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Is late-life dependency increasing or not? A comparison of the Cognitive Function and Ageing Studies (CFAS) (2017)
Journal Article
Kingston, A., Wohland, P., Wittenberg, R., Robinson, L., Brayne, C., Matthews, F. E., & Jagger, C. (2017). Is late-life dependency increasing or not? A comparison of the Cognitive Function and Ageing Studies (CFAS). Lancet, 390(10103), 1676-1684. https://doi.org/10.1016/S0140-6736%2817%2931575-1

Background: Little is known about how dependency levels have changed between generational cohorts of older people. We estimated years lived in different care states at age 65 in 1991 and 2011 and new projections of future demand for care. Methods: Tw... Read More about Is late-life dependency increasing or not? A comparison of the Cognitive Function and Ageing Studies (CFAS).

Heart failure - what's new and what's changed? (2017)
Journal Article
Callan, P. D., & Clark, A. L. (2017). Heart failure - what's new and what's changed?. Clinical Medicine, 16(Suppl_6), s37-s42. https://doi.org/10.7861/clinmedicine.16-6-s37

Physicians responsible for the care of patients with heart failure due to left ventricular systolic dysfunction have access to a broad range of evidence-based treatments that prolong life and reduce symptoms. In spite of the significant progress made... Read More about Heart failure - what's new and what's changed?.

This patient is not breathing properly: is this COPD, heart failure, or neither? (2017)
Journal Article
Pellicori, P., Salekin, D., Pan, D., & Clark, A. L. (2017). This patient is not breathing properly: is this COPD, heart failure, or neither?. Expert Review of Cardiovascular Therapy, 15(5), 389-396. https://doi.org/10.1080/14779072.2017.1317592

© 2017 Informa UK Limited, trading as Taylor & Francis Group. Introduction: Heart failure (HF) and chronic obstructive pulmonary disease (COPD) are two common, heterogeneous, long-term illnesses which cause significant morbidity and mortality. Alth... Read More about This patient is not breathing properly: is this COPD, heart failure, or neither?.

Xanthine oxidase inhibition for the treatment of cardiovascular disease: an updated systematic review and meta-analysis (2016)
Journal Article
Zhang, J., Dierckx, R., Mohee, K., Clark, A. L., & Cleland, J. G. (2017). Xanthine oxidase inhibition for the treatment of cardiovascular disease: an updated systematic review and meta-analysis. ESC Heart Failure, 4(1), 40-45. https://doi.org/10.1002/ehf2.12112

Background Previous studies have shown that xanthine oxidase inhibitors (XOI) might improve outcome for patients with cardiovascular disease. However, more evidence is required. Methods and results We published a meta-analysis of trials conducted bef... Read More about Xanthine oxidase inhibition for the treatment of cardiovascular disease: an updated systematic review and meta-analysis.

The effect of aortic morphology on peri-operative mortality of ruptured abdominal aortic aneurysm (2015)
Journal Article
IMPROVE Trial Investigators. (2015). The effect of aortic morphology on peri-operative mortality of ruptured abdominal aortic aneurysm. European Heart Journal, 36(21), 1328-1334. https://doi.org/10.1093/eurheartj/ehu521

Aims To investigate whether aneurysm shape and extent, which indicate whether a patient with ruptured abdominal aortic aneurysm (rAAA) is eligible for endovascular repair (EVAR), influence the outcome of both EVAR and open surgical repair. Methods an... Read More about The effect of aortic morphology on peri-operative mortality of ruptured abdominal aortic aneurysm.

Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2 (2011)
Journal Article
Konopatskaya, O., Matthews, S. A., Harper, M. T., Gilio, K., Cosemans, J. M., Williams, C. M., …Poole, A. W. (2011). Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2. Blood, 118(2), 416-424. https://doi.org/10.1182/blood-2010-10-312199

Platelets are highly specialized blood cells critically involved in hemostasis and thrombosis. Members of the protein kinase C (PKC) family have established roles in regulating platelet function and thrombosis, but the molecular mechanisms are not cl... Read More about Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2.

PKCα regulates platelet granule secretion and thrombus formation in mice (2009)
Journal Article
Konopatskaya, O., Gilio, K., Harper, M. T., Zhao, Y., Cosemans, J. M. E. M., Karim, Z. A., …Poole, A. W. (2009). PKCα regulates platelet granule secretion and thrombus formation in mice. Journal of Clinical Investigation, 119(2), 399-407. https://doi.org/10.1172/JCI34665

Platelets are central players in atherothrombosis development in coronary artery disease. The PKC family provides important intracellular mechanisms for regulating platelet activity, and platelets express several members of this family, including the... Read More about PKCα regulates platelet granule secretion and thrombus formation in mice.