Dr Frank Voncken's Outputs (13)

Ibrutinib enhances the bias of T cell responses towards staphylococcal superantigens sustaining inflammation in chronic lymphocytic leukaemia (2025)
Journal Article
Tantoush, F., Allsup, D., Naylor-Adamson, L., Voncken, F., & Caserta, S. (2025). Ibrutinib enhances the bias of T cell responses towards staphylococcal superantigens sustaining inflammation in chronic lymphocytic leukaemia. Frontiers in immunology, 16, Article 1531059. https://doi.org/10.3389/fimmu.2025.1531059

Chronic lymphocytic leukaemia (CLL) is an uncurable haematological malignancy and is associated with significant infection morbidity. Bruton’s tyrosine-kinase inhibitors (e.g., ibrutinib) have improved disease outcomes, but severe infections and poor... Read More about Ibrutinib enhances the bias of T cell responses towards staphylococcal superantigens sustaining inflammation in chronic lymphocytic leukaemia.

T cell exhaustion potential of bacterial superantigens relevant in severe infections and cancer (2023)
Thesis
Tantoush, F. A. A. T cell exhaustion potential of bacterial superantigens relevant in severe infections and cancer. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4373985

Bacterial superantigens (SAgs) trigger oligoclonal activation of T cells by crosslinking MHC-class-II, on Ag-presenting cells, to the T cell receptor (TCR)/CD28, on T cells, which can be independent of Lck, a critical kinase normally involved... Read More about T cell exhaustion potential of bacterial superantigens relevant in severe infections and cancer.

The mitochondrial phosphate carrier TbMCP11 is essential for mitochondrial function in the procyclic form of Trypanosoma brucei (2020)
Journal Article
Gao, F., Voncken, F., & Colasante, C. (2020). The mitochondrial phosphate carrier TbMCP11 is essential for mitochondrial function in the procyclic form of Trypanosoma brucei. Molecular and Biochemical Parasitology, 237, Article 111275. https://doi.org/10.1016/j.molbiopara.2020.111275

Conserved amongst all eukaryotes is a family of mitochondrial carrier proteins (SLC25A) responsible for the import of various solutes across the inner mitochondrial membrane. We previously reported that the human parasite Trypanosoma brucei possesses... Read More about The mitochondrial phosphate carrier TbMCP11 is essential for mitochondrial function in the procyclic form of Trypanosoma brucei.

Characterisation of a mitochondrial iron transporter of the pathogen Trypanosoma brucei (2019)
Journal Article
Zheng, F., Colasante, C., & Voncken, F. (2019). Characterisation of a mitochondrial iron transporter of the pathogen Trypanosoma brucei. Molecular and Biochemical Parasitology, 233, Article 111221. https://doi.org/10.1016/j.molbiopara.2019.111221

Similar to higher eukaryotes, the protist parasite T. brucei harbours several iron-containing proteins that regulate DNA and protein processing, oxidative stress defence and mitochondrial respiration. The synthesis of these proteins occurs either in... Read More about Characterisation of a mitochondrial iron transporter of the pathogen Trypanosoma brucei.

Identification and functional characterisation of putative mitochondrial nucleotide transporters from the human pathogen Trypanosome brucei (2018)
Thesis
Alshegifi, M. Identification and functional characterisation of putative mitochondrial nucleotide transporters from the human pathogen Trypanosome brucei. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4221223

Trypanosoma brucei is a medically important protozoan parasite that causes African sleeping sickness in humans. Although disease treatment is possible, it is hindered by the limited availability of effective drugs and the rapid emergence of drug resi... Read More about Identification and functional characterisation of putative mitochondrial nucleotide transporters from the human pathogen Trypanosome brucei.

A plant-like mitochondrial carrier family protein facilitates mitochondrial transport of di- and tricarboxylates in Trypanosoma brucei (2018)
Journal Article
Colasante, C., Zheng, F., Kemp, C., & Voncken, F. (2018). A plant-like mitochondrial carrier family protein facilitates mitochondrial transport of di- and tricarboxylates in Trypanosoma brucei. Molecular and Biochemical Parasitology, 221, 36-51. https://doi.org/10.1016/j.molbiopara.2018.03.003

The procyclic form of the human parasite Trypanosoma brucei harbors one single, large mitochondrion containing all tricarboxylic acid (TCA) cycle enzymes and respiratory chain complexes present also in higher eukaryotes. Metabolite exchange among sub... Read More about A plant-like mitochondrial carrier family protein facilitates mitochondrial transport of di- and tricarboxylates in Trypanosoma brucei.

Identification and functional characterization of putative mitochondrial iron transporters from the human pathogen Trypanosoma brucei (2017)
Thesis
Zheng, F. Identification and functional characterization of putative mitochondrial iron transporters from the human pathogen Trypanosoma brucei. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4221817

Trypanosoma brucei is a medically important protozoan parasite causing African sleeping sickness in humans. Treatment of this disease is possible, but is hindered by the limited availability of effective drugs as well as the rapid emergence of drug r... Read More about Identification and functional characterization of putative mitochondrial iron transporters from the human pathogen Trypanosoma brucei.

