Assessing the health economics of two home-based exercise programmes in obese adults Jun 1, 2018 - Dec 31, 2021
Obesity is a public health concern of epidemic proportions, increasing in prevalence across most demographics and increasingly younger ages (Ng et al., 2014) and is a risk factor for a myriad of other psychosocial, physiological, and musculoskeletal...
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All Projects (144)
ThrombiGlow: ‘Smart’ Multimodal Platelet Specific ‘Theranostic’ Drug Delivery Imaging Feb 1, 2017 - Jan 31, 2020
Cardiovascular diseases (CVD) including heart attacks and strokes constitute the leading cause of mortality in the UK. The pathology underlying CVD is called atherothrombosis and is a complex, multi-cellular-inflammatory disorder. Central to this is...
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Blood test for clinical therapy guidance of non-small cell lung cancer patients Jan 1, 2017 - Oct 31, 2022
Lung cancer is the most common cancer worldwide. NSCLC alone make up about 75% of all lung cancers and most hospitals currently test all NSCLC patients for EGFR mutations (pharmacogenomics) for treatment decision (personalised medicine) – i.e., patie...
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TRANSFORM: Reducing Inequalities in Cancer Outcomes in Yorkshire: Realising our potential for innovation in Diagnosis, Patient Management, Survivorship and Palliative Care Research Sep 1, 2017 - Dec 31, 2026
The death rate is higher in Yorkshire than the rest of England resulting in about 200 extra deaths each year of which more than half are in Hull. There are other significant cancer outcome inequalities between different groups; for example poorer pe...
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The role of bacteria in the skin: Cold atmospheric plasma for the treatment of pathological skin healing Apr 1, 2017 - Mar 31, 2020
Chronic wounds remain a major area of unmet clinical need, with infection a principle contributing factor to wound chronicity. This project builds upon strong preliminary data suggesting that healing outcome can be directly linked to both wound micro...
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Development and application of a multi-scale computational model of sarcoidosis to predict therapeutic approaches for non-self-resolving disease Jun 30, 2017 - Aug 31, 2020
An in silico computational model of sarcoidosis
MICA: The role of arginase in chronic delayed wound healing Aug 1, 2016 - Oct 17, 2017
FRAIL-HEART: Assessment of Frailty in Elderly People with Ischemic Heart Disease being considered for Revascularisation: An Observational study Apr 1, 2017 - Mar 31, 2020
To summarise the study, we will recruit patients aged 80 years or more who attend the cardiology and cardio-thoracic departments of Castle Hill Hospital, Hull and who have been given a diagnosis of coronary artery disease. The patients will be identi...
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The effect of corticosteroids on the release of immune modulating factors from Graves’ disease tissue maintained using microfluidic culture. Jun 1, 2017 - May 31, 2018
Graves’ disease (GD) affects approximately 2% of adult women. Current treatments for GD include anti-thyroid drugs, radioiodine therapy and surgery, of which none tackle the underlying pathogenic process. Immunosuppressive agents are therefore of gro...
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LIPS: A prospective registry-based cohort study to monitor the diagnosis and management of acute leukaemia in pregnancy Jun 1, 2018 - Feb 28, 2022
Acute leukaemia (AL) is an aggressive but potentially curable cancer that can affect women of childbearing age. When a pregnancy is complicated by a diagnosis of AL, clinicians face a complex dilemma: to balance risking the mother’s survival through...
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A study of the incorporation and release of tissue factor as cancer cell-derived microparticles. Aug 1, 2014 - Jul 31, 2017
CLL Research Jan 26, 2015 - Dec 31, 2028
Translational research project utilising prospective sample collection from patients attending the Haematology Clinic, Hull university Teaching Hospital Trust, to facilitate research within the University of Hull.
Can prevention of the activation of PAR2 prevent the release of procoagulant microvesicles from cancer cells, reduce the risk of VTE and contain the deterioration of the vasculature? Jul 1, 2015 - Jun 30, 2020
The study aims to demonstrate the indirect effect of Apixaban on suppressing the release of pro-inflammatory, pro-coagulant tissue factor-containing microvesicles, by inhibiting factor Xa and preventing the activation of PAR2. The study also demonstr...
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Development of a multipurpose small animal phantom for pre-clinical radiotherapy studies Apr 1, 2016 - Mar 31, 2019
The project aims to both reduce the total number of animals used for preclinical radiotherapy experiments whilst concurrently increasing the accuracy of such investigations in order to maximise their clinical impact. This will be achieved through the...
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Positron Emission Tomography research Mar 1, 2016 - Feb 28, 2017
The Hull-Norwich Gut-Brian Study May 31, 2016 - Jun 30, 2018
Objective To obtain mechanistic insights into how resident commensal gut bacteria (the microbiota) influences host physiology and in particular brain function and host behaviour. The focus is on identifying the pathways and molecules originating from...
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Development of Heavy Metal Free Quantum dot Lanthanide Conjugates for Sensing Aug 16, 2016 - Dec 31, 2018
The overall aim of this project to use innovative inorganic chemistry for the supramolecular self-assembly of novel heavy metal free nanocrystal (quantum dots) and lanthanide complexes to give multimodal contrast agents for molecular imaging. Key goa...
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Lab on a Chip NC3Rs Engagement Award Aug 15, 2016 - Aug 14, 2017
This project will deliver a programme of public engagement with innovative hands-on activities in the area of tissue/organ-on-a-chip which are emerging as life-like models to reduce and replace animal testing to school children and the general public...
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ISCHEMIA: Internation Study of Comparative Health Effectiveness with Medical and Invasive Approaches Apr 15, 2013 - Jun 30, 2019
Primary objective is to determine whether an invasive (INV) strategy of routine early cardiac catheterization with intent for optimal revascularization in addition to optimal medical therapy in patients with stable ischemic heart disease (SIHD) and a...
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