read More about Heterogeneity of phenotype and function reflects the multistage development of t follicular helper cells.

CMV-specific T-cell responses at older ages: broad responses with a large central memory component may be key to long-term survival (2017)
Journal Article
Bajwa, M., Vita, S., Vescovini, R., Larsen, M., Sansoni, P., Terrazzini, N., Caserta, S., Thomas, D., Davies, K. A., Smith, H., & Kern, F. (2017). CMV-specific T-cell responses at older ages: broad responses with a large central memory component may be key to long-term survival. The journal of infectious diseases : official publication of the Infectious Diseases Society of America, 215(8), 1212-1220. https://doi.org/10.1093/infdis/jix080

© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. Cytomegalovirus (CMV) infection sometimes causes large expansions of CMV-specific T cells, particularly in older people. This... Read More about CMV-specific T-cell responses at older ages: broad responses with a large central memory component may be key to long-term survival.

A new perspective of the structural complexity of HCMV-specific T-cell responses (2016)
Journal Article
Sylwester, A., Nambiar, K. Z., Caserta, S., Klenerman, P., Picker, L. J., & Kern, F. (2016). A new perspective of the structural complexity of HCMV-specific T-cell responses. Mechanisms of ageing and development, 158, 14-22. https://doi.org/10.1016/j.mad.2016.03.002

© 2016 The Authors Background In studies exploring the effects of HCMV infection on immune system aging (‘immunosenescence’), after organ transplantation or in other settings, HCMV-specific T-cell responses are often assessed with respect to purporte... Read More about A new perspective of the structural complexity of HCMV-specific T-cell responses.

Functional diversity of cytomegalovirus-specific T cells is maintained in older people and significantly associated with protein specificity and response size (2016)
Journal Article
Bajwa, M., Vita, S., Vescovini, R., Larsen, M., Sansoni, P., Terrazzini, N., Caserta, S., Thomas, D., Davies, K. A., Smith, H., & Kern, F. (2016). Functional diversity of cytomegalovirus-specific T cells is maintained in older people and significantly associated with protein specificity and response size. The journal of infectious diseases : official publication of the Infectious Diseases Society of America, 214(9), 1430-1437. https://doi.org/10.1093/infdis/jiw371

© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. Background. Parallel upregulation of several T-cell effector functions (ie, polyfunctionality) is believed to be critical for... Read More about Functional diversity of cytomegalovirus-specific T cells is maintained in older people and significantly associated with protein specificity and response size.

Circulating plasma microRNAs can differentiate Human Sepsis and Systemic Inflammatory Response Syndrome (SIRS) (2016)
Journal Article
Caserta, S., Kern, F., Cohen, J., Drage, S., Newbury, S. F., & Llewelyn, M. J. (2016). Circulating plasma microRNAs can differentiate Human Sepsis and Systemic Inflammatory Response Syndrome (SIRS). Scientific reports, 6(1), Article 28006. https://doi.org/10.1038/srep28006

Systemic inflammation in humans may be triggered by infection, termed sepsis, or non-infective processes, termed non-infective systemic inflammatory response syndrome (SIRS). MicroRNAs regulate cellular processes including inflammation and may be det... Read More about Circulating plasma microRNAs can differentiate Human Sepsis and Systemic Inflammatory Response Syndrome (SIRS).

Induction of human regulatory T cells with bacterial superantigens (2015)
Book Chapter
Caserta, S., Taylor, A. L., Terrazzini, N., & Llewelyn, M. J. (2016). Induction of human regulatory T cells with bacterial superantigens. In Superantigens; Methods in Molecular Biology (181-206). https://doi.org/10.1007/978-1-4939-3344-0_16

© Springer Science+Business Media New York 2016. Regulatory T cells (Tregs) that suppress the activation of immune effector cells limit immunopathology and are fast emerging as therapeutic targets for autoimmune and cancer disease. Tools enabling Tre... Read More about Induction of human regulatory T cells with bacterial superantigens.

Central and effector memory CD4 and CD8 T-cell responses to tumor-associated antigens (2012)
Journal Article
Caserta, S., Borger, J. G., & Zamoyska, R. (2012). Central and effector memory CD4 and CD8 T-cell responses to tumor-associated antigens. Critical reviews in immunology, 32(2), 97-126. https://doi.org/10.1615/critrevimmunol.v32.i2.10

Harnessing T-cell responses to constrain tumor growth is a realistic treatment aspiration in tumor medicine, as many tumors express specific tumor associated antigens that are recognized by the adaptive immune system. CD8 T cells have direct cytolyti... Read More about Central and effector memory CD4 and CD8 T-cell responses to tumor-associated antigens.

Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells (2012)
Journal Article
Caserta, S., Nausch, N., Sawtell, A., Drummond, R., Barr, T., MacDonald, A. S., Mutapi, F., & Zamoyska, R. (2012). Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells. PLoS ONE, 7(4), e35466. https://doi.org/10.1371/journal.pone.0035466

Certain parasites have evolved to evade the immune response and establish chronic infections that may persist for many years. T cell responses in these conditions become muted despite ongoing infection. Upregulation of surface receptors with inhibito... Read More about Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells.

Reduced functional avidity promotes central and effector memory CD4 T cell responses to tumor-associated antigens (2010)
Journal Article
Caserta, S., Kleczkowska, J., Mondino, A., & Zamoyska, R. (2010). Reduced functional avidity promotes central and effector memory CD4 T cell responses to tumor-associated antigens. Journal of Immunology, 185(11), 6545-6554. https://doi.org/10.4049/jimmunol.1001867

The effect of TCR signals on the differentiation of memory T cells is poorly defined. Conventional wisdom suggests that high-avidity interactions are best for the selection of vaccine Ag candidates or T cell specificities for adoptive T cell therapy... Read More about Reduced functional avidity promotes central and effector memory CD4 T cell responses to tumor-associated antigens.