The phosphoarginine energy-buffering system of Trypanosoma brucei is essential and involves multiple arginine kinase isoforms with different subcellular locations. (2013)
Journal Article
Voncken, F., Gao, F., Wadforth, C., Harley, M., & Colasante, C. (2013). The phosphoarginine energy-buffering system of Trypanosoma brucei is essential and involves multiple arginine kinase isoforms with different subcellular locations. PLoS ONE, 8(6), e65908. https://doi.org/10.1371/journal.pone.0065908

Phosphagen energy-buffering systems play an essential role in regulating the cellular energy homeostasis in periods of high-energy demand or energy supply fluctuations. Here we describe the phosphoarginine/arginine kinase system of the kinetoplastid... Read More about The phosphoarginine energy-buffering system of Trypanosoma brucei is essential and involves multiple arginine kinase isoforms with different subcellular locations..

Mitochondrial ATP production and energy-buffering in the human pathogen Trypanosoma brucei (2013)
Thesis
Gao, F. Mitochondrial ATP production and energy-buffering in the human pathogen Trypanosoma brucei. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4215678

The mitochondrion plays a vital role in the cellular energy (ATP) provision of the human pathogen Trypanosoma brucei. ATP is produced in the mitochondrial matrix from ADP and inorganic phosphate by substrate-level and oxidative phosphorylation. To ma... Read More about Mitochondrial ATP production and energy-buffering in the human pathogen Trypanosoma brucei.

Proteins and lipids of glycosomal membranes from Leishmania tarentolae and Trypanosoma brucei [version 1; peer review: 2 approved] (2013)
Journal Article
Colasante, C., Voncken, F., Manful, T., Ruppert, T., Tielens, A. G. M., van Hellemond, J. J., & Clayton, C. (2013). Proteins and lipids of glycosomal membranes from Leishmania tarentolae and Trypanosoma brucei [version 1; peer review: 2 approved]. F1000Research, 2, Article 27. https://doi.org/10.3410/f1000research.2-27.v1

In kinetoplastid protists, several metabolic pathways, including glycolysis and purine salvage, are located in glycosomes, which are microbodies that are evolutionarily related to peroxisomes. With the exception of some potential transporters for fat... Read More about Proteins and lipids of glycosomal membranes from Leishmania tarentolae and Trypanosoma brucei [version 1; peer review: 2 approved].

Functional characterization of TbMCP5, a conserved and essential ADP/ATP carrier present in the mitochondrion of the human pathogen Trypanosoma brucei (2012)
Journal Article
Peña-Diaz, P., Pelosi, L., Ebikeme, C., Colasante, C., Gao, F., Bringaud, F., & Voncken, F. (2012). Functional characterization of TbMCP5, a conserved and essential ADP/ATP carrier present in the mitochondrion of the human pathogen Trypanosoma brucei. Journal of Biological Chemistry, 287(50), 41861-41874. https://doi.org/10.1074/jbc.M112.404699

Trypanosoma brucei is a kinetoplastid parasite of medical and veterinary importance. Its digenetic life cycle alternates between the bloodstream form in the mammalian host and the procyclic form (PCF) in the bloodsucking insect vector, the tsetse fly... Read More about Functional characterization of TbMCP5, a conserved and essential ADP/ATP carrier present in the mitochondrion of the human pathogen Trypanosoma brucei.

An internal sequence targets Trypanosoma brucei triosephosphate isomerase to glycosomes (2010)
Journal Article
Galland, N., de Walque, S., Voncken, F. G., Verlinde, C. L., & Michels, P. A. (2010). An internal sequence targets Trypanosoma brucei triosephosphate isomerase to glycosomes. Molecular and Biochemical Parasitology, 171(1), 45-49. https://doi.org/10.1016/j.molbiopara.2010.01.002

In kinetoplastid protists, glycolysis is compartmentalized in glycosomes, organelles belonging to the peroxisome family. The Trypanosoma brucei glycosomal enzyme triosephosphate isomerase (TPI) does not contain either of the two established peroxisom... Read More about An internal sequence targets Trypanosoma brucei triosephosphate isomerase to glycosomes.

Mitochondrial carrier family inventory of Trypanosoma brucei brucei: identification, expression and subcellular localisation (2009)
Journal Article
Colasante, C., Peña Diaz, P., Clayton, C., & Voncken, F. (2009). Mitochondrial carrier family inventory of Trypanosoma brucei brucei: identification, expression and subcellular localisation. Molecular and Biochemical Parasitology, 167(2), 104-117. https://doi.org/10.1016/j.molbiopara.2009.05.004

The mitochondrial carrier family (MCF) is a group of structurally conserved proteins that mediate the transport of a wide range of metabolic intermediates across the mitochondrial inner membrane. In this paper, an overview of the mitochondrial carrie... Read More about Mitochondrial carrier family inventory of Trypanosoma brucei brucei: identification, expression and subcellular localisation.