Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release (2022)
Journal Article
Diego-Taboada, A., Sathyapalan, T., Courts, F., Lorch, M., Almutairi, F., Burke, B. P., …Mackenzie, G. (2022). Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release. Journal of controlled release : official journal of the Controlled Release Society, 350, 244-255. https://doi.org/10.1016/j.jconrel.2022.08.017

Sporopollenin exine capsules (SpECs) are microcapsules derived from the outer shells (exines) of plant spore and pollen grains. This work reports the first clinical study on healthy volunteers to show enhanced bioavailability of vitamin D encapsulate... Read More about Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release.

Synthesis and analysis of small molecules to restrain the function of tissue factor within tumour cells (2021)
Journal Article
Adeniran, O. I., Mohammad, M. A., Featherby, S., Maraveyas, A., Boa, A. N., & Ettelaie, C. (2021). Synthesis and analysis of small molecules to restrain the function of tissue factor within tumour cells. Frontiers in Bioscience-Landmark, 26(10), 752-764. https://doi.org/10.52586/4985

Introduction: The restriction of prolyl-protein cis/trans isomerase 1 (Pin1) activity has been shown to prevent the release of tissue factor (TF) leading to the accumulation of the latter protein within the cell. This study tested the ability of nove... Read More about Synthesis and analysis of small molecules to restrain the function of tissue factor within tumour cells.

Sporopollenin : applications in water purification (2021)
Thesis
Meichanetzoglou, A. (2021). Sporopollenin : applications in water purification. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4223849

Water pollution from emerging contaminants is increasingly in the spotlight, as research on the impacts on the environment is revealing more about the dangers to both animals in the aquatic environment and human health. Pharmaceuticals, personal care... Read More about Sporopollenin : applications in water purification.

The Uptake of Sporopollenin Exine Capsules and Associated Bioavailability of Adsorbed Oestradiol in Selected Aquatic Invertebrates (2021)
Journal Article
Chapman, E., Meichanetzoglou, A., Boa, A. N., Hetjens, H., Faetsch, S., Teuchies, J., …Rotchell, J. M. (2021). The Uptake of Sporopollenin Exine Capsules and Associated Bioavailability of Adsorbed Oestradiol in Selected Aquatic Invertebrates. Bulletin of Environmental Contamination and Toxicology, 107, 876–882. https://doi.org/10.1007/s00128-021-03364-8

Lycopodium clavatum sporopollenin exine capsules (SpECs) are known to both adsorb and absorb chemicals. The aim of the present work was to determine whether oestradiol (E2) is ‘bioavailable’ to bioindicator species, either pre-adsorbed to, or in the... Read More about The Uptake of Sporopollenin Exine Capsules and Associated Bioavailability of Adsorbed Oestradiol in Selected Aquatic Invertebrates.

Recent advances in drug discovery for diabetic kidney disease (2020)
Journal Article
Danta, C. C., Boa, A. N., Bhandari, S., Sathyapalan, T., & Xu, S. Z. (in press). Recent advances in drug discovery for diabetic kidney disease. Expert Opinion on Drug Discovery, https://doi.org/10.1080/17460441.2021.1832077

Introduction: Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease (ESRD), and 40% of patients with diabetes develop DKD. Although some pathophysiological mechanisms and drug targets of DKD have been described, the effectivenes... Read More about Recent advances in drug discovery for diabetic kidney disease.

Sporopollenin exine capsules (SpECs) derived from Lycopodium clavatum provide practical antioxidant properties by retarding rancidification of an ω-3 oil (2020)
Journal Article
Thomasson, M. J., Diego-Taboada, A., Barrier, S., Martin-Guyout, J., Amedjou, E., Atkin, S. L., …Mackenzie, G. (2020). Sporopollenin exine capsules (SpECs) derived from Lycopodium clavatum provide practical antioxidant properties by retarding rancidification of an ω-3 oil. Industrial Crops and Products, 154, Article 112714. https://doi.org/10.1016/j.indcrop.2020.112714

In recent years the use of natural antioxidants in foodstuffs and personal care products has become increasingly important for consumers and therefore manufacturers. In this work, sporopollenin exine capsules (SpECs), extracted from spores of the com... Read More about Sporopollenin exine capsules (SpECs) derived from Lycopodium clavatum provide practical antioxidant properties by retarding rancidification of an ω-3 oil.

The role of whole genome sequencing in characterizing the mechanism of action of para-aminosalicylic acid and its resistance (2020)
Journal Article
Satta, G., Witney, A. A., Begum, N., Ortiz Canseco, J., Boa, A. N., & McHugh, T. D. (2020). The role of whole genome sequencing in characterizing the mechanism of action of para-aminosalicylic acid and its resistance. Antimicrobial agents and chemotherapy, 64(9), Article e00675-20. https://doi.org/10.1128/AAC.00675-20

Para-aminosalicylic acid (PAS) remains one of the drugs of last resort for the treatment of tuberculosis, but its mechanism of action is not completely understood yet. The main aim of this project was to identify new potential mechanisms of action an... Read More about The role of whole genome sequencing in characterizing the mechanism of action of para-aminosalicylic acid and its resistance.

Evaluation of small molecule inhibitors of Pin1 for their effects on tissue factor within tumour cells (2019)
Thesis
Adeniran, O. I. (2019). Evaluation of small molecule inhibitors of Pin1 for their effects on tissue factor within tumour cells. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4222358

Most standard anticancer drugs are non-selective in their cytotoxicity towards cancerous versus normal cells. Therefore, there is a need for the development of selective and targeted anticancer agents. Previous studies have reported upregulation of t... Read More about Evaluation of small molecule inhibitors of Pin1 for their effects on tissue factor within tumour cells.

Chemically modified sporopollenin as a solid support for heterogeneous catalysts (2019)
Thesis
Abimbade, S. F. (2019). Chemically modified sporopollenin as a solid support for heterogeneous catalysts. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4222418

Application of the principles of ‘Green Chemistry’ has been a focus in recent years in the synthesis of fine chemicals, and solid-phase catalysts are useful tools in that endeavour compared to stoichiometric reagents. Another important principle of ‘... Read More about Chemically modified sporopollenin as a solid support for heterogeneous catalysts.

N-cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites (2019)
Journal Article
Chandrabalan, A., McPhillie, M. J., Morice, A. H., Boa, A. N., & Sadofsky, L. R. (2019). N-cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites. European Journal of Medicinal Chemistry, 170, 141-156. https://doi.org/10.1016/j.ejmech.2019.02.074

The transient receptor potential ankyrin 1 (TRPA1) channel is a non-selective cation channel, which detects noxious stimuli leading to pain, itch and cough. However, the mechanism(s) of channel modulation by many of the known, non-reactive modulators... Read More about N-cinnamoylanthranilates as human TRPA1 modulators: Structure-activity relationships and channel binding sites.