ThrombiGlow: ‘Smart’ Multimodal Platelet Specific ‘Theranostic’ Drug Delivery Imaging Feb 1, 2017 - Jan 31, 2020
Cardiovascular diseases (CVD) including heart attacks and strokes constitute the leading cause of mortality in the UK. The pathology underlying CVD is called atherothrombosis and is a complex, multi-cellular-inflammatory disorder. Central to this is...
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All Projects (151)
Blood test for clinical therapy guidance of non-small cell lung cancer patients Jan 1, 2017 - Oct 31, 2022
Lung cancer is the most common cancer worldwide. NSCLC alone make up about 75% of all lung cancers and most hospitals currently test all NSCLC patients for EGFR mutations (pharmacogenomics) for treatment decision (personalised medicine) – i.e., patie...
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The role of bacteria in the skin: Cold atmospheric plasma for the treatment of pathological skin healing Apr 1, 2017 - Mar 31, 2020
Chronic wounds remain a major area of unmet clinical need, with infection a principle contributing factor to wound chronicity. This project builds upon strong preliminary data suggesting that healing outcome can be directly linked to both wound micro...
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MICA: The role of arginase in chronic delayed wound healing Aug 1, 2016 - Oct 17, 2017
Translational Research in the Molecular Imaging Research Centre Aug 1, 2016 - Jul 31, 2018
The effect of corticosteroids on the release of immune modulating factors from Graves’ disease tissue maintained using microfluidic culture. Jun 1, 2017 - May 31, 2018
Graves’ disease (GD) affects approximately 2% of adult women. Current treatments for GD include anti-thyroid drugs, radioiodine therapy and surgery, of which none tackle the underlying pathogenic process. Immunosuppressive agents are therefore of gro...
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LIPS: A prospective registry-based cohort study to monitor the diagnosis and management of acute leukaemia in pregnancy Jun 1, 2018 - Feb 28, 2022
Acute leukaemia (AL) is an aggressive but potentially curable cancer that can affect women of childbearing age. When a pregnancy is complicated by a diagnosis of AL, clinicians face a complex dilemma: to balance risking the mother’s survival through...
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New technology to improve capability for clinical radiopharmaceutical production Jan 1, 2019 - Feb 28, 2022
Medical imaging techniques rely on radioactive atoms that don't last for a long time and so methods need to be developed to handle them on hospital sites or close by. Essentially this is drug factory near to the patient as the material is decaying al...
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EA Fisheries Framework Aug 1, 2009 - Mar 31, 2022
One of the major problems encountered at Environment Agency and Internal Drainage Board (IDB) pumping stations is the entrainment of fish and eels during pump operation. The extent of the problem and the proportion of fish and eels that are damaged o...
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A study of the incorporation and release of tissue factor as cancer cell-derived microparticles. Aug 1, 2014 - Jul 31, 2017
CLL Research Jan 26, 2015 - Dec 31, 2028
Translational research project utilising prospective sample collection from patients attending the Haematology Clinic, Hull university Teaching Hospital Trust, to facilitate research within the University of Hull.
Can prevention of the activation of PAR2 prevent the release of procoagulant microvesicles from cancer cells, reduce the risk of VTE and contain the deterioration of the vasculature? Jul 1, 2015 - Jun 30, 2020
The study aims to demonstrate the indirect effect of Apixaban on suppressing the release of pro-inflammatory, pro-coagulant tissue factor-containing microvesicles, by inhibiting factor Xa and preventing the activation of PAR2. The study also demonstr...
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Development of a multipurpose small animal phantom for pre-clinical radiotherapy studies Apr 1, 2016 - Mar 31, 2019
The project aims to both reduce the total number of animals used for preclinical radiotherapy experiments whilst concurrently increasing the accuracy of such investigations in order to maximise their clinical impact. This will be achieved through the...
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Positron Emission Tomography research Mar 1, 2016 - Feb 28, 2017
The Hull-Norwich Gut-Brian Study May 31, 2016 - Jun 30, 2018
Objective To obtain mechanistic insights into how resident commensal gut bacteria (the microbiota) influences host physiology and in particular brain function and host behaviour. The focus is on identifying the pathways and molecules originating from...
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Lab on a Chip NC3Rs Engagement Award Aug 15, 2016 - Aug 14, 2017
This project will deliver a programme of public engagement with innovative hands-on activities in the area of tissue/organ-on-a-chip which are emerging as life-like models to reduce and replace animal testing to school children and the general public...
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Training scientists to develop and Image materials for Tissue Engineering and Regenerative Medicine (iTERM) Oct 1, 2013 - Sep 30, 2017
With an increasingly aging population, new treatment solutions for diseased, defective, or damaged tissues need to be developed. Although human donor material would be preferable for these purposes, this is often not available and often associated wi...
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In vitro analysis of thyroid cancer and it's response to radiotherapy May 22, 2015 - May 21, 2018
Platelet cAMP signalling controls thrombosis through enhanced embolisation Oct 1, 2015 - Sep 30, 2018
The activation of protein kinase A (PKA) by prostacyclin inhibits platelet activation and therefore modulates arterial thrombosis. However, the role of PKA in controlling the stability of pre-existing thrombi is unclear. The stability of thrombi is r...
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