Interconvertible geometric isomers of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors exhibit multiple binding modes (2017)
Journal Article
McConkey, G. A., Bedingfield, P. T., Burrell, D. R., Chambers, N. C., Cunningham, F., Prior, T. J., …Boa, A. N. (2017). Interconvertible geometric isomers of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors exhibit multiple binding modes. Bioorganic and Medicinal Chemistry Letters, 27(16), 3878-3882. https://doi.org/10.1016/j.bmcl.2017.06.052

Two new tricyclic β-aminoacrylate derivatives (2e and 3e) have been found to be inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) with Ki 0.037 and 0.15 μM respectively. 1H and 13C NMR spectroscopic data show that these compo... Read More about Interconvertible geometric isomers of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors exhibit multiple binding modes.

Sulfonated sporopollenin as an efficient and recyclable heterogeneous catalyst for dehydration of D-xylose and xylan into furfural (2016)
Journal Article
Wang, Y., Len, T., Huang, Y., Diego Taboada, A., Boa, A. N., Ceballos, C., …Len, C. (2017). Sulfonated sporopollenin as an efficient and recyclable heterogeneous catalyst for dehydration of D-xylose and xylan into furfural. ACS Sustainable Chemistry and Engineering, 5(1), 392-398. https://doi.org/10.1021/acssuschemeng.6b01780

The natural acidity of sporopollenin, the biopolymer coating the outer walls of pollen grains, was enhanced by the sulfonation of its surface. Modified sporopollenin displaying sulfonic acid groups has been prepared, characterized by elemental analys... Read More about Sulfonated sporopollenin as an efficient and recyclable heterogeneous catalyst for dehydration of D-xylose and xylan into furfural.

The modulation of Transient Receptor Potential A1 channel by natural and novel semi-synthetic compounds via non-covalent modification (2016)
Thesis
Knaggs, J. D. (2016). The modulation of Transient Receptor Potential A1 channel by natural and novel semi-synthetic compounds via non-covalent modification. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4219218

Transient Receptor Potential A1 (TRPA1) is commonly known as the detector of a broad range of noxious chemical agents both exogenous and endogenous. TRPA1 detects these chemicals through a reversible covalent modification mechanism that allows most e... Read More about The modulation of Transient Receptor Potential A1 channel by natural and novel semi-synthetic compounds via non-covalent modification.

Sporopollenin, the least known yet toughest natural biopolymer (2015)
Journal Article
Mackenzie, G., Boa, A. N., Diego-Taboada, A., Atkin, S. L., & Sathyapalan, T. (2015). Sporopollenin, the least known yet toughest natural biopolymer. Frontiers in Materials, 2, 1-5. https://doi.org/10.3389/fmats.2015.00066

© 2015 Mackenzie, Boa, Diego-Taboada, Atkin and Sathyapalan. Sporopollenin is highly cross-linked polymer composed of carbon, hydrogen, and oxygen that is extraordinarily stable and has been found chemically intact in sedimentary rocks some 500 milli... Read More about Sporopollenin, the least known yet toughest natural biopolymer.

Synthesis of opiate derivatives : investigations into a key step from the manufacturing of buprenorphine and definitive preparation of degradation impurities related to naloxone (2015)
Thesis
Lovell, C. J. (2015). Synthesis of opiate derivatives : investigations into a key step from the manufacturing of buprenorphine and definitive preparation of degradation impurities related to naloxone. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4223288

The subject of this thesis is the synthesis and impurity profiling of semi-synthetic opiates, namely buprenorphine and naloxone. Opiates are a class of naturally occurring narcotic analgesic drugs produced from the opium poppy Papaver somniferum, in... Read More about Synthesis of opiate derivatives : investigations into a key step from the manufacturing of buprenorphine and definitive preparation of degradation impurities related to naloxone.

Sporopollenin as an efficient green support for covalent immobilization of a lipase (2015)
Journal Article
de Souza, S. P., Bassut, J., Marquez, H. V., Junior, I. I., Miranda, L. S. M., Huang, Y., …de Souza, R. O. M. A. (2015). Sporopollenin as an efficient green support for covalent immobilization of a lipase. Catalysis science & technology, 5(6), 3130-3136. https://doi.org/10.1039/c4cy01682c

Sporopollenin exine capsules (SECs), derived from the spores of Lycopodium clavatum, have been functionalised with 1,n-diamines and the resulting aminoalkyl microcapsules used to immobilize Candida antarctica lipase B (Cal B) via a glutaradehyde-base... Read More about Sporopollenin as an efficient green support for covalent immobilization of a lipase.

Novel applications of surface-modified sporopollenin exine capsules (2013)
Thesis
Huang, Y. (2013). Novel applications of surface-modified sporopollenin exine capsules. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4215614

The external shell (exine) of plant spores and pollen grains is composed of sporopollenin, which is an organic polymer renowned for its exceptional resistance to physical and chemical attack. The resilience of sporopollenin to high temperature, press... Read More about Novel applications of surface-modified sporopollenin exine capsules.

Protein free microcapsules obtained from plant spores as a model for drug delivery: Ibuprofen encapsulation, release and taste masking (2013)
Journal Article
Diego-Taboada, A., Maillet, L., Banoub, J. H., Lorch, M., Rigby, A. S., Boa, A. N., …Mackenzie, G. (2013). Protein free microcapsules obtained from plant spores as a model for drug delivery: Ibuprofen encapsulation, release and taste masking. Journal of Materials Chemistry B, 1(5), 707-713. https://doi.org/10.1039/c2tb00228k

Sporopollenin exine capsules (SEC) extracted from Lycopodium clavatum spores were shown to encapsulate ibuprofen as a drug model, with 97 ± 1% efficiency as measured by recovery of the loaded drug and absence of the drug on the SEC surface by scannin... Read More about Protein free microcapsules obtained from plant spores as a model for drug delivery: Ibuprofen encapsulation, release and taste masking.

Pharmacological comparison of novel synthetic fenamate analogues with econazole and 2-APB on the inhibition of TRPM2 channels (2012)
Journal Article
Chen, G., Zeng, B., Eastmond, S., Elsenussi, S. E., Boa, A. N., & Xu, S. (2012). Pharmacological comparison of novel synthetic fenamate analogues with econazole and 2-APB on the inhibition of TRPM2 channels. British Journal of Pharmacology, 167(6), 1232-1243. https://doi.org/10.1111/j.1476-5381.2012.02058.x

BACKGROUND: Fenamate analogues, econazole and 2-APB are inhibitors of TRPM2 channels, which have been used as research tools. However, these compounds have different chemical structures and therapeutic applications. Here we aimed to investigate the p... Read More about Pharmacological comparison of novel synthetic fenamate analogues with econazole and 2-APB on the inhibition of TRPM2 channels.

Sequestration of edible oil from emulsions using new single and double layered microcapsules from plant spores (2012)
Journal Article
Diego-Taboada, A., Cousson, P., Raynaud, E., Huang, Y., Lorch, M., Binks, B., …Mackenzie, G. (2012). Sequestration of edible oil from emulsions using new single and double layered microcapsules from plant spores. Journal of Materials Chemistry, 22(19), 9767-9773. https://doi.org/10.1039/c2jm00103a

Microcapsules were obtained conveniently from Lycopodium clavatum spores possessing either a single layered shell of sporopollenin (exine) or double layered shell of sporopollenin and cellulose with an inner layer (intine). These microcapsules were f... Read More about Sequestration of edible oil from emulsions using new single and double layered microcapsules from plant spores.